A commercial monovalent canine parvovirus vaccine performs better than a commercial combination vaccine in puppies

PDF
Published: Jan 21, 2023
DOI: https://doi.org/10.12681/jhvms.27960
Keywords:
Dogs Primodog Duramune enteritis and serum antibody
MU Asghar
Institute of Microbiology, Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore, Pakistan
AA Anjum
Institute of Microbiology, Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore, Pakistan
M Rabbani
Institute of Microbiology, Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore, Pakistan
MA Khan
Department of Surgery, Riphah College of Veterinary Sciences, Riphah International University, Lahore, Pakistan
MA Ali
Institute of Microbiology, Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore, Pakistan
S Azeem
University of Veterinary and Animal Sciences, Lahore, Pakistan
https://orcid.org/0000-0002-1261-2034
Abstract

Thirty puppies were randomly divided in to 3 groups for comparative evaluation of two commercial CPV vaccines. Each group was further subdivided in to < 6 months and < 3 months -old puppies and either vaccinated with a monovalent vaccine: Primodog, a combination vaccine: Duramune or maintained as a non-vaccinated control. Humoral immune response was determined by Hemagglutination Inhibition (HAI) on 21 and 35 -days after vaccination. The geometric mean titer (GMT) induced by Duramune, 21 and 35 -days post-vaccination was GMT 73.3 and 137.2, respectively. Comparatively, Primodog demonstrated higher GMT on 21 and 35 -days after vaccination: 97.0 and 168.9, respectively. The older puppies (< 6 months old) demonstrated higher seroconversion to both vaccines.

Article Details
  • Section
  • Research Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Downloads
Download data is not yet available.
Author Biography
S Azeem, University of Veterinary and Animal Sciences, Lahore, Pakistan

Assistant Professor, Institute of Microbiology

References
Anderson N, Smith I (2019) Assessing the immunogenicity of an inactivated monovalent vaccine in the endangered African wild dog (Lycaon pictus). Vaccine X 1:100006. https://doi.org/10.1016/j.jvacx.2019.100006
Crow SE, Walshaw SO, Boyle JE (2009) Blood collection. In: Manual of clinical procedures in dogs, cats, rabbits and rodents. 3rd ed. Wiley-Blackwell, Singapore: pp 19-34.
Gueorguieva R, Krystal JH (2004) Move over ANOVA: Progress in Analyzing Repeated-Measures Data and Its Reflection in Papers Published in the Archives of General Psychiatry. Arch Gen Psychiatry. 61:310–307.
Miyaji K, Suzuki A, Shimakura H, Takase Y, Kiuchi A, Fujimura M Kurita G, Tsujimoto H, Sakaguchi M 2012 Large-scale survey of adverse reactions to canine non-rabies combined vaccines in Japan. Vet Immunol Immunopathol 145:447–452. http://dx.doi.org/10.1016/j.vetimm.2011.12.023.
Mochizuki M, Hashimoto M, Hajima T, Takiguchi M, Hashimoto A, Une Y, Roerink F, Ohshima T, Parrish CR, Carmichael LE. (2002) Virologic and serologic identification of minute virus of canines (canine parvovirus type 1) from dogs in Japan. J Clin Microbiol 40:3993–3998.
Nandi S, Kumar M (2010) Canine parvovirus: Current perspective. Indian J Virol 21:31–44.
Nauta J (2011) Statistics in clinical vaccine trials. Netherlands: Springer-Verlag, Germany: pp. 20-21.
Palmer DF, Dowdle WR, Coleman MT, Schild GC (1975) Advanced laboratory techniques for influenza diagnosis. Washington: U.S. Dept. of Health, Education, and Welfare, Public Health Service. pp. 26-45.
Pratelli A, Cavalli A, Martella V, Tempesta M, Decaro N, Carmichael LE, Buonavoglia C. (2001) Canine parvovirus (CPV) vaccination: Comparison of neutralizing antibody responses in pups after inoculation with CPV2 or CPV2b modified live virus vaccine. Clin Diagn Lab Immunol 8:612–615.
Razmaraii N, Toroghi R, Babaei H, Khalili I, Sadigh-Eteghad S, Forghy L (2012) Immunogenicity of commercial, formaldehyde and binary ethylenimine inactivated Newcastle disease virus vaccines in specific pathogen free chickens. Razi Arch Razi Inst 67:21–25.
Shabbir MZ, Sohail MU, Chaudhary UN, Yaqub W, Rashid I, Saleem MH, Munir M (2017) Genetic Characterization of a canine parvovirus from dogs in Pakistan. Acta Virol 61:175–182.
Spickler AR, Roth JA (2003) Adjuvants in Veterinary Vaccines: Modes of Action and Adverse Effects. J Vet Intern Med 17:273–281.
Willem C, Lacheretz A, Latour S (2001) Control of canine parvovirus infection in breeding kennels : Study of the efficacy of a high titer attenuated canine parvovirus vaccine. Rev Med Vet (Toulouse). 152:373–378.
Most read articles by the same author(s)