Pregnancy toxaemia of ewes. A literature review

Published: Jan 31, 2018
pregnancy toxaemia gestation reproduction sheep

Pregnancy toxaemia is a metabolic disorder of ewes, occurring at the final stage of pregnancy. In this review article, the literature on the aetiology and the pathogenesis of the disease is reviewed, the clinical, laboratory and postmortem findings are described, the diagnosis is presented and the control of the disease is discussed.

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McClymont GL, Setchell BP. Ovine pregnancy toxaemia. 1. Tentative identification as a hypoglycaemic encepalopathy. Aus. vet. J. 31:53
Παπαστεριάδης Α. Διατροφικά νοσήματα των αιγοπροβάτων στην Ελλάδα και τρόποι αντιμετώπισης τους. Πρακτικά Διεθνοΰς Σεμιναρίου Παραγωγής και Αξιοποίησης Αιγο-
πρόβειου Γάλακτος (Αθήνα), 1985,173
Αργυροΰδης Σ., Ψΰχας Β., Καρατζάνος Π., Αεοντίδης Σ., Κυριακής ΣΚ. Επίκαιρα μεταβολικά νοσήματα της ελληνικής αιγοπροβατοτροφίας. Πρακτικά 2ου Πανελλήνιου Συμποσίου Κτηνιατρικής Μικρών Μηρυκαστικών (Καρδίτσα), 1998,42
Cantley CE, Ford CM, Heath MF. Serum fructosamide in ovine pregnancy toxaemia: a possible prognostic index. Vet Ree 1991,128:525
Goff JP, Horst RL. Physiological changes at parturition and their relationship to metabolic disorders. J Dairy Sci 1997, 80:1260
Bell AW. Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. J anim Sci 1995,73:2804
Guard C. Metabolic diseases: a herd approach. In: Rebhun W, Diseases of Dairy Cattle, Williams & Wilkins, Baltimore, 1995,497
Andrews A. Pregnancy toxaemia in the ewe. In Pract 1997, 19:306
Bertics SJ, Grummer RR, Valino CC, Stoddard EE. Effect of prepartum dry matter intake on liver triglyceride concentration and early lactation. J Dairy Sci 1992,75:1914
Grummer RR. Impact of changes in organic nutrient metabolism on feeding the transition dairy cow. J anim Sci 1995,73:2820
Godwin I, Kauter K, O'Shea T, McFarlane JR. Sexual dimorphism and pregnancy profiles of leptin in Merino sheep. Proceedings of the International Symposium on Reproduction
of Small Ruminants, 2000 (Sandnes, Norway), 52
Zaenuri L, Godwin I. Effects of pregnancy and lactation on reticulo-rumen motility in sheep. Proceedings of the International Symposium on Reproduction of Small Ruminants, 2000 (Sandnes, Norway), 53
Herdt TH. Fatty liver in dairy cows. Vet Clin Ν Am (Food Anim Pract) 1988,4:269
Fleming SA. Ketosis of ruminants (acetonemia). In: Smith B, Large Animal Internal Medicine, 2nd ed., Mosby, St Louis, 1996,1455
Kasari TR. Medical management of common physiologic and metabolic abnormalities in anorectic cattle. Food Anim Pract 1994, Sept:898
Heitmann RN, Dawes DJ, Sensenig SC. Hepatic ketonogenesis and peripheral ketone body utilization in the ruminant. J Nutr 1987,117:1174
Henze P, Bickhardt K, Fuhrmann H, Sallmann HP. Spontaneous pregnancy toxaemia (xetosis) in sheep and the role of insulin. Zblatt VetMed A1998,45:255
Hay LA, Baird GD. Pregnancy toxaemia. In: Martin WB, Aitken IA, Diseases of Sheep, 2nd ed., Blackwell, Oxford, 1994,254
Pearson EG, Maas J. Hepatic lipidosis. In: Smith B, Large Animal Internal Medicine, 2nd ed., Mosby, St Louis, 1996,937
Veenhuizen JJ, Drackley JK, Richard MJ, Sanderson TP, Miller LD, Young JW. Metabolic changes in blood and liver during development and early treatment of experimental fatty liver and ketosis in cows. J Dairy Sci 1991,74:4238
Drackley JK, Richard MJ, Beitz DC, Young JW. Metabolic changes in dairy cows with ketonemia in response to feed restriction and dietary 1,3-butanediol. J Dairy Sci. 1992,75:1622
Maisey I, Andrews AH, Laven RA. Efficacy of recombinant bovine somatotrophin in the treatment of fat cow syndrome. Vet. Ree. 1993,133:293
Grummer RR. Etiology of lipid-related metabolic disorders in periparturient dairy cows. J Dairy Sci 1993,76:3882
