Association of polymorphisms in the CSN2, CSN3, LGB and LALBA genes with milk production traits in Holstein cows raised in Turkey
Аннотация
A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) test was performed on DNA samples extracted from blood samples of 189 Holstein Friesian cows to detect genotypic distribution of polymorphic markers in the bovine beta-casein (CSN2), kappa-casein (CSN3), beta-lactoglobulin (LGB) and alfa-lactalbumin (LALBA) genes responsible for milk production traits. Statistical analysis was carried out using least square methods of the general linear model (GLM) procedure. CSN2 locus was significantly associated with the following traits: 305-day milk yield, days before peak milk production, fat percentage and protein yield. There was no significant effect of CSN3, LGB and LALBA markers on the traits analysed. These results suggested that CSN2 marker may be evaluated in selection programmes regarding not only milk content but also milk production.
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SOYUDAL, B., ARDICLI, S., SAMLI, H., DINCEL, D., & BALCI, F. (2019). Association of polymorphisms in the CSN2, CSN3, LGB and LALBA genes with milk production traits in Holstein cows raised in Turkey. Journal of the Hellenic Veterinary Medical Society, 69(4), 1271–1282. https://doi.org/10.12681/jhvms.19617
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- Том 69 № 4 (2018)
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- Research Articles
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Библиографические ссылки
Aleandri R, Buttazzoni L, Schneider J, Caroli A, Davoli R (1990) The effects of milk protein polymorphisms on milk components and cheese-producing ability. J Dairy Sci 73: 241-255.
Alexander LJ, Stewart AF, Mackinlay AG, Kapelinskaya TV, Tkach TM, Gorodetsky SI (1988) Isolation and characterization of the bovine k‐casein gene. The FEBS Journal 178: 395-401.
Aschaffenburg R (1961) Inherited casein variants in cow’s milk. Nature 192: 431-432.
Aschaffenburg R, Sen A, Thompson M (1968) Genetic variants of casein in Indian and African Zebu cattle. Comp Biochem Physiol 25: 177-180.
Bleck G (1993) Correlation of the alpha-lactalbumin (+ 15) polymorphism to milk production and milk composition of Holsteins. J Dairy Sci 76: 2292-2298.
Bleck GT and Bremel RD (1993) Sequence and single-base polymorphisms of the bovine α-lactalbumin 5’-flanking region. Gene 126:213-218.
Bleck GT, White BR, Miller DJ, Wheeler MB (1998) Production of bovine alpha-lactalbumin in the milk of transgenic pigs. J Anim Sci 76: 3072-3078.
Bobe G, Beitz D, Freeman A, Lindberg G (1999) Effect of milk protein genotypes on milk protein composition and its genetic parameter estimates. J Dairy Sci 82: 2797-2804.
Boettcher P, Caroli A, Stella A, Chessa S, Budelli E, Canavesi F, Ghiroldi S, Pagnacco G. (2004) Effects of casein haplotypes on milk production traits in Italian Holstein and Brown Swiss cattle. J Dairy Sci 87: 4311-4317.
Botstein D, White R L, Skolnick M, Davis RW (1980). Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 32: 314-331.
Caroli A, Chessa S, Bolla P, Budelli E, Gandini G (2004) Genetic structure of milk protein polymorphisms and effects on milk production traits in a local dairy cattle. J Anim Breed Genet 121: 119-127.
Caroli A, Chessa S, Erhardt G (2009) Invited review: Milk protein polymorphisms in cattle: Effect on animal breeding and human nutrition. J Dairy Sci 92: 5335-5352.
Chin D, Ng-Kwai-Hang KF (1997) Application of mass spectrometry for the identification of genetic variants of milk proteins. In: Proceedings of the International Dairy Federation (IDF), Brussels, Belgium: 334-339.
Comin A, Cassandro M, Chessa S, Ojala M, Dal Zotto R, De Marchi M, Carnier P, Gallo L, Pagnacco G, Bittante G (2008) Effects of composite β-and κ-casein genotypes on milk coagulation, quality, and yield traits in Italian Holstein cows. J Dairy Sci 91: 4022-4027.
