Οι κυριότερες μυκοτοξινώσεις στους χοίρους: μεταβολισμός και τοξινοκινητικη των υπευθύνων μυκοτοξινών

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Δημοσιευμένα: Νοε 30, 2017
DOI: https://doi.org/10.12681/jhvms.15092
Λέξεις-κλειδιά:
Μυκοτοξινώσεις χοίροι μεταβολισμός τοξινοκινητικη μυκοτοξίνες.
P. D. TASSIS (Π. Δ. ΤΑΣΣΗΣ)
Κλινική Παθολογίας Παραγωγικών Ζώων, Τμήμα Κτηνιατρικής, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης
C. ALEXOPOULOS (Κ. ΑΛΕΞΟΠΟΥΛΟΣ)
Κλινική Μαιευτικής και Τεχνητής Σπερματέγχυσης, Τμήμα Κτηνιατρικής, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης
S. K. KRITAS (Σ. Κ. ΚΡΗΤΑΣ)
Εργαστήριο Λοιμωδών και Παρασιτικών Νοσημάτων, Τμήμα Κτηνιατρικής, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης
E. D. TZIKA (Ε. Δ. ΤΖΗΚΑ)
Κλινική Παθολογίας Παραγωγικών Ζώων, Τμήμα Κτηνιατρικής, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης
K. SAOULIDIS (Κ. ΣΑΟΥΛΙΔΗΣ)
Κλινική Παθολογίας Παραγωγικών Ζώων, Τμήμα Κτηνιατρικής, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης
S. C. KYRIAKIS (ΚΥΡΙΑΚΗΣ Σ.Κ.)
Κλινική Παθολογίας Παραγωγικών Ζώων, Τμήμα Κτηνιατρικής, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης
Περίληψη

Οι μυκοτοξίνες είναι δευτερογενείς μεταβολίτες των μυκήτων που αναπτύσσονται σε διάφορες βασικές ζωοτροφές (συχνότερα στο καλαμπόκι, στο σιτάρι, στο κριθάρι κ.λπ.), οι οποίες χρησιμοποιούνται στα σιτηρέσια των χοίρων. Αναπτύσσονται είτε κατά την καλλιέργεια είτε κατά τη μεταφορά ή αποθήκευση των δημητριακών καρπών. Οι μυκοτοξίνες προσβάλλουν το 25% της παγκόσμιας παραγωγής δημητριακών καρπών προκαλώντας εκτεταμένες οικονομικές απώλειες. Οι κυριότερες μυκοτοξίνες πουπροκαλούν κλινικά συμπτώματα στους χοίρους είναι: από την ομάδα των αφλατοξινών η αφλατοξίνη Βΐ 5 από την ομάδα των τριχοθεσινών η δεοξυνιβαλενόλη (DON) και η ζεαραλενόνη (ZEN), από τις ωχρατοξίνες η ωχρατοξίνη Α (ΟΤΑ) και από τις φουμονισίνες η φουμονισίνη Bj. Η επίδραση των μυκοτοξινών στους χοίρους εξαρτάται από την έκταση και το ρυθμό απορρόφησης τους, από την κατανομή, τη σύνδεση ή την εντόπιση τους σε διάφορους ιστούς και από τον τρόπο αποβολή τους. Το ποσοστό συμμετοχής των παραπάνω διεργασιών, οι οποίες συμβάλλουν στην κινητική των τοξινών, εξαρτάται από τις χημικές και φυσικές τους ιδιότητες, καθώς και από την αλληλεπίδραση τους με τους ιστούς που είναι υπεύθυνοι για το μεταβολισμό και την απομάκρυνση τους. Σκοπός της συγκεκριμένης εργασίας είναι η καταγραφή των κυριότερων σταδίων του μεταβολισμού και η διερεύνηση της τοξινοκινητικής των παραπάνω μυκοτοξινών στους χοίρους. Επιπλέον,αναφέρονται τα συχνότερα κλινικά συμπτώματα που προκαλούνται στις περιπτώσεις των αντίστοιχων μυκοτοξινώσεων των χοίρων.

