Effects of wheat and corn gluten on growth performance, histopathologic and autoimmune metabolism of entero-hepatictissue in lambs
Abstract
This study investigated the effects of wheat gluten and corn gluten, alone as a protein source into rations as protein sources, on fattening performance and the histopathological and autoimmune metabolism of the small intestinal and hepatic tissues in lambs. The animals enrolled in the study were fed on isonitrogenous and isoenergetic diets. The protein sources provided to the animals were soybean meal and safflower meal in the control group, wheat gluten in Group Wheat, and corn gluten in Group Corn. The study animals included 24 male Morkaraman (Red Karaman) lambs, which were of a mean age of 9 months and assigned to three groups, each of 8 animals. Mean daily body weight gain (0-56 day) were observed to be significantly lower in Group Wheat (p<0.05). Mean daily feed intake were observed to be significantly lower in Group Wheat and Group Corn (p<0.05). At the end of the study, when compared to the control group, Group Wheat displayed significantly higher levels of villous atrophy, inflammation, crypt hyperplasia and transglutaminase immunopositivity in the small intestinal tissue as well as necrosis, inflammation, bile duct hyperplasia and transglutaminase immunopositivity in the hepatic tissue, and a lower level of degeneration in the liver (p<0.05). The findings detected in Group Corn were variable. In result, wheat gluten significantly affected both performance parameters and the histopathological and autoimmune metabolism of the intestinal and hepatic tissues in lambs.
Key words: Corn; gluten; lamb; wheat; histopathological
Article Details
- Zitationsvorschlag
-
Can, M., İmik, H., & Terim Kapakin, K. (2024). Effects of wheat and corn gluten on growth performance, histopathologic and autoimmune metabolism of entero-hepatictissue in lambs. Journal of the Hellenic Veterinary Medical Society, 75(3), 8007–8016. https://doi.org/10.12681/jhvms.36248
- Ausgabe
- Bd. 75 Nr. 3 (2024)
- Rubrik
- Research Articles
Dieses Werk steht unter der Lizenz Creative Commons Namensnennung - Nicht-kommerziell 4.0 International.
Authors who publish with this journal agree to the following terms:
· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
Downloads
Keine Nutzungsdaten vorhanden.
Literaturhinweise
Adamidou S, Nengas I, Alexis M, Foundoulaki E, Nikolopoulou D,
Campbell P, Karacostas I, Rigos G, Bell GJ, Jauncey K (2009) Ap
parent nutrient digestibility and gastrointestinal evacuation time in
European seabass (Dicentrarchuslabrax) fed diets containing different
levels of legumes. Aquaculture 289(1-2):106-112.
Allen DM, Grant RJ (2000) Interactions between forage and wet corn glu
ten feed as sources of fiber in diets for lactating dairy cows. J Dairy
Sci 83:322-331.
Baldassini WA, Ferreira MS, Santiago BM, Chardulo LAL, Curi RA,
Lanna DP, Ribeiro RV, Martins CL, Arrigoni M, Neto ORM (2021)
Intake, performance, meat quality and fatty acid profile of Nellore
bulls finished in feedlot with diets containing dry corn gluten feed.
Livest Sci 253:104715.
Banaszkiewicz T (2011) Nutritional value of soybean meal. Soybean and
nutrition 12:1-20.
Beauchemin KA, Koenig KM (2005) Feedlot cattle diets based on barley
or corn supplemented with dry corn gluten feed evaluated using the
NRC and CNCPS beef models. Canadian J Anim Sci 85:365-375.
Dokumacioglu E, İskender H, Yenice G, Kapakin K, Sevim C, Hayirli A,
Saral S, Comakli S (2018) Effects of astaxanthin on biochemical and
histopathological parameters related to oxidative stress on testes of
rats on high fructose regime. Andrologia 50(7):e13042.
Ehsani A, Mahdavi AH, Dolatkhah B, Samie AH (2014) Exogenous en
zyme improves immunocompetence in laying hens fed diets contain
ing safflower meal. Journal of Animal and Poultry Sciences 3(2):57
Fiems L, Boucqué C, Cottyn B (1995) Wheat gluten feed in diets for in
tensive bull beef production. In Ann. Zootech 44:41-47.
Gumus R, Uslu S, Uslu BA (2020) The effects of different dietary protein
sources on live weight, sperm quality and the histology of the testes
and accessory glands in male rats. Andrologia 52(6):e13601.
Gümüş R, Uslu, S, Aydoğdu, U, İmik A, Ekici M (2021) Investigation of
the Effects of Glutens on Serum Interleukin-1 Beta and Tumor Necro
sis Factor-Alpha Levels and the Immunohistochemical Distribution
of CD3 and CD8 Receptors in the Small Intestine in Male Rats.Braz.
