Aujeszky's Disease (Pseudorabies). An old threat in current pig industry? Part I. Pathogenetic information and implications
Published:
Nov 10, 2017
Keywords:
Aujeszky's Disease glycoproteins pathogenesis
Abstract
Aujeszky's disease (AD) (or Pseudorabies) is an important viral disease of swine causing neurological signs in neonatal pigs, respiratory problems in fatteners and reproductive disorders in breeding stock. Glycoproteins and enzymes of the AD virus (ADV) and their interactions with the cellular components majorly determine its pathogenesis. After primary replication in the epithelia of the upper respiratory tract, ADV travels via the nerves to the central nervous system and via the blood to secondary replication sites (lymph nodes, lungs, uterus etc). Depending on the age of the affected swine, it can cause neonatal mortality due to neurological disease, respiratory disease in growing and adult pigs and reproductive disorders in breeding animals. One of the characteristic features of ADV is latency. In this paper, its major points on etiology, pathogenesis, clinical and post mortem findings and diagnosis are presented.
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PAPAGEORGIOU (Κ.Β. ΠΑΠΑΓΕΩΡΓΙΟΥ) K. V., BURRIEL, A. R., FILIOUSSIS (Γ. ΦΙΛΙΟΥΣΗΣ) G., PSYCHAS (Β. ΨΥΧΑΣ) V., NAUWYNCK, H., & KRITAS (Σ.Κ. ΚΡΗΤΑΣ) S. (2017). Aujeszky’s Disease (Pseudorabies). An old threat in current pig industry? Part I. Pathogenetic information and implications. Journal of the Hellenic Veterinary Medical Society, 62(1), 29–37. https://doi.org/10.12681/jhvms.14833
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- Vol. 62 No. 1 (2011)
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- Review Articles
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References
Baskerville A (1971) The histopathology of pneumonia produced by aerosol infection of pigs with a strain of Aujeszky's disease virus. Res Vet.Sci 12:590-592.
Baskerville A (1972a) Ultrastructural changes in the pulmonary airways of pig infected with a strain of Aujeszky's disease virus. Res Vet Sci 13:127-132.
Baskerville A (1972b) Aujeszky's disease encephalitis in pigs produced by different modes of infection. Res Vet Sci 13:394-396.
Baskerville A (1972c) The influence of the dose of virus on the clinical signs in experimental Aujeszky's disease in pigs. Brit Vet J 128:394-401.
Baskerville A, McFerran, JB. and Dow C (1973) Aujeszky's disease in pigs. Vet Bull 43,9:465-480.
Center for Food Security & Public Health (2006) http://www.cfsph.iastate.edu/Factsheets/pdfs/aujeszkys_disease.pdf [accesed 30 January 2010]
Csontos L and Szeky A (1966) Gross and microscopic lesions in the nasopharynx of pigs with Aujeszky's disease. Acta Vet Acad Sci Hung. 1966;16(2):175-85
Dow, C and McFerran, J.B. (1962). The neuropathology of Aujeszky's disease in the pig, Res. Vet. Sci., 3,436-442.
Gutekunst DE, Pirtle EC (1979) Humoral and cellular immune responses in swine after vaccination with inactivated Pseudorabies virus. Am J Vet Res 40:1343-1346.
Huang C, Hung J, Wu C, Chien M (2004) Multiplex PCR for rapid detection of Pseudorabies virus, porcine parvovirus and porcine circoviruses. Vet Microbiol, 101:209-214.
Jakubik, J (1977) Comparative susceptibility of rabbits, rats, mice and pigs to infection with Aujeszky's disease virus (ADV) in the development and efficacy test for ADV vaccines. Zbl Vet Med Β 24:765-766.
Jamieson AT, Gentry GA and Subak-Sharpe JH (1974) Induction of both thymidine and deoxycytidine kinase activity by herpes viruses. J Gen Virol 24:465-480.
