Morphological characteristics of rabbits’ carpal tunnel: Evaluation of its potential for carpal tunnel research

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Publiée : Oct 25, 2024
DOI : https://doi.org/10.12681/jhvms.37030
F Turker Yavas
Department of Anatomy, Faculty of Veterinary Medicine, Aydin Adnan Menderes University, Aydin, Turkey
I Dabanoglu
Department of Anatomy, Faculty of Veterinary Medicine, Aydin Adnan Menderes University, Aydin, Turkey
Résumé

This study aimed to define the main anatomic components and describe the normal size and form of the carpal tunnel in rabbits using imaging techniques.  It was also aimed to evaluate the potential of rabbits as an animal model for carpal tunnel research. The forelimbs of eight adult New Zealand rabbits were investigated using histology, magnetic resonance, and computed tomography. Two cadavers were used for anatomical dissection to support the findings. The carpal tunnel was examined at proximal and distal levels, and it was found that the flexor retinaculum is two-layered in rabbits. Both vascular nerve bundles, including the median nerve and the ramus palmaris of the ulnar nerve, were within two layers of it and passed through the carpal tunnel. The deep digital flexor, superficial digital flexor, and radial carpal flexor tendons were observed within the carpal tunnel. The flexor pollicis longus tendon is not found in rabbits. The area of the carpal tunnel narrowed towards the distal end in three methods, and its depth decreased in CT and MRI. The length of the accessory carpal bone determined this depth. The study found that rabbits' carpal tunnels are morphologically similar to those of humans compared to dogs. This situation is thought to pave the way for more accurate approaches to carpal tunnel research in rabbits.

