Seroprevalence of Coxiella burnetii among ewes and associated risk factors in Constantine (Northeastern Algeria)


S. HIRECHE
A. AGABOU
Ο. BOUAZIZ
Аннотация
Q fever is a zoonotic disease caused by the rickettsia-like Coxiella burnetii and leads to abortions and decreased reproductive performances in domestic ruminants. A serological survey, using ELISA test, was conducted to assess the prevalence of this infection in 226 ewes belonging to 39 flocks localized in Constantine (North-eastern Algeria). A pretested questionnaire has been submitted to farmers/shepherds to collect information related to relevant risk factors. Results revealed the presence of C. burnetii antibodies in 12.4% (95% CI: 8.08%−16.72%) of individual animals while 35.9% (95% CI: 21.20%−52.82%) of sampled flocks accounted at least one seropositive ewe. Significant causative associations were observed for origin of animals (χ2=14.29, P=0.001), vaccination against enterotoxaemia (χ2=12.12, P=0.002) and pox (χ2=5.30, P=0.025), access to the farm by foreign visitors (χ2=10.87, P=0.004), farmers/shepherds’ visits to other farms (χ2=6.31, P=0.021), disinfection frequency (χ2=7.98, P=0.046), pest infestation within farms (χ2=9.55, P=0.049) and abortion history (χ2=5.54, P=0.029). This recorded prevalence of Coxiella infection would indicate a possible responsibility of this agent in causing abortion and reproductive failures in the tested flocks. Implementing active surveillance programs and further investigations using more accurate analyses and including large samples of more animal species from several provinces are needed to eluci date the real occurrence and dynamics of this infection in the national livestock.
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Abu-dalbouh MA, Ababneh MM, Giadinis ND, Lafi SQ (2012) Ovine and caprine toxoplasmosis (Toxoplasma gondii) in aborted animals in Jordanian goat and sheep flocks. Trop Anim Health Prod 44: 49-54.
Agag S, Kaidi R, Khelef D (2016) Seroprevalence of Q fever in cows in Bejaia area (Algeria). Rev Elev Med Vet Pay Trop 69: 155-159.
Anastácio S, Tavares N, Carolino N, Sidi-Boumedine K (2013) Serological evidence of exposure to Coxiella burnetii in sheep and goats in central Portugal. Vet Microbiol 167: 500-505.
Angelakis E, Raoult D (2010) Q fever. Vet Microbiol 140: 297-309.
Asadi J, Khalili M, Kafi M, Ansari-Lari M, Hosseini SM (2014) Risk factors of Q fever in sheep and goat flocks with history of abortion. Comparat Clin Pathol 23: 625-630.
Barkallah M, Gharbi Y, Hmani M, Mallek Z, Gautier M, Gdoura R, Fendri I (2018) Serological and molecular evidence of Coxiellosis and risk factors in sheep flocks in central-eastern Tunisia. Comp Immunol Microb 57: 15-21.
Benaissa MH, Ansel S, Mohamed-Cherif A, Benfodil K, Khelef D, Youngs CR, Kaidi R, Ait-Oudhia K (2017). Seroprevalence and risk factors for Coxiella burnetii, the causative agent of Q fever in the dromedary camel (Camelus dromedarius) population in Algeria. Onderstepoort J Vet 84:e1-e7.
Benkirane A, Essamkaoui S, El Idrissi A, Lucchese L, Natale A (2015) A sero-survey of major infectious causes of abortion in small ruminants in Morocco. Vet Ital 51: 25-30.
Berri M, Laroucau K, Rodolakis A (2000) The detection of Coxiella burnetii from ovine genital swabs, milk and fecal samples by the use of a single touchdown polymerase chain reaction. Vet Microbiol 72: 285-293.
Berri M, Rousset E, Champion JL, Russo P, Rodolakis A (2007) Goats may experience reproductive failures and shed Coxiella burnetii at two successiveparturitions after a Q fever infection. Res Vet Sci 83: 47-52.
Berri M, Souriau A, Crosby M, Crochet D, Lechopier P, Rodolakis A (2001) Relationships between the shedding of Coxiella burnetii, clinical signs and serological responses of 34 sheep. Vet Rec 148: 502-505.
Cantas H, Muwonge A, Sareyyupoglu B, Yardimci H, kjerve E (2011) Q fever abortions in ruminants and associated on-farm risk factors in northern Cyprus. BMC Vet Res 7: 13.
Cardinale E, Esnault O, Beral M, Naze F, Michault A (2014) Emergence of Coxiella burnetii in ruminants on Reunion Island? Prevalence and risk factors. PLoS Neglect Trop D 8: e3055.
Cruz R, Esteves F, Vasconcelos-Nóbrega C, Santos C, Ferreira AS, Mega C, Coelho AC, Vala H, Mesquita JR (2018) A nationwide seroepidemiologic study on Q fever antibodies in sheep of Portugal. Vector-Borne Zoonot 18: 601-604.
