A Case of Canine Renal Cell Carcinoma: an Immunohistochemical Approach


Δημοσιευμένα: Jul 11, 2024
Ενημερώθηκε: 2024-07-11
Εκδόσεις:
2024-07-11 (3)
M Usta
A Ayaz
F İlhan
M Karaman
H Özen
https://orcid.org/0000-0002-6820-2536
Περίληψη
Canine Renal Cell Carcinoma (Canine RCC) is a primary renal tumor in dogs. No definitive immunohistochemical marker for this tumor is yet defined in veterinary medicine. In this case presentation, a Canine RCC detected in an 8-year-old intact male Golden Retriever was described and suitability of RCC-PN15 mouse monoclonal antibody as a diagnostic marker in this tumor was investigated. The primary tumor mass was in the right kidney and there were metastases in liver, spleen, lung, and the left kidney. Solid, tubular, and papillary subtypes of Canine RCC were noted in the primary tumor mass. In immunohistochemical staining for RCC-PN15, weak to strong immunoreactivities were observed in the primary and metastatic nodules. In this case report, RCC-PN15 was shown to be successfully used in diagnosis of Canine RCC.
Λεπτομέρειες άρθρου
  • Ενότητα
  • Case Report
Λήψεις
Τα δεδομένα λήψης δεν είναι ακόμη διαθέσιμα.
Αναφορές
Bakshi, N., Kunju, L.P., Giordano, T., Shah, R.B. (2007). Expression of
renal cell carcinoma antigen (RCC) in renal epithelial and nonrenal
tumors: diagnostic implications. Applied Immunohistochemistry &
Molecular Morphology, 15(3), 310-315.
Birdane, F.M., Hatipoğlu F., Ortatatlı, M., Koç, Y., Turgut, K. (2004). Renal cell carcinoma in a dog: Pathologic and cytologic findings. Revue
de Medecine Veterinaire. 155(4), 212-216.
Carvalho, P.H., Conceicão, L.G., Barros, M.S., Moreira, J.C.L.M., Amorim, R.L., Pinczowski, P. (2011). Renal cell carcinoma with cutaneous metastasis in a dog. Brazilian Journal of Veterinary Pathology.
(2), 132-137.
Carvalho, S., Stoll, A.L., Priestnall, Ş.L., Suarez-Bonnet, A., Rassnick, K.,
Lynch, S., Schoepper, I., Romanelli, G., Buracco, P., Atherton, M.,
De Merlo, E.M., Lara-Garcia, A. (2017). Retrospective evaluation of
COX-2 expression, histological and clinical factors as prognostic indicators in dogs with renal cell carcinomas undergoing nephrectomy.
Veterinary and Comparative Oncology. 15(4), 1280-1294.
Delahunt, B., Eble, J.N., Egevad, L., Samaratunga, H. (2019). Grading of
renal cell carcinoma. Histopathology. 74(1), 4-17.
Edmondson, E.F., Hess, A.M., Powers, B.E. (2015). Prognostic significance of histologic features in canine renal cell carcinomas: 70 nephrectomies. Veterinary Pathology. 52(2), 260-268.
Fuhrman, S.A., Lasky, L.C., Limas, C. (1982). Prognostic significance of
morphologic parameters in renal cell carcinoma. The American Journal of Surgical Pathology. 6(7), 655-663.
Gil Da Costa, R.M., Oliveira, J.P., Saraiva, A.L., Seixas, F., Faria, F., Gärtner, F., Pires, M.A., Lopes, C. (2011). Immunohistochemical characterization of 13 canine renal cell carcinomas. Veterinary Pathology.
(2), 427-432.
Inamura, K. (2017). Renal cell tumors: Understanding their molecular
pathological epidemiology and the 2016 WHO classification. International Journal of Molecular Sciences. 18(10), 15-20.
Lucke, V.M. & Kelly, D.F. (1976). Renal carcinoma in the dog. Veterinary
Pathology. 13(4), 264-276.
McGregor, D.K., Khurana, K.K., Cao, C., Tsao, C.C., Ayala, G., Krishnan,
B., Truong, L.D. (2001). Diagnosing primary and metastatic renal cell
carcinoma: The use of the monoclonal antibody renal cell carcinoma
marker. The American Journal of Surgical Pathology, 25(12), 1485-
Meuten, D.J. & Meuten, T.L.K. (2016). Tumors of the Urinary System. In
D. J. Meuten (Ed.), Tumors in Domestic Animals. 4th ed., John Wiley
& Sons, Iowa, p 632-688.
Nielsen, S.W., Mackey, L.J., Misdorp, W. (1976). Tumors of the kidney.
Bull. World Health Organ. 53(2-3), 237-245.
Peat, T.J., Edmondson, E.F., Miller, M.A., Dusold, D.M., Ramos-Vara,
J.A. (2017). Pax8, Napsin A, and CD10 as immunohistochemical
markers of canine renal cell carcinoma. Veterinary Pathology. 54(4),
-594.
Shen, S.S., Truong, L.D., Scarpelli, M., Lopez-Beltran, A. (2012). Role
of immunohistochemistry in diagnosing renal neoplasms when is it
really useful? Archives of Pathology & Laboratory Medicine. 136(4),
-417.
Truong, L.D. & Shen, S.S. (2011). Immunohistochemical diagnosis of
renal neoplasms. Archives of Pathology & Laboratory Medicine.
(1), 92-109.
Woldemeskel, M. (2013). Renal cell carcinoma in humans and animals: A
brief literature review. Journal of Clinical & Experimental Pathology
(02), 1-7
Τα περισσότερο διαβασμένα άρθρα του ίδιου συγγραφέα(s)