Effect of pimobendan on TAPSE in dogs with cardiac valvular disease

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Δημοσιευμένα: Apr 20, 2024
DOI: https://doi.org/10.12681/jhvms.33507
R Gonul
Department of Internal Medicine, Faculty of Veterinary, Istanbul University-Cerrahpaşa, Avcilar-Istanbul / Turkiye
https://orcid.org/0000-0001-9425-0964
A Seddigh Nia
Department of Internal Medicine, Faculty of Veterinary, Istanbul University-Cerrahpaşa, Avcilar-Istanbul / Turkiye
Περίληψη

Many caridac and pulmonary disease affect right heart functions. Therefore, clinical examination of it’s systolic function has recently became important in humans, whereas it has been largely overlooked in dogs. So that in this research, the effects of pimobendan on right ventricular fractional area change (RVFAC), tricuspid annular plane systolic excursion (TAPSE), and systolic functions were analyzed in detail by echocardiography. For this purpose, 40 cases of mitral and/or tricuspid valve disease (group II) and 10 healthy dogs (group I) were included in the study. Echocardiographic examinations were repeated after giving of pimobendan (0.2 mg/kg x2 for 1 week) (group III). In the echocardiographic examinations, the values EF, EPSS, RV area (D), RV area (S), IVSd, IVSs, LVPWs, MV E, and MV A showed statistically significant differences between the groups. Also, we found that TAPSE was lower in group II (1.29) than in group I (2.25) (P<0.001), and after treatment with pimobendan, TAPSE was increased (1.41). RVFAC also decreased in the patient group, and this value increased after treatment with pimobendan, as did TAPSE, but these changes weren't statistically significant. Therefore, we concluded that right ventricular functions should be carefully monitored in patients with various heart diseases for better diagnosis, treatment, and prognosis.

