sTREM-1, MR-Pro-Adrenomedullin, clinical biochemistry and hematology in calves with neonatal sepsis
Περίληψη
This study aimed to determine the changes in biochemical and hematological parameters and the expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM 1) and mid-regional-pro-adrenomedullin (MR-Pro-ADM) on myeloid cells during treatment in calves with neonatal sepsis. The study group comprised 21 calves, aged 1–16 days, that fit the sepsis criteria. The control group comprised 10 healthy calves of the same age. The clinical examinations of the calves in the study group were performed at certain hours before the treatment (hour 0) and during the treatment (12th, 24th, 48th, and 72nd hours). The blood samples were taken from the vena jugularis before and during treatment from the sick calves and once from the healthy calves. The sTREM-1 levels before treatment (0 h), during treatment (12th, 24th, 48th, and 72nd hours) and control group was follows 59.17±2.58 ng/L, 57.07±1.65 ng/L, 57.27±2.07 ng/L, 56.64±1.97 ng/L, 57.58±2.18 ng/L and 75.60±2.57 ng/L,39 respectively. The MR-Pro-ADM levels before treatment (0 h), during treatment (12th, 24th, 48th, and 72nd hours) and control group was follows; 117.88±7.75 ng/L, 113.63±5.18 ng/L, 109.97±5.25 ng/L, 114.50±5.35 ng/L, 111,84±5.63 ng/L,65.31±2.81 ng/L, respectively. The serum MR-Pro-ADM levels in calves with sepsis were significantly higher than those in the control group before and during treatment (P < 0.05). Also, the serum sTREM-1 level was significantly lower before and after treatment in the sepsis group compared with the control group (P < 0.05). MR-Pro-ADM and sTREM-1 were more important, especially in terms of diagnosis in evaluating calves with neonatal sepsis.
Λεπτομέρειες άρθρου
- Πώς να δημιουργήσετε Αναφορές
-
Sezer, M., & Gökce, G. (2024). sTREM-1, MR-Pro-Adrenomedullin, clinical biochemistry and hematology in calves with neonatal sepsis. Περιοδικό της Ελληνικής Κτηνιατρικής Εταιρείας, 74(4), 6481–6490. https://doi.org/10.12681/jhvms.31046
- Τεύχος
- Τόμ. 74 Αρ. 4 (2023)
- Ενότητα
- Research Articles
Αυτή η εργασία είναι αδειοδοτημένη υπό το CC Αναφορά Δημιουργού – Μη Εμπορική Χρήση 4.0.
Οι συγγραφείς των άρθρων που δημοσιεύονται στο περιοδικό διατηρούν τα δικαιώματα πνευματικής ιδιοκτησίας επί των άρθρων τους, δίνοντας στο περιοδικό το δικαίωμα της πρώτης δημοσίευσης.
Άρθρα που δημοσιεύονται στο περιοδικό διατίθενται με άδεια Creative Commons 4.0 Non Commercial και σύμφωνα με την άδεια μπορούν να χρησιμοποιούνται ελεύθερα, με αναφορά στο/στη συγγραφέα και στην πρώτη δημοσίευση για μη κερδοσκοπικούς σκοπούς.
Οι συγγραφείς μπορούν να καταθέσουν το άρθρο σε ιδρυματικό ή άλλο αποθετήριο ή/και να το δημοσιεύσουν σε άλλη έκδοση, με υποχρεωτική την αναφορά πρώτης δημοσίευσης στο J Hellenic Vet Med Soc
Οι συγγραφείς ενθαρρύνονται να καταθέσουν σε αποθετήριο ή να δημοσιεύσουν την εργασία τους στο διαδίκτυο πριν ή κατά τη διαδικασία υποβολής και αξιολόγησής της.
Λήψεις
Τα δεδομένα λήψης δεν είναι ακόμη διαθέσιμα.
Αναφορές
Abd Elmouttaleb, A.T., Aly, H.A., Bayomy, E.M., Abdelhamed, M.R.,
Esmael, N.F., 2016. Plasma procalcitonin and proadrenomedullin
concentrations as predictive markers for early onset neonatal sepsis.
American Journal of Biochemistry 6(1), 6-15.
