Granulosa Cell Tumor In A Spayed Young Queen

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DOI: https://doi.org/10.12681/jhvms.18022
Z. GÜNAY UÇMAK
Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine
M. UÇMAK
Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University
Ç. TEK
Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Istanbul University
L. KOENHEMSI
Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University
Ö. ERDOGAN BAMAÇ
Department of Pathology, Faculty of Veterinary Medicine, Istanbul University
A. GÜREL
Department of Pathology, Faculty of Veterinary Medicine, Istanbul University
E. YILDAR
Institute of Health Sciences, Istanbul University
Аннотация

A four years old cat was presented to Clinic of Obstetrics and Gynaecology with complaints of weakness, inappetency, vomiting and estrus signs although it was spayed. Blood tests, radiography and ultrasonography revealed abdominal mass and uterine stump which were then removed surgically. Multilobular mass was defined as solid granulosa cell tumor (GCT). Increase of estrogen (E2) and insulin-like growth factor-1 (IGF-1) values were detected on the 10th postoperative day. On the 40th postoperative day, the cat was brought to Internal Medicine Clinic with the complaints of weakness, inappetency and cachexia. Anemia, leucocytosis, uremia, hyperglycemia, sensitiveness and pain in the right abdomen were determined. A tumor was detected in the liver by radiography and ultrasonography and was suspected to be GCT metastasis. Despite medical therapy, the cat died after four months. In conclusion; retained ovarian tissue after erroneous ovariohysterectomy may cause, regular estrus signs and GCT development. Even if GCTs are removed by surgical approach, they have metastatic potential that deteriorates the prognosis. Evaluating IGF-1 and E2 in the short postoperative term are beneficial for determining the metastatic potential of GCTs.

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  • Case Report
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Библиографические ссылки
Ball RL, Birchard SJ, May JR, Threlfall WR, Young GS (2010) Ovarian remnant syndrome in dogs and cats: 21 cases (2000-2007). J Am Vet Med Assoc 236:548-553.
Boormann EV (2002) Granulosa cell tumors. In: Proceedings ofUCLA Health Care 6:1-6. http://www.med.ucla.edu/modules/xfsection/article.php?articleid=177
Buijtels JJCWM, De Gier J, Kooistra HS, Veldhuıs Kroeze EJB, Okkens AC (2010) Alterations of the pituitary-ovarian axis in dogs with a functional granulosa cell tumor. Theriogenology 73:11-19.
Fontbonne A, Levy X, Fontaine E, Gilson C (2007) Guide pratique de reproduction clinique canine et feline. Med’com. Gelberg HB, Mc Entee K (1985) Feline ovarian neoplasms. Vet Pathol 22:572-576.
Giacoia MR, Maiorka PC, Oliveira CM, Sinhorini IL, Daglı MLZ (1999) Granulosa cell tumour with metastasis in a cat. Braz J Vet Res Anim Sci 36(5).
Gündüz MC, Kaşıkçı G, Kılıçarslan MR, Uçmak M, Düzgün O, Tek Ç (2010) Reproductive performance following unilateral ovariectomy for treatment of ovarian tumors in 7 mares. Turk J Vet Anim Sci 34(3):283-287.
Hayes A, Harvey HJ (1979) Treatment of metastatic granulosa cell tumor in a dog. JAVMA 174(12):1304-1306.
Holzworth J (1987) Tumours of the female reproductive system In: Diseases of the cat: medicine and surgery. 1st. ed., W.B. Saunders, Philadelphia: pp 520-521.
Maden M, Çuhadar F (2013) Kedi ve köpeklerde endokrin hastalıkların laboratuvar tanısı. Türkiye Klinikleri J Vet Sci 4(3):35-60.
Nielsen SW, Kennedy PC (1990) Tumours of the genital systems In: Tumours in domestic animals. 3rd. ed., Berkeley University of California Press, California: pp 458-475.
Noakes D. (2009). Endogenous and exogenous control of ovarian cyclicity In: Veterinary reproduction and obstetrics. 9th ed., Pa: Saunders, Philadelphia: pp 6-9.
Shanbhogue AKP, Shanbhogue DKP, Prasad SR, Surabhi VR, Fasih N, Menias CO (2010) Clinical Syndromes Associated with Ovarian Neoplasms: A Comprehensive Review. RadioGraphics 30(4): 903-919.
Shille VM, Lundström KE, Stabenfeldt GH (1979) Follicular function in domestic cat as determined by estradiol-17β concentrations in plasma: relation to estrous behaviour and cornification of exfoliated vaginal epithelium. Biology of Reproduction 23:953-963.
Spicer LJ, Echternkamp SE (1995) The ovarian insulin and insulin-like growth factor system with an emphasis on domestic animals. Domestic Animal Endocrinology 12: 223-245.
Spoor MS, Flesner BK, Trzil JE, Whitney MS, Shaw DP, Selting KA (2014) What is your diagnosis? Intra-abdominal mass in female spayed dog. Vet Clin Pathol 43(1): 109-110.