The Potential Role of Probiotics (nutraceuticals) in Gut Health of Domestic Animals; an Alternative to Antibiotic Growth Promoters


A. NAWAB
W. LIU
G. LI
F. IBTISHAM
D P. FOX
Y. ZHAO
J. WO
M. XIAO
Y. NAWAB
L. AN
Аннотация

The term gut health is currently becoming more important for domestic animals including poultry. Gut health refers to the fundamental organ system which covers multiple positive functions like effective digestion, stabilizing intestinal microbiota, gut pH and modulation of effective immune response. Gut health depends on proper balance of microbial population. A wide range of feed and pathogen associated factors influence this balance, and adversely affect the animal health status and production performance. Antibiotic stimulators have been used in farm animals to achieve maximum production. But drug resistance and residual effects of antibiotics in animal products (milk, meat and egg etc.) have raised serious issues in human life. Therefore, The European Union (EU) has strictly banned the application of antibiotic stimulators in livestock nutrition in several others countries including China. As a result, an alternative to antibiotic growth promoters are required to support the profitable and sustainable animal production system. Probiotics as nutraceuticals has been categorized as an alternative natural feed supplement for commercial utilization. Such products have been recognized as safe feed additives in animal industry. Very few studies have comparatively described the effect of probiotics on gut health of domestic animals. Therefore, the aim of this review is not only to explore the beneficial effects of probiotics in improving gut health of domestic animals as an alternative to antibiotic growth promoters, but also to evaluate the probiotics associated health and risk factors, and to provide comprehensive scientific information for researchers, scientists and commercial producers.

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Aattour N, Mohammed B, Daniel T, Ascension M, Daniel L (2002) Oral Ingestion of Lactic-Acid Bacteria by Rats IncreasesLymphocyte Proliferation and Interferon-Gamma Production. British J Nut 87: 367–373.
El-Ghani AA (2004) Influence of Diet Supplementation with Yeast Culture (Saccharomyces Cerevisiae) on Performance of Zaraibi Goats. Small Ruminant Res 52: 223–329.
El-Tawab MMA, Youssef IMI, Bakr HA, Fthenakis GC, Giadinis ND (2016) Role of Probiotics in Nutrition and Health of Small Ruminants. J Vet Sci 19: 893–906.
Afsharmanesh M, Sadaghi B (2014) Effects of Dietary Alternatives (Probiotic, Green Tea Powder , and Kombucha Tea) as Antimicrobial Growth Promoters on Growth , Ileal Nutrient Digestibility, Blood Parameters, and Immune Response of Broiler Chickens. Comparative Clinical Pathol 23: 717–724.
Alakomi H, Saarela M, Helander IM (2003) Effect of EDTA onSalmonella Enterica Serovar Typhimurium Involves aComponent Not Assignable to Lipopolysaccharide Release. Microbiol 149: 2015–2021.
Al-Saiady MY (2012) Effect of Probiotic Bacteria on Immunoglobulin G Concentration and Other Blood Components of Newborn Calves. J Anim Vet Adv 9: 604-609.
Alugongo GM, Jianxin X, Zhaohai W, Shengli L, Yajing W, ZhijunC (2017) Review: Utilization of Yeast of Saccharomyces Cerevisiae Origin in Artificially Raised Calves. J Anim Sci Biotechnol 8: 2–12.
Apata DF (2008) Growth Performance, Nutrient Digestibility andImmune Response of Broiler Chicks Fed Diets Supplemented with a Culture of Lactobacillus Bulgaricus. J Sci Food Agricul 88: 1253–1258.
Arcos-Garcıia JL, Castrejon FA, Mendoza GD, Perez-Gavilan EP (2000) Effect of Two Commercial Yeast Cultures with Saccharomyces Cerevisiae on Ruminal Fermentation and Digestion in Sheep Fed Sugar Cane Tops. Livestock Product Sci 63: 153–157.
Azevedo MSP, Zhang W, Wen K, Gonzalez AM, Saif LJ, Yousef AE, Yuan L (2012) Lactobacillus Acidophilus and L. Reuteri Modulate Cytokine Responses in Gnotobiotic Pigs Infected with Human Rotavirus. Benef Microbes 3: 33–42.
Azizpour K, Bahrambeygi S, Mahmoodpour S, Azizpour A (2009) History and Basic of Probiotics. Res J Bio Sci 4: 409-426.
Azzaz HH, Kholif AM, Murad HA, Hanfy MA, Gawad MHA (2012) Utilization of Cellulolytic Enzymes to Improve the Nutritive Value of Banana Wastes and Performance of Lactating Goats. Asian J Animal Vet Advances 8: 664-674.
Azzaz HH, Ebeid HM, Morsy TA, Kholif SM (2015) Impact of Feeding Yeast Culture or Yeast Culture and Propionibacteria 169 on the Productive Performance of Lactating Buffaloes. Int J Dairy Science 10: 107–116.
Bahari M (2017) A Review on the Consumption of Probiotics in Feeding Young Ruminants. Appro Poult Dairy Vet Sci 1: 1–3.
Bajagai YS, Klieve AV, Dart PJ, Bryden WL (2016) Probiotics inAnimal Nutrition– Production, Impact and Regulation. FAO animal production and health 24: 1-89. Rome, Italy.
Balevi T, Uçan US, Coşun B, Kurtoğu V, çetingül İS (2001) Effect of Dietary Probiotic on Performance and Humoral ImmuneResponse in Layer Hens. British Poult Sci 42: 456–461.
Bayatkouhsar J, Tahmasebi AM, Naserian AA, Mokarram RR, Valizadeh R (2013) Effects of Supplementation of Lactic Acid Bacteria on Growth Performance, Blood Metabolites and Fecal Coliform and Lactobacilli of Young Dairy Calves. Am Feed Science Technol 186: 1–11.
Bermudez-Brito M, Plaza-Diaz J, Munoz-Quezada S, Gomez-Llorente C, Gil A (2012) Probiotic Mechanisms of Action. Ann Nutr Metab 61: 160–174.
