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Addition of strength training modifies the aerobic exercise inflammatory response in heart failure patients – Comments on the underlying pathophysiology

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Published: Apr 5, 2022
DOI: https://doi.org/10.12681/healthresj.29806
Keywords:
Heart failure rehabilitation inflammatory response exercise training strength training
Dimitrios Delis
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Vasiliki Linardatou
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece - Nursing Education Office, Emergency & Critical care Nursing Specialty, General Hospital 'G. Gennimatas', Athens, Greece
Eleftherios Karatzanos
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Chris Kourek
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Anastasios Philippou
Laboratory of Physiology, Medical School, National and Kapodistrian University of Athens, Greece
Dimitrios Vagionas
Intensive Care Unit, 1st Dept of Respiratory Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, Athens, Greece
Niki Panagopoulou
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Manal Alshamari
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Theodoros Pittaras
Hematology Laboratory - Blood Bank, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens, Ath-ens, Greece
Serafim Nanas
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Ioannis Vasileiadis
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece - 6. 1st Critical Care Department, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Abstract

Aim: The present study investigates the effect of Strength Training addition in a High Intensity Interval Training (HIIT) program, on the inflammatory profile of chronic heart failure (CHF) patients.


Materials and Methods: Forty-six CHF patients were randomized into the two different exercise rehabilitation groups. A patient group (control) performed HIIT and another group performed Combined (HIIT and strength training) Exercise Training (COM) for a three- month period. Before and after rehabilitation, all patients performed a maximal cardiopulmonary exercise testing (CPET). Microcirculatory parameters were assessed by Near Infrared Spectroscopy; CRP, IL-2, IL-6, IL-10 and VEGF levels were measured in plasma.


Results: Cardiopulmonary parameters and microcirculatory indices improved after rehabilitation. CRP and the IL-6/IL-10 ratio decreased after rehabilitation. By linear regression analysis, a negative correlation was noted between IL-2, IL-6 and IL-10 changes (post-CPET values) and the VE/VCO2 slope change, for the entire patient cohort. The correlation was separately maintained only in the COM group.


Conclusions: Overall, the results of the present study reinforce the view of an anti-inflammatory effect of exercise in CHF patients. The significant correlations demonstrated between the cytokine responses and the ventilatory response to exercise, particularly in the COM group, probably ensue from the special effect of strength training on peripheral muscle function.

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