Opportunities to improve the immune status of broiler chickens

PDF (English)
Δημοσιευμένα: Apr 19, 2024
DOI: https://doi.org/10.12681/jhvms.30935
R Karakolev
National Diagnostic Science-and-Research Veterinary Medical Institute “Prof. Dr. G. Pavlov”, Sofia, Bulgaria
Ts Koynarski
Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
L Sotirov
Trakia University
https://orcid.org/0000-0002-5967-497X
R Petrova
National Diagnostic Science-and-Research Veterinary Medical Institute “Prof. Dr. G. Pavlov”, Sofia, Bulgaria
P Petrova-Tsenin
National Diagnostic Science-and-Research Veterinary Medical Institute “Prof. Dr. G. Pavlov”, Sofia, Bulgaria
Περίληψη

Since 2006, the European Community has banned the use of nutritional antibiotics as growth promoters in livestock husbandry. The utilization of modern poultry production systems with a high degree of concentration and automation has resulted in the health status of sensitive poultry strains and hybrids. Some humoral indicators of natural immunity in broiler chickens from the ROSS 308 hybrid and growing broiler breeders were studied. The experiment was conducted in control and experimental herds raised under the same production conditions. The experimental herds were reared without the use of antibiotics but were treated with the immunomodulator Avigen. The serum lysozyme concentrations, the alternative pathway of complement activity (APCA), and concentrations of IFN γ, IL-2, and IL-6 of broilers treated with Avigen significantly exceeded the values in the control birds. The same tendency is observed among the growing broiler breeders. Serum IgY concentrations show a significant difference in growing broiler breeders but not in broilers. Based on the obtained data, the treatment with the immunomodulator Avigen increases the natural resistance of birds, which allows them to be raised without the use of antibiotics in production conditions.

Λεπτομέρειες άρθρου
  • Ενότητα
  • Research Articles
Creative Commons License

Αυτή η εργασία είναι αδειοδοτημένη υπό το CC Αναφορά Δημιουργού – Μη Εμπορική Χρήση 4.0.

Οι συγγραφείς των άρθρων που δημοσιεύονται στο περιοδικό διατηρούν τα δικαιώματα πνευματικής ιδιοκτησίας επί των άρθρων τους, δίνοντας στο περιοδικό το δικαίωμα της πρώτης δημοσίευσης.

Άρθρα που δημοσιεύονται στο περιοδικό διατίθενται με άδεια Creative Commons 4.0 Non Commercial και σύμφωνα με την άδεια μπορούν να χρησιμοποιούνται ελεύθερα, με αναφορά στο/στη συγγραφέα και στην πρώτη δημοσίευση για μη κερδοσκοπικούς σκοπούς.

Οι συγγραφείς μπορούν να καταθέσουν το άρθρο σε ιδρυματικό ή άλλο αποθετήριο ή/και να το δημοσιεύσουν σε άλλη έκδοση, με υποχρεωτική την αναφορά πρώτης δημοσίευσης στο J Hellenic Vet Med Soc

Οι συγγραφείς ενθαρρύνονται να καταθέσουν σε αποθετήριο ή να δημοσιεύσουν την εργασία τους στο διαδίκτυο πριν ή κατά τη διαδικασία υποβολής και αξιολόγησής της.

