Effect of Ferula communis L. on reproductive parameters in Awassi ewes

PDF (English)
DOI: https://doi.org/10.12681/jhvms.21785
A.G. ONAL
Mustafa Kemal University Faculty of Agriculture, Hatay, Turkey
Resumen

Nutrient composition of the diet affects follicular activity, embryonic development and reproductive hormones in ruminants. The objective of the present study was to investigate the effects of Ferula communis L. on some reproductive parameters of Awassi sheep. The experiment was carried out on 29 (15-16 months old) Awassi ewes. All ewes were allocated to receive either a control (14% CP and 11.7 MJ ME/kg, n=9) or a diet supplemented with 5% (75g, n=10) or 10% (150g, n=10) powdered F. communis root, respectively for 21 days. Oestrus was synchronized using intravaginal sponges, while oestrus behaviour was observed 24, 36 and 48h after the sponge removal. Blood samples were collected for the assessment of oestradiol and LH. At the end of the 21-day period, animals were slaughtered and ovarian structures were recorded. Corpora lutea tissues were cultured in vitro, and progesterone production was measured. The results indicate that the treatment of animals with 5% of F. communis root increased the percentage of animals in heat (80%, 60% and 10% for 5C, 10C, and the control group, respectively). Furthermore, the number of small follicles (1-3 mm) in treated groups was significantly higher than those of the control group. Moreover, the number of large follicles (>4 mm) in the control group was higher than those of the treatment groups. Plasma concentration of oestrogen and LH peak were similar in the control and treatment groups. Progesterone production by luteal cells cultured in vitro was higher for both treatment groups compared to the control. Herewith, supplementation of the diet of Awassi Sheep with F. communis root during the breeding season may enhance ovulation rate and luteal activity. 

