The effect of Melissa officinalis on diet-induced hyperlipidemia, hypercholesterolemia, oxidative stress and inflammation

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Publicado: Jan 18, 2024
Actualizado: 2024-01-18
DOI: https://doi.org/10.12681/jhvms.30235
Ö Hazman
Department of Chemistry, Faculty of Science and Arts, Afyon Kocatepe University, Afyonkarahisar, Turkey
ME Göçeri
Ali Çağlar Anatolian High School, Afyonkarahisar, Turkey
I Fıçıcı
Ali Çağlar Anatolian High School, Afyonkarahisar, Turkey
B Demirer
Ali Çağlar Anatolian High School, Afyonkarahisar, Turkey
L Aksoy
Department of Chemistry, Faculty of Science and Arts, Afyon Kocatepe University, Afyonkarahisar, Turkey
Resumen

The Lamiaceae family is an essential medicinal plant family. Melissa officinalis L. is a well-known medicinal plant of Lamiaceae. It was aimed to investigate the effects of Melissa officinalis infusion given to rats with hyperlipidemia and hypercholesterolemia in this study. It is seen that the high-fat diet (HFD) group causes weight gain from the third week. VLDL, LDL, HDL and cholesterol levels were found statistically significant differences (p˂0.05), fed a cholesterol-enriched high-fat diet group (HFD) compared to the control. It is seen that the cholesterol level of the high-fat diet+Melissa officinalis infusion (HFD+MOI) group was statistically significantly (p˂0.05).  lower than the HFD group. In addition, the group in which Melissa officinalis was applied had positive effects on the antioxidant system and reduced the total oxidant system. The fact that the IFN-γ level of the HFD group was higher than the control indicates that the diet may have an inflammatory effect. As a result, HFD application with cholesterol caused hyperlipidemia and hypercholesterolemia in rats. The cholesterol-lowering effect of Melissa officinalis is observed. Remarkably, Melissa officinalis did not alter serum calcium levels while lowering cholesterol. In addition, it can said that HFD has a strengthening effect on the antioxidant system on oxidative stress.