Bhandari SK, Opapeju FO, Krause DO, Nyachoti CM (2010) Dietary Protein Level and Probiotic Supplementation Effects on Piglet Response to Escherichia Coli K88 Challenge: Performance and Gut Microbial Population. Livestock Sci 133: 185–188.
Biloni A, Quintana CF, Menconi A, Kallapura G, Latorre J, Pixley C, Layton S, et al., (2013) Evaluation of Effects of Early Bird Associated with FloraMax-B11 on Salmonella Enteritidis, Intestinal Morphology, and Performance of Broiler Chickens. Poult Sci 92: 2337–2346.
Binek M (2016) Assessment of Potentially Probiotic Properties of Lactobacillus Strains Isolated from Chickens. Polish J Vet Sci 19: 15–20.
Le Bon M, Davies HE, Glynn C, Thompson C, Madden M, Wiseman J, Dodd CER, et al. (2010) Influence of Probiotics on Gut Health in the Weaned Pig. Livestock Sci 133: 179–181.
Brisbin JT, Gong J, Parvizi P, Sharif S (2010) Effects of Lactobacilli on Cytokine Expression by Chicken Spleen and Cecal Tonsil Cells. Clinical Vaccine Immunol 17: 1337–1343.
Butaye P, Devriese LA, Haesebrouck F (2003) Antimicrobial Growth Promoters Used in Animal Feed : Effects of Less Well Known Antibiotics on Gram-Positive Bacteria. Clin Microbiol Rev 16:175–188.
Cao GT, Zeng XF, Chen AG, Zhou L, Zhang L, Xiao YP, Yang CM (2013) Effects of a Probiotic, Enterococcus Faecium, on Growth Performance, Intestinal Morphology, Immune Response, and Cecal Microflora in Broiler Chickens Challenged with Escherichia Coli K88. Poult Sci 92: 2949–2955.
Chang YH, Kim JK, Kim HJ, Kim WY, Kim YB, Park YH (2001) Selection of a Potential Probiotic Lactobacillus Strain and Subsequent in Vivo Studies. Antonie van Leeuwenhoek 80: 193–199.
Chaucheyras-Durand F, Durand H (2010) Probiotics in Animal Nutrition and Health. Beneficial Microbes 1: 3–9.
Chauhan S, Sharma Ak (2014) Utilization of Pectinases for Fiber Extraction from Banana Plant’s Waste. Int J Waste Resources 4:2–6.
Chawla S, Katoch S, Sharma KS, Sharma VK (2013) Biological Response of Broiler Supplemented with Varying Dose of Direct Fed Microbial. Vet World 6: 521–524.
Cheikhyoussef A, Pogori N, Chen W, Zhang H (2008) Antimicrobial Proteinaceous Compounds obtained from Bifidobacteria: From Production to their Application. Int J Food Micro 125: 215–222.
Chiquette J, Allison MJ, Rasmussen MA (2008) Prevotella Bryantii25A used as a Probiotic in Early-Lactation Dairy Cows: Effect on Ruminal Fermentation Characteristics, Milk Production, and Milk Composition. J Dairy Science 91: 3536–3543.
Chiquette J (2009) The Role of Probiotics in Promoting Dairy Production. Adv Dairy Technol 21: 143–157.
Cho JH, Zhao PY, Kim IH (2011) Probiotics as a Dietary Additive for Pigs: A Review. J Anim Vet Adv 10: 2127–2134.
Choct M (2009) Managing Gut Health through Nutrition. British Poult Sci 50: 9–15.
Chung YH, Walker ND, McGinn SM, Beauchemin KA (2011)Differing Effects of 2 Active Dried Yeast (Saccharomyces Cerevisiae) Strains on Ruminal Acidosis and Methane Production in Nonlactating Dairy Cows. J Dairy Sci 94: 2431–2439.
Collington GK, Parker DS, Armstrong DG (1990) The Influence ofInclusion of Either an Antibiotic or a Probiotic in the Diet on the Development of Digestive Enzyme Activity in the Pig. British J Nut 64: 59–70.
Corr SC, Li Y, Riedel CU, Toole PWO, Hill C, Gahan CG (2007) From the Cover : Bacteriocin Production as a Mechanism for the Antiinfective Activity of Bacteriocin Production as a Mechanism for the Antiinfective Activity of Lactobacillus Salivarius
UCC118. Proc Nat Acad Sci 104: 7617–7621.
Corthesy B, Gaskins HR, Mercenier A (2007) Cross-Talk between Probiotic Bacteria and the Host Immune System. J Nut 137:781–790.
Cotter PD, Hill C, Ross RP (2005) Bacteriocins: Developing Innate Immunity for Food. Nature Review Microbiol 3: 777–788.
Cowles KE, White RA, Whitehouse NL, Erickson PS (2006) Growth Characteristics of Calves Fed an Intensified Milk Replacer Regimen with Additional Lactoferrin. J Dairy Sci 89: 4835–4845.
Das L, Bhaumik E, Raychaudhuri U (2012) Role of Nutraceuticals in Human Health. J Food Sci Technol 49: 173–183.
Daudelin JF, Lessard M, Beaudoin F, Nadeau E, Bissonnette N,Boutin Y, Brousseau JP, Lauzon K, Fairbrother JM (2011)Administration of Probiotics Influences F4 (K88)-Positive Enterotoxigenic Escherichia Coli Attachment and Intestinal Cytokine Expression in Weaned Pigs. Vet Research 42: 2-11.
Ding J, Zhou ZM, Ren LP, Meng QX (2008) Effect of Monensin and Live Yeast Supplementation on Growth Performance, Nutrient Digestibility, Carcass Characteristics and Ruminal Fermentation Parameters in Lambs Fed Steam-Flaked Corn-Based Diets. Asian Aust J Anim Sci 21: 547–554.
Doron S, Snydman DR (2015) Risk and Safety of Probiotics. Clinical Infectious Diseases 60: 129-134.
Dowarah R, Verma AK, Agarwal N (2017) The Use of Lactobacillus as an Alternative of Antibiotic Growth Promoters in Pigs : A Review. Anim Nut 3: 1–6.
