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Problems encountered in LC-MS/MS analysis for the determination of pesticide residues in food

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G. MILIADIS, P. TSIANTAS, G. SIRAGAKIS
G. MILIADIS, P. TSIANTAS, G. SIRAGAKIS

Abstract


The most common problems encountered in LC-MS/MS analysis of food are cases of compounds with low recovery, low sensitivity in one transition, common transition with matrix or other analytes, as well as solvent and matrix effects. The significance of each case was experimentally investigated in this study by the use of representative compounds. The QuEChERS approach was used for the extraction of pesticides. The study involved analysis of 128 pesticides representing various chemical classes, polarities and molecular masses, in 8 products representing different commodities of food matrices. Blank matrices fortified at 33.3 and 167 μg/kg, were analysed using different LC-MS/MS conditions in order to evaluate the significance of each parameter. Additionally long term LC-MS/MS system suitability data of 18 months were used to evaluate the variability of retention time and ion ratio at the limit of detection. This was assessed by the use of 6 representative compounds and the respective control charts.

Keywords


pesticide residues; food; LC-MS/MS

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References


Anagnostopoulos C, Miliadis GE (2013). Development and validation of an easy multi-residue method for the determination of multi-class pesticide residues using GC-MS/MS and LC-MS/MS in olive oil and olives. Talanta. 112C, 1-10.

DG-SANCO (2013). Guidance Document on Analytical Quality Control and Validation Procedures for Pesticide Residues Analysis in Food and Feed. SANCO/12571/2013.

EN 15662 (2008). Foods of Plant Origin—Determination of pesticide residues using GC-MS and/or LC-MS/MS following acetonitrile extraction/partitioning and clean-up by dispersive SPE—QuEChERS method.

University of Hertfordshire (2007). http://sitem.herts.ac.uk/aeru/ppdb/ [accessed 19 December 2016].


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