Rhabdomyosarcomas arising from striated muscles in elderly dogs: pathological features of 4 cases

Published: Dec 19, 2017
alveolar dog immunohistochemistry pleomorphic rhabdomyosarcoma

Primary rhabdomyosarcomas are rare in dogs. Based on their classification, embryonal rhabdomyosarcoma is the most common, while alveolar and especially pleomorphic types occur less often. Four cases diagnosed as primary canine rhabdomyosarcomas of striated muscles were retrieved from our files. All the animals were cross-breeds, aged over 8 years. Two of them had died after developing disseminated intravascular coagulation and gastric ulcer, respectively, and two others were euthanized. Of those two, one had been admitted with neurological and cardiovascular symptoms and one with disseminated intravascular coagulation. Necropsy was performed and tissue samples were collected for histological and immunohistochemical examination. The first case was diagnosed as mixed rhabdomyosarcoma, pleomorphic type in the heart and the diaphragm and alveolar type in the lungs and the spleen. The three other cases were of alveolar type. One showed primary cardiac and oesophageal origin, with metastases in the skeletal muscles and non striated muscle tissues, one had primary cardiac, with mitral valve involvement, and skeletal muscle origin, with metastases in extra striated muscle tissues and one showed only skeletal muscle localization. Immunohistochemical examination revealed myoglobin and α-sarcomeric actin in tumour cells.

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Akkoc A, Ozyigit MO, Y ilmaz R , Alasonyalilar A, Cangul IT (2006) Cardiac metastasizing rhabdomyosarcoma in a great Dane. Vet Rec 158:803-804.
Aupperle H, März I, Ellenberger C, Buschatz S, R eischauer A, Schoon H-A (2007) Primary and secondary heart tumours in dogs and cats. J Comp Pathol 136:18-26.
Bae IH, Kim Y , Pakhrin B, Y ou MH, Hwang CY, Kim JH, Kim DY (2007) Genitourinary rhabdomyosarcoma with systemic metastasis in a young dog. Vet Pathol 44:518-520.
Brockus CW, Myers R K (2004) Multifocal rhabdomyosarcomas within the tongue and oral cavity of a dog. Vet Pathol 41:273-274.
Chapman S, Nabity M, Calise D. What is your diagnosis? Lingual mass in a dog (2008) Vet Clin Pathol 37:133-139.
Chijiwa K, Uchida K, Tateyama S (2004) Immunohistochemical evaluation of canine peripheral nerve sheath tumors and other soft tissue sarcomas. Vet Pathol 41:307-318.
Clegg PD, Coumbe A (1993) Alveolar rhabdomyosarcoma: an unusual cause of lameness in a pony. Eq Vet J 25:547-549.
Cooper BJ, Valentine BA (2002) Tumors of muscle. In: Tumors of domestic animals DJ Meuten, Ed, 4th ed, Iowa State Press, Ames, IA pp: 319-363.
Ginel PJ, Martín de las Mulas J, Lucena R , Millán Y , Novales M (2002) Skeletal muscle rhabdomyosarcoma in a dog. Vet R ec 151:736-738.
Gonin-Jmaa D, Paulsen DB, Taboada J (1996) Pericardial effusion in a dog with rhabdomyosarcoma in the right ventricular wall. J Small Anim Pract 37:193-196.
Illanes OG (2002) Juvenile Parameningeal rhabdomyosarcoma in a dog causing unilateral denervation atrophy of masticatory muscles. J Comp Pathol 126:303-307.
Kim D-Y, Hodgin EC, Cho D-Y, Varnado JE (1996) Juvenile rhabdomyosarcomas in two dogs. Vet Pathol 33:447-450.
Kobayashi M, Sakai H, Hirata A, Y onemaru K, Y anai T, Watanabe K, Yamazoe K, Kudo T, Masegi T (2004) Expression of myogenic regulating factors, myogenin and myoD, in two canine botryoid rhabdomyosarcomas. Vet Pathol 41:275-277.
Krotje LJ, Ware WA, Niyo Y (1990) Intracardiac rhabdomyosarcoma in a dog. J Am Vet Med Assoc 197:368-371.
Lascelles BD, McInnes E, Dobson JM, White R A (1998) Rhabdomyosarcoma of the tongue in a dog. J Small Anim Pract 39:587-591.
Machida N, Kobayashi M, Tanaka R , Katsuday S, Mitsumori K (2003) Primary malignant mixed mesenchymal tumour of the heart in a dog. J Comp Pathol 128:71-74.
Mincus G, Hillemanns M (1997) Botryoid-type embryonal rhabdomyosarcoma of liver in a young cat. Vet Pathol 4:618-621.
Murakami M, Sakai H, Iwatani N, Asakura A, Hoshino Y , Mori T, Y anai T, Maruo K, Masegi T (2010) Cytologic, histologic, and immunohistochemical features of maxillofacial alveolar rhabdomyosarcoma in a juvenile dog. Vet Clin Pathol 39:113-118.
Nakaichi M, Itamoto K, Hasegawa K, Morimoto M, Hayashi T, Une S, Taura Y , Tanaka K (2007) Maxillofacial rhabdomyosarcoma in the canine maxillofacial area. J Vet Med Sci 69:65-67. Pérez J, Pérez-Rivero A, Montoya A, Paz Martín M, Mozos E (1998) Right-sided heart failure in a dog with primary cardiac rhabdomyosarcoma. J Am Anim Hosp Assoc 34:208–211.
Sarnelli R , Grassi F, R omagnoli S (1994) Alveolar rhabdomyosarcoma of the greater omentum in a dog. Vet Pathol 31:473-475.
Seibold HR (1974) Juvenile alveolar rhabdomyosarcoma in a dog. Vet Pathol 11:558-560.
Suzuki K, Nakatani K, Shibuya H, Sato T (2006) Vaginal rhabdomyosarcoma in a dog. Vet Pathol 43:186–188.
Worley G, Gorham JR (1954) The comparative pathology of rhabdomyosarcoma with the report of a case in a dog. Am J Pathol 30:837-849.
Yamate J, Murai F, Izawa T, Akiyoshi H, Shimizu J, Ohashi F, Kuwamura M (2011) A rhabdomyosarcoma arising in the larynx of a dog J Toxicol Pathol 24:179-182.
Yanoff SR, Fuentealba C, Boothe HW, R ogers KS (1996) Tracheal defect and embryonal rhabdomyosarcoma in a young dog. Can Vet J 37:172-173.
Yasuda T, Perry KD, Nelson M, Bui MM, Nasir A, Goldschmidt R , Gnepp DR, Bridge JA (2009) Alveolar rhabdomyosarcoma of the head and neck region in older adults: genetic characterization and a review of the literature. Hum Pathol 40:341-348.
Yener Z (2001) Alveolar rhabdomyosarcoma of the limb in a sheep.Dtsch Tierarztl Wochenschr 108:315-316.
Yhee JY, Kim DH, Hwang DN, Moon CT, Y u CH, Kim HY, Doster AR, Sur JH (2008) Hematogenous metastasis of embryonal rhabdomyosarcoma originating from skeletal muscle in a young dog. J Vet Diagn Invest 20:243-246.
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