El-din ANMN (2015) Milk Production and Some Blood Metabolite Responses to Yeast Supplementation in Early Lactating Holstein Dairy Cows. Egyptian J Anim Prod 52: 11–17.
Enemark JMD (2008) The Monitoring, Prevention and Treatment of Sub-Acute Ruminal Acidosis (SARA): A Review. Vet J 176:32–43.
Fairbrother JM, Nadeau E, Gyles CL (2005) Escherichia Coli in Postweaning Diarrhea in Pigs: An Update on Bacterial Types, Pathogenesis, and Prevention Strategies. Anim Health Rese Reviews 6: 17–39.
Fajardo P, Pastrana L, Mendez J, Rodriguez I, Fucinos C, Guerra NP (2012) Effects of Feeding of Two Potentially Probiotic Preparations from Lactic Acid Bacteria on the Performance and Faecal Microflora of Broiler Chickens. Scienti World J 2012:1–9.
FAO/WHO (2002) Guidelines for the Evaluation of Probiotics in Food. A Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food, 1–11.
Farnell MB, Donoghue AM, De Los Santos FS, Blore PG, Hargis BM, Tellez B, Donoghue DJ (2006) Upregulation of Oxidative Burst and Degranulation in Chicken Heterophils Stimulated with Probiotic Bacteria. Poult Sci 85: 1900–1906.
Flynn S, Sinderen DV, Thornton GM, Holo H, Nes IF, Collins JK (2002) Characterization of the Genetic Locus Responsible for the Production of ABP-118, a Novel Bacteriocin Produced by the Probiotic Bacterium Lactobacillus Salivarius Subsp .Salivarius UCC118. Microbiology 148: 973–984.
Fuller R (2001) The Chicken Gut Microflora and Probiotic Supplements. J Poult Sci 38: 189–196.
Gangadharan D, Sivaramakrishnan S, Nampoothiri KM, Sukumaran RK, Pandey A (2008) Response Surface Methodology for the Optimization of Alpha Amylase Production by Bacillus Amyloliquefaciens. Bioresource Technol 99: 4597–4602.
Ghareeb K, Zentek J (2006) Effect of Addition of a Probiotic Microorganism to Broiler Diets Contaminated with Deoxynivalenol on Performance and Histological Alterations of Intestinal Villi of Broiler Chickens. Poult Sci 58: 974–979.
Giang, HH, Viet TQ, Ogle B, Lindberg JE (2012) Digestibility, Gut Environment and Health Status in Weaned Piglets Fed a Diet Supplemented with a Complex of Lactic Acid Bacteria Alone or in Combination with Bacillus Subtilis and Saccharomyces Boulardii. Livestock Sci 143: 132–41.
Goto H, Qadis AQ, Kim YH, Ikuta K, Ichijo T, Sato S (2016) Effects of a Bacterial Probiotic on Ruminal pH and Volatile Fatty Acids during Subacute Ruminal Acidosis (SARA) in Cattle. J Vet Medi Sci 78: 1595–1600.
Goudarzi M, Goudarzi H, Rashidan M (2014) Probiotics: An Update on Mechanisms of Action and Clinical Applications. Novelty in Biomedicine 2: 22–30.
Gu MJ, Song SK, Lee IK, Ko S, Han SE, Bae S, Ji SY, et al. (2016) Barrier Protection via Toll-like Receptor 2 Signaling in Porcine Intestinal Epithelial Cells Damaged by Deoxynivalnol. Veterinary Research 47: 1–11.
Guerra NP, Bernardez PF, Mendez J, Cachaldora P, Castro LP (2017) Production of Four Potentially Probiotic Lactic Acid Bacteria and Their Evaluation as Feed Additives for Weaned Piglets. Anim Feed Sci Technol 134: 89–107.
Gyles CL (2007) Shiga Toxin-Producing Escherichia Coli: An Overview. J Animal Science 85: 1–18.
Haddad SG, Goussous SN (2005) Effect of Yeast Culture Supplementation on Nutrient Intake, Digestibility and Growth Performance of Awassi Lambs. Anim Feed Sci Technol 118:343–348.
Han H, Ogata Y, Yamamoto Y, Nagao S, Nishino N (2014) Identification of Lactic Acid Bacteria in the Rumen and Feces of Dairy Cows Fed Total Mixed Ration Silage to Assess the Survival of Silage Bacteria in the Gut. J Dairy Sci 97: 5754–5762.
Hardy H, Harris J, Lyon E, Beal J, Foey AD (2013) Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology. Nutrients 5: 1869–1912.
Hayek SA., Gyawali R, Ibrahim SA (2013) Antimicrobial Natural Products. Formatex Info 910–921.
Hempel S, Newberry S, Ruelaz A, Wang Z, Miles JNV, Suttorp MJ, Johnsen B, et al. (2011) Safety of Probiotics to Reduce Risk and Prevent or Treat Disease. Evidence Report/Technology Assessment. Agency Healthcare Research Quality 200: 1–645.
Hillal H, El-sayaad G, Abdella M (2011) Effect of Growth Promoters (Probiotics) Supplementation on Performance, Rumen Activity and Some Blood Constituents in Growing Lambs Zusammenfassung. Arch Tierz 54: 607–617.
Hopwood DE, Pethick DW, Pluske JR, Hampson DJ (2004) Addition of Pearl Barley to a Rice-Based Diet for Newly Weaned Piglets Increases the Viscosity of the Intestinal Contents, Reduces Starch Digestibility and Exacerbates Post-Weaning Colibacillosis. British J Nut 92: 419–427.
Hou C, Zeng X, Yang F, Liu H, Qiao S (2015) Study and Use of theProbiotic Lactobacillus Reuteri in Pigs: A Review. J Anim Sci Biotechnol 6: 1-14.
Huang C, Qiao S, Li D, Piao X, Ren J (2004) Effects of Lactobacillion the Performance, Diarrhea Incidence, VFA Concentration and Gastrointestinal Microbial Flora of Weaning Pigs. Asian Australasian J Anim Sci 17: 401–409.
