Pituitary adenoma in aged rats. A case report

PDF (English)
Publicado: Mar 22, 2018
DOI: https://doi.org/10.12681/jhvms.14948
M KATSIMPOULAS
Center for Experimental Surgery,Biomedical Research Foundation of the Academy of Athens. Pathology Department, "Sotirìa" Hospital for Thoracic Disease of Athens
M FOTEINOU
Center for Experimental Surgery,Biomedical Research Foundation of the Academy of Athens. Pathology Department, "Sotirìa" Hospital for Thoracic Disease of Athens
E PARONIS
Center for Experimental Surgery,Biomedical Research Foundation of the Academy of Athens. Pathology Department, "Sotirìa" Hospital for Thoracic Disease of Athens
P ALEXAKOS
Center for Experimental Surgery,Biomedical Research Foundation of the Academy of Athens. Pathology Department, "Sotirìa" Hospital for Thoracic Disease of Athens
N KOSTOMITSOPOULOS
Center for Experimental Surgery,Biomedical Research Foundation of the Academy of Athens. Pathology Department, "Sotirìa" Hospital for Thoracic Disease of Athens
Resumen

The prevalence of neoplastic disease in the rat is well defined, because this species has been routinely used for decades in large-scale carcinogenic, aging and toxicological studies. Stock and strain-specific differences in the prevalence of some types of tumors are well documented. Pituitary adenoma is a neoplastic lesion which can be observed in older or aged rats of both sexes. In addition to sex, strain, diet, genetic factor, breeding history and accommodation may also play a role. Pituitary adenoma can also affect hamster, guinea pig and mice. The aim of this article is to report an incidence of pituitary adenomas, which was observed in a rat breeding colony of the Center for Experimental Surgery of the Biomedical Research Foundation of the Academy of Athens. During the clinical examination five female Wistar rats, at the age of 18 to 24 months old, expressed anorexia, weight loss, ataxia and bilateral blindness. At necropsy, the pituitary gland was enlarged with lobulations, often dark red to brown and hemorrhagic in appearance. In some cases there was a marked compression of the overlying mesencephalon. Histological examination with haematoxylin-eosin were observed cords and nests of glandular cells bound by strands of connective tissue, with an abundant capillary network. On immunohistochemical examination were observed strong positive reaction of synaptophysin. Findings were similar to pituitary adenoma. Pituitary adenoma is a serious non-reversible disease leading to the death of the animal. Laboratory animals with pituitary adenomas can be used as models in research of human pituitary adenoma.

