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Systemic effects of vibration under conditions of long-term bed rest: A Systematic Review

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Published: Oct 1, 2025
DOI: https://doi.org/10.12681/healthresj.41534
Keywords:
Whole-body vibration bed rest immobilization icu-aw
Athanasia Gializi
PT, MSc, PhD(c), “Evaggelismos” General Hospital, Athens, Greece
Marios Kalyviotis
PT, MSc, PhD(c), National Rehabilitation Center, Athens, Greece
Serafeim Nanas
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, ‘Evaggelismos’ General Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece
Anastassios Philippou
PhD, FACSM Professor Physiology-Exercise Physiology School of Medicine National and Kapodistrian University of Athens, Greece
Ioannis Vasileiadis
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, ‘Evaggelismos’ General Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece
Abstract

Background: Prolonged bed rest induces significant dysfunction across multiple physiological systems that can surpass normal aging. Whole-body vibration (WBV) has been proposed as a non-pharmacological countermeasure, yet its systemic impact remains inadequately investigated


Objective: This systematic review aimed to explore the effects of WBV under conditions of prolonged immobilization, not only on the musculoskeletal system but also on the endocrine, vascular, and metabolic systems. Particular attention was given to whether WBV alone can elicit systemic responses beyond the site of application.


Methods: Following PRISMA guidelines, literature was searched in PubMed, Cochrane, and Greynet until February 2024. Seventeen studies met the inclusion criteria. Methodological quality was assessed using the PEDro scale. Data extraction focused on vibration protocols, physiological outcomes, and the presence or absence of concomitant exercise.


Results: WBV demonstrated protective effects on muscle morphology, function, and contractility, as well as bone remodeling and mineral density. Favorable alterations were also reported in endocrine, metabolic, and vascular parameters. However, in most studies, WBV was combined with resistance exercises, limiting conclusions about its independent systemic action. Passive WBV protocols in healthy and critically ill individuals showed localized effects near the application site, but systemic extrapolation remains inconclusive.


Conclusions: WBV may confer multi-systemic benefits during prolonged immobilization, particularly when combined with resistance training. Nonetheless, definitive evidence of isolated systemic action is lacking. Future studies should employ rigorous experimental designs isolating WBV to clarify its therapeutic potential as a standalone modality.