Adly, A.A.M., Ismail, E.A., Andrawes, N.G., El-Saadany, M.A., 2014.
Circulating soluble triggering receptor expressed on myeloid cells-1
(sTREM-1) as diagnostic and prognostic marker in neonatal sepsis.
Cytokine 65, 184-191.
Akpınar, S., Rollas, K., Alagöz, A., Seğmen, F., Sipit, T., 2014. Performance evaluation of MR-proadrenomedullin and other scoring systems in severe sepsis with pneumonia. The Journal of Thoracic Disease 6(7), 921-929.
Akyüz, E., Naseri, A., Erkılıç, E.E., Makav, M., Uzlu, E., Kırmızıgül,
A.H., Gökce, G., 2017. Neonatal buzağı ishalleri ve sepsis. Kafkas
Üniversitesi Fen Bilimleri Enstitüsü Dergisi 10(2), 181-191.
Akyüz, E. 2020. Kars bölgesindeki neonatal buzağılarda sıklıkla
karşılaşılan ishal kaynaklı sepsis nedenleri. In: ‘Tüm Yönleri ile
Kuzey Doğu Anadolu Bölgesinde Hayvancılık’, (Ed.): Ayvazoğlu
Demir, P. İksad Yayınevi, Ankara, Türkiye, 401-423.
Akyüz, E.,Gökce, G., 2021. Neopterin, procalcitonin, clinical biochemistry, and hematology in calves with neonatal sepsis.Tropical Animal
Health and Production 53, 354.
Al, M., Balıkçı, E., 2012. Neonatal ishallibuzağılarda rotavirus, coronavirus, E. coliK99veCryptosporidium parvum’unhızlı test kitleriileteşhisiveenteropatojenile maternal immüniteilişkisi. Fırat ÜniversitesiSağ
lıkBilimleriVeterinerDergisi26(2), 73-78.
Allaker, R.P., Grosvenor, P.W., McAnerney, D.C., Sheehan, B.E., Srikanta, B.H., Pell, K., Kapas, S.,2006. Mechanisms of adrenomedullin
antimicrobial action. Peptides 27, 661-666.
Altuğ, N., Yüksek, N., Özkan, C., Keleş, İ., Başbuğan, Y., Ağaoğlu, Z.T.,
Kaya, A., Akgül, Y., 2013. Neonatal buzağı ishalerinin immunokromotografik test kitleri ile hızlı etiyolojik teşhisi. Van Veterinary Journal 24(3), 123-128.
Angeletti, S., Spoto, S., Fogolari, M., Cortigiani, M., Fioravanti, M., De
Florio, L., Curciob, R., Cavalieri, D., Costantino, S., Dicuonzo, G.,
Diagnostic and prognostic role of procalcitonin (PCT) and
Mr-pro-adrenomedullin (MR-proADM) in bacterial infections. Acta
Pathologica Microbiologica et Immunologica Scandinavica 123, 740-
Atlı, K., Yıldırım, Y., Hasırcıoğlu, S., Bulut, O., Avcı, O., 2018. Buzağılarda ishale neden olan başlıca viral etkenler. Ayrıntı Dergi 5(61), 70-74.
Aycan, A.E., 2006. İshalli buzağılarda rota virus enfeksiyonlarının enzyme linked immunosorbent assay (ELISA) ile saptanması. Selçuk
Üniversitesi Fen Bilimleri Enstitüsü Yüksek LisansTezi, Konya.
Aydın, Y., Akdeniz, Y.S., Çakmak, F., İpekci, A., Kıyak, S.K., Öztürk,
M.,İkizceli, İ., 2018. Acil servistekreatinkinaz (CK) yüksekliğisaptananhastalarınanalizi. Journal of Anatolian Medical Research 3(3),
-24.
Azkur, A.K., Aksoy, E., 2018. Buzağı hastalıklarında koruyucu önlemler.
Lalahan Hayvan Araştırma Enstitüsü Dergisi 58(Özel Sayı), 56-63.
Azkur, A.K., Tonbak, S., 2015. Schmallenberg virüsü. Fırat Üniversitesi
Veteriner Fakültesi Dergisi 29(2), 129-135.
