A case of giant cell osteosarcoma in a Scottish fold cat

PDF (English)
Veröffentlicht: Ιαν 25, 2023
DOI: https://doi.org/10.12681/jhvms.28130
B Dayı
Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pathology
https://orcid.org/0000-0002-9253-4012
AM Mutlu
Bursa Uludag University, Faculty of Veterinary Medicine, Department of Pathology
https://orcid.org/0000-0001-9745-4567
A Akkoç
Bursa Uludag University, Faculty of Veterinary Medicine, Department of Pathology
https://orcid.org/0000-0002-5090-7917
A Sevimli
Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pathology
https://orcid.org/0000-0003-0452-0129
Abstract

This study describes a case of giant cell osteosarcoma (GCO) localised on the right scapulae in a six-year-old neutered male Scottish Fold cat. GCO is a rare tumour in domestic animals. This tumour is also known as giant cell-rich osteosarcoma. Multinucleated giant cells and osteoid structures are observed in GCO. The mass was 4.6 x 4.4 x 4.3 cm in size and very firm. Microscopically, fusiform spindle-shaped cells and multinucleated giant cells were observed. There were 4-8 mitotic figures in three random high-power fields (400x). Osteoid structures and necrosis were detected in several areas. In these areas, atypia was observed in the cells. Immunohistochemically, vimentin expression was observed in neoplastic cells and multinucleated giant cells. No immunoreactivity against actin and cytokeratin was observed in neoplastic cells. Additionally, vimentin expression was detected in the periphery of blood vessels and actin expression in blood vessel smooth muscle cells. As a result of histopathological and immunohistochemical findings, the mass was determined to be GCO.

Article Details
  • Rubrik
  • Case Report
Creative-Commons-Lizenz
Dieses Werk steht unter der Lizenz Creative Commons Namensnennung - Nicht-kommerziell 4.0 International.

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Downloads
Keine Nutzungsdaten vorhanden.
Autor/innen-Biografien
B Dayı, Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pathology

Department of Pathology, Research Assistant

AM Mutlu, Bursa Uludag University, Faculty of Veterinary Medicine, Department of Pathology

Department of Pathology, PhD Student

A Akkoç, Bursa Uludag University, Faculty of Veterinary Medicine, Department of Pathology

Department of Pathology, Associate Professor

A Sevimli, Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pathology

Department of Pathology, Professor

Literaturhinweise
Bertoni F, Bacchini P, Staal EL (2003) Malignancy in giant cell tumor of bone. Cancer 97(10):2520-2529.
Cerilli L, Wick M (2002) Immunohistology of soft tissue and osseous neoplasms. In: Diagnostic Immunohistochemistry. 1st ed, Chruchill Livingstone, New York: pp 72-73.
Craig LE, Dittmer KE, Thompson KG (2016) Bones and joints. In: Jubb, Kennedy, and Palmer’s Pathology of Domestic Animals Volume 1. 6th ed, Elsevier, St. Louis: pp 16-163.
Dimopoulou M, Kirpensteijn J, Moens H, Kik M (2008) Histologic prognosticators in feline osteosarcoma: a comparison with phenotypically similar canine osteosarcoma. Vet Surg 37(5):466-471.
Ehrhart NP, Ryan SD, Fan TM (2006) Tumors of the skeletal system. In: Small Animal Clinical Oncology. 4th ed, Elsevier, St. Louis: p. 463.
Fain JS, Unni KK, Beabout JW, Rock MG (1993) Nonepiphyseal giant cell tumor of the long bones. Cancer 71(11):3514-3519.
Farjanikish G, Dezfoulian O, Mohammadi H (2018) Metastatic giant cell osteosarcoma in a cat. Vet Res Forum 9(3):289-292.
Fattahian H, Hesaraki S, Fazeli O, Kabir F, Hajiagha SRR (2008) Immunohistochemical study of giant cell osteosarcoma in a dog. Iran J Vet Surg 3(3):99-106.
Fu HH, Zhuang QW, He J, Wang LZ, He Y (2011) Giant cell-rich osteosarcoma or giant cell reparative granuloma of the mandible?. J Craniofac Surg 22(3):1136-1139.
Gambarotti M, Donato M, Alberghini M, Vanel D (2011) A strange giant cell tumor. Eur J Radiol 77(1):3-5.
Heldmann E, Anderson MA, Wagner-Mann C (2000) Feline osteosarcoma: 145 cases (1990-1995). J Am Anim Hosp Assoc 36(6):518-521.
Jaretta TA, Paganini MCM, Pinto ACJ, Silva HC, Flecher MC, Horta RS (2020) Correlaçao citologica e histopatologica do osteosarcoma rico em celulas gigantes em felino. Acta Scientiae Veterinariae 48:1-7.
Mikaelian I, Martineau-Doize B, Martineau D (1998) Giant-cell osteosarcoma in a female ranch mink (Mustela vision). J Vet Diagn Invest 10:301-302.
Negrin A, Bernardini M, Diana A, Castagnaro M (2006) Giant cell osteosarcoma in the calvarium of a cat. Vet Pathol 43(2):179-182.
Oryan A, Sadoughifar R, Shirian S, Kish GF, Daneshbod Y (2015) Giant cell-rich osteosarcoma of tibia in a dog: a pathological and immunohistochemical study. Comp Clin Pathol 24:177-179.
Quiegley PJ, Leedale AH (1983) Tumors involving bone in the domestic cat: a review of fifthy-eight cases. Vet Pathol 20(6):670-686.
Thompson KG, Dittmer KE (2017) Tumors of bone. In: Tumors in Domestic Animals 5th ed, John Wiley&Sons, Iowa Ames: pp 356-424.
Verma RK, Gupta G, Bal A, Yadav J (2011) Primary giant cell rich osteosarcoma of maxilla: an unusual case report. J Maxillofac Oral Surg 10(2):159-162.
Am häufigsten gelesenen Artikel dieser/dieses Autor/in