Diagnosis and management of Canine Renal Cell Carcinoma with special reference to Shear Wave Elastography

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Δημοσιευμένα: Oct 22, 2024
DOI: https://doi.org/10.12681/jhvms.34980
B Jena
Department of Veterinary Surgery and Radiology
https://orcid.org/0000-0001-9798-6387
J Mohindroo
Guru Angad Dev Veterinary Animal Science University, Ludhiana, Punjab, India
https://orcid.org/0000-0003-4842-2029
A Anand
Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
https://orcid.org/0000-0001-8759-2472
K Gupta
Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab
Περίληψη

This report focuses on the diagnosis and surgical management of unilateral renal cell carcinoma in a 7-year-old male intact German Shepherd dog. The dog was presented with fever, haematuria, inappetence, infrequent bouts of emesis, and progressive weight loss. Palpation revealed a hard, round mass in the right cranial abdomen. A presumptive diagnosis of unilateral renal neoplasm was made based on clinical signs, haematobiochemical analysis, and radiography. B-mode ultrasound examination demonstrated an enlarged right kidney extending up to the ventral midline. The kidney exhibited heterogenous echotexture, loss of renal architecture, and only a small healthy portion at the caudal pole. Point Shear Wave Elastography analysis revealed elevated values both in terms Shear Wave Velocity (m/sec) and Young’s Modulus Stiffness Value (kPa), indicating the presence of renal malignancy. To treat the condition, unilateral nephroureterectomy was performed under general anaesthesia. Histopathological examination confirmed the diagnosis of renal cell carcinoma. Consequently, it can be concluded that B-mode ultrasonography, Point Shear Wave Elastography, and nephroureterectomy played crucial roles in the successful diagnosis and surgical management of unilateral renal cell carcinoma.

Λεπτομέρειες άρθρου
  • Ενότητα
  • Case Report
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Βιογραφικά Συγγραφέων
J Mohindroo, Guru Angad Dev Veterinary Animal Science University, Ludhiana, Punjab, India

Professor, Department of Veterinary Surgery and Radiology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India – 141004

A Anand, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India

Professor, Department of Veterinary Surgery and Radiology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India – 141004

K Gupta, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab

Professor-cum-Head, Department of Veterinary Pathology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India – 141004