Article Details
  • Sección
  • Case Report
Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Descargas
Los datos de descargas todavía no están disponibles.
Citas
Altman ΝΗ, Goodman DG (1979) Biology and Diseases. In: The Laboratory Rat, Vol. 1.
Baker HJ, Lindsey JR, Weisbroth SH, eds, Academic Press, New York: 334-376.
Bielschowsky F (1953) Chronic iodine deficiency as cause of neoplasia in thyroid and pituitary of aged rats. Brit J Cancer, 7: 203-13.
Bryan WR, Klinck GH and Wolfe GM (1938) The unusual occurrence of a high incidence of spontaneous mammary tumors in the Albany strain of the rat. J Cancer Res, 14:1-115.
Carlton WW and Gries CL (1986a) Adenoma and Carcinoma, pars distalis rat. In monographs on Pathology of laboratory Animals: Endocrine System, ed. TC. Jones et al. New York: Springer -Verlag: 134-45.
Carlton WW and Gries CL (1986b) Adenoma, pars intermidia, anterior pituitary rat. In monographs on Pathology of laboratory Animals: Endocrine System, ed. TC Jones et al. New York: Springer -Verlag: 145-49.
Carretero J, Burks DJ, Vasquez G, Rubio M, Hernandez E, Bodego P, Vasquez R (2002) Expression of aromatase P450 is increased in spontaneous prolactinomas of aged rats. Pituitary, 5: 5-10.
Clifton KH, Meyer RK (1956) Mechanism of anterior pituitary tumor induction by estrogen. Anat Res, 125: 65-81.
Dunning WF, Curtis MR, Segaloff A (1947) Strain differences in response to diethylstilbesterol and the induction of mammary gland and bladder cancer in the rat. Cancer Res,7:511-521
Feldman JD and Woda Β A (1980) Pathology and tumor incidence in aged Lewis and BN rats. Clin Immunol Immunopathol,15: 331-343.
Goodman DG, Ward JM, Squires RA, Chu KC, Linhart MS (1979) Neoplastic and non-neoplastic lesions in aging F-344 rats. Toxicol Appi Pharmacol, 48: 237-248.
Goodman DG, Ward JM, Squires RA, Paxton MB, Reichardt WD, Chu KC, Linhart MS (1980) Neoplastic and non-neoplastic lesions in aging Osborne-Mendel rats. Toxicol Appi Pharmacol, 5: 433-447.
Goya RG, Lu JKH, Meites J (1990) Gonadal function in aging rats and its relation to pituitary and mammary pathology. Mech Ageing Dev, 56: 77-88.
Greenacre CB (2004) Spontaneous tumors of small mammals. Vet Clin North Am Exotic Anim Pract, 7: (3):64.
Kim U, Clifton KH, Fürth J (1960) Highly inbred line of Wistar rats yielding spontaneous mammo-somatotropic pituitary and other tumors. J Nat Cancer Inst, 24 :341-8.
Kovacs K., Horvath E, Corenblum B, Sirek AMT, Penz G, Ezrin C (1975) Pituitary chromophobe adenoma consisting of prolactin cells. A histologic, immunocytological and electron microscopical study. Virchows Arch A, 366:113-123.
Kovacs K, Horvath E, Use RG, Ezrin C, Ilse D (1977) Spontaneous pituitary adenomas in aging rats. A light microscopic, immunocytological and fine structural study. Beitr Pathol, 161:1-16.
Kroes R, Garbis-Berkvens JM, de Vries T, van Nesselrooy JHJ (1981) Histopathological profile of a Wistar rat stock including a survey of the literature. J Gerontol, 36: 259-279.
Lang PL (1990) Spontaneous Neoplastic Lesions in the CDF(F-344)/CrlBR Rat. Charles River Laboratories, Wilmington, Massachusetts. Lang PL (1992) Spontaneous neoplastic lesions and selected nonneoplastic lesions in the CrhCDBR Rat. Charles River Laboratories, Wilmington, Massachusetts.
Lee AK, DeLellis RA, Blount M, Nunnemache G, Wolfe HJ (1982) Pituitary proliferative lesions in aging male Long-Evans rats. A model of mixed endocrine neoplasia syndrome. Lab Invest, 47:595-602.
Lu JKH, Hooper BR, Vargo TM, Yen SSC (1979) Chronological changes in sex steroid, gonadotropin and prolactin secretion in aging female rats displaying different reproductive states. Biol Reprod, 21:193-203.
McComb DJ, Beri J, Zak F (1984) Pituitary adenomas in old Sprague-Dawley rats: A histologic, ultrastructural, and immunohistochemical study. J Natl Cancer Inst, 73:1143-66.
McEuen CS, Selyle H, Collip JB (1936) Some effects of prolonged administration of oestrin in rats. Lancet i : 775-776.
Morris RH, Bras GJ (1971) Lasting influence of early caloric restriction on prevalance of neoplasms in the rat. J Natl Cancer, 47:1095-1113.
Mukdsi JH, De Paul AL, Munoz S, Aoki A, Torres AI (2004) Immunolocalization of Pit-1 in gonadotroph nuclei is indicative of the transdifferantion of gonadotroph to lactotroph cells in prolactinomas induced by estrogen. Histochem Cell Biol, 121: 453-462.
Nolan LA, Lunness HR, Lightman SL, Levy A (1999) The effects of age and spontaneous adenoma formation on trophic activity in the rat pituitary gland: a comparison with trophic activity in the human pituitary and in human pituitary adenomas. J Neuroendocrinology,
:393-401.
Oberling CP and Guerin M (1950) Les tumeurs hypophysaires spontanées chez le rat. Bull Ass Franc Cancer, 16: 83-96.
Stone JP, Holtzman S, Shellabarger A (1979) Neoplastic responses and collateral plasma prolactin levels in diethylstilbesterol-treated ACI and Sprague-Dawley rats. Cancer Res, 7:511-521.
Takahashi S, Kawashima S (1983) Age-related changes in Prl cells in male and female rats of the Wistar/Tw strain. J Sci Hiroshima Univ, 31:185-191.
Tucker M J (1979) The effect of long-term food restriction on tumors in rodents. Int J Cancer, 23, 803-807.
Velkeniers B, Hooghe-Peters E (1998) From prolactin cell to prolactinoma: implications of ontogenic mechanisms in diagnosis and management. Endocr Relat Cancer, 5: 27-36.
Wolfe JM, Bryan WR, Wright AW (1938) Observations on histologic structure of anterior pituitaries of old female rats. Proc Soc Exp Biol, N. Y., 38:80-2.
Artículos más leídos del mismo autor/a