HER-2 positivity rate in dogs with mammary carcinoma: a systematic review and meta-analysis

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DOI: https://doi.org/10.12681/jhvms.23639
Keywords:
HER-2 meta-analysis canine mammary tumor
E. UZABACI
Department of Biostatistics, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, Turkey
M.O. OZYIGIT
Department of Pathology, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, Turkey
I. ERCAN
Department of Biostatistics, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey
O. ARDA
Department of Pathology, Uludag University Institute of Health Sciences, Bursa, Turkey
Abstract

Human epidermal growth factor receptor 2 (HER-2) plays an essential role in cell growth and survival. HER-2 overexpression occurs in 20-30% of human breast tumors and has prognostic value as it is associated with disease progression. HER-2 overexpression is also associated with tumor progression and metastasis in malignant mammary tumors of the canine. However, in the literature, different positivity classifications/scoring were used in the evaluation of HER-2 status, and there is no consensus in terms of scoring of HER-2 expression

in canine mammary tumors. In this study, it was aimed to estimate the HER-2 positivity rate by evaluating the results of the study using different positivity classifications by meta-analysis. In this context, by using ”HER-2 canine mammary tumor” keywords, Pubmed and Web of Science electronic databases were scanned until February 2019, and a total of 97 related studies were found. However, 20 of these studies were used for the analysis. Two different meta-analyses were performed to evaluate the HER-2 positivity status with “2+ and 3+” and “3+” scores. As a result, HER-2 positivity rates were determined at 25.87% and 25.99% for the studies using “2+ / 3+” scores and “3+” respectively for HER-2 positivity. Therefore, this result suggests that the rate of HER-2 positivity is similar between humans and dogs.

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