HealthResJ, health, medicine, nursing, research https://ejournals.epublishing.ekt.gr/index.php/HealthResJ/sitemap

Correlation between the duration of cardiopulmonary bypass (on-pump), mechanical support, and length of stay in the intensive care unit: A cross sectional study


Published: Apr 1, 2026
Keywords:
Extracorporeal circulation Cardiac surgery Intensive care unit Length of stay Mechanical ventilation
Georgios Palaiologos Narliotis
Abstract

Background: Length of stay in the Intensive Care Unit (ICU) is a significant indicator in the management of cardiac surgery patients. Cardiopulmonary bypass (CPB) is used in a large number of cardiac procedures, while the duration of mechanical ventilation may affect both the length of ICU stay and the prognosis of these patients.


Method and Material: This was a cross-sectional study with convenience sampling, where data were collected from June 2024 to September 2024. The study involved 100 patients who underwent cardiac surgery with cardiopulmonary bypass at the General Hospital of Athens “HIPPOKRATEIO.” Information was obtained from patients’ medical and nursing records, without any direct interventions. A specially designed form, developed by the researcher based on a thorough review of the literature and the most frequently reported perioperative variables associated with postoperative ICU outcomes. The form included sections on personal history, comorbid conditions, surgical details, intraoperative complications, ICU length of stay, and postoperative outcomes. Statistical tests included the Chi-square (x²) test, t-test, and Pearson correlation, with a significance level set at 5%. Statistical analysis was conducted using SPSS version 25.0.                                                                                  


Results: A total of 100 patients who underwent on-pump cardiac surgery were included. The majority were aged between 66 and 79 years, and 51% were male. A significant positive correlation was observed between the duration of cardiopulmonary bypass and both ICU length of stay (p=0.015) and the duration of mechanical ventilation (p=0.018). Similarly, longer surgery and aortic cross-clamp times were also associated with prolonged ICU hospitalization and extended respiratory support (p<0.001). These findings suggest that intraoperative time parameters significantly influence postoperative ICU outcomes.


Conclusions: The present study suggests that prolonged ICU stay is mainly influenced by comorbidities as well as intraoperative and postoperative factors, highlighting the need for optimization of perioperative management in cardiac surgery patients.