Hyronimus B, Le Marrec C, Sassi AH, Deschamps A (2000) Acid and Bile Tolerance of Spore-Forming Lactic Acid Bacteria. Int J Food Microbiol 61: 193–197.
Ibrahim HAM, Zhu Y, Wu C, Lu C, Ezekwe MO, Liao SF, Haung K (2012) Selenium-Enriched Probiotics Improves Murine Male Fertility Compromised by High Fat Diet. Biological Trace Element Res 147: 251–260.
Isobe H, Nishiyama A, Takano T, Higuchi W, Nakagawa S, Taneike I, Fukushima Y, Yamamoto T (2012) Reduction of Overall Helicobacter Pylori Colonization Levels in the Stomach of Mongolian Gerbil by Lactobacillus Johnsonii La1 (LC1) and Its in Vitro Activities against H. Pylori Motility and Adherence. Biosci Biotech Biochem 76: 850–852.
Isolauri E, Sütas Y, Kankaanpää P, Arvilommi H, Salminen S (2001) Probiotics: Effects on Immunity. American J Clinical Nut 73:444–450.
Isolauri E, Arvilommi H, Salminen S (2001) Probiotics: Effects on Immunity. Am J Clin Nutr 73: 444–450.
Jacobs DM, Gaudier E, Duynhoven JV, Vaughan EE (2009) Non-Digestible Food Ingredients, Colonic Microbiota and the Impact on Gut Health and Immunity: A Role for Metabolomics. Current Drug Metabolism 10: 41–54.
Jaiswal SK, Chaturvedani AK, Raza M, Dilliwar L, Dhruw K, Sahu V (2017) Review: Natural Growth Promoters, Alternative To Antibiotic Growth Promoters on Poultry. Int J Sci Env Technol 6: 254–259.
Jayaraman S, Thangavel G, Kurian H, Mani R, Mukkalil R, Chirakkal H (2013) Bacillus Subtilis PB6 Improves Intestinal Health of Broiler Chickens Challenged with Clostridium Perfringens-Induced Necrotic Enteritis. Poult Sci 92: 370–374.
Jeyanathan J, Martin C, Morgavi DP (2014) The Use of Direct-Fed Microbials for Mitigation of Ruminant Methane Emissions: A Review. Animal 8: 250–261.
Jia W, Slominski BA, Bruce HL, Blank G, Crow G, Jones O (2009) Effects of Diet Type and Enzyme Addition on Growth Performance and Gut Health of Broiler Chickens during Subclinical Clostridium Perfringens Challenge. Poult Sci 88:132–140.
Jin LZ, Ho YW, Abdullah N, Jalaludin S (2000) Digestive and Bacterial Enzyme Activities in Broilers Fed Diets Supplemented with Lactobacillus Cultures. Poult Sci 79: 886–891.
Jones SE, Versalovic J (2009) Probiotic Lactobacillus Reuteri Biofilms Produce Antimicrobial and Anti-Inflammatory Factors. Microbiology 9: 1–9.
Kabir SML (2009) The Role of Probiotics in the Poultry Industry. Int J Mol Sci 10: 3531–3546.
Kechagia M, Basoulis D, Konstantopoulou S, Dimitriadi D,Gyftopoulou K, Skarmoutsou N, Fakiri EM (2013) Health Benefits of Probiotics: A Review. Nutrition 2013: 2–7.
Kenny M, Smidt H, Mengheri E, Miller B (2011) Probiotics - DoThey Have a Role in the Pig Industry? Int J Animal Biosci 5:462–470.
Khaksefidi A, Ghoorchi T (2006) Effect of Probiotic on Performance and Immunocompetence in Broiler Chicks. J Poult Sci 43:296–300.
Khalid MF, Shahzad MA, Sarwar M, Rehman AU, Sharif M, Mukhtar N. 2011. Probiotics and Lamb Performance: A Review. J Agri Res 6: 5198–5203.
Khan RU, Naz S, Nikousefat Z, Tufarelli V, Javdani M, Qureshi MS, Laudadio V (2012) Potential Applications of Ginger (Zingiber Officinale) in Poultry Diets Potential Applications of Ginger (Zingiber of Fi Cinale) in Poultry Diets. World Poult Sci J 68:245–252.
Kim HB, Isaacson RE (2015) The Pig Gut Microbial Diversity: Understanding the Pig Gut Microbial Ecology through the next Generation High Throughput Sequencing. Vet Microbiol 177:242–251.
Kizerwetter-Swida M, Binek M (2005) Selection of Potentially Probiotic Lactobacillus Strains towards Their Inhibitory Activity against Poultry Enteropathogenic Bacteria. Polish J Microbiol 54:287–294.
Knap I, Kehlet AB, Bennedsen M, Mathis GF, Hofacre CL, Lumpkins BS, Jensen MM, Raun M, Lay A (2011) Bacillus Subtilis (DSM17299) Significantly Reduces Salmonella in Broilers. Poult Sci 90: 1690–1694.
Koenen ME, Kramer J, Van der Hulst R, Heres L, Jeurissen SHM, Boersma WJA (2004) Immunomodulation by Probiotic Lactobacilli in Layer- and Meat-Type Chickens. British Poult Sci 45: 355–366.
Kowalski ZM, Gorka P, Schlagheck A, Jagusiak W, MicekP (2009) Performance of Holstein Calves Fed Milk-Replacer and Starter Mixture Supplemented with Probiotic Feed Additive. J Anim Feed Sci 18: 399–411.
Kral M, Angelovicova M, Mrazova L (2012) Application of Probiotics in Poultry Production. Anim Sci and Biotechnols 45:55-57.
Krause DO, Bhandari SK, House JD, Nyachoti CM (2010) Response of Nursery Pigs to a Synbiotic Preparation of Starch and an Anti-Escherichia Coli K88 Probiotic. Applied Envir Microbiol 76:8192–8200.
Kritas SK, Govaris A, Christodoulopoulos G, Burriel AR (2006) Effect of Bacillus Licheniformis and Bacillus Subtilis Supplementation of Ewe’s Feed on Sheep Milk Production and Young Lamb Mortality. J Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine 53: 170–173.
