Serum ascorbic acid and calcidiol status in dogs with graded periodontitis

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Publicado: janv. 15, 2025
DOI: https://doi.org/10.12681/jhvms.35300
R Azargoun
Department of internal medicine and clinical pathology, faculty of veterinary medicine, Urmia University, Urmia, Iran
S Asri-Rezaei
Professor, department of internal medicine and clinical pathology, faculty of veterinary medicine, Urmia university, Urmia, Iran
Resumen

The relationship between oral health and vitamins has recently attracted much attention from a dental perspective. In human dentistry, certain vitamins are well-known as the essential component in the preservation of periodontal tissue integrity and deficient conditions can predispose individuals to periodontitis. However, similar studies in veterinary medicine are scarce. The main objective of our study was an evaluation of serum levels of ascorbic acid and calcidiol in healthy dogs and those with periodontitis. Sixty healthy adult dogs were divided into 3 groups based on the depth of the periodontal pocket: periodontally healthy (pocket depth less than 2 mm), moderate periodontitis (pocket depth between 3 and 5 mm) and severe periodontitis (pocket depth more than 5 mm). Serum ascorbic acid levels in dogs with severe periodontitis were significantly lower than periodontally healthy dogs and those with moderate periodontitis (1.86±0.40, 3.93±0.84 and 3.52±0.66 respectively). Serum calcidiol levels in periodontally healthy dogs were significantly higher than groups with periodontitis (33.49±18.43, 18.08±10.05 and 13.81±6.87 respectively). The results of this research clarified that the grade of periodontitis, gingivitis and plaque indices and the age of dogs are inversely associated with the serum levels of ascorbic acid and calcidiol. It can be considered that maintaining adequate levels of serum ascorbic acid and calcidiol may be beneficial in preventing the progression of gingivitis to periodontitis and managing periodontitis in dogs. 