Czerniawska-Piatkowska E, Szewczuk M, Olszewska A, Chocilowicz E (2011) Association between beta-lactoglobulin (LGB) polymorphism and yield and composition of milk Holstein-Friesian cows imported from Sweden. Acta Sci Pol Zootechnica 10: 9–18.
Davoli R, Dall’Olio S., Russo V (1990) Effect of Kappa-casein genotype on the coagulation properties of milk. J Anim Breed Genet 107: 458-464.
Eggen A and Fries R (1995) An integrated cytogenetic and meiotic map of the bovine genome. Anim Genet 26: 215-236.
Falconer DS, Mackay TFC (1996) Introduction to quantitative genetics, 4th ed. Pearson Education Ltd. Harlow, England. 280 pp.
Farrell HM, Jimenez-Flores R, Bleck GT, Brown EM, Butler JE, Creamer LK, Hicks CL, Holar CM, Ng-Kwai-Hang KF, Swaisgood HE (2004) Nomenclature of the Proteins of Cows’ Milk—Sixth Revision. J Dairy Sci 87: 1641-1674.
Ferretti L, Leone P, Sgaramella V (1990) Long range restriction analysis of the bovine casein genes. Nucleic Acids Res 18: 6829-6833.
Freyer BG, Liu Z, Erhardt G, Panicke L (1999) Casein polymorphism and relation between milk production traits. J Anim Breed Genet 116: 87-97.
Green MR, Sambrook J (2012) Isolation of high-molecular-weight DNA from mammalian cells using proteinase K and phenol, in: Molecular Cloning: A Laboratory Manual, 4, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA, 47-48.
Grosclaude F, Mahe MF, Mercier JC, Ribadeau-Dumas B (1972) Localisation des substitutions d’acides aminés différenciant les variants a et b de la caséine× bovine. Ann Genet Sel Anim 4-16: 515-521.
Habier D, Tetens J, Seefried FR, Lichtner P, Thaller G (2010) The impact of genetic relationship information on genomic breeding values in German Holstein cattle. Genet Sel Evol 42: 5.
Han S, Shin Y, Byun H (2000) Biochemical, molecular and physiological characterization of a new β-casein variant detected in Korean Cattle. Anim Genet 31: 49-51.
Heck J, Schennink A, Van Valenberg H, Bovenhuis H, Visker M, Van Arendonk J, Van Hooijdonk A (2009) Effects of milk protein variants on the protein composition of bovine milk. J Dairy Sci 92: 1192-1202.
Huang W, Peñagaricano F, Ahmad KR, Lucey JA, Weigel KA, Khatib H (2012) Association between milk protein gene variants and protein composition traits in dairy cattle. J Dairy Sci 95: 440-449.
Ikonen T, Ahlfors K, Kempe R, Ojala M, Ruottinen O (1999) Genetic parameters for the milk coagulation properties and prevalence of noncoagulating milk in Finnish dairy cows. J Dairy Sci 82:205-214.
Ikonen T, Bovenhuis H, Ojala M, Ruottinen O, Georges M (2001) Associations between milk protein polymorphism and first lactation milk production traits in Finnish Ayrshire cows. J Dairy Sci 82: 1026-1033.
Jann O, Ceriotti G, Caroli A, Erhardt G (2002) A new variant in exon VII of bovine β-casein gene (CSN2) and its distribution among European cattle breeds. J Anim Breed Genet 119: 65-68.
Kaminski S (1996). Bovine kappa-casein (CASK) gene-molecular nature and application in dairy cattle breeding. J App Genet 2: 176-196.
Kaminski S, Rymkiewicz-Schymczyk J, Wojcik E, Rusc A (2002) Associations between bovine milk protein genotypes and haplotypes and the breeding value of Polish Black-and-White bulls. J Anim Feed Sci 11: 205-222.
Keating AF, Smith TJ, Ross RP, Cairns MT (2008) A note on the evaluation of a beta-casein variant in bovine breeds by allelespecific PCR and relevance to β-casomorphin. Irish J Agr Food Res 47: 99-104.
