A case of kidney infection by Corynebacterium pseudotuberculosis in sheep

Published: Nov 13, 2017
Sheep Corynebacterium pseudotuberculosis kidney abscess

A three year-old female sheep was presented to the Clinic of Farm Animals, School of Veterinary Medicine, Aristotle University of Thessaloniki, with mild nasal seromucous discharge and progressive weight loss, while rectal temperature was normal. Hematological examination revealed mild leukocytosis, while traces of hemoglobin and protein were found in urinalysis. The animal was euthanized and forwarded for necropsy. An extremely enlarged, nodular right kidney, whose renal parenchyma was completely replaced by multiple abscesses, was the remarkable finding of the necropsy. Microbiological and molecular examinations were performed to establish the diagnosis and rule out Maedi/Visna infection. Tissue samples from the kidney and other organs were, also, examined histologically. Corynebacterium pseudotuberculosis was isolated in microbiological tests. A kidney infection by C. pseudotuberculosis, presented as a clinical case with scant symptoms, is discussed in this case report.

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AYERS JL (1977) Caseous lymphadenitis in goats and sheep: a review of diagnosis, pathogenesis and immunity. J Am Vet Med Assoc, 171:1251-1254.
BATEY RG (1986a) Pathogenesis of caseous lymphadenitis in sheep and goats. Aust Vet J, 63:269-272.
BATEY RG (1986b) Aspects of pathogenesis in a mouse model of infection by Corynebacterium pseudotuberculosis. Aust J Exp Biol Med Sci, 64:237-249.
BAIRD GJ, FONTAINE MC (2007) Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis. J Comp Path, 137:179-210.
FERRER LM, LACASTA D, CHACON G, RAMOS JJ, VILLA A, GOMEZ P, LATRE MV. (2009) Clinical diagnosis of visceral casceous lymphadenitis in a Salz ewe. Small Ruminant Research, 87:126-127.
FONTAINE MC, BAIRD G, CONNOR KM, RUDGE K, SALES J, DONACHIE W (2006) Vaccination confers significant protection of sheep against infection with a virulent United Kingdom strain of Corynebacterium pseudotuberculosis. Vaccine, 24:5986-5996.
GRANT MM and NEWMAN SJ (2007) Embolic Supparative nephritis. In: Pathology of domestic animals, vol 2,5th ed. Saunders Elsevier, ρ 480.
JECKEL S, BROWNE E, ALONY Y, NEVEL M (2009) Case study: Unusual presentations of pathological lesions due to caseous lymphadenitis in adult sheep. In: Proceedings of the 7th International Sheep Veterinary Congress, (Stavanger) Norway, ρ 78.
JOLLY RD (1965) The pathogenesis of experimental Corynebacterium ovis infection in mice. Ν Ζ Vet J, 13:141-147.
KRAMER JW (2000) Normal hematology of cattle, sheep and goats. In: Schalm's Veterinary Hematology. Blackwell Scientific Publications, USA, pp 305-318.
LOFSTEDT J (2002) Caseous lymphadenitis. In: Large animal internal medicine, 3r d ed Mosby, St Louis, Missouri, USA, pp 583-584.
PANOUSIS NK, KRITSEPI-KONSTANTINOU M, GIADINIS ND, KALAITZAKIS E, POLYZOPOULOU Ζ (2007) Haematology values and effect of age and reproductive stage on haematological parameters of Chios sheep. J Hel Vet Med Soc, 58:124-136.
PATON MW, WALKER SB, ROSE IR, WATT GF (2003) Prevalence of caseous lymphadenitis vaccines in sheep flocks. Aust Vet J, 81:91-95.
PEEL MM, PALMER GG, STACPOOLE AM, KERR TG (1997) Human lymphadenitis due to Corynebacterium pseudotuberculosis: report of ten cases from Australia and review. Clin Infect Dis, 24:185-191.
PEPIN M, PITTET JC, OLIVIER M, GOHIN I (1994) Cellular composition of Corynebacterium pseudotuberculosis pyogranulomas in sheep. J Leukoc Biol, 56:666-670.
PRITCHARD GC, DAWSON M (2002) Maedi-Visna. In: Diseases of Sheep. Blackwell Science, UK, pp 187-191.
QUINN PJ, CARTER ME, MARKEY B, CARTER GR (1999) Corynebacterium species and Rhodococcus equi. In: Clinical Veterinary Microbiology, Mosby Harcourt Publishers Limited, pp 137-143.
RADOSTITS OM (2007) Caseous lymphadenitis of sheep and goats. In: Veterinary Medicine, A textbook of the diseases of cattle, horse, sheep, pigs and goats. 10th ed. Saunders Elsevier, pp 795-798.
ROUBIES N, PANOUSIS N, FYTIANOU A, KATSOULOS PD, GIADINIS N, KARATZIAS H (2006) Effects of age and reproductive stage on certain serum biochemical parameters of Chios sheep under Greek rearing conditions. J Vet Med A Physiol Pathol Clin Med, 53:277-281.
SCOTT PR, COLLIE DDS, HUME LH (1997) Caseous lymphadenitis in a commercial ram study in Scotland. Vet Ree, 141:548-549.
STOOPS SG, RENSHAW HW, THILSTED JP (1984) Ovine caseous lymphadenitis: disease prevalence, lesion distribution and thoracic manifestations in a population of mature culled sheep from western United States. Am J Vet Res, 45:557-561.
VALLI VEO (2007) Ulcerative lymphangitis. In: Pathology of domestic animals, vol 3,5th ed. Saunders Elsevier, pp 292-294.
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