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Citas
Alizadeh K, Ahmadi S, Sarchahi AA, Mohri, M (2022) The effects of age,
sex, breed, diet, reproductive status and housing condition on the
amounts of 25 (OH) vitamin D in the serum of healthy dogs: Reference
values. Vet med sci 8(6):2360-2366.
Alzahrani AAH, Alharbi RA, Alzahrani MSA, Sindi MA, Shamlan G, Alzahrani
FA, Albanghali MA, Sindi AAA (2021) Association between
periodontitis and vitamin D status: A case-control study. Saudi J Biol
Sci 28(7):4016-4021.
Barbudo-Selmi GR, Carvalho MB, Selmi AL, Martins SEC (2004) Periodontal
disease characterization in dogs with normal renal function or
chronic renal failure. Ciencia Rural 34(1):113-118.
Bayirli BA, Öztürk A, Avci B (2020) Serum vitamin D concentration is associated
with antimicrobial peptide level in periodontal diseases. Arch
Oral Biol 117:104827.
Cagetti MG, Wolf TG, Tennert C, Camoni N, Lingström P, Campus G
(2020) The Role of Vitamins in Oral Health. A Systematic Review and
Meta-Analysis. Int J Environ Res Public Health 3;17(3):938.
Carreira LM, Dias D, Azevedo P (2015) Relationship between gender, age,
and weight and the serum ionized calcium variations in dog periodontal
disease evolution. Top Companion Anim Med 30(2):51-56.
Corbee RJ (2020) Vitamin D in Health and Disease in Dogs and Cats. Advances
in Small Animal Care 1(2):265-277.
Gallagher JC (2013) Vitamin D and aging. Endocrinol Metab Clin North
Am 42(2):319-332.
Gordon DS, Rudinsky AJ, Guillaumin J, Parker VJ, Creighton KJ (2020)
Vitamin C in Health and Disease: A Companion Animal Focus. Top
Companion Anim Med 39:100432.
Fitzgerald BP, Hawley CE, Harrold CQ, Garrett JS, Polson AM, Rams
TE (2022) Reproducibility of manual periodontal probing following
a comprehensive standardization and calibration training program. J
Oral Biol 8(1).
Harvey CE, Laster L, Shofer F, Miller B (2008) Scoring the full extent of
periodontal disease in the dog: development of a total mouth periodontal
score (TMPS) system. J Vet Dent 25(3):176-180.
Hennet P (2002) Effectiveness of a dental gel to reduce plaque in beagle
dogs. J Vet Dent 19(1):11-14.
Hesta M, Ottermans C, Krammer-Lukas S, Zentek J, Hellweg P, Buyse J,
Janssens GP (2009) The effect of vitamin C supplementation in healthy
dogs on antioxidative capacity and immune parameters. J Anim Physiol
Anim Nutr 93(1):26-34.
Hishiyama N, Kayanuma H, Matsui T, Yano H, Suganuma T, Funaba M,
Fujise H (2006) Plasma concentration of vitamin C in dogs with a portosystemic
shunt. Can J Vet Res 70(4):305-307.
Hu Z, Zhou F, Xu H (2022) Circulating vitamin C and D concentrations
and risk of dental caries and periodontitis: A Mendelian randomization
study. J Clin Periodontol 49(4):335-344.
Khan S, Ahad A (2021) Application of adjunct vitamin D supplementation
in the management of periodontal disease: A three-pronged approach. J
Dent Sci 16(1):534-535.
Kinane DF, Stathopoulou PG, Papapanou PN (2017) Periodontal diseases.
Nat Rev Dis Primers 3(1):1-14.
Kouki MI, Papadimitriou SA, Kazakos GM, Savas I, Bitchava D (2013)
Periodontal disease as a potential factor for systemic inflammatory response
in the dog. J Vet Dent 30(1):26-29.
Kyaw A (1978) A simple colorimetric method for ascorbic acid determination
in blood plasma. Clin Chim Acta 86(2):153-157.
Lee MR, Han SJ, Kim HE, Choi JS (2021) Relationship between Vitamin D
Deficiency and Periodontitis in Korean Adults Aged ≥60 Years: Analysis
of Data from the Korea National Health and Nutrition Examination
Survey (2013-2014). Int J Environ Res Public Health 15;18(8):4181.
Li W, Song J, Chen Z (2022) The association between dietary vitamin C
intake and periodontitis: result from the NHANES (2009-2014). BMC
Oral Health 8;22(1):390.
Lykkesfeldt J, Moos T (2005) Age-dependent change in Vitamin C status:
a phenomenon of maturation rather than of ageing. Mech Ageing Dev
(8):892-898.
O’Brien MA, McMichael MA, Le Boedec K (2018) 25-Hydroxyvitamin
D concentrations in dogs with naturally acquired blastomycosis. J Vet
Intern Med 32(5):1684-1691.
Özavci V, Erbas G, Parin U, Yüksel HT, Kirkan Ş (2019) Molecular detection
of feline and canine periodontal pathogens. Vet Anim Sci 8,100069.
Parker VJ, Rudinsky AJ, Chew DJ (2017) Vitamin D metabolism in canine
and feline medicine. J Am Vet Med Assoc 1;250(11):1259-1269.
Pavithra RS, Ramaprabha G, Rajasekar S, Lakshmi sree S (2017) Vitamin
Deficiency And Periodontal Disease - A Tie- in Relationship. Sch J App
Med Sci 5(1A):74-81.
Rawlinson JE, Goldstein RE, Reiter AM, Attwater DZ, Harvey CE (2011)
Association of periodontal disease with systemic health indices in dogs
and the systemic response to treatment of periodontal disease. J Am Vet
Med Assoc 1;238(5):601-609.
Rodriguez-Cortes A, Martori C, Martinez-Florez A, Clop A, Amills M,
Kubejko J, Llull J, Nadal JM, Alberola J (2017) Canine Leishmaniasis
Progression is Associated with Vitamin D Deficiency. Sci Rep
;7(1):3346.
Stella JL, Bauer AE, Croney CC (2018) A cross-sectional study to estimate
prevalence of periodontal disease in a population of dogs (Canis familiaris)
in commercial breeding facilities in Indiana and Illinois. PLoS
One 18;13(1):e0191395.
Tada A, Miura H (2019) The Relationship between Vitamin C and Periodontal
Diseases: A Systematic Review. Int J Environ Res Public
Health 11;16(14):2472.
Thatcher G (2020) Performing dental procedures in dogs and cats without
dental radiographs: Malpractice? Can Vet J 61(2):197-200.
Van der Velden U (2020) Vitamin C and Its Role in Periodontal Diseases -
The Past and the Present: A Narrative Review. Oral Health Prev Dent
(1):115-124.
Varela-López A, Navarro-Hortal MD, Giampieri F, Bullón P, Battino M,
Quiles JL (2018) Nutraceuticals in Periodontal Health: A Systematic
Review on the Role of Vitamins in Periodontal Health Maintenance.
Molecules 20;23(5):1226.
Waldron JL, Ashby HL, Cornes MP, Bechervaise J, Razavi C, Thomas OL,
Chugh S, Deshpande S, Ford C, Gama R (2013) Vitamin D: a negative
acute phase reactant. J Clin Pathol 66(7):620-622.
Wallis C, Holcombe LJ (2020) A review of the frequency and impact of
periodontal disease in dogs. J Small Anim Pract 61(9):529-540.
Weidner N, Verbrugghe A (2017) Current knowledge of vitamin D in dogs.
Crit Rev Food Sci Nutr 12;57(18):3850-3859.
Woelber JP, Bremer K, Vach K, König D, Hellwig E, Ratka-Krüger P,
Al-Ahmad A, Tennert C (2016) An oral health optimized diet can reduce
gingival and periodontal inflammation in humans - a randomized
controlled pilot study. BMC Oral Health 26;17(1):28.