The efficacy of Contoya (Lobelia decurrens cav.) in the control of eimeriosis in vivo in rabbits


Publiée : Apr 23, 2024
Mis à jour : 2024-04-23
Versions :
2024-04-23 (2)
G Reyna-Cotrina
T Torrel Pajares
J Rojas-Moncada
L Vargas Rocha
Résumé

The search for alternatives in the control of eimeriosis and the lack of studies on local bioactive plants led to the present research to evaluate the efficacy of Contoya (Lobelia decurrens cav.) under two presentations in the control of Eimeria spp. in rabbits in Cajamarca (Peru). Fifty-six rabbits with a parasite load greater than 400 oocysts per gram of feces were selected and divided into a control group and six treatments of eight replicates. The first three treatment groups were administered in extract presentation and the following three in infusion. The coproparasitoscopic evaluation was performed using the McMaster technique on days 1, 3, and 8 post-dosing. The results showed that both presentations and volumes of Contoya achieve the reduction of parasite load, so this plant can be used in Extract and Infusion of 1 to 3 mL per rabbit indistinctly (p > 0.05). The decrease in efficacy in the days was significant (p < 0. 10), in the treatments with extract a maximum reduction of 99.04% (Day 1) and a minimum of 89.35% (Day 8) was observed. Although, in the group treated with infusion, the maximum reduction of oocysts was achieved (99.62% - Day 1), also in this group the lowest value was obtained (84.96% - Day 8). It is inferred that Lobelia decurrens cav. is effective in controlling eimeriosis in rabbits, both in extract and infusion presentations.

