Investigation of cytokine levels in calves with sepsis

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Veröffentlicht: Ιουλ 10, 2022
DOI: https://doi.org/10.12681/jhvms.26655
H Guzelbektes
Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey. 2Department of Internal Medicine, Faculty of Veterinary Medicine, Kyrgyz Turkish Manas University, Bishkek, Kyrgyzstan.
I Sen
Department of Internal Medicine, Faculty of Veterinary Medicine, Kyrgyz Turkish Manas University, Bishkek, Kyrgyzstan.
U Aydogdu
Department of Internal Medicine, Faculty of Veterinary Medicine, Balikesir University, Balikesir, Turkey. 4Department of Internal Medicine, Faculty of Ceyhan Veterinary Medicine, Cukurova University, Adana, Turkey
C Er
Department of Internal Medicine, Faculty of Ceyhan Veterinary Medicine, Cukurova University, Adana, Turkey.
Alparslan Coşkun
Sivas Cumhuriyet University,
https://orcid.org/0000-0002-2242-9647
Abstract

This study aimed to detect changes in clinical parameters, biochemical and serum cytokine levels in calves with sepsis. In the study, 34 calves diagnosed with sepsis according to clinical and laboratory results and 7 calves deemed to be healthy according to clinical and laboratory results were used. The blood sample was taken from vena jugularis for determination of hematological, biochemical, and cytokine levels. Significant changes were observed in the clinical parameters of calves with sepsis. Serum concentrations of IL-1β, IL-6, IL-10, TNF-α, and INF-γ were significantly increased (p < 0.05) in calves with sepsis compared to the control group. Also, a significant increase (p < 0.05) in serum BUN, creatinine, CK, and CK-MB levels and a significant decrease in TP level (p < 0.05) were determined in calves with sepsis compared to the control group.

In conclusion, it was concluded that varying degrees of tissue/organ damage developed in calves with sepsis and cytokines played an important role in the development of inflammatory damage during sepsis.

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