Enzootic bovine leukosis accompanied by splenomegaly in an 8-month-old calf

PDF (English)
DOI : https://doi.org/10.12681/jhvms.22969
S. OKADA
Fukushima Prefecture Agricultural Mutual Aid Association, Fukushima, Japan
K. TAGAWA
Fukushima Prefecture Agricultural Mutual Aid Association, Fukushima, Japan
R. WADA
Fukushima Prefecture Agricultural Mutual Aid Association, Fukushima, Japan
Y. YAGUCHI
Northern Livestock Health Sanitation Center in Ibaraki Prefecture, Ibaraki, Japan
Y. KASHIMA
Northern Livestock Health Sanitation Center in Ibaraki Prefecture, Ibaraki, Japan
A. NISHIMORI
National Institute of Animal Health, National Agriculture and Food Research Organization, Ibaraki, Japan
Résumé

In this report, an 8-month-old calf (crossbred, Holstein × Japanese Black) developed fever and accompanied abomasum displacement. Blood chemical test showed remarkably high values of white blood cell count and heteromorphic lymphocytes. In pathological appraisal, enlarged splenomegaly and swelling of the lymph nodes were observed. Histopathological examination revealed invasion of tumor cells derived from B1 cells into systemic lymph nodes, liver and spleen. The provirus loads of bovine leukemia virus (BLV) was 1,439 copies per 10 ng DNA by using real time PCR. In conclusion, this case was diagnosed as bovine leukemia caused by BLV infection with a huge splenomegaly.

Article Details
  • Rubrique
  • Case Report
Creative Commons License

Ce travail est disponible sous licence Creative Commons Attribution - Pas d’Utilisation Commerciale 4.0 International.

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Téléchargements
Les données relatives au téléchargement ne sont pas encore disponibles.
Références
Agresti A, Ponti W, Rocchi M., (1993) Use of polymerase chain reaction to diagnose bovine leukemia virus infection in calves at birth. Am j vet res, 54 (3) 373-378.
Burton AJ, Nydam DV, Long ED, Divers TJ, (2010) Signalment and clinical complaints initiating hospital admission, methods of diagnosis, and pathological findings associated with bovine lymphosarcoma (112 cases). J Vet Intern Med 24, 960.
Da,Y. Shanks RD, Stewart JA, Lewin HA, (1993) Milk and fat yields decline in bovine leukemia virus-infected Holstein cattle with persistent lymphocytosis. Proc. Natl. Acad. Sci. USA. 90, 6538-6541.
Emanuelson U, Scherling K, Pettersson H, (1992) Relationships between herd bovine leukemia virus infection status and reproduction, disease incidence, and productivity in Swedish dairy herds. Prev Vet Med, 12 (1-2), 121-131.
Fatihu MY, Adamu S, Umar IA, Ibrahim ND, Eduvie LO, Esievo KA, (2008) Studies on effects of lactose on experimental Trypanosoma vivax infection in Zebu cattle. 1. Plasma kinetics of intravenously administered lactose at onset of infection and pathology. Onderstepoort J Vet Res. Jun; 75 (2), 163-72.
Ferrer JF, Piper CE, Abt DA, Marshak RR, Bhatt DM. (1975) Natural mode of transmission of the bovine C type leukemia virus (BLV). Bibl. Haematol. 43,235-237.
Gutiérrez G, Rodríguez SM, de Brogniez A, Gillet N, Golime R, Burny A, Jaworski JP, Alvarez I, Vagnoni L, Trono K, Willems L, (2014) Vaccination against δ-retroviru ses: the bovine leukemia virus paradigm. Viruses. 6 (6), 2416-27.
Jaswal H, Bal MS, Singla LD, Gupta K, Brar AP. (2015) Pathological observations on clinical Anaplasma marginale infection in cattle. J Parasit Dis. Sep; 39 (3), 495-8.
Kettmann, R. (1994) Bovine leukemia virus. In: The Retroviridae Vol. 3, NewYork, Plenum Press, pp.39~81.
Matsuda K, Nomoto H, Kawamura Y, Someya Y, Koiwa M, Taniyama H. (2010) Hemophagocytic histiocytic sarcoma in a Japanese black cow. Vet Pathol. Mar;47(2):339-42.
Mekata H, Sekiguchi S, Konnai S, Kirino Y, Honkawa K, Nonaka N, Horii Y, Norimine J, (2015) Evaluation of the natural perinatal transmission of bovine leukaemia virus. Vet Rec. 176 (10), 254.
Murakami K, Kobayashi S, Konishi M, Kameyama K, Tsutsui T. (2013) Nationwide survey of bovine leukemia virus infection among dairy and beef breeding cattle in Japan from 2009-2011, J Vet Med Sci, 75, 1123-1126.
Nishimori A, Konnai S, Okagawa T, Maekawa N, Goto S, Ikebuchi R, Nakahara A, Chiba Y, Ikeda M, Murata S, Ohashi K. (2017) Identification of an Atypical Enzootic Bovine Leukosis in Japan by Using a Novel Classification of Bovine Leukemia Based on Immunophenotypic Analysis. Clin Vaccine Immunol. Sep 5 ; 24 (9).
Oguma K, Suzuki M, Sentsui H, (2017) Enzootic bovine leukosis in a two-month-old calf, Virus Res, 233:120-124.
Rodríguez SM, Florins A, Gillet N, de Brogniez A, Sánchez-Alcaraz MT, Boxus M, Boulanger F, Gutiérrez G, Trono K, Alvarez I, Vagnoni L, Willems L. (2011) Preventive and therapeutic strategies for bovine leukemia virus: lessons for HTLV. Viruses. 3,1210-1248.
Sagata N, Yasunaga T, Tsuzuku-Kawamura J, Ohishi K, Ogawa Y, Ikawa Y. (1985) Complete nucleotide sequence of 64 genome of bovine leukemia virus: its evolutionary relationship to other retroviruses. Proc. Natl. Acad. Sci. USA. 82, 677-681.
Schwartz I, Lévy D, (1994) Pathobiology of bovine leukemia virus, Vet Res, 25, 521-536.
Soumura Y, Akase S, Kurono H, Murakami K, (2007) Investigation of Bovine Leukemia Diagnosis by Real Time PCR. Journal of the veterinary medicine, 60 (12), 1005-1012.
Vernau W, Jacobs RM, Valli VE, Heeney JL. (1997) The immunophenotypic characterization of bovine lymphomas. Vet Pathol 34:222.