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Αναφορές
Alexopoulos C (2001). Association of fusarium mycotoxicosis with failure in applying an induction of parturition program with pgf2 alpha and oxytocin in sows. Theriogenol. 55:1746-1 757.
Barnikol H and Thalmann A (1988). Clinical observations in the pig in relation to the mycotoxins ochratoxin A and zearalenone. Tierarzt. Umsch.. 43, 74-82.
Bauer J (1995). The metabolism of trichothecenes in swine. Deutsc. Tierarzt. Wochensch. 102:50-52.
Bauer J, Heinritzi K, Gareis M and Gedek Β (1987). Veränderungen am Genitaltrakt des weiblichen Schweines nach Verfutterung praxisrelevanter zearalenon mengen. Tierarzt. Praxis. 15, 33-36.
Biehl ML, Prelusky DB, Koritz GD, Hartin K, Buck WB and Trenholm HL (1993). Biliary excretion and enterohepatic cycling of zearalenone in immature pigs. Toxic. Appi. Pharmac. 121:1, 152-159.
Bondy GS, Pestka JJ (2000). Immunomodulation by fungal toxins. Journal of Toxic. Environm.Health Β Critical Revues; 3(2):109-43.
Constable PD, Smith GW, Rottinghaus GE, Tumbleson ME, Haschek WM (2003). Fumonisin-induced blockade of ceramide synthase in sphingolipid biosynthetic pathway alters aortic input impedance spectrum of pigs. Amer. J. of Phys.. Heart Circuì. Physiol. 284(6):H2034-44.
Coppock RW, Swanson SP, Gelberg HB, Koritz GD, Hoffman WE, Buck WB and Vesonder RF (1985). Preliminary study of the pharmacokinetics and toxicopathy of deoxynivalenol
(vomitoxin) in swine. Amer. J. of Vet. Res. 46,169-174.
Corner DE (1991). Mycotoxicosis: mechanisms of immunosuppression. Vet. Immun. Immunopath., 30(l):73-87.
Dänicke S, Matthäus Κ, Lebzien Ρ, Valenta Η, Stemme Κ, Ueberschär Κ-Η, Razzazi-Fazeli Ε, Böhm J, Flachowsky G (2004α). Effects of Fusarium toxin-contaminated wheat grain on nutrient turnover, microbial protein synthesis and metabolism of deoxynivalenol and zearalenone in the rumen of dairy cows. J. of Anim. Physiol. Anim. Nutrii., http://www.blackwellsynergy. eom/links/doi/10.llll/j.1439-0396.2005.00513.x/abs/Blackwell publishing online early.
Dänicke S, Valenta H, Doll S (2004ß). On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig. Arch. Anim. Nutrii. 58, 169-180.
Dänicke S, Valenta H, Doll S, Ganter M, Flachowsky G (2004γ). On the effectiveness of a detoxifying agent in preventing fusariotoxicosis in fattening pigs. Anim. Feed Science and Techn.. 114,141-157.
Dänicke S, Goyarts Τ, Valenta Η, Razzazi E, Böhm J (2004ο).On the effects of increasing deoxynivalenol (DON) concentrations in pig feed on growth performance and utilization
of nutrients and on DON metabolism. J. of Anim. and Feed Scienc. 13:4, 539-556.
Dänicke S, Valenta H, Klobasa F, Doll S, Ganter M, Flachowsky G (2004ε). Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth
performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Arch. Anim. Nutrii.. 58, 1-17.
Dilkin P, Zorzete P, Mallmann CA, Gomes JD, Utiyama CE, Oetting LL, Correa Β (2003). Toxicological effects of chronic low doses of aflatoxin B(l) and fumonisin Β(1)-containing Fusarium moniliforme culture material in weaned piglets. Food and Chem. Toxicol. 41(10):1345-53.
