Cutaneous transmissible venereal tumor with internal metastases in two dogs

PDF
Published: Dec 15, 2017
DOI: https://doi.org/10.12681/jhvms.15395
Keywords:
dog transmissible venereal tumor chemotherapy resistance leishmaniosis
K. THEODOROU (Κ. ΘΕΟΔΩΡΟΥ)
Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki
M. E. MYLONAKIS (Μ.Ε. ΜΥΛΩΝΑΚΗΣ)
Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki
R. FARMAKI (Ρ. ΦΑΡΜΑΚΗ)
Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki
M. N. PATSIKAS (M.N. ΠΑΤΣΙΚΑΣ)
Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki
P. LOUKOPOULOS (Π. ΛΟΥΚΟΠΟΥΛΟΣ)
laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki
T. POUTAHIDIS (Θ. ΠΟΥΤΑΧΙΔΗΣ)
laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki
N. SOUBASIS (Ν. ΣΟΥΜΠΑΣΗΣ)
Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki
H. VERVERIDIS (Χ. ΒΕΡΒΕΡΙΔΗΣ)
Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki
A. F. KOUTINAS (Α. ΚΟΥΤΙΝΑΣ)
Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki
Abstract

Two intact male dogs, a 6-ycar-old Siberian husky (case one) and an 18-year-old Old Fnglish sheepdog-cross (case two), were admitted to the Companion Animal Clinic, Faculty of Veterinary Medicine, Aristotle University of Thcssaloniki (AUTh), with a single or multiple cutaneous masses, respectively. Fine needle aspiration (FNA) smears obtained
from the masses revealed the typical cytological features of transmissible venereal tumor (TVT) in both instances, while Leishmania infantum infection was diagnosed in the second case. In both dogs, distant metastases within the spleen and liver were diagnosed by ultra sonography-assisted FN A cytology, laparotomy-facilitated hi stop atho logy and computed tomography (case one) or post-mortem cytology and histopathology (case two). Vincristine sulphate (two weekly sessions) followed by doxorubicin chemotherapy (five .1-week sessions) failed to achieve clinical remission in case one, while the dog in case two was euthanized without any therapeutic effort. This study describes the clinical, imaging, cytologic and pathologic findings of two dogs with primary cutaneous TVT metastasized internally, Chemotherapy resistance, rarely recorded in TVT, was documented in one of them, whereas concurrent Leishmania infection in the other dog might have provoked the dissemination of TVT presumably due to the Le is h mania associated immunosuppression.

