Cardiac Biomarkers in Cryptosporidium-Induced Diarrhea: Evaluating Sepsis-Associated Myocardial Dysfunction in Calves

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Δημοσιευμένα: Feb. 12, 2026
DOI: https://doi.org/10.12681/jhvms.41393
C Balıkçı
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Harran, Şanlıurfa, Türkiye
https://orcid.org/0000-0001-7473-5163
E Gülersoy
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Harran, Şanlıurfa, Türkiye
https://orcid.org/0000-0001-8511-0150
N Paksoy
Department of Biochemistry, Faculty of Veterinary Medicine, University of Harran, Şanlıurfa, Türkiye
A Şahan
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Harran, Şanlıurfa, Türkiye
İ Günal
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Harran, Şanlıurfa, Türkiye
https://orcid.org/0000-0003-3679-4132
Περίληψη

The aim was to investigate the relationship between cardiovascular damage and sepsis in calves infected with Cryptosporidium spp. and to evaluate the efficacies of certain biomarkers. 21 calves were selected from 133 calves under the inclusion/exclusion criteria. Diarrheic calves with (n=7) and without sepsis (n=7) all affected by Cryptosporidium spp., and clinically healthy calves (n=7) were studied. The diagnostic efficacies of NT-proBNP and cTnI concentrations were evaluated across three groups. cTnI concentration exhibited significant differences among all the groups (p<0.001), with the highest level observed in the Sepsis group (256.13±88.23 pg/mL). The serum NT-proBNP concentration was highest in the sepsis group (162.12 ± 117.52 pg/mL). A statistically significant difference was observed between the sepsis and healthy groups (25.58 ± 13.24 pg/mL), as well as between the non-sepsis (112.39 ± 54.99 pg/mL) and healthy groups. Cardiovascular disorders may occur in neonatal diarrhea caused by Cryptosporidium spp., even without sepsis. When treating calf diarrhea caused by Cryptosporidium spp., it is crucial to consider cardiac involvement during prognosis evaluation and treatment planning.