Λήψεις
Τα δεδομένα λήψης δεν είναι ακόμη διαθέσιμα.
Αναφορές
Abasht B, Sandford E, Arango J, Settar P, Fulton JE, Neil P, Abebe H,
David H, Fernando RL, Dekkers JCM, Lamont SJ (2009) Extent
and consistency of linkage disequilibrium and identification of DNA
markers for production and egg quality traits in commercial layer
chicken populations. BMC Genomics 10 (Suppl 2): S2.
Abdel-Latif MA, El-Far AH, Elbestawy AR, Ghanem R, Mousa SA,
Abd El-Hamid HS (2017) Exogenous dietary lysozyme improves
the growth performance and gut microbiota in broiler chickens targeting the antioxidant and non-specific immunity mRNA expression. PLoS ONE 12(10): e0185153. https://doi.org/10.1371/journal.
pone.0185153
Al-Mansour S, Al-Khalf A, Al-Homidan I (2011) Feed efficiency and
blood hematology of broiler chicks given a diet supplemented with
yeast culture. Int J Poult Sci 10:603-7.
Bain W, Li H, Geest R, Moore S, Olonisakin T, Ahn B, Papke E, Moghbeli
K, DeSensi R, Rapport S, Saul M, Hulver M , Xiong Z, Mallampalli
R, Ray P, Morris A, Ma L, Doi Y, Zhang Y, Kitsios G, Kulkarni H,
McVerry B, Ferreira V, Nouraie M, Lee J (2020) Increased Alternative Complement Pathway Function and Improved Survival during
Critical Illness. Am J Respir Crit Care Med 202:230-240.
Bedrania L, Helloin E, Guyot N, Nys Y (2013) Systemic administration of
lipopolysaccharide in laying hens stimulate antimicrobial properties
of egg white against Staphylococcus aureus. Vet Immunol Immunopathol 152:225-236.
Besarabov BF (2013) The natural resistance and productivity of birds.
Poultry 5:16-17.
Bonovska M, Karakolev R, Sotirov L, Gyurov B, Savova T, Nikolov D,
Angelov A (2014) Induction of egg-white lysozyme in layer hens.
ComptesRendus de l ‘AcademieBulg des Sci 67:1311-1314.
Bozakova N, Sotirov L, Denev S,Koynarski T (2020) Possibilities for
Improvement of Humoral Innate Immunity in Turkeys and Hens in
Conditions of Thermal Stress by the Immunomodulator Immunobeta.
Iran J Appl Anim Sci 10:349-54.
Denev S, Sotirov L, Chobanova S, Koynarski T, Bozakova N, Stoev S
(2020) Effect of Silymarin and Ochratoxin A on Humoral Natural Immunity of Broiler Chickens. J Cent Eur Agric 21:492-98.
EL-Deep MH, Amber KA, Eid YZ, Alrashood ST, Khan HA, Sakr MS,
Dawood MAO (2020) The Influence of Dietary Chicken Egg Lysozyme on the Growth Performance, Blood Health, and Resistance
Against Escherichia coli in the Growing Rabbits’ Cecum. Front Vet
Sci 7:579-576. doi: 10.3389/fvets.2020.579576
EL-Deep MH, Amber KA, Eid YZ, Aboelenin SM, Soliman MM, Sakr
MS, Dawood MAO (2021) The Influence of Chicken Egg Lysozyme
or Zinc-Bacitracin Antibiotic on the Growth Performance, Antibacterial Capacity, Blood Profiles, and Antioxidative Status of Rabbits:
A Comparative Study. Animals 11:1731. https://doi.org/10.3390/
ani11061731
Fathi MM, Al-Mansour S, Al-Homidan A (2012) Effect of yeast culture
supplementation on carcass yield and humoral immune response of
broiler chicks Vet. World 11:651-7.
FerraboschiP, Ciceri S, Grisenti P (2021) Applications of Lysozyme, an
Innate Immune Defense Factor, as an Alternative Antibiotic. Antibiotics 10:1534. https://doi.org/10.3390/antibiotics10121534
Fan Q, Abouelezz KFM, Li L, Gou Z, Wang Y, Lin X, Ye J, Jiang Sh
(2020) Influence of mushroom polysaccharide, nano-copper, copper
loaded chitosan, and lysozyme on intestinal barrier and immunity of
LPS-mediated yellow-feathered chickens. Animals 2020, 10, 594;
doi:10.3390/ani10040594
Gadde U, Kim W H, Oh S T,Lillehoj HS (2017) Alternatives to antibiotics
for maximizing growth performance and feed efficiency in poultry: a
review. Anim Health Res Rev 18:26-45.DOI: https://doi.org/10.1017/
S1466252316000207
Gong M, Anderson D, Rathgeber B, MacIsaac J (2017) The effect of dietary lysozyme with EDTA on growth performance and intestinal microbiota of broiler chickens in each period of the growth cycle. J Appl
Poult Res 26:1-8. https://doi.org/10.3382/japr/pfw041
