| More

Late osteosarcoma development following osteosynthesis of a diaphysial femoral fracture in a dog

Views: 68 Downloads: 111
I. K. SIDERI (ΑΙΚ. Ι. ΣΙΔΕΡΗ), P. LOUKOPOULOS (Π. ΛΟΥΚΟΠΟΥΛΟΣ), N. N. PRASSINOS (Ν. Ν. ΠΡΑΣΙΝΟΣ), G. KAZAKOS (Γ. ΚΑΖΑΚΟΣ), P. PAPADOPOULOS (Π. ΠΑΠΑΔΟΠΟΥΛΟΥ), A. SIDIROPOULOS (Α. ΣΙΔΗΡΟΠΟΥΛΟΣ)
I. K. SIDERI (ΑΙΚ. Ι. ΣΙΔΕΡΗ), P. LOUKOPOULOS (Π. ΛΟΥΚΟΠΟΥΛΟΣ), N. N. PRASSINOS (Ν. Ν. ΠΡΑΣΙΝΟΣ), G. KAZAKOS (Γ. ΚΑΖΑΚΟΣ), P. PAPADOPOULOS (Π. ΠΑΠΑΔΟΠΟΥΛΟΥ), A. SIDIROPOULOS (Α. ΣΙΔΗΡΟΠΟΥΛΟΣ)

Abstract


Α 5.5 - year - old Great Dane was admitted for evaluation of a progressive lameness of the right hind limb of twenty days duration. The dog had sustained a mid-shaft fracture of the right femur five years ago in a traffic accident, which was initially managed unsuccessfully with the application of external stabilization, and was later successfully treated using a bone plate and screws. Radiographs revealed a fracture of the mid-shaft of the femur, under the bone plate, increased radiodensity of the surrounding soft tissues and the presence of bone spicules out of the limits of the femur. Histopathology revealed the presence of a high-grade osteoblastic productive osteosarcoma, whereas Staphylococcus spp were identified on culture. Due to the poor prognosis associated with osteosarcoma and the rapid deterioration of the dog's general condition, the owners decided to have the animal euthanized. Fractured associated sarcoma is a known, but rarely reported condition. The long-standing presence of metal implants, the tissue damage, as well as the presence of infection have been suggested as possible predisposing factors to the altered cellular activity leading to neoplasia.


Keywords


fracture-associated osteosarcoma; fracture complications; dog

Full Text:

PDF

References


Banks WC, Morris Ε, Herron MR, Green RW (1975) Osteogenic sarcoma associated with internal fracture fixation in two dogs. J Am Vet Med Assoc, 167:166-167.

Bennett D, Campbell JR, Brown Ρ (1979) Osteosarcoma associated with healed fractures. J Small Anim Pract, 20:13-18.

Breton L, Bonneau NH, Beauregard M (1984) Un ostéosarcome de la diaphyse du fémur d'un chien, associé à un implant métallique. Can Vet J, 25: 426-428.

Denny HR, Butterworth SJ (2006) Bone Neoplasia. In: A guide to Canine and Feline Orthopaedic Surgery. 4th ed, Blackwell Science Ltd, Oxford, pp 618-621.

Harrison JW, McLain DL, Hohn RB, Wilson GP, Chalman JA, MacGowan KN (1976) Osteosarcoma associated with metallic implants. Report of two cases in dogs. Clin Orthop Relat Res, 16:253-257.

Keel SB, Jaffe KA, Petur Nielsen G Rosenberg AE (2001) Orthopaedic implant-related sarcoma: a study of twelve cases. Mod Pathol, 14: 969-77.

Liu Si-Kwang (1993) Tumors of bone and cartilage. In: Bojrab MJ (ed.): Disease Mechanisms in Small Animal Surgery. Lea & Febiger, Malvern, pp 900-904.

Loukopoulos Ρ (2002) Studies on the pathobiology and management of canine osteosarcoma. Doctor of Philosophy thesis. School of Veterinary Science. University of Queensland, Brisbane, Queensland, Australia.

Loukopoulos P, Robinson WF (2007) Clinicopathological relevance of tumour grading in canine osteosarcoma. J Comp Pathol, 136:65-73.

Madewell BR, Pool RR, Leighton RL (1977) Osteogenic sarcoma at the site of a chronic nonunion fracture and internal fixation device in a dog. J Am Vet Med Assoc, 171:187-189.

Marcellin-Little DJ, DeYoung DJ, Thrall DE, Merrill CL (1999) Osteosarcoma at the site of bone infarction associated with total hip arthroplasty in a dog. Vet Surg, 28: 54-60.

Murphy ST, Parker RB, Woodard JC (1997) Osteosarcoma following total hip arthroplasty in a dog. J Small Anim Pract, 38: 263-267.

Roe SC, DeYoung D, Weinstock D, Kyles A (1996) Osteosarcoma eight years after total hip arthroplasty. Vet Surg, 25: 70-74.

Rose BW, Novo RE, Olson EJ (2005) Osteosarcoma at the site of a triple pelvic osteotomy in a dog. J Am Anim Hosp Assoc, 41: 327-331.

Sinibaldi KR, Pugh J, Rosen H, Liu SK (1982) Osteomyelitis and neoplasia associated with use of the Jonas intramedullary splint in small animals. J Am Vet Med Assoc, 181: 885-890.

Stevenson S, Hohn RB, Pohler OE, Fetter AW, Olmstead ML, Wind AP (1982) Fracture-associated sarcoma in the dog. J Am Vet Med Assoc, 180:1189-1196.

Straw M (2005) What is your diagnosis? Fracture/implant-associated osteosarcoma following TPLO procedures. J Small Anim Pract, 46: 457-459.

Van Bree H, Verschooten F, Hoorens J, Mattheeuws D (1980) Internal fixation of a fractured humerus in a dog and late osteosarcoma development. Vet Ree, 107:501-502.

Ward JJ, Thornbury DD, Lemons JE, Dunham WK (1990) Metalinduced sarcoma. A case report and literature review. Clin Orthop Relat Res, 252: 299-306.

Waters DJ (1993). Musculoskeletal System. In: Slatter D (ed.): Textbook of Small Animal Surgery. 2nd ed, WB Saunders, Philadelphia, pp 2213-2230.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 I. K. SIDERI (ΑΙΚ. Ι. ΣΙΔΕΡΗ), P. LOUKOPOULOS (Π. ΛΟΥΚΟΠΟΥΛΟΣ), N. N. PRASSINOS (Ν. Ν. ΠΡΑΣΙΝΟΣ), G. KAZAKOS (Γ. ΚΑΖΑΚΟΣ), P. PAPADOPOULOS (Π. ΠΑΠΑΔΟΠΟΥΛΟΥ), A. SIDIROPOULOS (Α. ΣΙΔΗΡΟΠΟΥΛΟΣ)