Article Details
  • Sección
  • Research Articles
Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Descargas
Los datos de descargas todavía no están disponibles.
Citas
Adams NR (1995) Detection of the effects of phytoestrogens on sheep and cattle. J Anim Sci. 73: 1509-1515.
Akaberi M, Iranshahy M, Iranshahi M (2015) Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis). Iran J Basic Med Sci. 18:1050-1062.
Appendino G, Cravotto G, Sterner O, Ballero M (2001) Oxygenated sesquiterpenoids from a nonpoisonous sardinian chemotype of giant fennel (Ferula communis). J Nat Prod. 64: 393-395.
Arispe SA, Adams B, Adams TE (2013) Effects of phytoestrogens on basal and GnRH-induced gonadotropin secretion. J Endocrinol. 3:243-250.
Billig H, Furuta I, Hsueh AJ (1993) Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Endocrinology. 133: 2204-2212.
Bindon BM, Adams NR, Piper LR (1982) Effects of oestrogenic pasture on luteinizing hormone levels and the response to GnRH in female lambs. Animal Reproduction Science. 5: 7-13.
Birdwhistell K, Basinger R, Hayes B, Norton N, Hurley DJ, Franklin SP (2017) Validation of commercial ELISAs for quantifying anabolic growth factors and cytokines in canine ACD-A anticoagulated plasma. J Vet Diagn Invest. 29:143-147.
Canogullari S, Baylan M, Copur G, Sahin A (2009). Effects of dietary Ferula elaeochytris root powder on the growth and reproductive performance of Japanese quail (Coturnix coturnix japonica): it is not recommended in a breeder diet. Arch. Geflügelk. 73:56-60.
Colborn T, Dumanoski D, Myers JP (1996). Our Stolen Future: Are We Threatening Our Fertility, Intelligence, and Survival? - a Scientific Detective Story. 1st ed, Little, Brown, pp 306.
Damewood MD, Bellantoni JJ, Bachorik PS, Kimball AW, Jr., Rock JA (1989) Exogenous estrogen effect on lipid/lipoprotein cholesterol in transsexual males. J Endocrinol Invest. 12: 449-454.
Findlay JW, Smith WC, Lee JW, Nordblom GD, Das I, DeSilva BS, Khan MN, Bowsher RR (2000) Validation of immunoassays for bioanalysis: a pharmaceutical industry perspective. J Pharm Biomed Anal. 21: 1249-1273.
Guan L, Yeung SY, Huang Y, Chen ZY (2006) Both soybean and kudzu phytoestrogens modify favorably the blood lipoprotein profile in ovariectomized and castrated hamsters. J Agric Food Chem. 54: 4907-4912.
Hadidi KA, Aburjai T, Battah AK (2003) A comparative study of Ferula hermonis root extracts and sildenafil on copulatory behaviour of male rats. Fitoterapia. 74: 242-246.
Ikeda K, Arao Y, Otsuka H, Nomoto S, Horiguchi H, Kato S, Kayama F (2002) Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta. Biochem Biophys Res Commun. 291: 354-360.
Kundu P, Patel S, Meling DD, Deal K, Gao L, Helferich WG, Flaws JA (2018) The effects of dietary levels of genistein on ovarian follicle number and gene expression. Reprod Toxicol. 81: 132-139.
Lamnaouer D (1999) Anticoagulant activity of coumarins from Ferula communis L. Therapie. 54: 747-751.
Manolakau S, Tzakou O, Yannitsaros A (2013) Volatile constituents of Ferula communis L. subsp. communis growing spontaneously in Greece. Rec. Nat. Prod. 7:54-58.
Oldham CM, Lindsay DR (1980) Laparoscopy in the ewe: A photographic record of the ovarian activity of ewes experiencing normal or abnormal oestrous cycles. Animal Reproduction Science. 3: 119-124.
Piotrowska E, Jakobkiewicz-Banecka J, Baranska S, Tylki-Szymanska A, Czartoryska B, Wegrzyn A, Wegrzyn G (2006) Genistein-mediated inhibition of glycosaminoglycan synthesis as a basis for gene expression-targeted isoflavone therapy for mucopolysaccharidoses. Eur J Hum Genet. 14: 846-852.
Prakash AO, Pathak S, Mathur R (1991) Postcoital contraceptive action in rats of a hexane extract of the aerial parts of Ferula jaeschkeana. J Ethnopharmacol. 34: 221-234.
Rahali FZ, Kefi S, Rebey IB, Hamdaoui G, Tabart J, Kevers C, Franck T, Mouithys-Mickalad A, Sellami IH (2018) Phytochemical composition and antioxidant activities of different aerial parts extracts of Ferula communis L. Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, DOI: 10.1080/11263504.2018.1461696
Raymer AM, Hoefling NA, Banz WJ, Winters TA (1999) Soy isoflavones: Effects on in situ apoptosis in swine ovarian granulosa cells. Proceedings of the Sixth World Soybean Research Conference, Global Soy Forum 99, Chicago, IL, Aug.7, pg. 686.
Rizzo A, Rocino MT, Binetti F, Sciorsci RL (2012) Roles of reactive oxygen species in female reproduction. Reprod. Dom. Anim. 47:344-352.
Robinson JJ (1996) Nutrition and reproduction. Animal Reproduction Science. 42: 25-34.
Sacchetti G, Appendino G, Ballero M, Loy C, Poli F (2003) Vittae fluorescence as a tool to differentiate between poisonous and non-poisonous populations of giant fennel (Ferula communis) of the island Sardinia (Italy). Biochemical Systematics and Ecology. 31: 527-534.
Scaramuzzi RJ, Adams NR, Baird DT, Campbell BK, Downing JA, Findlay JK, Henderson KM, Martin GB, McNatty KP, McNeilly AS, Tsonis CG (1993) A model for follicle selection and the determination of ovulation rate in the ewe. Reprod Fertil Dev. 5: 459-478.
Shah VP (2007) The history of bioanalytical method validation and regulation: Evolution of a guidance document on bioanalytical methods validation. AAPS J. 9: E43–E47.
Valentin MA, Ma S, Zhao A, Legay F, Avrameas A (2011) Validation of immunoassay for protein biomarkers: bioanalytical study plan implementation to support pre-clinical and clinical studies. J Pharm Biomed Anal. 55: 869-877.
Woclawek-Potocka I, Mannelli C, Boruszewska D, Kowalczyk-Zieba I, Wasniewski T, Skarzynski DJ (2013) Diverse effects of phytoestrogens ın the reproductive performance: Cow as a model. Int J Endocrinol. 2013: 1-15.
Yildiz S, Uzun M, Cenesiz M, Ucar O, Kaya M, Onder F (2002) Effect of Sexually Activated Rams or Ewes on Pulsatile LF Secretion in Anoestrous Sheep. Acta Veterineria Brno. 71: 297-302.
Zamaraeva MV, Hagelgans AI, Abramov AY, Ternovsky VI, Merzlyak PG, Tashmukhamedov BA, Saidkhodzjaev AI (1997) Ionophoretic properties of ferutinin. Cell Calcium. 22: 235-241.
Zanoli P, Zavatti M, Geminiani E, Corsi L, Baraldi M (2009) The phytoestrogen ferutinin affects female sexual behavior modulating ERalpha expression in the hypothalamus. Behav Brain Res. 199: 283-287.