Bal, D., 2019. Manisa yöresinde neonatal buzağı ishalleri üzerine etiyolojik araştırmalar. Afyon Kocatepe Üniversitesi Sağlık Bilimleri Enstitüsü Yüksek Lisans Tezi,Afyonkarahisar.
Başer, D.F., Civelek, T., 2013. Akut ishalli neonatal buzağılarda venöz
asit-baz durumu ve renal fonksiyon arası korelasyon. Kocatepe Veteriner Dergisi 6(1), 25-31.
Bernal-Morell, E., García-Villalba, E., del CarmenVera, M., Medina, B.,
Martinez, M., Callejo, V., Valero, S., Cinesi, C., Piñera, P., Alcaraz,
A., Marin, I., Munoz, A., Cano, A., 2018. Usefulness of midregional pro-adrenomedullin as a marker of organ damage and predictor
of mortality in patients with sepsis. The Journal of Infection 76(3),
-257.
Beydilli, Y., Gökçe, H.İ., 2019. Sepsisli neonatal buzağılarda bazı
hematolojik ve biyokimyasal parametrelerin araştırılması. Mehmet
Akif Ersoy University Journal of Health Sciences Institute 7(2), 55-
Constable, P.D., 2007. General Medicine. In: Radostits OM. (Ed) Veterinary Medicine,10th edition,Salinders, U.S.A., 51-58.
Costello, M.F., Drobatz, K.J., Aronson, L.R., King, L.G., 2004. Underlying cause, pathophysiologic abnormalities, and response to treatment
in cats with septic peritonitis: 51 cases (1990-2001). Journal of the
American Veterinary Medical Association 225, 897-902.
Coura, F.M., Freitas, M.D., Ribeiro, J., de Leme, A.R., de Souza, C., Alfieri, A.A., Filho, E.J.F., de Carvalho, A.U., Silva, M.X., Lage, A.P.,
Heinemann, M.B., 2015. Longitudinal study of salmonella spp. diarrheagenic escherichia coli, rotavirus, and coronavirus isolated from
healthy and diarrheic calves in a Brazilian dairy herd. Tropical animal
health and production 47(1), 3-11.
Eroğlu, M.S., Kırbaş, A., 2020. Sistemik inflamatuar yanıt sendromu ve
sepsis. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi 34(1), 61-
Fahmey, S.S., Mostafa, H., Abd Elhafeez, N., Hussain, H., 2018. Diagnostic and prognostic value of proadrenomedullin in neonatal sepsis.
Korean Journal of Pediatrics 61(5), 156-159.
Gamez-Diaz, L.Y., Enriquez, L.E., Matute, J.D., Velásquez, S., Iván, D.G.,
Toro, F., Ospina, S., Bedoya, V., Arango, C.M., Valencia, M.L., De La
Rosa, G., Gómez, C.I., García, A., Patiño, P.J., Jaimes, F.A., 2011.
Diagnostic accuracy of HMGB-1, s-TREM-1, and CD64 as markers
of sepsis in patients recently admitted to the emergency department.
Academic Emergency Medicine 18, 807-815.
Garayoa, M., Martinez, A., Lee, S., Pio, R., An, W.G., Neckers, L., Trepel, J., Montuenga, L.M., Ryan, H., Johnson, R., Gassmann, M.,
Cuttitta, F., 2000. Hypoxia-inducible factor-1 (HIF-1) up-regulates
adrenomedullin expression in human tumor cell lines during oxygen
deprivation: A possible promotion mechanism of carcinogenesis. Molecular Endocrinology 14(6), 848-862.
Garazzino, S., Altieri, E., Denina, M., 2019. The role of Pro-adrenomedullin as a marker of severe bacterial infection in children: A Review.
Reports 2,17.
Geven, C., Kox, M., Pickkers, P., 2018.Adrenomedullin and Adrenomedullin- targeted therapy as treatment strategies relevant for sepsis.
Frontiers in Immunology 9, 292.
Ghobrial, E.E., Khorshied, M.M., Adly, S.B., Aziz, M.M., 2020. Proadrenomedullin as a prognostic biomarker for critically-ill septic children.
Research Square 1,15.
Gülaçtı, İ., Sözdutmaz, İ., Işıdan, H., 2016. Molecular characterization
of the bovine norovirüses from diarrheic calves in Turkey. Turkısh
Journal of Veterınary and Anımal Scıences 40, 428-433.