Kit S, Kit M and Pirtle EC (1985) Attenuated properties of thymidine kinase-negative deletion mutant of Pseudorabies virus. Am J Vet Res 46, 6:1359-1367.
Kritas S (1994) Thesis in Neuropathogenesis of wild-type and deleted Aujeszky's disease virus strains in pigs with and without specific maternal antibodies. Faculty of Veterinary Medicine, University of Gent, Belgium.
Kritas SK, Pensaert MB, Mettenleiter TC (1994a) Invasion and spread of single glycoprotein deleted mutants of Aujeszky's disease virus (ADV) in the trigeminal nervous pathway of pigs after intranasal inoculation. Vet Microbiol 40:323-334.
Kritas SK, Pensaert MB, Mettenleiter TC (1994b) Role of envelope glycoproteins gl, gp63 and gill in the invasion and spread of Aujeszky's disease virus in the olfactory nervous pathway of the pig. J Gen Virol 75:2319-2327.
Kritas SK, Nauwynck HJ and Pensaert MB (1995) Dissemination of wild-type and gC-, gE- and gl-deleted mutants of Aujeszky's disease virus in the maxillary nerve and trigeminal ganglion of pigs after intranasal inoculation. J Gen Virol 76:2063-2066
Kritas SK, Nauwynck HJ, Pensaert MB, Kyriakis SC (1997) Effect of the concentration of maternal antibodies on the neural invasion of Aujeszky's disease virus in neonatal pigs. Vet Microbiol 55:29-36.
Kritas SK, Nauwynck HJ, Pensaert MB, Kyriakis SC (1998) Infection of fattening pigs by a virulent strain of Aujeszky's disease virus and its spread in the pig. Bulletin of the Hellenic Veterinary Medical Society 50,4,310-314 [in greek].
Kritas SK, Nauwynck HJ, Pensaert MB, Kyriakis SC (1999a) Neural invasion of two virulent suis herpesvirus 1 strains in neonatal pigs with or without maternal immunity. Vet Microbiol 69:143-156.
Kritas SK, Nauwynck HJ, Pensaert MB, Kyriakis SC (1999b) Safety of genetically engineered vaccines against suid herpesvirus 1: Comparison of gE- and TK- single deleted mutants in the pig. Hellenic Virology 4 (1): 51-56. [in greek]
Kritas SK, Nauwynck HJ, Pensaert MB, Kyriakis SC (1999c) Invasion and spread of a gG-deleted mutant of Aujeszky's disease virus (Suid herpesvirus 1) in the trigeminal nervous pathway of neonatal pigs. Hellenic Virology, 4 (2):108-116. [in greek]
Kritas SK, Nauwynck HJ, Pensaert MB, Kyriakis SC (1999d) Invasion and spread of a gG-deleted mutant of Aujeszky's disease virus (Suid herpesvirus 1) in the olfactory nervous pathway of neonatal pigs. Hellenic Virology, 4 (2): 117-125 [in greek]
Lee JYS and Wilson MR (1979) A review of Pseudorabies (Aujeszky's disease) in pigs. Can Vet J 20:65-69.
McFerran JB and Dow C (1975) Studies on immunisation of pigs with the Bartha strain of Aujeszky's disease virus. Res Vet Sci 19:17-22.
McGregor S, Easterday BC, Kaplan AS and Ben-Porat Τ (1985) Vaccination of swine with thymidine kinase-deficient mutants of Pseudorabies virus. Am J Vet Res 46:1494-1497.
Mengeling WL (1991) Virus reactivation in pigs latently infected with a thymidine kinase negative vaccine strain of Pseudorabies virus. Arch Virol 120:57-70.
Mettenleiter TC (2000) Aujeszky's disease (Pseudorabies) virus: the virus and molecular pathogenesis-State of the art. Vet Res 31:99-115.
Narita M, Ishi M (2006) Brain lesions in pigs dually infected with porcine reproductive and respiratory syndrome virus and Pseudorabies virus. J Comp Path 134:111-114.