Αναφορές
Baskin GB, De Paoli A (1977) Primary Renal Neoplasms of the Dog. Vet
Pathol 14:591-605. https://doi.org/10.1177/030098587701400606
Bennett F (2004) Unilateral renal cell carcinoma in a Labrador retriever.
Can Vet J 45:860- 862. https://pubmed.ncbi.nlm.nih.gov/15532889
Bob F, Grosu I, Sporea I, Bota S, Popescu A, Sima A, Şirli R, Petrica L,
Timar R, Schiller A (2017) Ultrasound-based shear wave elastography in the assessment of patients with diabetic kidney disease. Ultrasound Med Biol 43:2159-2166. https://doi.org/10.1016/j.ultrasmedbio.2017.04.019
Bryan JC, Henry CJ, Turnquist SE, Tyler JW, Liptak JM, Rizzo SA,
Sfiligoi G, Steinberg SJ, Smith AN, Jackson T (2006) Primary Renal Neoplasia of Dogs. J Vet Intern Med. 20:1155-1160. https://doi.
org/10.1111/j.1939-1676.2006.tb00715.x
Carvalho S, Stoll AL, Priestnall SL, Suarez‐Bonnet A, Rassnick K, Lynch
S, Schoepper I, Romanelli G, Buracco P, Atherton M, De Merlo EM
(2017) Retrospective evaluation of COX-2 expression, histological
and clinical factors as prognostic indicators in dogs with renal cell
carcinomas undergoing nephrectomy. Vet Comp Oncol 15:1280-
https://doi.org/10.1111/vco.12264
Chen M, Fu X, Shen Y(2021) Evaluation of multimode color doppler flow
imaging in the diagnosis of solid renal tumor. Contrast Media Mol
Imaging2021:1-7. https://doi.org/10.1155/2021/6656877
Chiang YC, Liu CH, Ho SY, Lin CT, Yeh LS (2007) Hypertrophic osteopathy associated with disseminated metastases of renal cell carcinoma in the dog: a case report. J Vet Med 69:209-212. https://doi.
org/10.1292/jvms.69.209
Cobrin AR, Blois SL, Kruth SA, Abrams‐Ogg AC, Dewey C (2013) Biomarkers in the assessment of acute and chronic kidney diseases in the
dog and cat. J Small Anim Pract. 54:647-655. https://doi.org/10.1111/
jsap.12150
Darakamas P, Chandrasakha P, Suwannaprapha P, Banjathammarak S,
Chuaychoo K, Kongtasai T. Clear Cell Renal Cell Carcinoma in a
Dog. J Appl Anim Res 15:51-64.
Dong F, Xu J, Du D, Jiao Y, Zhang L, Li M, Liu H, Xiong Y, Luo H(2016)
D analysis is superior to 2D analysis for contrast-enhanced ultrasound in revealing vascularity in focal liver lesions-A retrospective analysis of 83 cases. Ultrasonics 70: 221-226.https://doi.
org/10.1016/j.ultras.2016.05.007
Edmondson EF, Hess AM, Powers BE. (2015) Prognostic Significance of
Histologic Features in Canine Renal Cell Carcinomas. Vet Pathol 52:
-268. https://doi.org/10.1177/0300985814533803
Ferraioli G, Barr RG, Farrokh A, Radzina M, Cui XW, Dong Y, Rocher
L, Cantisani V, Polito E, D’Onofrio M, Roccarina D (2022) How to
perform shear wave elastography. Part II. Med Ultrason 24:196-210.
https://doi.org/10.11152/mu-3342
Finco DR, Brown SA, Brown CA, Crowell WA, Cooper TA, Barsanti JA (1999) Progression of chronic renal disease in the dog. J Vet
Intern Med 13:516-528. https://doi.org/10.1111/j.1939-1676.1999.
tb02204.x
Göya C, Daggulli M, Hamidi C, Yavuz A, Hattapoglu S, Cetincakmak
MG, Teke M (2015) The role of quantitative measurement by acoustic
radiation force impulse imaging in differentiating benign renal lesions
from malignant renal tumours. La Radiologia Medica 120:296-303.
https://doi.org/10.1007/s11547-014-0443-7
Groman RP, Bahr A, Berridge BR, Lees GE (2004) Effects of serial ultrasound‐guided renal biopsies on kidneys of healthy adolescent
dogs.Vet Radiol Ultrasound 45:62-69. https://doi.org/10.1111/j.1740-
2004.04010.x
Iyama T, Sugihara T, Takata T, Isomoto (2021) Renal Ultrasound Elastography: A Review of the Previous Reports on Chronic Kidney Diseases. Appl Sci 11:9677. https://doi.org/10.3390/app11209677
Klein MK, Cockerell GL, Harris CK, Withrow SJ, Lulich JP, Ogilvie GK,
Norris AM, Harvey HJ, Richardson RF, Fowler JD (1988) Canine primary renal neoplasms: a retrospective review of 54 cases. J Am Anim
Hosp Assoc 24:443-452. https://agris.fao.org/agris-search/search.
do?recordID=US8857240
Lees GE (2004) Early diagnosis of renal disease and renal failure. Vet Clin
North Am Small Anim Pract 34:867-885. https://doi.org/10.1016/j.
cvsm.2004.03.004
Li QY, Tang J, He EH, Li YM, Zhou Y, Zhang X, Chen G (2012) Clinical utility of three-dimensional contrast-enhanced ultrasound in the
differentiation between noninvasive and invasive neoplasms of urinary bladder. EurJRadiol 81: 2936-2942.https://doi.org/10.1016/j.
ejrad.2011.12.024
Lu Q, Wen JX, Huang BJ, Xue LY, Wang WP (2015) Virtual Touch quantification using acoustic radiation force impulse (ARFI) technology for
the evaluation of focal solid renal lesions: preliminary findings. Clin
Radiol 70:1376-1381. https://doi.org/10.1016/j.crad.2015.08.002
Lucke VM, Kelly DJ (1976) Renal Carcinoma in the Dog. Vet Pathol
:264-276. https://doi.org/10.1177/030098587601300403
MacPhail CM (2013) Surgery of the kidney and ureter. In: Fossum TW
editor. Small Animal Surgery. 4th ed, Elsevier, pp. 705-734.
McAloney CA, Sharkey LC, Feeney DA, Seelig DM, Avery AC, Jessen
CR (2018) Evaluation of the diagnostic utility of cytologic examination of renal fine-needle aspirates from dogs and the use of ultrasongraphic features to inform cytologic diagnosis. J Am Vet Med Assoc 252:1247-1256. https://doi.org/10.2460/javma.252.10.1247
Meuten DJ, Meuten TL (2016) Tumors of the urinary System. In: Meuten
DJ editor. Tumors in domestic animals. 5th ed, John Wiley & Sons.
Inc. Publishing, Ames: pp 632-688.
Noh D, Shim J, Choi S, Choi H, Lee Y, Lee K (2022) Computed tomographic findings of primary renal tumors in dogs and cats. Thai J Vet
Med 52:499-505. https://digital.car.chula.ac.th/tjvm/vol52/iss3/8
Noh D, Shim JW, Choi S, Choi H, Lee Y, Lee K (2022) Computed tomographic findings of primary renal tumors in dogs and cats. Thai J Vet
Med52:499-505. https://doi.org/10.56808/2985-1130.3242
Petterino C, Luzio E, Baracchini L, Ferrari AP, Ratto A (2011) Paraneoplastic leukocytosis in a dog with a renal carcinoma. Vet Clin Pathol
:89-94. https://doi.org/10.1111/j.1939-165x.2011.00296.x
Rawlings CA, Diamond H, Howerth EW, Neuwirth L, Canalis C (2003)
Diagnostic quality of percutaneous kidney biopsy specimens obtained
with laparoscopy versus ultrasound guidance in dogs. J Am Vet Med
Assoc 223: 317- 321. https://doi.org/10.2460/javma.2003.223.317
Relford R, Robertson J, Clements C (2016) Symmetric dimethylarginine: improving the diagnosis and staging of chronic kidney disease
in small animals. Vet Clin North Am Small Anim Pract 46:941-960.
https://doi.org/10.1016/j.cvsm.2016.06.010
Song Y, Cheng J, Zhang R (2018) Contribution of 3‐Dimensional Contrast‐Enhanced Ultrasonography (CEUS) Compared With 2‐Dimensional CEUS in the Analysis of Liver Tumors. J Ultrasound Med37:
-1128.https://doi.org/10.1002/jum.14458
Waters D, Prueter JC. (1988) Secondary polycythemia associated with renal disease in the dog: two case reports and review of literature. J Am.
Anim Hosp Assoc 24:109-114.
Wei S, Fu N, Yao C, Liu P, Yang B (2013) Two‐and Three‐Dimensional
Contrast‐Enhanced Sonography for Assessment of Renal Tumor Vasculature: Preliminary Observations. J Ultrasound Med 32: 429-437.
https://doi.org/10.7863/jum.2013.32.3.429