EFSA (2004a) European Food Safety Authority. Opinion of the Scientific panel on contaminants in the food chain on a request from the Commission related to aflatoxin Bl as undesirable substance in animal feed. The EFSA journal http://www.efsa.eu.int/science/contam/contam_opinions/294/opin ion_contam_02_en_finall.pdf 39, 1-27.
EFSA (2004β) European Food Safely Authority. Opinion of the Scientific panel on contaminants in the food chain on a request from the Commission related to Deoxynivalenol (DON) as undesirable substance in animal feed. The EFSA journal, http://www.efsa.eu.int/science/contam/contam_opinions/478/opin ion05_contam_ej73_deoxynivalenol_v2_enl.pdf 73, 1-41.
EFSA (2004γ) European Food Safety Authority. Opinion of the Scientific panel on contaminants in the food chain on a request from the Commission related to ochratoxin A (OTA) as undesirable substance in animal feed. The EFSA journal http://www.efsa.eu.int/science/contam/contam_opinions/645/opin
ion_contam09_ejl01_ochratoxina_enl.pdf 101, 1-36.
EFSA (2004Ô) European Food Safety Authority. Opinion of the Scientific panel on contaminants in the food chain on a request from the Commission related to Zearalenone (ZEN) as undesirable substance in animal feed. The EFSA journal, http://www.efsa.eu.int/science/contam/contam_opinions/527/opin
ion_contamQ6_ej89_zearalenone_v3_enl.pdf 89,1-35.
EMAN European Mycotoxins Awareness Network, (2005a). Fact sheet 3: Ochratoxin A .
http://www.Ifra.co.uk/eman2/fsheet3.asp
EMAN European Mycotoxins Awareness Network, (2005β). Fact sheet 5: Fumonisins .
http://www.Ifra.co.uk/eman2/fsheet5.asp
EMAN European Mycotoxins Awareness Network, (2005γ). Fact sheet 8: Trichothecenes http://www.Ifra.co.uk/eman2/fsheet8.asp
EMAN European Mycotoxins Awareness Network, (20056). Fact sheets on analytical methods, 5:Zearalenol. http://www.Ifra.co.uk/eman2/fsheet2_5.asp
EMAN European Mycotoxins Awareness Network (2005ε). Fact sheets on analytical methods, 7:Aflatoxins. http://www.Ifra.co.uk/eman2/fsheet2_7.asp
Eriksen GS, Pettersson H, Lindberg JE (2003). Absorption, metabolism and excretion of 3-acetyl DON in pigs. Arch.Tierern. Oct;57(5):335-45.
Galtier Ρ (1998). Biological fate of mycotoxins in animals. Rev. med. Veterin., 149, 549-554
Galtier P, Camguilhem R, Bodin G (1980). Evidence for in vitro and in vivo interaction between ochratoxin A and three acidic drugs. Food Cosm. Toxicol.. 18(5), 493-6.
Galtier P, Alvinerie M and Charpenteau JL (1981). The pharmacokinetic profiles of ochratoxin A in pigs, rabbits and chickens. Food Cosm. Toxicol.. 19(6), 735-8.
Gennari A, Pazos P, Boveri M, Callaghan R, Casado J, MauriciD, Corsini E, Prieto Ρ (2004). New insights into the mechanisms involved in renal proximal tubular damage induced in vitro by ochratoxin. J. Bioch.. Mol. Toxicol.. 18(l):43-9.
Gorelick NJ (1990). Risk Assessment for aflatoxin: I. Metabolism of aflatoxin Bl by different species. Risk Anal.. 10: 539-559
Gumprecht LA, Smith GW, Constable PC, Haschek WM (2001).Species and organ specificity of fumonisin-induced endothelial alterations: potential role in porcine pulmonary edema. Toxic. 7;160(l-3):71-9.
Harvey RB, Kubena LF, Huff WE, Corrier DE, Rottinghaus GE, Phillips TD (1990). Effects of treatment of growing swine with aflatoxin and T-2 toxin. Amer. J. Vet. Res. 51(10):1688-93.