Güngör, Ö., Baştan, A., 2004. Gebe ineklerde uygulanan aşıların kolostrum ve buzağıda IgG konsantrasyonu üzerine etkileri. Ankara
Üniversitesi Veteriner Fakültesi Dergisi 51, 7-11.
Güngör, Ö., Özyurtlu, N., 2005. The test used for detection of the failure
of passive transfer in neonatal calves. Kafkas Üniversitesi Veteriner
Fakültesi Dergisi 11(2), 185-188.
Gruys, E., Toussaint, M.J., Niewold, T.A., Koopmans, S.J., 2005. Acute
phase reaction and acute phase proteins. Journal of Zhejiang Science
, 1045-1056.
Hacıoğlu, İ.K., Alkan, F., 2018.Yenidoğan buzağı ishallerinin önemli viral etkenlerinden caliciviruslar. Etlik Veteriner Mikrobiyoloji Dergisi
(2), 167-174.
Hart, K.A., MacKay, R.J., 2015. Endotoxemia and sepsis In: Smith BP.
(Ed)Large Animal Internal Medicine.5th edition, Elsevier, St.Louis,
U.S.A., 682-695.
Jordan, I., Corniero, P., Balaguer, M., Ortiz, J., Vila, D., Velasco, J., Cambra, F.J., Esteban, E., 2014. Adrenomedullin is a useful biomarker for
the prognosis of critically ill septic children. Biomarkers in Medicine
(9), 1065-1072.
Kutlu, Y., Toprak, İ.D., Gokden, Y., Eruzun, H., Arman, Y., Yoldemir, Ş.A.,
Toprak, Z., Tukek, T., 2021. The relationship between sTREM-1 and
activation of inflammatory bowel diseases.Journal of İstanbul Faculty of Medicine 84, 318-323.
Latour-Perez, J., Alcala-Lopez, A., Garcia-Garcia, M.A., Sanchez-Hernandez, J.F., Abad-Terrado, C., Viedma-Contreras, J.A., Masia, M.,
Gonzalez-Tejera, M., Arizo-Leon, D., Broch Porcar, M.J., Bonilla-Rovira, F., Gutierrez, F., 2010. Diagnostic accuracy of sTREM-1 to
identify infection in critically ill patients with systemic inflammatory
response syndrome. Clinical Biochemistry 43, 720-724.
Marino, R., Struck, J., Maisel, A.S., Magrini, L., Bergmann, A., Di Somma, S., 2014. Plasma adrenomedullin is associated with short-term
mortality and vasopressor requirement in patients admitted with sepsis. Critical Care 18(1), R34.
Merhan, O., Bozukluhan, K., Gökçe, G., Yılmaz, O., 2016. İshalli
buzağılarda haptoglobin, seruloplazmin ve bazı biyokimyasal
parametre düzeylerinin araştırılması. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi 30 (3), 195-198.
Miguel, D., Prieto, B., Costa, M., Coto, D., Alvarez, F.V., 2011. Cord
blood plasma reference intervals for potential sepsis markers: Pro-adrenomedullin, pro-endothelin, and pro-atrial natriuretic peptide. Clinical Biochemistry 44, 337-341.
Özkan, C., Akgül, Y., 2004. Neonatal ishalli buzağılarda hematolojik, biyokimyasal ve elektrokardiyografik bulgular. Van Veterinary Journal
(1-2), 123-129.
Palmiere, C., Augsburger, M., 2014. Markers for sepsis diagnosis in the
forensic setting: State of the art. Croatian Medical Journal 55, 103-
Pazarçeviren, B., 2008. İshalli buzağılarda akut faz proteinleri düzeylerinin belirlenmesi ve klinik önemi. Adnan Menderes Üniversitesi
Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi, Aydın.
Rey, C., Garcia-Hernandez, I., Concha, A., Martinez-Camblor, P., Botran,
M., Medina, A., Prieto, B., Lopez-Herce, J., 2013. Pro-adrenomedullin, pro-endothelin-1, procalcitonin, C-reactive protein and mortality
risk in critically ill children: A prospective study. Critical Care 17,
R240.