Idowu PA, Idowu AP, Zishiri OT, Mpofu TJ, Veldhuizen EJA,
NephaweKA,Mtileni B (2021) Activity of Mannose-Binding Lectin
on Bacterial-Infected Chickens—A Review. Animals,11:787.https://
doi.org/10.3390/ani11030787
Karakolev R, Sotirov L, Angelov A, Koynarski Ts,Bozakova N (2015)
Egg white lysozyme concentrations in White Plymouth Rock hens
treated with the immunomodulator Helpankar. IJDR 5:4713-4715.
KarakolevR, Gospodinova K, Sotirov L, Nikolov D, Angelov A, Koynarski Ts (2015) Blood serum interferon-alpha and -gamma concentrations in broiler chickens treated with the immunomodulator Helpankar Int J Curr Microbiol App Sci 4:296-299
KarakolevR, KoynarskiTs, Petrova-TseninP,PetrovaR (2023) Influence of
“AVIGEN DUCK” Immunomodulator on some humoral factors of
non-specific protection in White Pekin ducks parents C R AcadBulg
Sci 76:970-976.
Lalev M, Oblakova M, Sotirov L, Hristakieva P, Mincheva N, Ivanova I,
KoynarskiT,Bozakova N (2015) Effect of the Immunomodulator Natstim ® on Innate Humoral Immunity and Productive Traits of White
Plymouth Rock Hens. Jokull 65:72-78.
Lie O (1985) Markers of Resistance to Infection in Dairy Cattle. Thesis,
National Veterinary Institute, Oslo, Norway, chapt V.
Lillehoj HS, Lee KW (2012) Immune modulation of innate immunity
as alternatives-to-antibiotics strategies to mitigate the use of drugs
in poultry production. Poult Sci 91:1286-1291 http://dx.doi.org/
3382/ps.2012-02374
Linares JA, Martin M (2010) Encyclopedia of Animal Behavior. Poultry,
Behavior and Welfare Assessment, Academic Press, USA, pp. 750-
Ma XK, Zhang S, Pan L, Piao XS (2017) Effects of lysozyme on the
growth performance, nutrient digestibility, intestinal barrier, and
microbiota of weaned pigs fed diets containing spray-dried whole
egg or albumen powder. Can J Anim Sci 97:466-475. https://doi.
org/10.1139/cjas-2016-0171
Millet S, Maerten L (2011) The European ban on antibiotic growth
promoters in animal feed: from challenges to opportunities. Vet J
:143-4.
Niewold TA (2007) The nonantibiotic anti-inflammatory effect of antimicrobial growth promoters, the real mode of action? A hypothesis.
Poult Sci 86:605-9. doi: 10.1093/ps/86.4.605.
Rosenberger CM, Scott MG, Gold MR, Hancock RE, Finlay BB (2000)
Salmonella typhimurium infection and lipopolysaccharide stimulation induce similar changes in macrophage gene expression. J Immunol 164:5894-5904.
Sato A, Iwasaki A (2005) Peyer’s patch dendritic cells as regulators of
mucosal adaptive immunity. Cell Mol Life Sci 62:1333-1338.
Seo HK, Holt P, Brackett R, Gast R, Stone H (2002) Mucosal humoral immunity to experimental Salmonella enteritidis infection in the
chicken. Avian Dis 46:1015-1020.
Sotirov L (1991) Phenotype characteristic and inheritance of lysozyme
and complement activity in swine, Ph.D. thesis, Trakia University,
Stara Zagora.
Sotirov L,Koinarsky T (2003) Lysozyme and complement activity in
broiler-chickens with coccidiosis. Rev Med Vet 154:780-784.
TagashiraA,Nishim K, Matsumoto Sh, Sugahara T (2015) Anti-inflammatory effect of lysozyme from hen egg white on mouse peritoneal
macrophages. Cytotechnology, 70:929-938, https://doi.org/10.1007/
s10616-017-0184-2
Tirado TC, Bavia L, Ambrosio AR, Campos MP, Santiago MA, Messias-Reason IJ, Figueiredo FB (2021) A comparative approach on
the activation of the three complement system pathways in different hosts of Visceral Leishmaniasis after stimulation with Leishmania infantum. Dev Comp Immunol 120, https://doi.org/10.1016/j.
dci.2021.104061
Tizard I (2002) The avian antibody response. Semin avian exot pet med
:2-14.
Wigley P, Kaiser P (2003) Avian cytokines in health and disease. Braz J
Polt Sci 5:1-14.
Xia Y, Kong J, Zhang G, Zhang X, Seviour R, Kong Y (2019) Effects of dietary supplementation with lysozyme on the structure and function of
the cecal microbiota in broiler chickens. PLoS ONE, 14(6):e0216748.
https://doi. org/10.1371/journal.pone.0216748