Harvey RB, Elissalde MH, Kubena LF, Weaver EA, Corrier DE, Clement Β A (1992). Immunotoxicity of ochratoxin A to growing gilts. Amer. J. Vet. Res. 53(10):1966-70.
Haschek WM, Gumprecht LA, Smith G, Tumbleson ME, Constable PD (2001). Fumonisin toxicosis in swine: an overview of porcine pulmonary edema and current perspectives. Environm. Health Persp. 109 Suppl 2:251-7.
Huit Κ, Hokby E, Hagglund U, Gatenbeck S, Rutqvist L and Sellyey G (1979). Ochratoxin A in pig blood: method of analysis and use as a tool for feed studies. Appi. Environm. Microb. 38(5) 772-776.
Kuiper-Goodman T, Scott PM and Watanabe H (1987). Risk assessment of the mycotoxin zearalenone. Regul. Toxic. Pharm., 7, 253-306.
Kyriakis SC, Kostoglou P, Saoulidis K, Alexopoulos C, Tsinas A (1994). Control of disorders on sows' reproductive performance because of hypovitaminosis A and F2 mycotoxicosis (zearalenone). J. Hellen. Vet. Med. Soc. 45(4): 312-316.
Liu BH, Yu FY, Chan MH, Yang YL (2002). The effects ofmycotoxins, fumonisin Bl and aflatoxin Bl, on primary swine alveolar macrophages. Toxic. Appi. Pharm. l;180(3):197-204.
Lusky K, Goebel R, Tesch D, Doberschuetz K-D, Lusky Κ and Haider W (2001). Sole and combined administration of the mycotoxins OTA, ZEA and DON. Investigations on animal health and residue behavior. Fleischw. 81, 98-102.
MacDonald EJ, Cavan DR and Smit, TK (1988). Effect of acute oral doses of T-2 toxin on tissue concentrations of biogenic amines in the rat. J. Anim. Sci. 66:434-441.
Marin DE, Taranu I, Bunaciu RP, Pascale F, Tudor DS, Avram N, Sarca M, Cureu I, Criste RD, Suta V, Oswald IP (2002). Changes in performance, blood parameters, humoral and cellular immune responses in weanling piglets exposed to low doses of aflatoxin. J. Anim. Sci. 80(5): 1250-7.
McLean M and Dutton MF (1995). Cellular interactions, metabolism of aflatoxin: an update. Pharm, and Therap. 65,163-192
Miles CO, Erasmuson AF, Wilkins AL, Towers NR, Smith BL, Garthwaite I, Scahill BG and Hansen RP (1996). Ovine metabolism of zearalenone to alpha-zearalanol (zeranol). J.
Agric. Food Chem., 44, 3244-3250.
Mirocha CJ, Pathre SV, Robison TS (1981). Comparative metabolism of zearalenone and transmission into bovine milk. Food Cosmet. Toxic. 19, 25-30.
Mortensen HP, Hald Β and Madsen A (1983a). Feeding experiments with ochratoxin A contaminated barley for bacon pigs. 5. Ochratoxin A in pig blood. Acta Agric. Scandin. 33, 235-239.
Mortensen HP, Hald B, Eklundh Larsen A and Madsen A (1983β). Ochratoxin contaminated barley for sows and piglets. Pig performance and residue in milk and pigs. Acta Agric. Scandin. 33, 349-352.
Müller G, Kielstein Ρ, Rosner Η, Berndt Α, Heller M, Kohler H (1999α ). Studies on the influence of combined administration of ochratoxin A, fumonisin Bl, deoxynivalenol and T2 toxin on immune and defence reactions in weaner pigs. Mycoses. 42(7-8):485-93.
Müller G, Kielstein Ρ, Rosner Η, Berndt Α, Heller M, Kohler H (1999ß). Studies of the influence of ochratoxin A on immune and defence reactions in weaners. Mycoses. 42(7-8):495-505.