Silverstein, D., Otto, C.M., 2012. SepsisIn: Greene CE. (Ed) Infectious
Diseases of the Dog and Cat. 4th edition, St. Louis, U.S.A., 359-369.
Simon, T.P., Martin, L., Doemming, S., Humbs, A., Bruells, C., Kopp, R.,
Hartmann, O., Struck, J., Bergmann, A., Marx, G., Schuerholz, T.,
Plasma adrenomedullin in critically ill patients with sepsis after
majör surgery: A pilot study. The Journal of Critical Care 38, 68-72.
Smok, B., Domagalski, K., Pawłowska, M., 2020. Diagnostic and prognostic value of IL-6 and sTREM-1 in SIRS and sepsis in children.
Mediators of Inflammation 2020, 8201585.
Sönmezer, M.Ç., Tülek, N., 2015. Bakteriyel infeksiyonlarda ve sepsiste
biyobelirteçler. Klimik Dergisi 28(3), 96-102.
Stolz, D., Christ-Crain, M., Morgenthaler, N.G., Miedinger, D., Leuppi,
J., Miiller, C., Bingisser, R., Struck, J., Miiller, B., Tamm, M., 2008.
Plasma pro-adrenomedullin but not plasma pro-endothelin predicts
survival in exacerbations of COPD. Chest Jounal 134, 263-272.
Su, L., Feng, L., Zhang, J., Xiao, Y., Jia, Y., Yan, P., Feng, D., Xie, L.,
Diagnostic value of urine sTREM-1 for sepsis and relevant
acute kidney injuries: A prospective study. Critical Care 15, 2-10.
Şahal, M., Terzi, O.S., Ceylan, E., Kara, E., 2018. Buzağı ishalleri ve
korunma yöntemleri. Lalahan Hayvan Araştırma Enstitüsü Dergisi
(Özel Sayı), 41-49.
Şen, İ., Güzelbekteş, H., Yıldız, R., 2013. Neonatal buzağı ishalleri:
Patofizyoloji, epidemiyoloji, klinik, tedavi ve koruma. Turkiye
Klinikleri Journal of Veterinary Sciences 4(1), 71-78.
Topal, O., 2018. Buzağılarda neonatal dönem sağlığını değerlendirmede
ilk onbeş günde önemli olan klinik bulguların belirlenmesi. Uludağ
Üniversitesi Sağlık Bilimleri Enstitüsü, Doktora Tezi, Bursa.
Torres, A.G., Zhou, X., Kaper, J.B., 2005. Adherence of diarrheagenic
Escherichia coli strains to epithelial cells. Infection and Immunity
Journal 73(1), 18-29.
Trefz, F.M., Lorenz, I., Lorch, A., Constable, P.D., 2017. Clinical signs,
profound acidemia, hypoglycemia, and hypernatremia are predictive
of mortality in 1,400 critically ill neonatal calves with diarrhea. PloS
One Journal 12, e0182938.
Uzlu, E., Karapehlivan, M., Çitil, M., Gökçe, E., Erdoğan, H.M., 2010.
İshal semptomu belirlenen buzağılarda serum sialik asit ile bazı biyokimyasal parametrelerin araştırılması. Van Veterinary Journal
(2), 83-86.
Valenzuela Sanchez, F., Valenzuela Mendez, B., Bohollo de Austria, R.,
Gutierrez, J.F.R., Franco, M.J., García, M.A.G., Chaumel, A.J., 2015.
Diagnostic and prognostic usefulness of mid-regional pro-adrenomedullin levels in patients with severe sepsis. Intensive Care Medicine Experimental 3(Suppl 1), A306.
Valenzuela-Sanchez, F., Valenzuela-Mendez, B., Rodriguez-Gutierrez,
J.F., Estella-Garcia, A., Gonzalez-Garcia, M.A., 2016. New role of
biomarkers: Mid-regional pro-adrenomedullin, the biomarker of organ failure. The Annals of Translational Medicine’s 4(17), 329.
Zeybek, S., 2013. Akut ishalli neonatal buzağılarda intravenöz izotonik
sodyum bikarbonat uygulamasının venöz asit-baz durumu ve renal
fonksiyon üzerine zamana bağlı etkileri. Afyon Kocatepe Üniversitesi
Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi, Afyonkarahisar.