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Αναφορές
Al-Sadi R, Boivin M, Ma T (2009). Mechanism of cytokine modulation
of epithelial tight junction barrier. Front. Biosci., 14:2765-
Aygün O, Yıldız R (2018). Evaluation of thrombomodulin and pentraxin-
as diagnostic biomarkers in calves with sepsis. Vet.
Med., 63:313-320.
Ayvazoğlu C, Akyüz E, Harmankaya A, Sezer M, Batı Y, Gezer
T, Kuru M (2024). Cardiac Biomarkers in Calves with Diarrhea-
Induced Neonatal Sepsis. J. Hellenic Vet. Med. Soc.,
(1):6871-6878.
Ayvazoğlu C, Akyüz E, Öğün M, Demir PA, Gökçe G (2023). Cardiac
biomarkers and biochemical changes in cattle with traumatic
pericarditis. Med. Weter., 79(04):177-181.
Basit M, Bakshi N, Hashem M, Allebban Z, Lawson N, Rosman HS,
Maciejko JJ (2007). The effect of freezing and long-term storage
on the stability of cardiac troponin T. Am. J. Clin. Pathol.,
(1):164-167.
Blanchard PC (2012). Diagnostics of dairy and beef cattle diarrhea.
Vet. Clin. North Am. Food Anim. Pract., 28:443-464.
Cauliez B, Guignery J, Marinier S, Mariau I, Lavoinne A (2008).
Two-year stability of NT-proBNP in frozen samples using the
Roche Elecsys system. Ann. Clin. Biochem., 45(3):318-319.
Chiurcihiu V, Izzi V, D’Aquilio F, Carotenuto F, Di Nardo P, Baldini
PM (2008). Brain natriuretic peptide (BNP) regulates the
production of inflammatory mediators in human THP-1 macrophages.
Regul. Pept., 148:26-32.
Cho YI, Yoon KJ (2014). An overview of calf diarrhea-infectious
etiology, diagnosis, and intervention. J. Vet. Sci., 15(1):1-17.
Constable PD, Hinchcliff KW, Done SH, Grünberg W (2017). Veterinary
medicine a textbook of the diseases of cattle, horses,
sheep, pigs, and goats. Elsevier.
Drosatos K, Lymperopoulos A, Kennel PJ, Pollak N, Schulze PC,
Goldberg IJ (2015). Pathophysiology of sepsis-related cardiac
dysfunction: driven by inflammation, energy mismanagement,
or both? Curr. Heart Fail. Rep., 12(2):130-140.
Ewaschuk JB, Zello GA, Naylor JM, Brocks DR (2002). Metabolic
acidosis: separation methods and biological relevance of organic
acids and lactic acid enantiomers. J. Chromatogr. B., 781:39.
Fadeeva MV, Skhirtladze MR, Ivashkin VT (2019). Small Intestinal
Bacterial Overgrowth Syndrome as a Risk Factor for Ventricular
Tachycardia in Chronic Heart Failure with Left Ventricular
Systolic Dysfunction. Russ. J. Gastroenterol. Hepatol. Coloproctology.,
(3):38-48.
Faul F, Erdfelder E, Buchner A, Lang AG (2009). Statistical power
analyses using G* Power 3.1: Tests for correlation and regression
analyses. Behav. Res. Methods, 41(4):1149-1160.
Fayer R, Xiae L (2008). Cryptosporidium and Cryptosporidiosis.
(2nd eds.), Acid free paper; PP:187.
Fayer R (2010). Taxonomy and species delimitation in Cryptosporidium.
Exp. Parasitol., 124:90-97.
Fecteau G, Paré J, Van Metre DC, Smith BP, Holmberg CA, Guterbock
W, Jang S (1997). Use of a clinical sepsis score for
predicting bacteremia in neonatal dairy calves on a calf rearing
farm. Can. Vet. J., 38(2):101-104.
Fecteau G, Smith BP, George LW (2009). Septicemia and meningitis
in the newborn calf. Vet. Clin. North. Am. Food. Anim.
Pract., 25:195-208.
Feng Y, Huang Y, Wang Y, Wang P, Song H, Wang F (2019). Antibiotics
induced intestinal tight junction barrier dysfunction is
associated with microbiota dysbiosis, activated NLRP3 inflammasome
and autophagy. Plos One., 14:e0218384.
Hosmer DW, Lemeshow S (2000). Applied logistic regression. (2nd
edn.), John Wiley and Sons, Inc.
REFERENCES
Hotchkiss E, Thomson S, Wells B, Innes E, Katzer F (2015). Update
on the role of cryptosporidiosis in calf diarrhoea. Livest.,
(6):316-322.
Işık N, İlhan C (2018). Oxidative status and organ damage marker
parameters in calf cryptosporidiosis. Bionature., 38(3):139-145.
Kroff S, Katus HA, Giannitsis E (2006). Differential diagnosis of
elevated troponins. Heart., 92(7):987-993.
Kumar A, Chatterjee I, Anbazhagan AN, Jayawardena D, Priyamvada
S, Alrefai WA Sun J, Borthakur A, Dudeja PK (2018).
Cryptosporidium parvum disrupts intestinal epithelial barrier
function via altering expression of key tight junction and adherens
junction proteins. Cell Microbiol., 20(6):e12830.
Lee DJ, Aw TC (2023). Natriuretic peptides in clinical practice: a
current review. J. Immunol. Sci., 7: 28-34.
Li JY, Chassaing B, Tyagi AM, Vaccaro C, Luo T, Adams J, Darby
TM, Weitzmann MN, Mulle JG, Gewirtz AT, Jones RM,
Pacifici R (2016). Sex steroid deficiency-associated bone loss
is microbiota dependent and prevented by probiotics. J. Clin.
Invest., 126:2049-2063.
Lin CW, Tang W, Wen F, Chen JJ, Zeng XL, Chen Z (2016). Diagnostic
Accuracy of NT-ProBNP for Heart Failure with Sepsis in
PatientsYounger than 18 Years. Plos One., 11(1):1-10.
Lofstedt J, Dohoo IR, Duizer G (1999). Model to predict septicemia
in diarrheic calves. J. Vet. Intern. Med., 13:81-88.
Lorenz I (2021). Calf health from birth to weaning-an update. Ir.
Vet. J., 74(1):5.
McGuirk SM (2008). Disease management of dairy calves and heifers.
Vet. Clin. North. Am. Food Anim. Pract., 24(1):139-153.
McMurray JJV, Adamopoulos S, Anker SD, Auricchio A, Böhm M,
Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez
MA, Jaarsma T, Køber L, Lip GYH, Maggioni AP, Parkhomenko
A, Pieske BM, Popescu BA, Rønnevik PK, Rutten FH,
Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA,
Zannad F, Zeiherm A (2012). ESC guidelines for the diagnosis
and treatment of acute and chronic heart failure. Eur. Heart. J.,
(14):1787-1847.
Mehta NJ, Khan IA, Gupta V, Jani K, Gowda RM, Smith PR (2004).
Cardiac troponin I predicts myocardial dysfunction and adverse
outcome in septic shock. Int. J. Cardiol., 95(1):13-17.
Menard S, Cerf-Bensussan N, Heyman M (2010). Multiple facets
of intestinal permeability and epithelial handling of dietary
antigens. Mucosal Immunol., 3:247-259.
Nagy DW (2009). Resuscitation and critical care of neonatal calves.
Vet. Clin. Food Anim., 25:1-11.
Naseri A, Sen I, Turgut K, Guzelbektes H, Constable PD (2019).
Echocardiographic assessment of left ventricular systolic function
in neonatal calves with naturally occurring sepsis or septic
shock due to diarrhea. Res. Vet. Sci., 126:103-112.
Naylor JM (2009). Neonatal Calf Diarrhea. Food Anim. Pract.,
-77.
Pas ML, Bokma J, Lowie T, Boyen F, Pardon B (2023). Sepsis and
survival in critically ill calves:risk factors and antimicrobial
use. J. Vet. Intern. Med., 37(1):374-389.
Peek SF, Apple FS, Murakami MA, Crump PM, Semrad SD (2008).
Cardiac isoenzymes in healthy Holstein calves and calves
with experimentally induced endotoxemia. Can. J. Vet. Res.,
(4):356.
Shehta A, El-Zahar H, Mansour A, Mustafa B, Shety T (2022).
Clinical, hematological and some biochemical alterations during
diarrhea in Friesian calves naturally infected with E. coli and
Salmonella. Beni Suef Univ. J. Basic Appl. Sci., 11(1):1-8.
Şen İ, Constable, PD (2013). General overview to treatment of
strong ion (metabolic) acidosis in neonatal calves with diarrhea.
Eurasian J. Vet. Sci., 29(3):114-120.
Yıldız R, Beslek M, Beydilli Y, Özçelik M, Biçici Ö (2018). Evaluation
of platelet activating factor in neonatal calves with sepsis.
Vet. Hekim Der. Derg., 89(2):66-73.
Zello GA, Abeysekara AWAS, Wassef AWAS (2005). Evidence
for D-lactic acid as a neurotoxic agent in acidotic diseases. S.
African J. Clin. Nutr., 49:291.
Zhang H, Wang Y, Chang Y, Luo H, Brito LF, Dong Y, Shi R, Wang
Y, Dong G, Liu L (2019). Mortality-culling rates of dairy calves
and replacement heifers and its risk factors in Holstein cattle.
Animals., 9(10):730.
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