Eosinophilic dermatitis with edema (Wells'-like syndrome) possibly triggered by cooked fish in a dog


Published: Nov 13, 2017
Keywords:
Dog eosinophilic dermatitis with edema food-induced
G. D. GIANNOULOPOULOS (Γ.Δ. ΓΙΑΝΝΟΥΛΟΠΟΥΛΟΣ)
R. FARMAKI (Ρ. ΦΑΡΜΑΚΗ)
Ch. K. KOUTINAS (Χ.Κ. ΚΟΥΤΙΝΑΣ)
A. F. KOUTINAS (Α.Φ. ΚΟΥΤΙΝΑΣ)
Abstract

 A 2-year old intact female mongrel dog was admitted with multifocal skin lesions appearing suddenly and extending symmetrically over most of the body. The dog was living indoors and one day before the admission it had consumed cooked fish. Neither medication, nor vaccination had been given to the dog, at least during the last 3 months. Physical examination revealed only non-pruritic and non-painful macules, papules and plaques that were distributed mainly over the head, pinnae, neck and thorax. The lesions were annular, aeriform or serpiginous with a tendency to coalesce. Skin histopathology (H-E) revealed a superficial dermal edema, post-capillary venule congestion and perivascular to interstitial eosinophilic dermatitis as the main pattern. The dog was initially placed on oral vitamin E, sulphasalazine and doxycycline, but to no avail. As soon as the diagnosis of eosinophilic dermatitis with edema was confirmed by histopathology, the former treatment stopped and oral prednisolone was given for two months during which there was a remarkable improvement of skin lesions and complete disappearance with no relapse. The cooked fish, consumed by the dog the night before the incident, was assumed to be the cause of the acute eosinophilic hypersensitivity reaction.

Article Details
  • Section
  • Case Report
Downloads
Download data is not yet available.
References
Bloom PB (2006) Canine and Feline Eosinophilic Skin Diseases. The Veterinary clinics of North America. Small animal practice 36:141-160
Brehmer-Andersson E, Kaaman T, Skog E and Frithz A (1986) The histopathogenesis of the flame figure in Wells' syndrome based on five cases. Acta Derm Venereol 66:213-219
Dijkstra JW, Bergfeld WF, Steck WD and Tuthill RJ (1986) Eosinophilic cellulitis associated with urticaria. A report of two cases. J Am Acad Dermatol 14:32-38
Gerber BO and Pichler WJ (2004) Cellular mechanisms of Τ cell mediated drug hypersensitivity. Curr Opin Immunol 16:732-737
Gerber BO and Pichler WJ (2006) Non-covalent interactions of drugs with immune receptors may mediate drug-induced hypersensitivity reactions. AAPS J 8:E160-165
Grodecki Κ (2000) Leucocyte disorders: selected topics; Eosinophilia. In: Manual of Canine and Feline Hematology and Transfusion Medicine, ed, BSAVA, pp 131-138
Gross TL (2005) Skin diseases of the dog and cat: clinical and histopathologic diagnosis. 2nd ed, Blackwell Science, Ames, Iowa: pp224
Harvey JW (2001) Leucocytes. In: Atlas of Veterinary Hematology, Blood and Bone Marrow of Domestic Animals, ed, WB Saunders, Philadelphia: pp 45-74
Holm KS, Morris DO, Gomez SM, Peikes H, Byrne KP and Goldschmidt ΜΗ (1999) Eosinophilic dermatitis with edema in nine dogs, compared with eosinophilic cellulitis in humans. J Am Vet Med Assoc 215:649-653
Howes R, Girgis L and Kossard S (2008) Eosinophilic annular erythema: a subset of Wells' syndrome or a distinct entity? Australas J Dermatol 49:159-163
Itoh T, Nibe K, Kojimoto A, Mikawa M, Mikawa K, Uchida Κ and Shii Η (2006) Erythema multiforme possibly triggered by food substances in a dog. J Vet Med Sci 68:869-871
Leiferman KM and Peters MS (2007) Eosinophils in Cutaneous diseases. In: Fitzpatrick's Dermatology in General Medicine. 7th ed, McGraw-Hill Professional, pp 307-318
Mauldin EA, Palmeiro BS, Goldschmidt ΜΗ and Morris DO (2006) Comparison of clinical history and dermatologie findings in 29 dogs with severe eosinophilic dermatitis: a retrospective analysis. Vet Dermatol 17:338-347
McKee PH, Calonje JE and Granter SR (2005) Pathology of the Skin - with clinical correlations, ed, Mosby Ltd - Elsevier, pp 697-699
Moossavi M and Mehregan DR (2003) Wells' syndrome: a clinical and histopathologic review of seven cases. Int J Dermatol 42:62-67
Moriello KA (2003) Eosinophilic dermatoses. In: Manual of small animal dermatology, ed, BSAVA, pp 233-241
Peters MS, Schroeter AL and Gleich GJ (1983) Immunofluorescence identification of eosinophil granule major basic protein in the flame figures of Wells' syndrome. Br J Dermatol 109:141-148
Raskin RE, Latimer KS and Tvendten H (2004) Leukocyte Disorders. In: Small Animal Clinical Diagnosis by Laboratory Methods, ed, WB Saunders, St Louis: pp 63-91
Scott DW, Miller WH and Griffin CE (2001) Miscellaneous skin diseases. In: Small Animal Dermatology. 6th ed, WB Saunders, Philadelphia: pp 1125-1184
Stetson C (2003) Eosinophilic dermatoses. In: Dermatology, ed, Mosby, Edinburgh: pp 403-409
Vitale CB, Ihrke PJ and Gross TL (1994) Putative Diethylcarbamazine-induced Urticaria with Eosinophilic Dermatitis in a Dog. Veterinary Dermatology 5:197-203
Weedon D (2009) Weedon's Skin Pathology. 3rd ed, Churchill Livingstone - Elsevier, pp 940-941
Wood C, Miller AC, Jacobs A, Hart R and Nickoloff BJ (1986) Eosinophilic infiltration with flame figures. A distinctive tissue reaction seen in Wells' syndrome and other diseases. Am J Dermatopathol 8:186-193
Most read articles by the same author(s)