Kiddy C, Peterson R, Kopfler F (1966) Genetic control of variants of beta-casein A. J Dairy Sci 49: 742.
Kucerova J, Matejicek A, Jandurova O, Sorensen P, Nemcova E, Stipkova M, Kott T, Bouska J, Frelich J (2006) Milk protein genes CSN1S1, CSN2, CSN3, LGB and their relation to genetic values of milk production parameters in Czech Fleckvieh. Czech J Anim Sci 51: 241-247.
Lee P, Chung HK, Lee HG, Lee HC, Woo JS, Lee S, Jo SJ, Chang WK, Lee HT, Kwon M (2008) Cloning and characterization of 5′-untranslated region of porcine beta casein gene (CSN2). Domest Anim Endocrinol 35: 245-253.
Litwinczuk A, Barlowska J, Krol J, Kedzierska-Matysek M (2003) Polimorfizm bialek mleka u krow ras mlecznych i miesnych z region srodkowozachodniej Polski. Przegląd Hodowlany 10: 10-13.
Lucy M, Hauser S, Eppard P, Krivi G, Clark J, Bauman D, Collier R (1993) Variants of somatotropin in cattle: gene frequencies in major dairy breeds and associated milk production. Domest Anim Endocrinol 10: 325-333.
Lunden A, Nilsson M, Janson L (1997) Marked effect of β-lactoglobulin polymorphism on the ratio of casein to total protein in milk. J Dairy Sci 80: 2996-3005.
Martins L, Milazzotto M, Feitosa W, Coutinho A, Simoes R, Marques M, Assumpcao M, Visintin J (2008) Sequence variation of the α-lactalbumin gene in Holstein and Nellore cows. Anim Biotechnol 19: 195-199.
Matějíček A, Matějíčková J, Němcová E, Jandurová O, Štípková M, Bouška J, Frelich J (2007) Joint effects of CSN3 and LGB genotypes and their relation to breeding values of milk production parameters in Czech Fleckvieh. Czech J Anim Sci 52: 83-87.
Menezes MPC, Martinez AM, Ribeiro MN, Pimenta Filho EC, Bermejo JVD (2006) Genetic characterization of Brazilian native breeds of goats using 27 markers microsatellites. R Bras Zootec 35: 1336-1341.
Micinski J, Pogorzelska J, Baranski W (2008) Parametry uzytkowe pierwiastek rasy hf w zaleznosci od genetycznych wariantow wybranych bialek mleka. Med Weter 9: 1136-1140.
Miluchova M, Trakovicka A, Gabor M (2009) Analysis of polymorphism of beta casein of Slovak Pinzgau cattle by PCR-RFLP for allels A1 and A2. Scientific Papers Animal Science and Biotechnologies (SPASB) 42: 288-292.
Mitra A, Schlee P, Krause I, Blusch J, Werner T, Balakrishnan C, Pirchner F (1998a) Kappa‐casein polymorphisms in Indian dairy cattle and buffalo: A new genetic variant in buffalo 1. Anim Biotechnol 9: 81-87.
Mitra A, Yadav BR (1998b) Alpha-lactalbumin polymorphism in three breeds of Indian Zebu cattle, J Anim Breed Genet 115: 403-405.
Neamt RI, Saplacan G, Acatincai S, Cziszter LT, Gavojdian D, Ilie DE (2017) The influence of CSN3 and LGB polymorphisms on milk production and chemical composition in Romanian Simmental cattle. Acta Biochim Pol 64: 493-497.
Nei M, Roychoudhury A (1974) Sampling variances of heterozygosity and genetic distance. Genetics 76: 379-390.
Ng-Kwai-Hang K, Hayes J, Moxley J, Monardes H (1984) Association of genetic variants of casein and milk serum proteins with milk, fat, and protein production by dairy cattle. J Dairy Sci 67: 835-840.
Ng-Kwai-Hang K., Monardes H, Hayes J (1990) Association between genetic polymorphism of milk proteins and production traits during three lactations. J Dairy Sci 73: 3414-3420.