Kubiszewska I, Januszewska M, Rybka J, Gackowska L (2014) Lactic Acid Bacteria and Health: Are Probiotics Safe for Human. Postepy Higieny I Medycyny Dosw 68: 1325–1334.
Kullen MJ, Klaenhammer TR (2000) Genetic Modification of Intestinal Lactobacilli and Bifidobacteria. Mol. Biol 2: 41–50.
Kumar U, Sareen VK, Singh S (1994) Effect of Saccharomyces Cerevisiae Yeast Culture Supplement on Ruminal Metabolism in Buffalo Calves given a High Concentrate Diet. Anim Sci 59:209–215.
Lalles JP, Bosi P, Smidt H, Stokes CR (2007) Nutritional Management of Gut Health in Pigs around Weaning. Proc. Nutr. Soc 66: 260–268.
De Lange CFM, Pluske J, Gong J, Nyachoti CM (2010) Strategic Use of Feed Ingredients and Feed Additives to Stimulate Gut Health and Development in Young Pigs. Livestock Sci 134:124–134.
Lebeer S, Vanderleyden J, De Keersmaecker SCJ (2010) Host Interactions of Probiotic Bacterial Surface Molecules: Comparison with Commensals and Pathogens. Nature Reviews. Microbiol 8: 171–184.
Lee YJ, Kim BK, Lee BK, Jo KI, Lee NK, Chung CH, Lee YC, Lee JW (2008) Purification and Characterization of Cellulase Produced by Bacillus Amyoliquefaciens DL-3 Utilizing Rice Hull. Bioresource Technol 99: 378–386.
Lehloenya KV, Krehbiel CR, Mertz KJ, Rehberger TG, Spicer LJ (2008) Effects of Propionibacteria and Yeast Culture Fed to Steers on Nutrient Intake and Site and Extent of Digestion1. J Dairy Sci 91: 653–662.
Li LL, Hou ZP, Li TJ, Wu GY, Huang RL, Tang ZR, Yang CB, et al. (2008) Effects of Dietary Probiotic Supplementation on Ileal Digestibility of Nutrients and Growth Performance in 1- to 42-Day-Old Broilers. J Sci Food Agr 88: 35–42.
Liao SF, Nyachoti M (2017) Using Probiotics to Improve Swine Gut Health and Nutrient Utilization. Anim Nut 3: 331-343.
Liu H, Zhang J, Zhang S, Yang F, Thacker PA, Zhang G, Qiao S, Ma X (2014) Oral Administration of Lactobacillus Fermentum I5007 Favors Intestinal Development and Alters the Intestinal Microbiota in Formula-Fed Piglets. J Agr Food Chem 62: 860–866.
Liu X, Yan H, Lv L, Xu Q, Yin C, Zhang K, Wang P, Hu J (2012) Growth Performance and Meat Quality of Broiler Chickens Supplemented with Bacillus Licheniformis in Drinking Water. Asian Australasian J Anim Sci 25: 682–689.
Lv CH, Wang T, Regmi N, Chen X, Huang K, Liao SF (2015) Effects of Dietary Supplementation of Selenium-Enriched Probiotics on Production Performance and Intestinal Microbiota of Weanling Piglets Raised under High Ambient Temperature. J
Anim Physiol Anim Nut 99: 1161–1171.
Mahfuz SU, Nahar MJ, Mo C, Ganfu Z, Zhongjun L, Hui S (2017) Inclusion of Probiotic on Chicken Performance and Immunity : A Review. International J Poult Sci 16: 328–35.
Maliselo PS, Nkonde GK (2015) Ammonia Production in Poultry Houses and its Effect on the Growth of Gallus Gallus Domestica ( Broiler Chickens ): A Case Study of a Small Scale Poultry House in Riverside, Kitwe, Zambia. Int J Sci Technol Res 4:141–45.
Markowiak P, Śliżewska k (2018) The Role of Probiotics, Prebiotics and Synbiotics in Animal Nutrition. Gut Pathogens 10: 2-20.
Marteau P (2001) Safety Aspects of Probiotic Products. Food Nut Res 45: 22-24.
Martinez-Vaz BM, Fink RC, Diez-Gonzalez F, Sadowsky MJ (2014) Enteric Pathogen-Plant Interactions: Molecular Connections Leading to Colonization and Growth and Implications for Food Safety. Microbes Environments 29: 123–135.
McDonald DE, Pethick DW, Mullan BP, Hampson DJ (2001) Increasing Viscosity of the Intestinal Contents Alters Small Intestinal Structure and Intestinal Growth, and Stimulates Proliferation of Enterotoxigenic Escherichia Coli in Newly-Weaned Pigs. British J Nut 86: 487–498.
Meng QW, Yan L, Ao X, Zhou TX, Wang JP, Lee JH, Kim IH (2010) Influence of Probiotics in Different Energy and Nutrient Density Diets on Growth Performance, Nutrient Digestibility, Meat Quality, and Blood Characteristics in Growing-Finishing Pigs. J Anim Sci 88: 3320–3326.
Metzler B, Bauer E, Mosenthin R (2005) Microflora Management in the Gastrointestinal Tract of Piglets. Asian Australasian J Anim Sci 18: 1353–1362.
Mohamed MI, Maareck YA, Abdel-Magid SS, Awadalla IM (2009) Feed Intake, Digestibility, Rumen Fermentation and Growth Performance of Camels Fed Diets Supplemented with a Yeast Culture or Zinc Bacitracin. Anim Feed Sci Technol 149: 341–345.
Montagne L, Cavaney FS, Hampson DJ, Lalles JP, Pluske JR (2004) Effect of Diet Composition on Postweaning Colibacillosis in Piglets. J Anim Sci 82: 2364–2374.
Mookiah S, Chin S, Ramasamy K, Abdullah N, Ho YW (2014) Effects of Dietary Prebiotics, Probiotic and Synbiotics on Performance, Caecal Bacterial Populations and Caecal Fermentation Concentrations of Broiler Chickens. J Sci Food Agr 94: 341-348.