Article Details
  • Section
  • Research Articles

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Downloads
Download data is not yet available.
References
Albanese F, Poli A, Millanta F, Àbramo F (2002) Primary cutaneous extragenital canine transmissible venereal tumour with Leishmania-laden neoplastic cells: a further suggestion of histiocytic origin? Vet Dermatol 13:243-246.
Albanese F, Salerni FL, Giordano S, Marconato L (2006) Extragenital transmissible venereal tumour associated with circulating neoplastic cells in an immunologically compromised dog. Vet Comp Oncol 4:57-62.
Amber ET, Henderson RA, Adeyanju JB, Gyang FO {1990) Single-drug chemotherapy of canine transmissible venereal tumor with cyclophosphamide, methotrexate or vincristine. J. Vet Intern Med 4: 144-147.
Bergman PJ (2007) Paraneoplastic syndromes. In: Withrow and Mac Ewen's Small Animal Clinical Oncology. 4th cd, Saunders Elsevier, St. Louis Missouri: pp 77-94.
Boscos CM, Ververidis HN, Tondis DK, Stamou AI, Samarlzi FC (1998) Ocular involvement of transmissible venereal tumor in a dog. Vet Ophthalmol 1:167-170.
Boscos CM, Ververidis HN (2004) Canine TVT-Clinical findings, diagnosis and treatment. In: Proceedings of the 29th World Small Animal Veterinary Association Congress, Rhodes, Greece: ρρ 758-761
Brown NO, Calvert C, MacEwen GE (1980) Chemotherapeutic management of transmissible venereal tumors in .10 dogs. J Am Vet Med Assoc 176:983-986.
Calvert CA, Leifer CE, MacEwen GE (1982) Vincristine for treatment of transmissible venereal tumor in the dog, J Am Vet Med Assoc 181:163-164.
Cruz-Arambulo R, Wringley R, Powers Β (2004) Sonographic features of histiocytic neoplasms in the canine abdomen Vet Radiol & Ultrasound 45:554-558.
Das U, Das AK (2000) Review of canine transmissible venereal sarcoma. Vet Res Commun 24:545-556.
De Lorimier LP, Fan TM (2007) Canine Transmissible Venereal Tumor, In; Withrow and MacFwen's Small Animal Clinical Oncology. 4th ed, Saunders Elsevier, St. Louis Missouri: pp 799-804
Ferreira A J A, Jaggy A, Varejao AP, Ferreira MLP, Correia JMJ, Mulas JM, Almeida O, Oliveira P, Prada J (2000) Brain and ocular metastases from a transmissible venereal tumour in a dog. J Small Anim Pract 41:165-168.
Gatone G, Marino G, Poglayen G, Gramiccia M, Ludovisi A, Zanghi A (2003) Canine transmissible venereal tumour parasitized by Leishmania infantum. Vet Res Commun 27:549-553.
Gross TL, Ihrke .IP, Wälder FJ, Affolter VK (2005) Transmissible venereal tumor. In: Skin diseases of the dog and cat. 2nd ed, Blackwell Science Ltd, Oxford: pp 800-803.
Hess PR, English RV, Hegarty BC Brown DG, Breitschwerdt FB (2006) Experimental Ehrlichia canis infection in the dog does not cause immunosuppression. Vet Immunol Immunopathol 109:117-125.
Levy F, Mylonakis MF, Saridomichelakis MN Polizopoulou ZS, Psychogios V, Koulinas AF (2006) Nasal and oral masses in a dog. Vet Clin Pathol 35:115-118.
Marcos Rj Santos M, Marrinhas C. Rocha E (2006) Cutaneous transmissible venereal tumor without genital involvement in a prepubertal female dog. Vet Clin Pathol 35:106-109.
Mylonakis ME, Saridomichelakis MN, Lazaridis V, Leonlides LS, Kostoulas P Koutinas AF (2008) A retrospective study of 61 cases of spontaneous canine epistaxis (1998 to 2001) J Small Anim Pract 49:191-196.
Nak D, Nak Y, Cangul IT, Tuna Β (2005) A clinico-pathological study on the effect of vincristine on transmissible venereal tumour in dogs. J Vet Med 52:366-370.
Papazoglou L, Koulinas AF, Plevraki AG, Tonlis D (2001) Primary intranasal transmissible venereal tumour in the dog: A retrospective study of six spontaneous cases. J Vet Med A Physiol Pathol Clin Med 48:391-400
Park M, Kim Y, Kang M, Oh S, Cho D, Shin N, Kim D (2006) Disseminated transmissible venereal tumor in a dog. J Vet Diagn Invest 18:130-133.
Rogers KS, Walker MA, Dillon HB (1998) Transmissible venereal tumor: A retrospective study of 29 cases. J Am Anim Hosp Assoc 34:463-470.
Rogers KS (1997) Transmissible venereal tumor. Compend Cont Educ Pract Vet 19:1036-1045.
Scalpelli KC Valladao ML, Metze Κ (2010) Predictive factors for the regression of canine transmissible venereal tumor during vincristine therapy. Vet J 183:362-363.
Singh J, Rana J S, Sood N, Pangawkar OR, Gupta PP (1996) Clinicopathological studies on the effect of different anti-ncoplastic chemotherapy regimens on transmissible venereal tumours in dogs. Vet Res Commun 20:71-81.
Thrall DF (1982) Orthovoltage radiotherapy of canine transmissihlc venereal rumors. Vet Radiol 23:217-219.
Most read articles by the same author(s)