Muller G, Burkert Β, Moller U, Diller R, Rohrmann Β, RosnerΗ, Kohler Η (2004). Ochratoxin A and some of its derivatives modulate radical formation of porcine blood monocytes and granulocytes. Toxicology. Jul 1,199(2-3):251-9.
Olsen M, Malmlof Κ, Pettersson Η, Sandholm Κ and Kiessling K-H (1985α). Plasma and urinary levels of zearalenone and alpha-zearalenol in a prepubertal gilt fed zearalenone. Acta pharm, toxic. 56, 239-243.
Olsen M, Pettersson H, Sandholm Κ and Kiessling K-H (1985β). Quantitative liquid chromatographic method using fluorescence detecton for determining zearalenone and its metabolites in blood plasma and urine. J. -Assoc. Offic. Analyt. Chem., 68, 632-635.
Olsen Μ, Pettersson Η, Sandholm Κ, Visconti A and Kiessling ΚΗ (1987). Metabolism of zearalenone by sow intestinal mucosa in vitro. Food Chem. Toxic. 25, 681-683.
Olsen M, Malmlof Κ, Pettersson Η and Grajewski J (1991). Influence of dietary fibre on plasma and urinary levels of zearalenone and metabolites in swine. Myc. Res. 7, 8-11.
Oswald IP, Desautels C, Laffitte J, Fournout S, Peres SY, Odin M, Le Bars P, Le Bars J, Fairbrother JM (2003). Mycotoxin fumonisin Bl increases intestinal colonization by pathogenic Escherichia coli in pigs. Appi. Environm. Microb. 69(10):5870-4.
Osweiler GD (1999). Mycotoxins. In: Diseases of Swine (8th edn), Straw B.E., D'Allaire S., Mengeling W. L. Taylor D.J. (eds), Iowa State University Press / Ames, Iowa U.S.A. pp. 731-742.
Osweiler GD; Hopper DL and Debey BM (1990). Taste aversion in swine induced by deoxynivalenol. J. Anim. Sci. 68 (Suppl 1):403.
Panangala VS, Giambrone JJ, Diener UL, Davis ND, Hoerr FJ, Mitra A, Schultz RD, Wilt GR (1986). Effects of aflatoxin on the growth performance and immune responses of weanling swine. Amer. J. Vet. Res. 47(9):2062-7.
Papaioannou DS, Kyriakis SC, Papasteriadis A, Roumbies N, Yannakopoulos A, Alexopoulos C (2002). A field study on the effect of in-feed inclusion of a natural zeolite (clinoptilolite) on health status and performance of sows/gilts and their litters. Res. Vet. Sci. 72(l):51-9.
Patterson DS, Roberts BA and Small BJ (1976). Metabolism of ochratoxins A and Β in the pig during early pregnancy and the accumulation in body tissues of ochratoxin A only. Food Cosmet. Toxic 14(5) 439-42.
Pier AC 1981. Mycotoxins and animal health. Adv. Vet. Sci. Comp. Med. 25:185-243.
Petzinger E, Ziegler Κ (2000). Ochratoxin A from a toxicological perspective. J. Vet. Pharm. Therap.23(2):91-8.
Prelusky DB (1993). The effect of low-level deoxynivalenol on neurotransmitter levels measured in pig cerebral spinal fluid. J. Environm. Sci. Health Β 28:731-761.
Prelusky DB (1996). A study on the effect of deoxynivalenol on serotonin receptor binding in pig brain membranes, J. Environm. Sci. Health Β 31:1103-1117.
Prelusky DB and Trenholm HL (1991). Tissue distribution of deoxynivalenol in swine dosed intravenously. J. Agric. Food Chem.. 39, 748-751.
Prelusky DB, Hartin KE, Trenholm HL, Miller JD (1988). Pharmacokinetic fate of 14C-labeled deoxynivalenol in swine. Fund. Appi. Toxic. 10(2):276-86.
Prelusky DB, Yeung JM, Thompson BK and Trenholm HL (1992). Effect of deoxynivalenol on neurotransmitters in discrete regions of swine brain. Arch. Environm. Contam. Toxic. 22:36-40.
