Squamous cell carcinoma of the dog

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Published: Jan 31, 2018
DOI: https://doi.org/10.12681/jhvms.15718
E. KALDRYMIDOU (Ε. ΚΑΛΔΡΥΜΙΔΟΥ)
Εργαστήριο Παθολογικής Ανατομικής Τμήμα Κτηνιατρικής Α.Π.Θ.
G. KANAKOUDIS (Γ. ΚΑΝΑΚΟΥΔΗΣ)
Εργαστήριο Παθολογικής Ανατομικής Τμήμα Κτηνιατρικής Α.Π.Θ.
Th. TOLIOU (Θ. ΤΟΛΙΟΥ)
Εργαστήριο Παθολογικής Ανατομικής Τμήμα Κτηνιατρικής Α.Π.Θ.
Th. POUTAHIDIS (Θ. ΠΟΥΤΑΧΙΔΗΣ)
Εργαστήριο Παθολογικής Ανατομικής Τμήμα Κτηνιατρικής Α.Π.Θ.
M. KARAGIANNOPOULOU (Μ. ΚΑΡΑΓΙΑΝΝΟΠΟΥΛΟΥ)
Εργαστήριο Παθολογικής Ανατομικής Τμήμα Κτηνιατρικής Α.Π.Θ.
Abstract
Squamous cell carcinoma is the most common skin neoplasm with cellular evidence of malignancy. Neoplastic cells preserve characteristics of the stratum spinosum and infiltrate dermis. Squamous cell carcinomas classification is based on the degree of cell differentiation and tumor architecture and includes more than one categories. Immunohistochemistry is often applied in order to distinguish this carcinoma from other epithelial neoplasms. In the present study four squamous cell carcinomas of the dog were examined and classified. Three of them (2,3,4) presented low rates of differentiation so, immuhistochemical detection of cellular keratin was performed, in order to avoid confusion with other keratinizing epithelial neoplasms. Two out of the three above mentioned tumors (3,4) exhibited acantholysis and pseudogranular structures. Immunohistochemical detection of the carcinoembryonic antigen provided evidence to distinguish them from adenocarcinomas. Finally, in the fourth tumor (4) areas of diffuse cellular proliferation, without obvious keratinization, were observed. Many of these cells appeared elongated. In this case, the immunohistochemical detection of vimentin was performed in order to find out if these cells belonged to the connective tissue or to a spindle-cell squamous cell carcinoma.
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References
Goldshmidt M Η and Shoefer F S: Skin Tumors of the Dog and Cat. Pergamon Press- Oxford 1992, pp 37-49.
Yager J A and Wilcock Β Ρ: Color Atlas and Text of Surgical Pathology of the Dog and Cat. Wolfe, 1994, pp 249-250
Vail D M and Withrow S J: Tumors of the skin and subcutaneous tissue. In Small Animal Clinical Oncology, (2nd Ed) W.B. Saunders Company 1996, pp 173-176, and 186-187.
Gross Τ L, Ihrke Ρ J, Wadler E J : Veterinary Dermatology (1st Ed) Mosby Year Book, Baltimore 1992, pp 336-341.
Strafuss A C, Cook J E and Smith J E: Squamous cell carcinoma in dogs. J. Am. Vet. Med. Assoc. 1976,168:425-427.
Murphy G F and Eiden D E: Non-Melanocytic Tumours of the skin. In Atlas of Tumor Pathology. Armed Forces Institute of Pathology. Washington. D.C 1990 pp 38-47.
Madewell Β R, Conroy J D and Hodgins Ε M: Sunlight-Skin cancer association in the dog: A report of tree cases. J. Cut. Pathol. 1981,8: 434-443.
Hargis A M, Thomassen R W and Phemister R D: Chronic dermatosis and cutaneous squamous cell carcinoma in the beagle dog. Vet. Pathol. 1977,14: 218-228.
Henderson R A and Brewer W G: Skin and subcuts. In Textbook of Small Animal Surgery, W.B. Saunders Company, Philadelphia, 1993, pp 2079.
Baer Κ E and Helton K: Multicentric squamous cell carcinoma in situ resembling Bowens disease in cats. Vet. Pathol. 1993, 30: 535-543.
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