Cutler SJ, Bouzid M, Cutler RR (2007) Q fever. J Infect 54: 313-318.
de Lange MM, Schimmer B, Vellema P, Hautvast JL, Schneeberger PM, van Duijnhoven YT (2014) Coxiella burnetii seroprevalence and risk factors in sheep farmers and farm residents in The Netherlands. Epidemiol Infect 142:1231-1244.
deValk H (2012) Q fever: new insights, still many queries. Eurosurveillance 17: 20062.
Filioussis G, Theodoridis A, Papadopoulos D, Gelasakis AI, Vouraki S, Bramis G, Arsenos G (2017) Serological prevalence of Coxiella burnetii in dairy goats and ewes diagnosed with adverse pregnancy outcomes in Greece. Ann Agric Environ Med 24: 702-705.
Gardon J, Heraud JM, Laventure S, Ladam A, Capot P, Fouquet E, Favre J, Weber S, Hommel D, Hulin A, Couratte Y, Talarmin A (2001) Suburban transmission of Q fever in French Guiana: evidence of a wild reservoir. J Infect Dis 184: 278-284.
Georgiev M, Afonso A, Neubauer H, Needham H, Thiery R, Rodolakis A, Roest H, Stark K, Stegeman J, Vellema P, van der Hoek W, More S (2013) Q fever in humans and farm animals in four European countries, 1982 to 2010. Eurosurveillance 18: 20407.
Hatchette T, Campbell N, Hudson R, Raoult D, Marrie TJ (2003) Natural history of Q fever in goats. Vector-Borne Zoonotic Dis 3: 11-15.
Horigan MW, Bell MM, Pollard TR, Sayers AR, Pritchard GC (2011) Q fever diagnosis in domestic ruminants: comparison between complement fixation and commercial enzyme-linked immunosorbent assays. J Vet Diagn Invest 23: 924-931.
Kennerman E, Rousset E, Golcu E, Dufour P (2010) Seroprevalence of Q fever (Coxiellosis) in sheep from the Southern Marmara Region, Turkey. Comp Immunol Microbiol 33: 37-45.
Kersh GJ, Fitzpatrick KA, Self JS, Priestley RA, Kelly AJ, Lash RR, Marsden-Haug N, Nett RJ, Bjork A, Massung RF, Anderson AD (2013) Presence and persistence of Coxiella burnetii in the environments of goat farms associated with a Q fever outbreak. Appl Environ Microb 79: 1697-1703.
Keyvani Rad N, Azizzadeh M, Taghavi Razavizadeh AR, Mehrzad J, Rashtibaf M (2014) Seroepidemiology of coxiellosis (Q fever) in sheep and goat populations in the northeast of Iran. Iran J Vet Res 15 (1): 1-6.
Khaled H, Sidi-Boumedine K, Merdja S, Dufour P, Dahmani A, Thiery R, Rousset E, Bouyoucef A, (2016) Serological and molecular evidence of Q fever among small ruminant flocks in Algeria. Comp Immunol Microbiol 47: 19-25.
Knobel DL, Maina AN, Cutler SJ, Ogola E, Feikin DR, Junghae M, Halliday JE, Richards AL, Breiman RF, Cleaveland S (2013) Coxiella burnetii in humans, domestic ruminants, and ticks in rural western Kenya. Am J Trop Med Hyg 88: 513-518.
MADR: Ministry of Agriculture and Rural Development (2014) Agricultural statistics (Areas and productions. Series B). Algiers.
Mahdavi-Roshan H, Saadati D, Najimi M (2018) Molecular detection of Brucella melitensis, Coxiella burnetii and Salmonella abortusovis in aborted fetuses of Baluchi sheep in Sistan region, south-eastern Iran. Iran J Vet Res 19: 128-132.
Mancini F, Di Luca M, Toma L, Vescio F, Bianchi R, Khoury C, Marini L, Rezza G, Ciervo A (2014) Prevalence of tick-borne pathogens in an urban park in Rome, Italy. Ann Agr Env Med 21: 723-727.
Menadi SE, Mura A, Santucciu C, Ghalmi F, Hafsi F, Masala G (2010) Seroprevalence and risk factors of Coxiella burnetii infection in cattle in northeast Algeria. Trop Anim Health Prod 2019: 1-8.
McQuiston JH, Childs JE (2002) Q fever in humans and animals in the United States. Vector-Borne Zoonot 2: 179-191.
Mori M, Boarbi S, Michel P, Bakinahe R, Rits K, Wattiau P, Fretin D (2013) In vitro and in vivo infectious potential of Coxiella burnetii: a study on Belgian livestock isolates. PloS One 8: e67622.
Palmer NC, Kierstead M, Key DW, Williams JC, Peacock MG, Vellend H (1983) Placentitis and abortion in goats and sheep in Ontario caused by Coxiella burnetii. Canadian Vet J 24: 60-61.