Prelusky DB, Trenholm HL, Rotter BA, Miller JD, Savard ME, Yeung JM, Scott PM (1996). Biological fate of fumonisin Bl in food-producing animals. Adv. Experim. Med. Biol. 392:265-78.
Rotter BA, Prelusky DB, Pestka JJ (1996a). Toxicology of deoxynivalenol (vomitoxin). J. Toxic. Environm. Health. 48(1):1-34.
Rotter BA, Thompson BK, Prelusky DB, Trenholm HL, Stewart B, Miller JD, Savard ME (1996β). Response of growing swine to dietary exposure to pure fumonisin Bl during an eight-week period: growth and clinical parameters. Nat. Tox. 4(l):42-50.
Shane SM (1994). Economic issues associated with aflatoxins. In: Eaton, D.L. and Groopman, J.D. (Eds.). The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural Significance. Academic Press. NY, U.S.A. pp 513-527.
Silvotti L, Petterino C, Bonomi A, Cabassi E (1997). Immunotoxicological effects on piglets of feeding sows diets containing aflatoxins. Vet. Ree. l;141(18):469-72.
Solti L, Pecsi T, Barna-Vetro I, Szasz F Jr, Biro K, Szabo E (1999). Analysis of serum and seminal plasma after feeding ochratoxin A with breeding boars. Anim. Repr. Sci. 28;56(2):123-32.
Stoev SD, Vitanov S, Anguelov G, Petkova-Bocharova T, Creppy EE (2001). Experimental mycotoxic nephropathy in pigs provoked by a diet containing ochratoxin A and penicillic acid. Vet. Res. Com.25(3):205-23.
Swamy HV, Smith TK, MacDonald EJ (2004). Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on brain regional neurochemistry of starter pigs and broiler chickens. Anim. Sci. 82(7):2131-9.
Tassis PD, Alexopoulos C, Saoulidis K, Lymberopoulos AG, Kyriakis SC (2005). Investigation upon the levels of certain mycotoxins in raw feed materials and rations of two Greek industrial pig units with relative reproductive disorders. Proceedings of the 4th Hellenic Congress of Productive Animals' Veterinary Medicine, p. 219-220.
Taylor DJ (1999). Mycotoxicoses. In: Pig Diseases (7th ed), D.J.Taylor (Ed)., Bury St Edmunds, Suffolk, St Edmundsburry Press Ltd, pp. 255-264.
Trucksess MW, Stoloff L, Brumley WC, Wilson DM, Hale OM,Sangster LT, Miller DM (1982). Aflatoxicol and aflatoxins Bl and Ml in the tissues of pigs receiving aflatoxin. J. - Assoc. Offic. Analyt. Chem. 65(4):884-7.
Van Dolah FM, Richard JL (1999). Advances in detection methods for fungal and algal toxins. Nat. Tox. Nov;7(6):343-345.
WHO/FAO (World Health Organization/Food and Agriculture Organization) (2001a). Aflatoxin Ml. In: "Safely Evaluation of Certain Mycotoxins in Food". Prepared by the fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives, pp. 2-102.
WHO/FAO (World Health Organization/Food and Agriculture Organization) (2001ß). Deoxynivalenol. In: "Safety Evaluation of Certain Mycotoxins in Food". Prepared by the fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives, pp. 420-555.
WHO/FAO (World Health Organization/Food and Agriculture Organization) (2001γ). Fumonisins. In: "Safely Evaluation of Certain Mycotoxins in Food". Prepared by the fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives, pp. 104-279.
WHO/FAO (World Health Organization/Food and Agriculture Organization) (2001Ô). Ochratoxin A. In: "Safety Evaluation of Certain Mycotoxins in Food". Prepared by the fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives, pp. 282-415.
Zomborszky-Kovacs M, Vetesi F, Horn P, Repa I, Kovacs F (2002). Effects of prolonged exposure to low-dose fumonisin Bl in pigs. J. Vet. Med. Β 49(4):197-201.
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