Article Details
  • Rubrique
  • Short Communication
Téléchargements
Les données relatives au téléchargement ne sont pas encore disponibles.
Références
Anthony JP, Fyfe L, Smith H (2005) Plant active components - a resource for antiparasitic agents? Trends Parasitol21:462-8.
Appendino G, Minassi A, Taglialatela-Scafati O (2014) Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs. Nat Prod Rep 31:880-904.
Burke JM, Miller JE (2020) Sustainable Approaches to Parasite Control in Ruminant Livestock. Vet Clin North Am Food Anim Pract 36:89-107.
Choi WH, Lee IA (2016) The anti-tubercular activity of Melia azedarach L. and Lobelia chinensis Lour. and their potential as effective anti-Mycobacterium tuberculosis candidate agents. Asian Pac J Trop Biomed6:830-5.
Coles GC, Bauer C, Borgsteede FH, Geerts S, Klei TR, Taylor MA, Waller PJ (1992) World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol44:35-44.
Duszynski DW, Couch L (2013) Chapter 1 - Introduction, in: The Biology and Identification of the Coccidia (Apicomplexa) of Rabbits of the World. 1st ed, Elsevier: pp 1-15
El-Ghoneimy A, El-Shahawy I (2017) Evaluation of amprolium and toltrazuril efficacy in controlling natural intestinal rabbit coccidiosis. Iran J Vet Res 18:164-9.
Forbes A (2013) Liver fluke control in cattle: why, when and how? Cattle Pract21:150-6.
Hanada S, Omata Y, Umemoto Y, Kobayashi Y, Furuoka H, Matsui T, et al (2003) Relationship between liver disorders and protection against Eimeria stiedai infection in rabbits immunized with soluble antigens from the bile of infected rabbits. VetParasitol 111:261-6.
IPE - Instituto Peruano de Economía (2022) 1 de cada 3 infantes en Cajamarca tuvo anemia en 2021. Informe IPE - El Nuevo Diario (Cajamarca) https://www.ipe.org.pe/portal2/1-de-cada-3-infantes-en-cajamarca-tuvo-anemia-en-2021/ [accessed 23 August 2023].
Jing J, Liu C, Zhu S-X, Jiang Y-M, Wu L-C, Song H-Y, et al (2016) Pathological and ultrastructural observations and liver function analysis of Eimeria stiedai-infected rabbits. Vet Parasitol 223:165-72.
Luo YP, Zhang Y, Zhang HM, Zhang H, Zhang L, et al (2018) Antiparasitic effects of water-soluble alkaloid fractions from ethanolic extracts of Sophora moorcroftiana seeds in Caenorhabditis elegans. Chin J Nat Med16:665-73.
Mali RG, Wadekar RR (2008)In vitro anthelmintic activity of Baliospermummontanum Muell. Arg roots. Indian J Pharm Sci70:131-3.
Mwamula AO, Kabir MF, Lee D (2022) A Review of the Potency of Plant Extracts and Compounds from Key Families as an Alternative to Synthetic Nematicides: History, Efficacy, and Current Developments. Plant Pathol J38:53-77.
Ogolla KO, Gathumbi PK, Waruiru RM, Okumu PO, Chebet J, Kitala PM (2018) Efficacy of Sulphachloropyrazine, Amprolium Hydrochloride, Trimethoprim-Sulphamethoxazole, and Diclazuril against Experimental and Natural Rabbit Coccidiosis. J Vet Med 2018:5402469.
Ohri P, Pannu SK (2010) Effect of phenolic compounds on nematodes- A review. J Appl Nat Sci 2:344-50.
Qamar MF, SharifR, Qamar MM, Basharat A (2013) Comparative efficacy of sulphadimidine sodium, toltrazuril and amprolium for Coccidiosis in Rabbits. SciInt(Lahore) 25:295-8.
Ramírez ME, Mendoza JA, Arreola RH, Ordaz C (2010) Flavonoids with antiprotozoal activity. Rev Mex Cienc Farm 41:6-21.
Ranasinghe S, Aspinall S, Beynon A, Ash A, Lymbery A (2023) Traditional medicinal plants in the treatment of gastrointestinal parasites in humans: A systematic review and meta‐analysis of clinical and experimental evidence. Phytother Res 37:3675-87.
Sánchez J (2005) Fitochemical study of the Lobelia decurrens Cav. and its effect in the Distomatosis induced in Cavia porcellus. Rev Mundo Veter 3:21.
Sharma UNS, Fernando DD, Wijesundara KK, Manawadu A, Pathirana I, Rajapakse RPVJ (2021) Anticoccidial effects of Phyllanthusemblica (Indian gooseberry) extracts: Potential for controlling avian coccidiosis. Vet Parasitol Reg Stud Rep 25:100592.
Silva F dos S, Albuquerque UP, Costa LM, Lima A. da S, Nascimento ALB do, Monteiro JM (2014) An ethnopharmacological assessment of the use of plants against parasitic diseases in humans and animals. J Ethnopharmacol 155:1332-41.
Stolom S, Oyemitan IA, Matewu R, Oyedeji OO, Oluwafemi SO, Nkeh-Chungag BN, et al (2016) Chemical and biological studies of Lobelia flaccida (C. Presl) A.DC leaf: a medicinal plant used by traditional healers in Eastern Cape, South Africa. Trop J Pharm Res 15:1715-21.
Ueno H, Gonçalves PC (1998) Manual para diagnóstico das helmintoses de ruminantes. 4th ed, Japan International Cooperation Agency, Tokyo.
Wang H, Li Y, Huang Y, Zhao C, Cheung H-Y (2018) Chemical Profiling of Lobelia chinensis with High-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry (HPLC/Q-TOF MS) Reveals Absence of Lobeline in the Herb. Molecules23:3258.
Wood IB, Amaral NK, Bairden K, Duncan JL, Kassai T, Malone Jr JB, Pankavich JA, Reinecke RK, Slocombe O, Taylor SM, Vercruysse J (1995) World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine). Vet
Parasitol 58:181-213.
Zheng X, Gallot G (2020) Dynamics of Cell Membrane Permeabilization by Saponins Using Terahertz Attenuated Total Reflection. Biophys J 119:749-755