Porten K, Rissland J, Tigges A, Broll S, Hopp W, Lunemann M, van Treeck U, Kimmig P, Brockmann SO, Wagner-Wiening C, Hellenbrand W, Buchholz U (2006) A super-spreading ewe infects hundreds with Q fever at a farmers’ market in Germany. BMC Infect Dis 6: 147.
Rahal K, Khaled H, Dahmani A, Bouyoucef A (2012) True prevalence of Coxiella burnetii in sheep at Ksar Boukhari region (Algeria). In: Proceedings of the 13th International Symposium on Veterinary Epidemiology and Economics, Belgium-Netherlands: p 425.
Rodolakis A (2009) Q fever in dairy animals. Ann NY Acad Sci 1166: 90-93.
Rodolakis A, Berri M, Hechard C, Caudron C, Souriau A, Bodier CC, Blanchard B, Camuset P, Devillechaise P, Natorp JC, Vadet JP, Arricau-Bouvery N (2007) Comparison of Coxiella burnetii shedding in milk of dairy bovine, caprine and ovine herds. J Dairy Sci 90: 5352-5360.
Roest HJ, van Gelderen B, Dinkla A, Frangoulidis D, van Zijderveld F, Rebel J, van Keulen L (2012) Q fever in pregnant goats: pathogenesis and excretion of Coxiella burnetii. PLoS One 7(11): e48949.
Ruiz-Fons F, Astobiza I, Barandika JF, Hurtado A, Atxaerandio R, Juste RA, García-Pérez AL (2010) Seroepidemiological study of Q fever in domestic ruminants in semi-extensive grazing systems. BMC Vet Res 6: 3.
Schimmer B, Ter Schegget R, Wegdam M, Zuchner L, de Bruin A, Schneeberger PM, Veenstra T, Vellema P, van der Hoek W (2010) The use of a geographic information system to identify a dairy goat farm as the most likely source of an urban Q-fever outbreak. BMC Infect Dis 10: 69.
Scott GH, Williams JC (1990) Susceptibility of Coxiella burnetii to chemical disinfectants. Ann NY Acad Sci 590: 291-296.
Scott PR, Penny CD, Macrae AI (2011) Q fever. In: Cattle Medicine. Manson Publishing, London: p 38.
Sidibe SS, Coulibaly KW, Dakouo M, Tarnagda Z, Sery A, Niang M, Traore K, Nantoume H, Diarra S, Seyni H (2013) Fièvre Q chez les petits ruminants au Mali. Résultats d’une enquête sérologique. Rev Elev Med Vet Pay Trop 66: 11-18.
Sprong H, Tijsse-Klasen E, Langelaar M, De Bruin A, Fonville M, Gassner F, Takken W, Van Wieren S, Nijhof A, Jongejan F, Maassen CB, Scholte EJ, Hovius JW, Emil-Hovius K, Spitalska E, Van Duynhoven YT (2012) Prevalence of Coxiella burnetii in ticks after a large outbreak of Q fever. Zoonoses Public Hlth 59: 69-75.
Stephen S, Ambroise S, Pradeep J, Gunasekaran D, Sangeetha B, Sarangapani K (2017) Unreliability of three commercial Coxiella burnetii Phase II IgM ELISA kits for the diagnosis of acute Q fever in human cases in Puducherry, India. Indian J Med Res 146: 386-391.
Thrusfield M (2007) Simple random sampling. In: Veterinary epidemiology. 3rd ed. Blackwell Science, Oxford: pp 231-245.
Tissot-Dupont H, Raoult D (2008) Q fever. Infect Dis Clin N Am 22: 505-514.
Ullah Q, El-Adawy H, Jamil T, Jamil H, Qureshi ZI, Saqib M, Ullah S, Shah MK, Khan AZ, Zubair M, Khan I, Mertens-Scholz K, Henning K, Neubauer H (2019) Serological and molecular investigation of Coxiella burnetii in small ruminants and ticks in Punjab, Pakistan. Int J Environ Res Public Health 16: 4271.
Vanderburg S, Rubach MP, Halliday JE, Cleaveland S, Reddy EA, Crump JA (2014) Epidemiology of Coxiella burnetii infection in Africa: a One health systematic review. PLoS Neglect Trop D 8: e2787.
Villari S, Galluzzo P, Arnone M, Alfano M, Geraci F, Chiarenza G (2018) Seroprevalence of Coxiella burnetii infection (Q fever) in sheep farms located in Sicily (Southern Italy) and related risk factors. Small Ruminant Res 164: 82-86.
Yahiaoui WI, Afri-Bouzebda F, Bouzebda Z, Dahmani A (2013) Sondage sérologique de la fièvre Q chez les ovins par la méthode ELISA et prevalence des avortements dans la région de Ksar El Boukhari (Algérie). Tropicultura 32: 22-27.
Zecchini M, Harouna A, Cattaneo C, Belli P, Pecile A, Moroni P, Alborali L, Idi-Adamou G, Crimella C (2008) Seroprevalence of brucellosis, chlamydiosis, Q fever and mastitis in small ruminants in the urban and periurban area of Niamey (Niger). Large Anim Rev 14: 234.