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Effects of left ventricular assist device implantation on respiratory drive

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Published: Jul 1, 2019
DOI: https://doi.org/10.12681/healthresj.20877
Keywords:
Heart failure left ventricular assist device LVAD respiratory drive reverse remodeling
Athanasios Tasoulis
1st Critical Care Medicine Department, Cardiopulmonary Exercise Testing and Rehabilitation Laboratory, “Evgenidio” Hospital, National and Kapodistrian University of Athens
Georgios Tzanis
1st Critical Care Medicine Department, Cardiopulmonary Exercise Testing and Rehabilitation Laboratory, “Evgenidio” Hospital, National and Kapodistrian University of Athens
Ioannis Vasileiadis
1st Department of Respiratory Medicine, Sotiria Hospital, National and Kapodistrian University of Athens,
Stavros Dimopoulos
1st Critical Care Medicine Department, Cardiopulmonary Exercise Testing and Rehabilitation Laboratory, “Evgenidio” Hospital, National and Kapodistrian University of Athens
Eleftherios Karatzanos
1st Critical Care Medicine Department, Cardiopulmonary Exercise Testing and Rehabilitation Laboratory, “Evgenidio” Hospital, National and Kapodistrian University of Athens
Serafim Nanas
1st Critical Care Medicine Department, Cardiopulmonary Exercise Testing and Rehabilitation Laboratory, “Evgenidio” Hospital, National and Kapodistrian University of Athens
Christos Charitos
Department of Cardiac Surgery, “Evangelismos” General Hospital, Athens
Abstract

Background: Patients with heart failure (HF) suffer from ventilatory abnormalities that are related to poor prognosis.

Aim: The aim of the study was to investigate the respiratory drive in HF patients early after left ventricular assist device (LVAD) implantation.

Methods: We enrolled eight HF patients after LVAD (HeartMate II) implantation and 8 patients with advanced HF (control group). Patients were evaluated with cardiopulmonary exercise testing, respiratory function tests and transthoracic echocardiographic examination at 1, 3 and 6 months. Respiratory drive was estimated by the mouth occlusion pressure-P0.1 and the P0.1/Pimax ratio.

Results: LVAD patients at 1, 3 and 6 months after implantation had significantly improved P0.1/Pimax% ratio (4.17±0.43 vs 3.29±1.0 vs 2.56±0.35 respectively,p<0.01) as well as significantly increased in Pimax. No changes where observed in the HF control group. A significant decrease in LVEDD, LVESD and an improvement in LVEF is also observed during follow up.

Conclusions: Our results imply LVAD implantantion induces a progressive and significant improvement of respiratory drive and Left ventricle reverse remodeling during a 6 month follow-up period.

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