Mosoni P, Chaucheyras-Durand F, Bera-Maillet C, Forano E (2007) Quantification by Real-Time PCR of Cellulolytic Bacteria in the Rumen of Sheep after Supplementation of a Forage Diet with Readily Fermentable Carbohydrates: Effect of a Yeast Additive. J Applied Microbiol 103: 2676–2685.
Mukhtar N, Sarwar M, Nisa MU, Sheikh MA (2010) Growth Response of Growing Lambs Fed on Concentrate with or without Ionophores and Probiotics. Int J Agric Biol 12: 734–738.
Murali Eswara S, Kavitha BTVV, Srikanth JG, Velmani G (2010) Probiotics as Potential Therapies in Human Gastrointestinal Health. International J Advances Pharmaceutical Sci 1: 96–110.
Musa HH, Wu SL, Zhu CZ, Seri HI, Zhu GQ (2009) The Potential Benefits of Probiotics in Animal Production and Health. J Animal Vet Adv 8: 313–321.
Nagaraja TG, Titgemeyer EC (2007) Ruminal Acidosis in Beef Cattle: The Current Microbiological and Nutritional Outlook. J Dairy Sci 1: 17-38.
Nayebpor M, Farhomand P, Hashemi A (2007) Effects of Different Levels of Direct Fed Microbial (Primalac) on Growth Performance and Humoral Immune Response in Broiler Chickens. J Anim Vet Adv 6: 1308-1313.
Ng SC, Hart AL, Kamm MA, Stagg AJ, Knight SC (2009) Mechanisms of Action of Probiotics: Recent Advances. Inflammatory Bowel Diseases 15: 300–310.
Niba AT, Beal TD, Kudi AC, Brooks PH (2009) Bacterial Fermentation in the Gastrointestinal Tract of Non-Ruminants: Influence of Fermented Feeds and Fermentable Carbohydrates. Tropical Anim Health Production 41: 1393–1407.
Oetzel GR, Emery KM, Kautz WP, Nocek JE (2007) Direct-Fed Microbial Supplementation and Health and Performance of Pre- and Postpartum Dairy Cattle: A Field Trial. J Dairy Sci 90:2058–2068.
Olatoye IO, Ehinwomo AA (2010) Oxytetracycline Residues in Edible Tissues of Cattle Slaughtered in Akure, Nigeria. Nigerian Vet J 31: 93–102.
De Oliveira GH, Junior AB, Barrow PA (2000) Prevention of Salmonella Infection by Contact Using Intestinal Flora of Adult Birds And/or a Mixture of Organic Acids. Brazilian J Microbiol 31: 116–120.
Palliyeguru MW, Rose SP, Mackenzie AM (2010) Effect of Dietary Protein Concentrates on the Incidence of Subclinical Necrotic Enteritis and Growth Performance of Broiler Chickens. Poult Sci 89: 34–43.
Pan C, Zhao Y, Liao SF, Chen F, Qin S, Wu X, Zhou H, Huang K (2011) Effect of Selenium-Enriched Probiotics on Laying Performance, Egg Quality, Egg Selenium Content, and Egg Glutathione Peroxidase Activity. J Agri Food Chemistry 59:11424–11431.
Park YH, Hamidon F, Rajangan C, Soh KP, Gan CY, Lim TS, Nadiah W, Abdullah W, Liong MT (2016) Application of Probiotics for the Production of Safe and High-Quality Poultry Meat. Korean J Food Sci 36: 567–576.
Parvez S, Malik KA, Kang SA, Kim H (2006) Probiotics and Their Fermented Food Products Are Beneficial for Health. J Applied Microbiology 100: 1171–1185.
Patil AK, Kumar S, Verma AK, Baghel RPS (2015) Probiotics as Feed Additives in Weaned Pigs : A Review. Livestock Res Int 3:31–39.
Patterson JA, Burkholder KM (2003) Application of Prebiotics and Probiotics in Poultry Production. Poultry Science 82: 627–631.
Peterson R, Klopfenstein TJ, Erickson GE (2007) Effect of Lactobacillus Acidophilus Strain N P51 on Escherichia Coli 0157: H7 Fecal Shedding and Finishing Performance in Beef Feedlot Cattle. J Food Protection 70: 287–291.
Pluske J, Pethick D, Hopwood DE, Hampson D (2003) Nutritional Influences on Some Major Enteric Bacterial Diseases of Pig. Nut Res Reviews 15: 333-371.
Pollmann DS, Danielson DM, Peo ER (1980) Effects of Microbial Feed Additives on Performance of Starter and Growing- Finishing Pigs. J Anim Sci 51: 577–581.
Qiao GH, Shan AS, Ma N, Ma QQ, Sun ZW (2010) Effect of Supplemental Bacillus Cultures on Rumen Fermentation and Milk Yield in Chinese Holstein Cows. J Anim Physiol Anim Nut 94: 429–436.
Qin C, Gong L, Zhang X, Wang Y, Wang Y, Wang B, Li, Y Li W (2018) Effect of Saccharomyces Boulardii and Bacillus Subtilis B10 on Gut Microbiota Modulation in Broilers. Anim Nut 1–9.
Rachmilewitz D, Katakura K, Karmeli F, Hayashi T, Reinus C, Rudensky B, Akira S, et al. (2004) Toll-like Receptor 9 Signaling Mediates the Anti-Inflammatory Effects of Probiotics in Murine Experimental Colitis. Gastroenterology 126: 520–528.
Rastogi P, Saini H, Dixit J, Singhal R (2011) Probiotics and oral Health. National J Maxillofacial Surgery 2: 6–9.
Reid G, Friendship R (2002) Alternatives to Antibiotic Use: Probiotics for the Gut. Animal Biotechnology 13: 97–112.
Retta KS (2016) Role of Probiotics in Rumen Fermentation and Animal Performance: A Review. Int J Livestock Production 7: 24–32.
Gaskins HR (2000) Intestinal Bacteria and Their Influence on Swine Growth. In: Lewis, A.J. and Southern, L.L., Eds., Swine Nutrition, 2nd Edition, Taylor and Francis Inc., Boca Roca, 585-608.
