Assessment for the passage of tylosin into the milk of Anatolian buffaloes

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DOI: https://doi.org/10.12681/jhvms.28502
U ACAROZ
Afyon Kocatepe University, Veterinary Faculty, Department of Food Hygiene and Technology, Afyonkarahisar, Turkey
I KUCUKKURT
Afyon Kocatepe University, Veterinary Faculty, Department of Biochemistry, Afyonkarahisar, Turkey
S INCE
Afyon Kocatepe University, Veterinary Faculty, Department of Pharmacology and Toxicology, Afyonkarahisar, Turkey
D ARSLAN-ACAROZ
Afyon Kocatepe University, Bayat Vocational School, Bayat, Turkey
Z GURLER
Afyon Kocatepe University, Veterinary Faculty, Department of Food Hygiene and Technology, Afyonkarahisar, Turkey
A ERYAVUZ
Afyon Kocatepe University, Veterinary Faculty, Department of Physiology, Afyonkarahisar, Turkey
Abstract

Tylosin is a broad-spectrum macrolide antibiotic commonly employed in veterinary medicine to treat bacterial infections. The present study assessed the milk-passage patterns of tylosin up to the 16th milking after a single intramuscular injection at the dose of 10 mg/kg/b.w. to Anatolian buffaloes. The residue levels of tylosin in milk samples of each animal were analysed by LC-MS/MS. The detection and determination limits of the employed method were 0.19 μg/kg and 0.64 μg/kg, respectively. The highest level of tylosin was found to be at the second milking. At the ninth milking, tylosin residue level decreased under the maximum residue limit of 50 μg/kg. Additionally, the employed LC-MS/MS method is used to assess tylosin residue in 40 milk samples and all of the samples were found to be tylosin free. In conclusion, this study determined the milk passaged levels of tylosin into milk of Anatolian buffaloes using an LC-MS/MS method.

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Riferimenti bibliografici
Acaroz U, Arslan-acaroz D, Ince S (2019) A Wide Perspective on Nutrients in Beverages. In: Grumezescu AM and Holban AM (Ed) Nutrients in Beverages. Academic Press: pp 1-39.
Acaroz U, Ince S, Arslan-Acaroz D, Kucukkurt I, Eryavuz A (2020) Determination of kanamycin residue in anatolian buffalo milk by LCMS/MS. Kafkas Univ Vet Fak Derg 26: 97-102.
Aguilera-Luiz MM, Vidal JLM, Romero-González R, Frenich AG (2008) Multi-residue determination of veterinary drugs in milk by ultra-high-pressure liquid chromatography-tandem mass spectrometry. J Chromatogr A 1205: 10-16.
Al-Wabel NA (2008) The pharmacokinetics and milk residual behaviour of tylosin in lactating Najdi ewes. Iran J Vet Res 9: 138-143.
Avci T, Elmas M (2014) Milk and blood pharmacokinetics of Tylosin and Tilmicosin following parenteral administrations to cows. Sci World J 2014: 869096.
Bogialli S, Di Corcia A, Laganà A, Mastrantoni V, Sergi M (2007) A simple and rapid confirmatory assay for analyzing antibiotic residues of the macrolide class and lincomycin in bovine milk and yoghurt: hot water extraction followed by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 21: 237-246.
Burkin M, Galvidis I (2012) Simultaneous separate and group determination of tylosin and tilmicosin in foodstuffs using single antibody-based immunoassay. Food Chem 132: 1080-1086.
Cháfer-Pericás C, Maquieira Á, Puchades R (2010) Fast screening methods to detect antibiotic residues in food samples. TrAC - Trends Anal Chem 29: 1038-1049.
Draisci R, Palleschi L, Ferretti E, Achene L, Cecilia A (2001) Confirmatory method for macrolide residues in bovine tissues by micro-liquid chromatography-tandem mass spectrometry. J Chromatogr A 926:97-104.
Dubois M, Fluchard D, Sior E, Delahaut P (2001) Identification and quantification of five macrolide antibiotics in several tissues, eggs and milk by liquid chromatography-electrospray tandem mass spectrometry. J. Chromatogr. B Biomed Sci Appl 753: 189-202.
Dudriková E, Jozef S, Jozef N (1999) Liquid chromatographic determination of tylosin in mastitic cow’s milk following therapy. J AOAC Int 82: 1303-1307.
EU No37/2010, n.d. COMMISSION REGULATION (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin.
Fan H, Li L, Wijlaars L, Gilbert RE (2019) Associations between use of macrolide antibiotics during pregnancy and adverse child outcomes: A systematic review and meta-analysis. PLoS One 14: 1-14.
Graham F, Paradis L, Bégin P, Paradis J, Babin Y, Des Roches A (2014) Risk of allergic reaction and sensitization to antibiotics in foods. Ann Allergy, Asthma Immunol 113: 329-330.
Le T, Zhu L, Yang X (2015) A quantum dot-based immunoassay for screening of tylosin and tilmicosin in edible animal tissues. Food Addit Contam - Part A Chem Anal Control Expo Risk Assess 32: 719-724.
Pasquini M, Osimani A, Tavoletti S, Moreno I, Clementi F, Trombetta MF (2018) Trends in the quality and hygiene parameters of bulk Italian Mediterranean buffalo (Bubalus bubalis) milk: A three year study. Anim Sci J 89: 176-185.
Quintanilla P, Beltrán MC, Peris B, Rodríguez M, Molina MP (2018) Antibiotic residues in milk and cheeses after the off-label use of macrolides in dairy goats. Small Rumin Res 167: 55-60.
Rigos G, Nengas I, Tyrpenou AE, Alexis M, Troisi GM (2003) Pharmacokinetics and bioavailability of oxytetracycline in gilthead sea bream (Sparus aurata) after a single dose. Aquaculture 221: 75-83.
Şanli S, Palabiyik IM, Şanli N, Guzel-Seydim ZB, Alsancak G (2011) Optimization of the experimental conditions for macrolide antibiotics in high performance liquid chromatography by using response surface methodology and determination of tylosin in milk samples. J Anal Chem 66: 838-847.
Sugawara A, Maruyama H, Shibusawa S, Matsui H, Hirose T, Tsutsui A, Froyman R, Ludwig C, Koebberling J, Hanaki H, Kleefeld G, Omura S, Sunazuka T (2017) 5-O-Mycaminosyltylonolide antibacterial derivatives: Design, synthesis and bioactivity J Antibiot (Tokyo) 70:878-887.
Vishnuraj MR, Kandeepan G, Rao KH, Chand S, Kumbhar V (2016) Occurrence, public health hazards and detection methods of antibiotic residues in foods of animal origin: A comprehensive review. Cogent Food Agric 2: 1235458.
Wang J, Leung D, (2007) Analyses of macrolide antibiotic residues in eggs, raw milk, and honey using both ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry and high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 21: 3213-3222.
Wang J, Leung D, Lenz SP (2006) Determination of five macrolide antibiotic residues in raw milk using liquid chromatography-electrospray ionization tandem mass spectrometry. J. Agric Food Chem 54: 2873-2880.
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