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Epidemiological - clinical features of primary malignant brain tumors of patients who underwent surgical resection and / or radiotherapy

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Anthoula Lagiou, Ioannis Papagiannopoulos, Nikoletta Margari, Georgios Vasilopoulos
Anthoula Lagiou, Ioannis Papagiannopoulos, Nikoletta Margari, Georgios Vasilopoulos

Abstract


The aim of the present study was to describe the demographic characteristics of patients diagnosed with primary brain tumor, the clinical features and prognostic indicators of disease progression and treatment they received.
Methods: A retrospective descriptive study was conducted on a convenience sample of 47 patients who attended the radiotherapeutic department of General Hospital of Athens over three years, from May 2011 until May 2014.
For analysis used the statistical program SPSS 18.0.
Results: 59.6% of patients were male and 40.4% of patients were between 61 and 69 years. 85.1% of patients had glioblastomamultiforme and meningioma 8.5%. 57.5% of patients with glioblastomamultiforme were men and 50.0% of patients with meningioma. It was found that the patients with grade I-III were considerably higher percentage between 61 and 69 years as compared to patients with grade IV (p = 0,021). Patients with grade IV underwent chemotherapy significantly higher rate compared with patients with grade I-III. No significant difference was found in the course of radiotherapy among patients with grade IV and patients with grade I-III. Differed significantly Ki-67 among patients with grade IV and of patients with grade I-III patients with grade IV were higher Ki-67.
Conclusion: Glioblastoma multiforme (GBM) is the most frequently diagnosed intracranial malignant tumor in adults. Typical treatment for glioblastomas, with surgical resection followed by radiation and chemotherapy with temozolomide and anti - angiogenic therapy bevacizumab , have significantly improved the overall survival.


Keywords


Brain tumors; histological classification; Ki-67; radiotherapy; chemotherapy

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