Rinttila T, Apajalahti J (2013) Intestinal Microbiota and Metabolites-Implications for Broiler Chicken Health and Performance. J Appl Poult Res 22: 647–658.
Roca M, Nofrarías M, Majó N (2014) Changes in Bacterial Population of Gastrointestinal Tract of Weaned Pigs Fed with Different Additives. Biomed Res Int 2014: 2–14.
Rodriguez-Fragoso L, Sandoval-Ocampo A, Corbala-Nava M, Arjona-Canul CA, Gomez-Galicia DL (2012) Evaluation Regarding the Efficacy and Safety of a Probiotic Mixture in Healthy Volunteers with Evacuation Disorders. Food and Nut Sci 3: 117–122.
Roselli M, Pieper R, Rogel-Gaillard C, de Vries H, Bailey M, Smidt H, Lauridsen C (2017) Immunomodulating Effects of Probiotics for Microbiota Modulation, Gut Health and Disease Resistance in Pigs. Anim Feed Sci Technol 233: 104–119.
Rossi F, Luccia AD, Vincenti D, Cocconcelli PS (2004) Effects of Peptidic Fractions from Saccharomyces Cerevisiae Culture on Growth and Metabolism of the Ruminal Bacteria Megasphaera Elsdenii. Czech J Anim Sci 51: 73–77.
Sanchez B, Delgado S, Blanco-Miguez A, Lourenc A, Gueimonde M, Margolles A (2017) Probiotics, Gut Microbiota, and Their Influence on Host. Mol Nutr Food Res 61: 1–15.
Sarangi NR, Babu LK, Kumar A, Pradhan CR, Pati PK, Mishra JP (2016) Effect of Dietary Supplementation of Prebiotic, Probiotic, and Synbiotic on Growth Performance and Carcass Characteristics of Broiler Chickens. Vet World 9: 313–319.
Sassone-Corsi M, Nuccio SP, Liu H, Hernandez D, Vu CT, Takahashi AA, Edwards RA, Raffatellu M (2016) Microcins Mediate Competition among Enterobacteriaceae in the Inflamed Gut. Nature 540: 280–283.
Seo JK, Kim SW, Kim MH, Upadhaya SD, Kam DK, Ha JK (2010) Direct-Fed Microbials for Ruminant Animals. Asian Aust J Anim Sci 23: 1657–1667.
Servin AL (2004) Antagonistic Activities of Lactobacilli and Bifidobacteria against Microbial Pathogens. FEMS Microbiol Reviews 28: 405–440.
Servin AL (2006) The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota. Clinical Microbiology Reviews 19: 315–337.
Sethiya NK (2016) Review on Natural Growth Promoters Available for Improving Gut Health of Poultry: An Alternative to Antibiotic Growth Promoters. Asian J Poult Sci 10: 1–29.
Setia A, Bhandari SB, House JD, Nyachoti CM, Krause DO (2009) Development and in Vitro Evaluation of an Escherichia Coli Probiotic Able to Inhibit the Growth of Pathogenic Escherichia Coli K88. J Anim Sci 87: 2005–2012.
Sgouras DN, Panayotopoulou EG, Martinez-gonzalez B, Petraki K, Michopoulos S (2005) Lactobacillus Johnsonii La1 Attenuates Helicobacter Pylori-Associated Gastritis and Reduces Levels of Proinflammatory Chemokines in C57BL / 6 Mice. Clinical and Diagnostic Labaratory Immunology 12: 1378–1386.
Shanahan F (2012) A Commentary on the Safety of Probiotics. Gastroenterology Clinics of North America 41: 869–876.
Sherman M, Bennett S (2004) Neonatal Small Bowel Epithelia: Enhancing Anti-Bacterial Defense with Lactoferrin and Lactobacillus GG Lactoferrin and Lactobacillus GG. BioMetals 17: 285–289.
Smith DL, Harris AD, Johnson JA, Silbergeld EK, Morris JG (2002) Animal Antibiotic Use Has an Early but Important Impact on the Emergence of Antibiotic Resistance in Human Commensal Bacteria. Proc Nat Acad Sci 99: 6434–6439.
Sommer F, Bäckhed F (2013) The Gut Microbiota-Masters of Host Development and Physiology. Nature Reviews Microbiol 11:227–238.
Song D, Ibrahim S, Hayek S (2012) Recent Application of Probiotics in Food and Agricultural Science. Intech Open Access Publisher. 1-34.
Soren NM, Tripathi MK, Bhatt RS, Karim SA (2013) Effect of Yeast Supplementation on the Growth Performance of Malpura Lambs. Tropical Animal Health Production 45: 547–554.
Sugiharto S (2016) Role of Nutraceuticals in Gut Health and Growth Performance of Poultry. J Saudi Society Agricultural Sciences 15: 99–111.
Syngai GG, Gopi R, Bharali R, Dey S, Lakshmanan GMA, Ahmed G (2016) Probiotics - the Versatile Functional Food Ingredients. J Food Sci Technol 53 (2): 921–933.
Taras D, Vahjen W, Macha M, Simon O (2006) Performance, Diarrhea Incidence, and Occurrence of Escherichia Coli Virulence Genes during Long-Term Administration of a Probiotic Enterococcus Faecium Strain to Sows and Piglets. J Anim Sci 84: 608–617.
Thrune M, Bach A, Ruiz-Moreno M, Stern MD, Linn JG (2009) Effects of Saccharomyces Cerevisiae on Ruminal pH and Microbial Fermentation in Dairy Cows. Yeast Supplementation on Rumen Fermentation. Livestock Sci 124: 261–265.
Timbermont L, Haesebrouck F, Ducatelle R, Van Immerseel F (2011) Necrotic Enteritis in Broilers: An Updated Review on the Pathogenesis. Avian Pathol 40: 341–347.
Timmerman HM, Mulder L, Everts H, van Espen DC, van der Wal E, Klaassen G, Rouwers SMG, Hartemink R, Rombouts FM, Beynen AC (2005) Health and Growth of Veal Calves Fed Milk Replacers with or without Probiotics. J Dairy Sci 88: 2154–2165.