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Ahmed OM, Moneim AA, Yazid IA, Mahmoud AM (2010) Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable
mechanisms of action of ruta graveolens infusion and rutin in nicotinamide-streptozotocin-induced diabetıc rats.Diabetol Croat 39: 15-35.
Aicha BB,Rouabhi R,Gasmi S, Bensouici C, Mohammedi H, Mennai I
(2020) LC-MS Analysis and Antioxidant Activity of the Hydro-Alcoholic Extract of Melissa officinalis L. from Algeria. ChemJ Mold
(2):78-87.
Arulselvan P, Fard MT, Tan WS, Gothai S, Fakurazi S, Norhaizan ME,
Kumar SS (2016)Role of antioxidants and natural products in inflammation. Oxid Med Cell Longev 2016: 5276130.
Bağdat RB, Coşge B (2006)The essential oil of lemon balm (Melissa
officinalis L.), its components and using fields. J Fac Agric 21(1):
-121.
Barros L, Dueñas M, Dias MI, Sousa MJ, Santos-Buelga C, Ferreira
ICFR(2013) Phenolicprofiles of cultivated, in vitro cultured andcommercial samples of Melissa officinalis L. infusions. Food Chem 136
(1): 1-8.
Başkal G, Köngül E, Karatoprak GŞ (2017)Traditional usage of Melissa
officinalis .J Health Sci26: 267-269
Bhardwaj SS, Chalasani N (2007) Lipid-lowering agents that cause
drug-induced hepatotoxicity. Clin Liver Dis11(3):597-613.
Bonovas S, Nikolopoulos G, Sitaras NM (2011) Efficacy and safety of
more intensive lowering of LDL cholesterol. Lancet26 (377): 715-
Capecka E, Mareczek A, Leja M (2004) Antioxidant activity of fresh and
dry herbs of some Lamiaceae species. Food Chem93: 223-226.
Carović-Stanko K, Petek M, Grdiša M, Pintar J, Bedeković D, Ćustić MH,
Satovic Z (2016)Medicinal plants of the family lamiaceae as functional foods - a Review. Czech J Food Sci34(5): 377-390.
Coussens LM, Werb Z (2002) Inflammation and cancer. Nature
(6917):860-867.
Das S, Choudhuri D (2020) Calcium supplementation shows a hepatoprotective effect against high-fat diet by regulating oxidative-induced
inflammatory response and lipogenesis activity in male rats. J Tradit
Complement Med 10(5): 511-519.
Ertaş FS (2009) Statins with a perspective of lifelong therapy. Arch Turk
Soc Cardiol 37 (2): 29-36.
Federico A, Morgillo F, Tuccillo C, Ciardiello F, Loguercio C (2007)
Chronic inflammation and oxidative stress in human carcinogenesis.
IntJ Cancer121(11):2381-2386.
Ferguson LR (2001) Role of plant polyphenols in genomic stability. Mut
Res 475: 89-111.
Gürbüz B, Bahtiyarca R, İpek A, Arslan Y, Akar T, Coşge B, Gümüşçü A,
Başalma D, Telli H (2008)An investigation on herb yield and some
features of selected lemon balm (Melissa officinalis L.) lines in Ankara Conditions.Mediterr Agric Sci21(1): 85-96
Hazman Ö, Aksoy L, Büyükben A (2016) Effects of crocin on experimental obesity and Type-2 diabetes. Turk J Med 46: 1593-1602.
Hohmann J, Zupkó I, Rédei D, Csányi M, Falkay G, Máthé I, Janicsák
G (1999) Protective effects of the aerial parts of Salvia officinalis,
Melissa officinalis and Lavandula angustifolia and their constituents
against enzyme-dependent and enzyme-independent lipid peroxidation. Planta Med 65(6): 576-578.
Jones P, Kafonek S, Laurora I, Hunninghake D (1998) Comparative dose
efficacy study of atorvastatin versus simvastatin, pravastatin, lo-vastatin, and fluvastatin in patients with hypercholesterolemia (the
CURVES study). Am J Cardiol 81:582-587.
Kızıl S (2009)The effect of different harvest stages on some agronomical
characteristics of Lemon Balm (Melissa officinalis L.). J Agric Sci
(1): 20-24.
Locksley RM, Killeen N, Lenardo MJ (2001) The TNF and TNF receptor
superfamilies: integrating mammalian biology. Cell 104(4): 487-501.
Malik VS, Willett WC, Hu FB (2013) Global obesity: trends, risk factors
and policy implications. Nat Rev Endocrinol 9: 13-27
Marques C, Meireles M, Norberto S, Leite J, Freitas J, Pestana D, Faria A,
Calhau C (2016) High-fat diet-induced obesity rat model: a comparison between Wistar and Sprague-Dawley rat. Adipocyte 5(1): 11-21.
Matos SL, de Paula H, Pedrosa ML, dos Santos RC, de Oliveira EL,
Chianca JDA, Silva ME (2005) Dietary models for inducing hypercholesterolemia in rats. BrazArch BiolTechnol48(2): 203-209.
Mulkens A,Kapetanidis I (1987)Flavonoides des feuilles de Melissa officinalis L. (Lamiaceae). Pharm Acta Helv 62(1):19-22.
Nieto G (2017) Biological activities of three essential oils of the Lamiaceae family. Medicines4(3): 63.
Nilsson C, Raun K, Yan FF, Larsen MO, Tang-Christensen M (2012) Laboratory animals as surrogate models of human obesity. Acta Pharmacol Sinica 33: 173-181.
O’Rourke RW, White AE, Metcalf MD, Winters BR, Diggs BS, Zhu X,
Marks DL (2012) Systemic inflammation and insulin sensitivity in
obese IFN-γ knockout mice. Metabolism 61(8): 1152-1161.
Ozarowski M, Mikolajczak PL, Piasecka A, Kachlicki P, Kujawski R, Bogacz A, Bartkowiak-WieczorekJ, SzulcM, KaminskaE, Kujawska M,
Jodynis-Liebert J, Gryszczynska A (2016) Influence of the Melissa
officinalis leaf extract on long-term memory inscopolamine animal
model with assessment of mechanism of action. Evid Based ComplementAlternat Complement Med2016:9729818.
Pacifico L, Di Renzo L, Anania C, Osborn JF, Ippoliti F, Schiavo E, Chiesa C (2006) Increased T-helper interferon-gamma-secreting cells in
obese children. Eur J Endocrinol154(5): 691-697.
Poyton RO, Ball KA, Castello PR (2009) Mitochondrial generation
of free radicals and hypoxic signaling. Trends Endocrinol Metab20(7):332-340.
Ravipati AS, Zhang L, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett
J, Smith PT, Shanmugam K, Münch G, Wu MJ, Satyanarayanan M,
Vysetti B (2012) Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant
content. BMC Complement Altern Med 12: 173
Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB (2010) Oxidative
stress, inflammation, and cancer: how are they linked? Free Radical
Biology and Medicine 49(11):1603-1616.
Rocha VZ, Folco EJ, Sukhova G, Shimizu K, Gotsman I, Vernon AH,
Libby P, 2008: Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res, 103(5):
- 476
Rosenson RS, Miller K, Bayliss M, Sanchez RJ, Baccara-Dinet MT,
Chibedi-De-Roche D, Taylor B, Khan I, Manvelian G, White M,
Jacobson TA (2017) The statin-associated muscle symptom clinical
index (SAMS-CI): Revision for clinical use, content validation, and
inter-rater reliability. Cardiovasc Drugs Ther 31:179-186.
Shakeria A, SahebkarA, Javadi B (2016)Melissa officinalis L. - A review
of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 188 (21): 204-228.
Tagashira M, Ohtake Y (1998) A new antioxidative 1,3 Benzodioxole
from Melissa officinalis . Planta Med 64: 555-558.
Zhang Z, Wen H, Peng B, Weng J, Zeng F. 2021, HFD-induced