Nauwynck HJ and Pensaert MB (1992) Abortion induced by cellassociated Aujeszky's disease virus in vaccinated sows. Am J Vet Res 53:489-493.
Nauwynck HJ and Pensaert MB (1995) Cell-free and cell-associated viremia in pigs after oronasal infection with Aujeszky's disease virus. Vet Microbiol 43:307-314.
Nauwynck H (1997) Fuctional aspects of Aujeszky's disease (Pseudorabies) viral proteins with relation to invasion, virulence and immunogenicity. Vet Microbiol 55:3-11.
Nauwynck H, Glorieux S, Favoreel H, Pensaert M (2007) Cell biological and molecular characteristics of Pseudorabies virus infections in cell cultures and in pigs with emphasis on the respiratory tract. Vet Res 38:229-241.
Olander HJ, Saunders JR, Gustafson DP and Jones,RK (1966) Pathologic findings in swine affected with a virulent strain of Aujeszky's virus. Path Vet 3:64 - 82.
Papatsas J, Paschaleri-Papadopoulou E, Koubati-Artopiou M, Kritas SK, Kyriakis SC (1995) Aujeszky's Disease in pigs: Update review and proposed measures for its control and eradication in Greece. Bulletin of the Hellenic Veterinary Medical Society 46:19-29 [in greek]
Pejsak ZK and Truszczynski MJ (2006) Aujeszky's Disease (Pseudorabies). In Diseases of Swine. 9th ed, Blackwell Publishing, pp 419-433.
Pensaert MB and Kluge JP (1989) Pseudorabies virus (Aujeszky's disease). In Virus infections of vertebrates, Horzinec M.C series editor, vol. 2, ρρ 37-64, Virus infections of porcines, Pensaert M.B. volume editor, Elsevier science publisers BV, Amsterdam-Oxford-New York- Tokyo.
Sabo A, Rajkani J and Blaskovic D (1968) Studies on the pathogenesis of Aujeszky's disease. I. The distribution of virulent virus in piglets after peroral infection,. Acta Virol 12:214-221.
Sabo A, Rajkani J and Blaskovic D (1969) Studies on the pathogenesis of Aujeszky's disease. III. The distribution of virulent virus in piglets after intranasal infection. Acta Virol 13:407-414.
Shope, R.E. (1931). An experimental study of "mad itch" with especial reference to its relationship to Pseudorabies. J Exp Med 54,233-248.
Tenser RB (1991) Role of herpes simplex virus thymidine kinase expression in viral pathogenesis and latency. Intervirology 32:76-92.
Wittmann G, Ohlinger V and Höhn U (1982) Die Vermehrung von Aujeszkyvirus (AV) in vakzinierten Schweinen nach experimenteller Infektion mit hohen und niederen Virusmengen. Zbl Vet Med Β 29:24-30.
Yoon HA, Eo SK, Aleyas AG, Park SO, Lee JH, Chae JS, Cho JG, Song HJ (2005) Molecular survey of latent Pseudorabies virus infection in nervous tissues of slaughtered pigs by nested and realtime PCR. J Microbiol 43,5:430-436.
Yoon HA, Eo SK, Aleyas AG, Cha S, Lee JH, Chae JS, Jang HK, Cho JG, Song HJ (2006) Investigation of Pseudorabies virus latency in nervous tissues of seropositive pigs exposed to field strains. J Vet Med Sci 68,2:143-148
Yue F, Cui S, Zhang C, Yoon KJ (2009) A multiplex PCR for rapid and stimultaneous detection of porcine circovirus type 2, porcine parvovirus, porcine Pseudorabies virus, and porcine reproductive and respiratory syndrome virus in clinical specimens. Vir Gen 38:392-397.
Van Oirschot JT, Rziha HJ, Moonen PJLM, Pol JM, van Zaane D (1986) Differentiation on serum antibodies from pigs vaccinated or infected with Aujeszky's disease virus by a competitive enzyme immunoassay. J Gen Virol 67:1179-1182.