Torok VA, Hughes RJ, Mikkelsen LL, Perez-Maldonado R, Balding K, MacAlpine R, Percy NJ, Ophel-Keller K (2011) Identification and Characterization of Potential Performance-Related Gut Microbiotas in Broiler Chickens across Various Feeding Trials. Applied Env Microbiol 77: 5868–5878.
Tuohy KM, Probert HM, Smejka CW, Gibson GR (2003) Use of Probiotics to Combat Diarrhoea. Drug Discovery Today 8:692–700.
Upadhaya SD, Kim SC, Valientes RA, Kim IH (2015) The Effect of Bacillus-Based Feed Additive on Growth Performance, Nutrient Digestibility, Fecal Gas Emission, and Pen Cleanup Characteristics of Growing-Finishing Pigs. Asian Australasian J Anim Sci 28: 999–1005.
Uyeno Y, Sekiguchi Y, Kamagata Y (2010) rRNA-Based Analysis to Monitor Succession of Faecal Bacterial Communities in Holstein Calves. Applied Microbiol 51: 570–577.
Vandenbergh PA (1993) Lactic Acid Bacteria, Their Metabolic Products and Interference with Microbial Growth. FEMS Microbiology Reviews 12: 221–237.
Vinderola G, Matar C, Perdigon G (2005) Role of Intestinal Epithelial Cells in Immune Effects Mediated by Gram-Positive Probiotic Bacteria: Involvement of Toll-Like Receptors. Clinical Diagnostic Laboratory Immunology 12: 1075–1084.
Vitini E, Alvarez S, Medina M, Medici M, de Budeguer MV, Perdigon G (2000) Gut Mucosal Immunostimulation by Lactic Acid Bacteria. Biocell 24: 223–232.
Wang A, Yu H, Gao X, Li X(2009) Influence of Lactobacillus Fermentum I5007 on the Intestinal and Systemic Immune Responses of Healthy and E . Coli Challenged Piglets. Antonie van Leeuwenhoek 96: 89–98.
Wang X, Hu W, Zhu L, Yang Q (2017) Bacillus Subtilis and Surfactin Inhibit the Transmissible Gastroenteritis Virus from Entering the Intestinal Epithelial Cells. Bioscience Reports 37:1- 10.
Wang YB, Du W, Fu AK, Zhang XP, Huang Y, Lee KH, Yu K, Li WF, Li YL (2016) Intestinal Microbiota and Oral Administration of Enterococcus Faecium Associated with the Growth Performance of New-Born Piglets. Beneficial Microbes 7: 529–538.
Wang Y, Sun J, Zhong H, Li N, Xu H, Zhu Q, Liu Y (2017) Effect of Probiotics on the Meat Flavour and Gut Microbiota of Chicken. Scientific Reports 7: 1–13.
Weinberg ZG, Muck RE, Weimer PJ, Chen Y, Gamburg M (2004) Lactic Acid Bacteria Used in Inoculants for Silage as Probiotics for Ruminants. Applied Biochem Biotechnol 118: 1–9.
Weiss WP, Wyatt GJ, McKelvey TR (2008) Effect of Feeding Propionibacteria on Milk Production by Early Lactation Dairy Cows. J Dairy Sci 91: 646–652.
Whitley NC, Cazac D, Rude BJ, Jackson-o Brien D, Parveen S (2009) Use of a Commercial Probiotic Supplement in Meat Goats. J Anim Sci 87: 723–728.
Wilberts BL, Arruda PH, Kinyon JM, Frana TS, Wang C, Magstadt DR, Madson DM, Patience JF, Burrough ER (2014) Investigation of the Impact of Increased Dietary Insoluble Fiber through the Feeding of Distillers Dried Grains with Solubles (DDGS) on the Incidence and Severity of Brachyspira-Associated Colitis in Pigs. PLoS ONE 9: e114741.
Yang F, Hou C, Zeng X, Qiao S (2015) The Use of Lactic Acid Bacteria as a Probiotic in Swine Diets. Pathogens 4: 34–45.
Yegani M, Korver DR (2008) Review Factors Affecting Intestinal Health in Poultry. Poult Sci 87: 2052–2063.
Yirga H (2015) The Use of Probiotics in Animal Nutrition. J Prob Health 3: 2–10.
Yitbarek A, Brady J, Sharif S, Cavanagh MD, Crow G (2015) The Effect of Microbial-Nutrient Interaction on the Immune System of Young Chicks after Early Probiotic and Organic Acid Administration. J Anim Sci 90: 2246–2254.
Yu HF, Wang AN, Li XJ, Qiao SY (2008) Effect of Viable Lactobacillus Fermentum on the Growth Performance, Nutrient Digestibility and Immunity of Weaned Pigs. J Anim Feed Sci 17:61–69.
Yurong Y, Ruiping S, Shimin Z, Yibao J (2005) Effect of Probiotics on Intestinal Mucosal Immunity and Ultrastructure of Cecal Tonsils of Chickens. Archives Anim Nut 59: 237–246.
Yutaka U, Shigemori S, Shimosato T (2015) Effect of Probiotics/Prebiotics on Cattle Health and Productivity. Microbes Environments 30: 126–132.
Zhang ZF, Kim IH (2014) Effects of Multistrain Probiotics on Growth Performance, Apparent Ileal Nutrient Digestibility, Blood Characteristics, Cecal Microbial Shedding, and Excreta Odor Contents in Broilers. Poult Sci 93: 364–370.
Zoetendal EG, Collier CT, Koike S, Mackie RI, Gaskins HR (2004) Molecular Ecological Analysis of the Gastrointestinal Microbiota: A Review. J Nut 134: 465–472.
Zulkifli I, Abdulllah N, Azrin NM, Ho YW (2000) Growth Performance and Immune Response of Two Commercial Broiler Strains Fed Diets Containing Lactobacillus Cultures and Oxytetracycline under Heat Stress Conditions. British Poult Sci 41: 593–597.