Olsen H, Gomez-Raya L, Vage D, Olsaker I, Klungland H, Svendsen M, Adnoy T, Sabry A, Klemetsdal G, Schulman N (2002) A genome scan for quantitative trait loci affecting milk production in Norwegian dairy cattle. J Dairy Sci 85: 3124-3130.
Patel RK, Chauhan JB, Singh KM, Soni KJ (2008) Allelic frequency of kappa-casein and beta-lactoglobulin in Indian crossbred (Bos taurus x Bos indicus) dairy bulls. Turk J Vet Anim Sci 31: 399-402.
Penagaricano F, Khatib H (2012) Association of milk protein genes with fertilization rate and early embryonic development in Holstein dairy cattle. J Dairy Res 79: 47-52.
Prinzenberg EM, Krause I, Erhardt G (1999) SSCP analysis at the bovine CSN3 locus discriminates six alleles corresponding to known protein variants (A, B, C, E, F, G) and three new DNA polymorphisms (H, I, A1). Anim Biotechnol 10: 49-62.
Ron M, Yoffe O, Ezra E, Medrano J, Weller J (1994) Determination of effects of milk protein genotype on production traits of Israeli Holsteins. J Dairy Sci 77, 1106-1113.
Sabour M, Lin C, Lee A, McAllister A (1996) Association Between Milk Protein Genetic Variants and Genetic Values of Canadian Holstein Bulls for Milk Yield Traits1. J Dairy Sci 79: 1050-1056.
Sashikanth AM, Yadav B (1998) Alpha-lactalbumin polymorphism in three breeds of Indian zebu cattle. J Anim Breed Genet 115:403-405.
Spelman R, Garrick D (1997) Utilisation of marker assisted selection in a commercial dairy cow population. Liv Prod Sci 47: 139-147.
Strzalkowska N, Krzyzewski J, Zwierzchowski L, Ryniewicz Z (2002) Effects of kappa-casein and beta-lactoglobulin loci polymorphism, cows’ age, stage of lactation and somatic cell count on daily milk yield composition in Polish Black-and-White cattle. Anim Sci Pap Rep 20: 21-35.
Sulimova G, Azari MA, Rostamzadeh J, Abadi MM, Lazebny O (2007) κ-casein gene (CSN3) allelic polymorphism in Russian cattle breeds and its information value as a genetic marker. Russ J Genet 43: 73-79.
Sulimova G, Sokolova S, Semikozova O, Nguet L, Berberov E (1992) Analysis of DNA polymorphism of cluster genes in cattle: casein genes and major histocompatibility complex (MHC) genes. Tsitol Genet 26: 18-26.
Tsiaras A, Bargouli G, Banos G, Boscos C (2005) Effect of kappacasein and beta-lactoglobulin loci on milk production traits and reproductive performance of Holstein cows. J Dairy Sci 88:327-334.
Viitala SM, Schulman N F, de Koning DJ, Elo K, Kinos R, Virta A, Virta J, Maki-Tanila A., Vilkki J (2003) Quantitative trait loci affecting milk production traits in Finnish Ayrshire dairy cattle. J Dairy Sci 86: 1828-1836.
Visser S, Slangen CJ, Lagerwerf FM, Van Dongen WD, Haverkamp J (1995) Identification of a new genetic variant of bovine ß-casein using reversed-phase high-performance liquid chromatography and mass spectrometric analysis. J Chromatogr A 711: 141-150.
Visser S, Slangen CJ, Rollema HS (1991) Phenotyping of bovine milk proteins by reversed-phase high-performance liquid chromatography. J Chromatogr A 548: 361-370.
Voelker GR, Bleck GT, Wheeler MB (1997) Single-base polymorphisms within the 5’flanking region of the bovine α-lactalbumin gene. J Dairy Sci 80: 194-197.
Voglino G (1972) A new β‐casein variant in Piedmont cattle. Anim Blood Groups Biochem Genet 3: 61-62.
Zepeda-Batista JL, Saavedra-Jiménez LA, Ruíz-Flores A, Núñez-Domínguez R, Ramírez-Valverde R (2017) Potential influence of κ-casein and β-lactoglobulin genes in genetic association studies of milk quality traits. Asian-Australas J Anim Sci 30: 1684-1688.