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Références
Bower JA, Stanisz GJ, Keir PJ (2006) An MRI evaluation of carpal tun
nel dimensions in healthy wrists: Implications for carpal tunnel syn
drome. Clin Biomech, 21: 816-825.
Craige EH (1948) Practical Anatomy of the Rabbit. (5th ed.), The Blakis
ton Company, Philadephia,
Deak N, Black AC, Bordoni B (2022) Anatomy, Shoulder and Upper
Limb, Wrist Flexor Retinaculum. In StatPearls. StatPearls Publishing.
Deruddere KJ, Milne ME, Wilson KM, Snelling SR (2014) Magnetic
resonance imaging, computed tomography, and gross anatomy of the
canine tarsus. Vet Surg, 43: 912-919.
Diao E, Shao F, Liebenberg E, Rempel D, Lotz JC (2005). Carpal tunnel
pressure alters median nerve function in a dose-dependent manner:
a rabbit model for carpal tunnel syndrome. J. Orthop. Res., 23: 218
Ekim O, Oto Ç, Algın O (2014) Magnetic Resonance (MR) Imaging of
The Carpal Tunnel and Related Structures In New Zealand Rabbit
(Oryctolagus Cuniculus): An Anatomic and Radiologic Evaluation
On An Animal Model. Vet J Ankara Univ, 61:1-7.
Ettema AM, Zhao C, An KN, Amadio PC (2006) Comparative anatomy
of the subsynovial connective tissue in the carpal tunnel of the rat,
rabbit, dog, baboon, and human. Hand, 1: 78-84.
Horch R, Allmann KH, Laubenberger J, Langer M, Stark GB (1997) Me
dian nerve compression can be detected by magnetic resonance imag
ing of the carpal tunnel. Neurosurgery 41: 76- 82
Kamolz LP, Schrögendorfer KF, Rab M, Girsch W, Grube, H, Frey M
(2001) The precision of ultrasound imaging and its relevance for car
pal tunnel syndrome. Surg Radiol Anat, 23: 117-121.
Luna, LG (1968) Manual of histologic staining methods of the Armed
Forces Institute of Pathology. 3rd Edition, McGraw-Hill, New York.
Mogk JP and Keir PJ (2008) Wrist and carpal tunnel size and shape mea
surements: effects of posture. Clin Biomech, 23: 1112-1120.
Moriya T, Zhao C, Cha SS Schmelzer JD, Low PA, An KN, Amadio PC
(2011) Tendon injury produces changes in SSCT and nerve physi
ology similar to carpal tunnel syndrome in an in vivo rabbit model.
Hand, 6: 399-407.
Ng AWH, Griffith JF, Tong CSL, Law EKC, Tse WL, Wong CWY, Ho PC
(2020) MRI criteria for diagnosis and predicting severity of carpal
tunnel syndrome. Skeletal Radiol, 49: 397- 405.
Oh S, Ettema AM, Zhao C, Zobitz ME, Wold LE, An KN, Amadio PC
(2008) Dextrose-induced subsynovial connective tissue fibrosis in the
rabbit carpal tunnel: A potential model to study carpal tunnel syn
drome? Hand, 3: 34-40.
Pacek CA, Tang J, Goitz RJ, Kaufmann RA, Li ZM (2010) Morphological
analysis of the carpal tunnel. Hand, 5: 77-81.
Park JS, Won HC, Oh JY, Kim DH, Hwang SC, Yoo JI (2020) Value of
cross-sectional area of median nerve by MRI in carpal tunnel syn
drome. Asian J Surg, 43: 654-659.
Presazzi A, Bortolotto C, Zacchino M, Madonia L, Draghi F (2011) Car
pal tunnel: Normal anatomy, anatomical variants and ultrasound tech
nique. J Ultrasound, 14: 40-46.
Rodríguez P, Casado A, Potau JM (2022) Quantitative anatomical analysis
of the carpal tunnel in women and men. Ann Anat, 243: 151956.
Schrier VJMM, Vrieze A, Amadio PC (2020) Subsynovial connective
tissue development in the rabbit carpal tunnel. Vet Med Sci, 6: 1025
Sora MC and Genser-Strobl B (2005) The sectional anatomy of the carpal
tunnel and its related neurovascular structures studied by using plas
tination. Eur J Neurol, 12: 380-384.
Stapleton MJ (2006) Occupation and carpal tunnel syndrome. ANZ J
Surg, 76: 494-496.
Taqi SA, Sami SA, Sami LB, Zaki SA (2018). A review of artifacts in
histopathology. JOMFP, 22: 279.
Tung WL, Zhao C, Yoshii Y, Su FC, An KN, Amadio PC (2010) Compar
ative study of carpal tunnel compliance in the human, dog, rabbit, and
rat. J Orthop Res, 28: 652-656.
Turan E and Erden H (2003) Computed tomography and morphometry of
the carpal canal in the dog. Ann Anat, 185: 173-178.
Vogl TJ, Harth M, Siebenhandl P (2010). Different imaging techniques in
the head and neck: Assets and drawbacks. World J Radiol, 2: 224-229.
Wright AR and Atkinson RE (2019) Carpal Tunnel Syndrome: An Update
for the Primary Care Physician. Hawai’i J Health Soc Welf, 78: 6-10.
Yamaguchi T, Osamura N, Zhao C, Zobitz ME, An KN, Amadio PC
(2008) The mechanical properties of the rabbit carpal tunnel subsy
novial connective tissue. J Biomech, 41: 3519- 3522.
Yoshii Y, Zhao C, Schmelzer JD, Low PA, An KN, Amadio PC (2014)
Effects of multiple injections of hypertonic dextrose in the rabbit car
pal tunnel: a potential model of carpal tunnel syndrome development.
Hand, 9: 52-57.
Yoshioka S, Okuda Y, Tamai K, Hirasawa Y, Koda Y (1993) Changes in
carpal tunnel shape during wrist joint motion - MRI evaluation of
normal volunteers. J Hand Surg, 18B: 620- 623.
Zuniga AF and Keir PJ (2019) Diagnostic and Research Techniques in
Carpal Tunnel Syndrome. Crit Rev Biomed Eng, 47: 457-471.