Arch. Biol. and Technol 64.
Gümüş R, Terim Kapakin KA, Manavoğlu Kirman E, Bolat İ, İmik A, Er
can N (2024) The effect of adding wheat and corn gluten to the diet of
rats on the autoimmune and histopathological parameters in the intes
tine and liver. Revista Cientifica de la Facultad de Veterinaria 34(1):9
Hardwick JE, Glatz, CE (1989) Enzymic hydrolysis of corn gluten meal.
J Agric Food Chem 37(4):1188-1192.
Hudacko R, Kathy Zhou X, Yantiss RK (2013) Immunohistochemical
stains for CD3 and CD8 do not improve detection of gluten-sensitive
enteropathy in duodenal biopsies. Modern Pathol 26(9):1241-1245.
İmik A, Gezer C, Terim Kapakin KA (2024) Investigation of the Effect of
Wheat and Corn Gluten on Inflammation, Transglutaminase, Gliadin
and Ig A Levels in Healthy Rat Intestines. Veterinary Sciences and
Practices. (AUJVS-2023-49 - 190) In Press).
İmik H, Kapakin KAT, Karabulutlu Ö, Gümüş R, Çomaklı S, Özkaraca
M (2022) The Effects of Dietary Wheat and Corn Glutens on the His
topathological and Immunohistochemical Structure of the Ovarian
Tissue and Serum and Ovarian Tissue LH and FSH Levels and Lipid
Profiles in Rats. Braz Arch Biol and Technol 66.
Jaster EH, Staples CR, McCoy GC, Davis CL (1984) Evaluation of wet
corn gluten feed, oatlage, sorghum-soybean silage, and alfalfa hay
lage for dairy heifers. J Dairy Sci 67(9):1976-1982.
Jiang X, Liu X, Liu S, Li Y, Zhao H, Zhang Y (2019) Growth, rumen
fermentation and plasma metabolites of Holstein male calves fed fer
mented corn gluten meal during the postweaning stage. Anim Feed
Sci Technol 249:1-9.
Kalliokoski S, Piqueras VO, Frías R, Sulic AM, Määttä JA, Kahkönen
N, Viiri K, Huhtala H, Pasternack A, Laurila K, Sblattero D, Kor
ponay-Szabó IR, Maki M, Caja S, Kaukinen K, Lindfors K (2017)
Transglutaminase 2-specific coeliac disease autoantibodies induce
morphological changes and signs of inflammation in the small-bowel
mucosa of mice. Amino Acids 49:529-540.
Kaushik R, Kumar N, Sihag MK, Ray A (2015) Isolation, characterization
of wheat gluten and its regeneration properties. J Food Sci Technol
:5930-5937.
Kara K (2020) The Comparison of Saturated and Unsaturated Fatty Acid
Compositions in Safflower Herbage and Safflower Straw as Alterna
tive Forage for Ruminant. Erciyes Üniversitesi Veteriner Fakültesi
Dergisi 17(3):248-254.
Kellems RO, Church DC (2002). Livestock feeds and feeding (No. 04;
SF95, K4 2002.). Upper Saddle River: Prentice Hall.
Korponay-Szabó IR, Sulkanen S, Halttunen T, Maurano F, Rossi M,
Mazzarella G, Laurila K, Tronkon R, Maki M (2000) Tissue trans
glutaminase is the target in both rodent and primate tissues for ce
liac disease-specific autoantibodies. J Pediatr Gastroenterol Nutr
(5):520-527.
Kumar M, Kumar V, Roy D, Kushwaha R, Vaiswani S (2014) Application
of herbal feed additives in animal nutrition-a review. Int J Livest Res
(9):1-8.
Lin H, Deng Y, Zhu D, Yang Q, Zhou X, Tan B, Feng L, Chi S (2023). Ef
fects of partially replacing fishmeal with corn gluten meal on growth,
feed utilization, digestive enzyme activity, and apparent nutrient di
gestibility for juvenile white shrimp, Litopenaeus vannamei. Fron
tiers in Veterinary Science 10:1162599.
Mackie A, Macierzanka A (2010) Colloidal aspects of protein digestion.
Adv Colloid Interface Sci 15(1-2):102-108.
Maiuri L, Ciacci C, Ricciardelli I, Vacca L, Raia V, Auricchio S, Picard J,
Osman M, Quaratino S, Londei M (2003) Association between innate
response to gliadin and activation of pathogenic T cells in coeliac
disease. Lancet 362(9377):30-37.
