Drug targeting in cancer therapy

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Publiée : Mar 19, 2020
DOI : https://doi.org/10.12681/osj.22596
L. Nys
Gymnasium dew Kreuzschwestern
P. Raeuschl
Gymnasium der Kreuzschwetstern
S. Ess
Dept. Biosciences, University of Salzburg
R. Nestelbacher
Dept. Biosciences, University of Salzburg
I.A. Joubert
Dept. Biosciences, University of Salzburg
Μ. Geppert
M. Himly
Résumé
Drug targeting enables the local reslease of medication at the desired site or organ. This ensures that the drug asserts its effects focused to a small site, minimising systematic side effects. Drug targeting has been successfully applied in cancer therapy and can be performed actively or passively. During passive drug targeting, carriers containing the active cancer drug concentrate within the tumour tissue due to increased blood circulation and vascular permeation (enhanced penetration retention principle). Active drug targeting on the other hand, facilitates ligand-recepto interacions.
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Biographie de l'auteur
M. Himly
Dept. Biosciences, University of Salzburg
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