Article Details
  • Section
  • Original Articles
Downloads
Download data is not yet available.
References
Li Q, Yang J, Zhang J, Yang C, Fan Z, Yang Y, Zheng T, Yang J. Effect of Perioperative Glucose-Insulin-Potassium Therapy in Patients Undergoing On Pump Cardiac Surgery: A Meta-Analysis. Heart Surg Forum. 2020 Feb 25;23(1):E063-E069. doi: 10.1532/hsf.2735. PMID: 32118546.
World Health Organization. Cardiovascular diseases (CVDs): Key facts. Geneva: World Health Organization; 2023. Available from: https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
Zacharis, A., & Kampourelli, A. (2011). Perioperative edu-cation of patients undergoing cardiac surgery. The Step of Asclepius, 10(2), 186–198.
Lagier D, Fischer F, Fornier W, Huynh TM, Cholley B, Guinard B, Heger B, Quintana G, Villacorta J, Gaillat F, Gomert R, Degirmenci S, Colson P, Lalande M, Benkouiten S, Minh TH, Pozzi M, Collart F, Latremouille C, Vidal Melo MF, Velly LJ, Jaber S, Fellahi JL, Baumstarck K, Guidon C; PROVECS Study Group. Effect of open-lung vs conven-tional perioperative ventilation strategies on postoperative pulmonary complications after on-pump cardiac surgery: the PROVECS randomized clinical trial. Intensive Care Med. 2019 Oct;45(10):1401-1412. doi: 10.1007/s00134-019-05741-8. Epub 2019 Oct 1. PMID: 31576435; PMCID: PMC9889189.
Anastasiadis, K., Polychronis, A., & Deliopoulos, A. (2020). Extracorporeal circulation in cardiac surgery (1st ed.). Thessaloniki: University Studio Press.
Newland RF, Starinieri P. Monitoring during Cardiopulmo-nary Bypass. In: Falter F, Perrino, Jr AC, Baker RA, eds. Car-diopulmonary Bypass. Cambridge University Press; 2022:25-33.
Jiménez Rivera JJ, Llanos Jorge C, López Gude MJ, Pérez Vela JL; en representación del GTCICYRCP. Perioperative management in cardiovascular surgery. Med Intensiva (Engl Ed). 2021 Apr;45(3):175-183. English, Spanish. doi: 10.1016/j.medin.2020.10.006. Epub 2020 Dec 25. PMID: 33358388.
Wahba A, Milojevic M, Boer C, De Somer FMJJ, Gudbjarts-son T, van den Goor J, Jones TJ, Lomivorotov V, Merkle F, Ranucci M, Kunst G, Puis L; EACTS/EACTA/EBCP Commit-tee Reviewers. 2019 EACTS/EACTA/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery. Eur J Cardiothorac Surg. 2020 Feb 1;57(2):210-251. doi: 10.1093/ejcts/ezz267. PMID: 31576396.
Suero OR, Ali AK, Barron LR, Segar MW, Moon MR, Chat-terjee S. Postoperative atrial fibrillation (POAF) after cardi-ac surgery: clinical practice review. J Thorac Dis. 2024 Feb 29;16(2):1503-1520. doi: 10.21037/jtd-23-1626. Epub 2024 Feb 23. PMID: 38505057; PMCID: PMC10944787.
Vieira Junior FU, Antunes N, Vieira RW, Alvares LM, Costa ET. Hemolysis in extracorporeal circulation: relationship between time and procedures. Rev Bras Cir Cardiovasc. 2012 Dec;27(4):535-41. English, Portuguese. doi: 10.5935/1678-9741.20120095. PMID: 23515726.
Trivedi V, Bleeker H, Kantor N, Visintini S, McIsaac DI, McDonald B. Survival, Quality of Life, and Functional Sta-tus Following Prolonged ICU Stay in Cardiac Surgical Pa-tients: A Systematic Review. Crit Care Med. 2019 Jan;47(1):e52-e63. doi: 10.1097/CCM.0000000000003504. PMID: 30398978.
Curran TF, Sunkara B, Leis A, Lim A, Haft J, Engoren M. Outcomes After Prolonged ICU Stays in Postoperative Car-diac Surgery Patients. Fed Pract. 2022 Nov;39(Suppl 5):S6-S11c. doi: 10.12788/fp.0300. Epub 2022 Nov 9. PMID: 36923547; PMCID: PMC10010497.
Bills S, Wills B, Boyd S, Elbeery J. Impact of an Enhanced Recovery after Surgery Protocol on Postoperative Out-comes in Cardiac Surgery. J Pharm Pract. 2023 Dec;36(6):1397-1403. doi: 10.1177/08971900221119013. Epub 2022 Aug 13. PMID: 35968826.
Stephens RS, Whitman GJ. Postoperative Critical Care of the Adult Cardiac Surgical Patient: Part II: Procedure-Specific Considerations, Management of Complications, and Quality Improvement. Crit Care Med. 2015 Sep;43(9):1995 2014. doi: 10.1097/CCM.0000000000001171. PMID: 26136101.
Nambiar PM, Bhan A, Mehta Y. Prolonged Stay in ICU after Cardiac Surgery: Challenges – A Review. J Card Crit Care TSS. 2024;8:70-9. doi: 10.25259/JCCC_70_2023
De Cocker J, Messaoudi N, Stockman BA, Bossaert LL, Rodrigus IE. Preoperative prediction of intensive care unit stay following cardiac surgery. Eur J Cardiothorac Surg. 2011 Jan;39(1):60-7. doi: 10.1016/j.ejcts.2010.04.015. PMID: 20627608.
Hein OV, Birnbaum J, Wernecke K, England M, Konertz W, Spies C. Prolonged Intensive Care Unit Stay in Cardiac Sur-gery: Risk Factors and Long-Term Survival. Ann Thorac doi:10.1016/J.ATHORACSUR.2005.09.077 S
Au E, Thangathurai G, Saripella A, Yan E, Englesakis M, Nagappa M, Chung F. Postoperative Outcomes in Elderly Patients Undergoing Cardiac Surgery With Preoperative Cognitive Impairment: A Systematic Review and Meta-Analysis. Anesth Analg. 2023 Jun 1;136(6):1016-1028. doi: 10.1213/ANE.0000000000006346. Epub 2023 Jan 11. PMID: 36728298.
Almashrafi A, Alsabti H, Mukaddirov M, Balan B, Aylin P. Factors associated with prolonged length of stay follow-ing cardiac surgery in a major referral hospital in Oman: a retrospective observational study. BMJ Open. 2016 Jun 8;6(6):e010764. doi: 10.1136/bmjopen-2015-010764. PMID: 27279475; PMCID: PMC4908878.
Osinaike, Okikiolu B, Olusesin O. Prolonged intensive care unit stay after coronary artery bypass graft surgery: Role of perioperative factors. Niger Postgrad Med J. 2015;22(4):213. doi:10.4103/1117-1936.173968
Taylor M, Apparau D, Mosca R, Nwaejike N. Does early extubation after cardiac surgery lead to a reduction in in-tensive care unit length of stay? Interact Cardiovasc Thorac Surg. 2022 May 2;34(5):731-734. doi: 10.1093/icvts/ivac008. PMID: 35143677; PMCID: PMC9070463.
Odor PM, Bampoe S, Gilhooly D, Creagh-Brown B, Moonesinghe SR. Perioperative interventions for preven-tion of postoperative pulmonary complications: systemat-ic review and meta-analysis. BMJ. 2020 Mar 11;368:m540. doi: PMC7190038.
Zhang Z, Tang W, Ren Y, Zhao Y, You J, Wang H, Zhao S, Zuo X. Prediction of ventilator weaning failure in postop-erative cardiac surgery patients using vasoactive-ventilation-renal score and nomogram analysis. Front Car-diovasc Med. 2024 Mar 14;11:1364211. doi: 10.3389/fcvm.2024.1364211. PMID: 38550521; PMCID: PMC10977076.
Almashrafi A, Elmontsri M, Aylin P. Systematic review of factors influencing length of stay in ICU after adult cardiac surgery. BMC Health Serv Res. 2016;16:318. doi: 10.1186/s12913-016-1591-3.
Most read articles by the same author(s)