Marsh MN (1992) Gluten, major histocompatibility complex, and the
small intestine: a molecular and immunobiologic approach to the
spectrum of gluten sensitivity (‘celiac sprue’). Gastroenterology
(1):330-354.
Molberg Ø, McAdam S, Lundin KE, Kristiansen C, Arentz‐Hansen H,
Kett K, Sollid LM (2001) T cells from celiac disease lesions recog
nize gliadin epitopes deamidated in situ by endogenous tissue trans
glutaminase. Eur J Immunol 31(5):1317-1323.
Parsons CH, Vasconcelos JT, Swingle RS, Defoor PJ, Nunnery GA, Sa
lyer GB, Galyean ML (2007) Effects of wet corn gluten feed and
roughage levels on performance, carcass characteristics, and feeding
behavior of feedlot cattle. J Anim Sci 85:3079- 3089.
Richards CJ, Stock RA, Klopfenstein TJ, Shain DH (1998) Effect of wet
corn gluten feed, supplemental protein, and tallow on steer finishing
performance. J Anim Sci 76(2):421-428.
Rodríguez GB, Kholif AEKM, Álvarez NIO, Montoya MD, Flores RRS,
Salem AZ (2015) Effect of Safflower Seeds on Production Perfor
mance of Finishing Cattle. Life Science Journal 12(2s).
Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA (2013)
ACG clinical guidelines: diagnosis and management of celiac dis
ease. Am J Gastroenterol 108(5):656-676.
Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M,
Kaukinen K, Rostami K, Sanders DS, Schumann M (2012) Spectrum
of gluten-related disorders: consensus on new nomenclature and clas
sification. BMC Med 10:1-12.
Schrage MP, Woody HD, Young AW (1991) Net energy of ensiled wet
corn gluten feed in corn silage diets for finishing steers. Journal of
Animal Science 69:2204-2210.
Schroeder JW (1997) Corn Gluten Feed: Composition, Storage, Handling,
Feeding and Value. North Dakota State University, Department of
Agriculture and Applied Science, ND, USA.
Shewry PR (2007) Improving the protein content and composition of ce
real grain. J Cereal Sci 46(3):239-250.
Siverson AV, Titgemeyer EC, Montgomery SP, Oleen BE, Preedy GW,
Blasi DA (2014) Effects of corn processing and dietary wet corn glu
ten feed inclusion on performance and digestion of newly received
growing cattle. J Anim Sci 92:1604-1612.
Sollid LM, Jabri B (2013) Triggers and drivers of autoimmunity: lessons
from coeliac disease. Nat Rev Immunol 13(4):294-302.
St‐Hilaire S, Sheppard C, Tomberlin JK, Irving S, Newton L, McGuire
MA, Mosley EE, Hardy RW, Sealey W (2007) Fly prepupae as a feed
stuff for rainbow trout, Oncorhynchus mykiss. J World Aquac Soc
(1):59-67.
Sulkanen S, Halttunen, T, Laurila K, Kolho KL, Korponay-Szabó IR, Sar
nesto B, Savilahti E, Collin P, Maki M (1998) Tissue transglutami
nase autoantibody enzyme-linked immunosorbent assay in detecting
celiac disease. Gastroenterology 115(6):1322- 1328.
Taylor CR, Cote RJ (2006) Immunomicroscopy: a diagnostic tool for the
surgical pathologist. WB Saunders Company.
Tufarelli V, Vicenti A, Ragni M, Pinto F, Selvaggi M (2013) Feeding of
safflower (Carthamus tintorius) cake in small ruminant total mixed
rations: effects on growth traits and meat fatty acid composition. Iran
J Appl Anim Sci 3:243-247.
Wang P, Chen H, Mohanad B, Xu L, Ning Y, Xu J, Wu F, Yang N, Jin Z,
Xu X (2014) Effect of frozen storage on physico-chemistry of wheat
gluten proteins: Studies on gluten-, glutenin-and gliadin-rich frac
tions. Food Hydrocolloids 39:187-194.
Zhang Y, Wang L, Dong Z, Changarawe SM, Huang L, Hu J, Storebakken
T, Shi B (2023). The effects of replacing fish meal or soy protein
concentrate with wheat gluten on growth, whole-body composition,
and the retention and apparent digestibility coefficient of amino acids
in Japanese seabass (Lateolabrax japonicus). Frontiers in Physiology
:1220192.
Zervas G, Tsiplakou E (2011) The effect of feeding systems on the charac
teristics of products from small ruminants. Small Rumin Res 101(1
:140-149.