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Αναφορές
Borgarelli M, Abbott J, BrazRuivo L, Chiavegato D, Crosara S,Lamb K, Haggstrom J (2015) Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease. J Vet Intern Med 29 (2): 569-574.
Chapel E. H, Scansen BA, Schober KE, BonaguraJD (2018) Echocardiographic estimates of right ventricular systolic function in dogs with myxomatous mitral valve disease. J Vet Intern Med 32 (1): 64-71.
Cunningham SM, Aona BD, Antoon K, Rush JE, BartonBA (2018) Echocardiographic assessment of right ventricular systolic function in Boxers with arrhythmogenic right ventricular cardiomyopathy. J Vet Cardiol 20 (5): 343-353.
Damy T, Kallvikbacka-Bennett A, Goode K, Khaleva O, Lewinter C,Hobkirk J, Cleland JG (2012) Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure. J Card Fail 18 (3): 216-225.
Dini FL, Cont, U, Fontanive P, Andreini D, Banti S,Braccini L, De Tommasi SM (2007) Right ventricular dysfunction is a major predictor of outcome in patients with moderate to severe mitral regurgitation and left ventricular dysfunction. Am Heart J 154 (1): 172-179.
Ghio S, Recusani F, Klersy C, Sebastiani R, Laudisa ML,Campana C, Tavazzi L (2000) Prognostic usefulness of the tricuspid annular plane systolic excursion in patients with congestive heart failure secondary to idiopathic or ischemic dilated cardiomyopathy. AmJCard 85 (7): 837-842.
Ghio S, Gavazzi A, Campana C, Inserra C, Klersy C,Sebastiani R, Tavazzi L(2001) Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure. J Am Coll Cardiol 37 (1): 183-188.
Holler PJ, Wess G (2014) Sphericity index and E‐point‐to‐septal‐separation (EPSS) to diagnose dilated cardiomyopathy in Doberman pinschers. J Vet Intern Med 28 (1): 123-129.
Hsue W, VisserLC (2020) Reproducibility of echocardiographic indices of left atrial size in dogs with subclinical myxomatous mitral valve disease. J Vet Intern Med 34 (5): 1779-1786.
Kaul S, Tei C, Hopkins JM, ShahPM (1984) Assessment of right ventricular function using two-dimensional hocardiography. Am Heart J 107 (3): 526-531.
Kjaergaard J, Iversen KK, Akkan D, Moller JE, Kober LV,Torp-Pedersen C, Hassager C (2009) Predictors of right ventricular function as measured by tricuspid annular plane systolic excursion in heart failure. JCardiovas Ultrasound 7 (1): 1-7.
Koch J, Pedersen HD, Jensen AL, FlagstadA (1996) M‐mode echocardiographic diagnosis of dilated cardiomyopathy in giant breed dogs, J Vet Med A 43 (1‐10): 297-304.
Lance CV, Brian AS, Karsten ES, JohnDB (2015) Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs: Repeatability and reference intervals. J Vet Cardiol 17, 83-96.
Laster SB, Ohnishi Y, Saffitz JE, GoldsteinJA (1994) Effects of reperfusion on ischemic right ventricular dysfunction. Disparate mechanisms of benefit related to duration of ischemia. Circulation 90 (3): 1398-1409.
Lee JZ, Low SW, Pasha AK, Howe CL, Lee KS,Suryanarayana PG (2018) Comparison of tricuspid annular plane systolic excursion with fractional area change for the evaluation of right ventricular systolic function: a meta-analysis. Open Heart 5:e000667.
Le Tourneau T, Deswarte G, Lamblin N, Foucher-Hossein C, Fayad G,Richardson M, Bauters C (2013) Right ventricular systolic function in organic mitral regurgitation: impact of biventricular impairment. Circulation 127 (15): 1597-1608.
Lombard CW, Jöns O, BussadoriCM (2006) Clinical efficacy of pimobendan versus benazepril for the treatment of acquired atrioventricular valvular disease in dogs. J Am Anim Hosp Assoc 42 (4): 249-261.
Martha JW, Pranata R, Wibowo A, LimMA (2021) Tricuspid annular plane systolic excursion (TAPSE) measured by echocardiography and mortality in COVID-19: A systematic review and meta-analysis. Int JInfect Dis 105, 351-356.
Mauritz GJ, Kind T, Marcus JT, Bogaard HJ, Veerdonk M,Postmus PE, Vonk-Noordegraaf A(2012) Progressive changes in right ventricular geometric shortening and long-term survival in pulmonary arterial hypertension. Chest 141 (4): 935-943.
Meluzin J,Spinarová L,Hude P, Krejcí J,KinclV,Panovský R, Dusek L(2005)Prognostic Importance of Various Echocardiographic Right Ventricular Functional Parameters in Patients with Symptomatic Heart Failure. J Am Soc Echocardiogr18 (5): 435-444,
Morita T, Nakamura K, Osuga T, Hanazono K, Morishita K,Takiguchi M(2019) Change in right ventricular function in an American cocker spaniel with acute pulmonary thromboembolism. J Vet Med Sci 81 (9): 1259-1265.
O’Grady MR, Minors SL, O’sullivan ML, HorneR (2008) Effect of pimobendan on case fatality rate in Doberman Pinschers with congestive heart failure caused by dilated cardiomyopathy. J Vet Intern Med 22 (4): 897-904.
Pariaut R, Saelinger C, StricklandKN, Beaufrère H, Reynolds CA,Vila J(2012) Tricuspid annular plane systolic excursion (TAPSE) in dogs: reference values and impact of pulmonary hypertension. J Vet Intern Med 26 (5): 1148-1154.
Sabbah HN, Shimoyama H, Kono T, Gupta RC, Sharov VG,Scicli G, Goldstein S(1994) Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction. Circulation 89 (6): 2852-2859.
Sehgal A, Gwini SM, Menahem S, Allison BJ, Miller SL,Polglase GR(2019) Preterm growth restriction and bronchopulmonary dysplasia: the vascular hypothesis and related physiology. J Physiol 597 (4): 1209-1220.
Smith PJ, French AT, Van Israr̈l N, Smith SGW, Swift ST,Lee AJ, Dukes‐McEwan J(2005) Efficacy and safety of pimobendan in canine heart failure caused by myxomatous mitral valve disease. J Small Anim Pract 46 (3): 121-130.
Smolarek D, Gruchała M, SobiczewskiW (2017) Echocardiographic evaluation of right ventricular systolic function: The traditional and innovative approach. Cardiol J24 (5): 563-572.
Suzuki S, Fukushima R, Ishikawa T, Hamabe L, Aytemiz D,Huai Che H, Tanaka R(2011)The effect of pimobendan on left atrial pressure in dogs with mitral valve regurgitation. J Vet Intern Med 25 (6): 1328-1333.
Teichholz LE, Kreulen T, Herman MV, et al. (1976) Problems in echocardiographic volume determinations: hocardiographicangiographic correlations in the presence or absence of asynergy. Am J Cardiol 37:7-11.
Thomas WP, Gaber CE, Jacobs GJ, et al. (1993) Recommendations for standards in transthoracic two-dimensional echocardiography in dogs and cats. J Vet Intern Med 7:247-252.
van Meel JC, Diederen W (1989) Hemodynamic profile of the cardiotonic agent pimobendan. J Cardiovasc Pharmacol. 14 Suppl 2:S1-6. PMID: 2478784.
Vezzosi T, Domenech O, Costa G, Marchesotti F, Venco L,Zini E, Tognetti R(2018) Echocardiographic evaluation of the right ventricular dimension and systolic function in dogs with pulmonary hypertension. J Vet Intern Med 32 (5): 1541-1548.
Visser LC, Scansen BA, Brown NV, Schober KE, BonaguraJD (2015a) Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs following a single dose of pimobendan versus atenolol. J Vet Cardiol 17 (3): 161-172.
Visser LC, Scansen BA,Schober KE, BonaguraJD (2015b) Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs: repeatability and reference intervals. J Vet Cardiol 17 (2): 83-96.
Visser LC (2017)Right ventricular function: imaging techniques. Vet Clin Small Anim Pract47 (5): 989-1003.
Visser LC, Sintov DJ, OldachMS (2018a) Evaluation of tricuspid annular plane systolic excursion measured by two-dimensional echocardiography in healthy dogs: repeatability, reference intervals, and comparison with M-mode assessment. J Vet Cardiol 20 (3): 165-174.
Visser LC, Kaplan JL, Nishimura S, Gunther Harrington CT, Bélanger C, Oldach MS, Mueller MS(2018b) Acute echocardiographic effects of sotalol on ventricular systolic function in dogs with ventricular arrhythmias. J Vet Intern Med 32 (4): 1299-1307.
Vitarelli A, Barillà F, Capotosto L, D’Angeli I, Truscelli G,De Maio M, Ashurov R (2014) Right ventricular function in acute pulmonary embolism: a combined assessment by three-dimensional and speckle-tracking echocardiography. J Am Soc Echocardiogr 27 (3): 329-338.
Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD,Meldrum DR, Gail DB(2006) Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation 114 (17): 1883-1891