Moore DA, Ishler V. Managing dairy cows during the transition period: focus on ketosis. Food Anim Pract 1997, Dec: 1061
Kleppe BB, Aiello RJ, Grummer RR, Armentano LE. Triglyceride accumulation and very low density lipoprotein secretion by the rat and goat hepatocytes in vitro. J Dairy Sci 1988,71:1813
Grummer RR, Carroll DJ. Effects of dietary fat on metabolic disorders and reproductive performance of dairy cattle. J anim Sci 1991,69:3838
Strang BD, Bertics SJ, Grummer RR, Armentano LE. Effect of long-chain fatty acids on triglyceride accumulation, gluconeogenesis and ureagenesis in bovine hepatocytes. J Dairy Sci 1998,81:728.
Tveit B, Lingaas F, Svedsen M, Sjaastad OV. Etiology of acetonemia in Norwegian cattle. 1. Effect of ketogenic silage, season, energy level and genetic factors. J Dairy Sci 1992, 75:2421
Reid IM, Roberts CJ, Treacher RJ, Williams LA. Effect of body condition at calving on tissue mobilization, development of fatty liver and blood chemistry of dairy cows. Anim Prod 1986,43:7
Lean IJ, Bruss ML, Troutt HF, Galland JC, Farver TB, Rostami J, Holmberg CA, Weaver LD. Bovine ketosis and somatotrophin: risk factors for ketosis and effects of ketosis on health and production. Res, vet. Sci. 1994,57:200
Treacher RJ, Reid IM, Roberts CJ. Effect of body condition at calving on the health and performance of dairy cows. Anim Prod 1986,43:1
Vasquez MA, Bertics S J, Grummer RR. The effect of dietary energy source during mid to late lactation on liver triglyceride and lactation performance of dairy cows. J Dairy Sci 1997, 80:2504
Studer VA, Grummer RR, Bertics SJ, Reynolds CK. Effect of prepartum propylene glycol administration on periparturient fatty liver in dairy cows. J Dairy Sci 1993,76:2931
Scott PR. Analysis of cerebrospinal fluid from field cases of some common ovine neurological diseases. Br vet J 1992, 148:15
Scott PR, Woodman MP. An outbreak of pregnancy toxaemia in a flock of Scottish blackface sheep. Vet Ree 1993,133:597
Thomson RW. Pregnancy toxaemia: a cautionary tale of economic pressures. Proc Sheep Vet Soc, 1999,23:97
Scott PR, Sargison ND, Penny CD. Evaluation of recombinant bovine somatotropin in the treatment of ovine pregnancy toxaemia. Vet J. 1998,155:197
Scott PR, Sargison ND, Penny CD, Pirie RS, Kelly JM. Cerebrospinal fluid and plasma glucose concentration of ovine pregnancy toxaemia cases, inappetant ewes and normal ewes during late gestation. Br vet J 1995,151:39
Ford EJ, Evans J, Robinson I. Cortisol in pregnancy toxaemia in sheep. Br. vet. J. 1990,146:539
Bickherdt K, Henze P, Ganter M. [Clinical findings and differential diagnosis in ketosis and hypocalcemia in sheep.] (De) Dtsch Tierarzt! Wochenschr 1998,105:413
Scott P. Differential diagnosis of common metabolic disorders of sheep. In Pract 1995,17:266
Studer E. A veterinary perspective of on-farm evaluation of nutrition and reproduction. J Dairy Sci 1998,81:872.
Foster LA. Clinical ketosis. Vet Clin Ν Am (Food Anim Pract) 1988,4:253
Sakai T, Hayakawa T, Hamakawa M, Ogura K, Kubo S. Therapeutic effects of simultaneous use of glucose and insulin in ketotic dairy cows. J Dairy Sci 1993,76:109
Shpigel NY, Chen R, Avidar Y, Bogin E. Use of corticosteroids alone or combined with glucose to treat ketosis in dairy cows. J am vet med Assoc 1996,208:1702
Rüssel A. Nutrition of the pregnant ewe. In Pract 1985,7:23
Menzies, P.I. Reproductive health management problems. In: Youngquist RS, Current Therapy in Large Animal Theriogenology, Saunders, Philadelphia, 1997,643
Himonas C, Fthenakis GC, Papadopoulos E. Effects of moxidectin treatment on milk yield of ewes and on growth of lambs. Proceedings of the 4th International Symposium for Sheep Veterinarians, 1997 (Annidale, Australia), 431
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