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Effects of left ventricular assist device implantation on respiratory drive

Published: Ιουλ 1, 2019
Heart failure left ventricular assist device LVAD respiratory drive reverse remodeling
Athanasios Tasoulis
Georgios Tzanis
Ioannis Vasileiadis
Stavros Dimopoulos
Eleftherios Karatzanos
Serafim Nanas
Christos Charitos

Background: Patients with heart failure (HF) suffer from ventilatory abnormalities that are related to poor prognosis.

Aim: The aim of the study was to investigate the respiratory drive in HF patients early after left ventricular assist device (LVAD) implantation.

Methods: We enrolled eight HF patients after LVAD (HeartMate II) implantation and 8 patients with advanced HF (control group). Patients were evaluated with cardiopulmonary exercise testing, respiratory function tests and transthoracic echocardiographic examination at 1, 3 and 6 months. Respiratory drive was estimated by the mouth occlusion pressure-P0.1 and the P0.1/Pimax ratio.

Results: LVAD patients at 1, 3 and 6 months after implantation had significantly improved P0.1/Pimax% ratio (4.17±0.43 vs 3.29±1.0 vs 2.56±0.35 respectively,p<0.01) as well as significantly increased in Pimax. No changes where observed in the HF control group. A significant decrease in LVEDD, LVESD and an improvement in LVEF is also observed during follow up.

Conclusions: Our results imply LVAD implantantion induces a progressive and significant improvement of respiratory drive and Left ventricle reverse remodeling during a 6 month follow-up period.

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