Diagnostic approach of canine Pancytopenia

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Published: Nov 27, 2017
DOI: https://doi.org/10.12681/jhvms.15012
Keywords:
Pancytopenia peripheral blood bone marrow dog
M. E. MYLONAKIS (Μ.Ε. ΜΥΛΩΝΑΚΗΣ)
Clinic of Companion Animal Medicine, School of Veterinary Medicine, Aristotle University of Thessaloniki
A. F. KOUTINAS (Α.Φ. ΚΟΥΤΙΝΑΣ)
Clinic of Companion Animal Medicine, School of Veterinary Medicine, Aristotle University of Thessaloniki
D. KASABALIS (Δ. ΚΑΣΑΜΠΑΛΗΣ)
Clinic of Companion Animal Medicine, School of Veterinary Medicine, Aristotle University of Thessaloniki
Abstract

Canine pancytopenia in the peripheral blood is often the result of monocytic ehrlichiosis (Ehrlichia canis), parvoviral enteritis, sepsis and the use of various drugs (antineoplastic, nonsteroidal anti-inflammatory, antimicrobial, antiparasitic, antiepileptic, estrogens) accounting for bone marrow hypoplasiaaplasia. Sporadic cases of pancytopenia, induced by neoplastic myelophthisis, myelodysplastic and hemophagocytic syndromes, myelofibrosis, myelonecrosis and systemic lupus erythematosus may also be seen. A comprehensive diagnostic plan may include a detailed history (i.e. recent drug exposure), a thorough clinical examination, complete blood count, routine serum biochemistry and the microscopic examination of peripheral blood smears, to rule out false thrombocytopenia or leukopenia and to search for E canis morulae, leukemic cells and toxic neutrophilic changes. However, the diagnostic cornerstone in the pancytopenic dog is bone marrow cytology, for the undisputable differentiation between myelosuppressive and non-myelosuppressive monocytic ehrlichiosis and the confirmation of hemopoietic tumors, myelodysplastic or hemophagocytic syndromes and bone marrow aplasia. Bone marrow core biopsy and histopathology is the method of choice for the definitive diagnosis of myelofibrosis, myelonecrosis and occasionally of bone marrow aplasia. Also, serology for E canis and antinuclear antibodies and fecal ELISA for parvovirus antigen are strongly recommended, along with the application of various imaging techniques, especially for the detection of ovarian tumors.

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