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  • Systematic Reviews

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References
Kehler D., Theou O., Rockwood K. Bed rest and accel-erated aging in relation to the musculoskeletal and cardiovascular systems and frailty biomarkers: A re-view. Experimental gerontology. 2019;124:110643.
Sen I.E, Esmaeilzadeh S., Eskiyurt N. Effects of whole-body vibration and high impact exercises on the bone metabolism and functional mobility in postmenopau-sal women. Journal of bone and mineral metabolism. 2020;38(3):392-404.
Abbasi M., Yoosefinejad K.A., Poursadeghfart M., Jahromi P.F., Motealleh A., Sobhani S. et al. Whole body vibration improves core muscle strength and en-durance in ambulant individuals with multiple sclero-sis: A randomized clinical trial. Multiple sclerosis and related disorders. 2019;32:88-93.
Games KE, Sefton JM. Whole-body vibration influ-ences lower extremity circulatory and neurological function. Scand J Med Sci Sports. 2012;22(4):556-563.
Moher D., Shamseer L., Clarke M., Ghersi D., Liberati A., Petticrew M. et al. PRISMA-P Group: Preferred report-ing items for systematic review and meta- analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1).
Cashin G.A., Mcauley H.J. Clinimetrics: Physiotherapy Evidence Database (PEDro) Scale. Journal of physio-therapy. 2019;66(1):59.
Bleeker W.P.M., De Groot C.E.P., Rongen A.G., Rittweger J., Felsenberg D., Smits P. et al. Vascular ad-aptation to deconditioning and the effect of an exer-cise countermeasure: results of the Berlin Bed Rest study. Journal of applied physiology. 2005;99(4):1293-300.
Blottner D., Salanova M., Püttmann B., Schiffl G., Felsenberg D., Buehring B. et al. Human skeletal mus-cle structure and function preserved by vibration mus-cle exercise following 55 days of bed rest. European journal of applied physiology. 2006;97(3):261-71.
Mulder R.E., Stegeman F.D., Gerrits H.L.K., Paalman I.M., Rittweger J., Felsenberg D. et al. Strength, size and activation of knee extensors followed during 8 weeks of horizontal bed rest and the influence of a counter-measure. European journal of applied physiology. 2006;97(6):706-15.
Belavý L.D., Hides A.J., Wilson J.S., Stanton W., Dimeo C.F., Rittweger J. et al. Resistive simulated weightbear-ing exercise with whole body vibration reduces lumbar spine deconditioning in bed-rest. Spine. 2008;33(5):E121-31.
Salanova M, Schiffl G, Rittweger J, Felsenberg D, Blottner D. Ryanodine receptor type-1 (RyR1) expres-sion and protein S-nitrosylation pattern in human so-leus myofibres following bed rest and exercise coun-termeasure. Histochem Cell Biol. 2008;130(1):105-118.
Mulder R.E., Gerrits H.L.K, Rittweger J., Felsenberg D., Stegeman F.D., De Haan A. Characteristics of fast vol-untary and electrically evoked isometric knee exten-sions during 56 days of bed rest with and without ex-ercise countermeasure. European journal of applied physiology. 2008;103(4):431-40.
Van Duijnhoven T.L.N., Bleeker W.P.M., De Groot C.E.P., Thijssen H.J.D., Felsenberg D., Rittweger J. et al. The effect of bed rest and an exercise countermeasure on leg venous function. European journal of applied physiology. 2008;104(6):991-98.
Mulder R.E., Gerrits H.L.K., Kleine U.B., Rittweger J., Felsenberg D., De Haan A. et al. High-density surface EMG study on the time course of central nervous and peripheral neuromuscular changes during 8 weeks of bed rest with or without resistive vibration exercise. Journal of Electromyography and Kinesiology. 2009;19(2):208-18.
Mendis D.M., Hides A.J., Wilson J.S., Grimaldi A., Belavý L.D., Stanton W. et al. Effect of prolonged bed rest on the anterior hip muscles. Gait & posture. 2009;30(4):533-37.
Rittweger J., Beller G., Armbrecht G., Mulder E., Bueh-ring B., Gast U. et al. Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vi-bration exercise. Bone. 2010;46(1):137-47.
Armbrecht G., Belavý L.D., Gast U., Bongrazio M., Touby F., Beller G. et al. Resistive vibration exercise at-tenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism. Osteo-porosis international. 2010;21(4):597-607.
Buehring B., Belavý L.D., Michaelis I., Gast U., Felsen-berg D., Rittweger J. Changes in lower extremity mus-cle function after 56 days of bed rest. Journal of ap-plied physiology. 2011;111(1):87-94.
Belavý L.D., Wilson J.S., Armbrecht G., Rittweger J., Felsenberg D., Richardson A.C. Resistive vibration ex-ercise during bed-rest reduces motor control changes in the lumbo-pelvic musculature. Journal of Electro-myography and Kinesiology. 2012;22(1):21-30.
Belavý L.D., Seibel J.M., Roth J.H., Armbrecht G., Rittweger J., Felsenberg D. The effects of bed-rest and countermeasure exercise on the endocrine system in male adults: evidence for immobilization-induced re-duction in sex hormone-binding globulin levels. Jour-nal of endocrinological investigation. 2012;35(1):54-62.
Sun S., Henriksen K., Karsdal A.M., Byrjalsen I., Rittweger J., Armbrecht G. et al. Collagen type III and VI turnover in response to long-term immobilization. PLoS One. 2015;10(12):e0144525.
Wollersheim T, Haas K., Wolf S., Mai K., Spies C., Steinhagen-Thiessen E. et al. Whole-body vibration to prevent intensive care unit-acquired weakness: safety, feasibility, and metabolic response. Critical care. 2017;21(1):1-10.
Saxena H, Ward KR, Krishnan C, Epureanu BI. Effect of multi-frequency whole-body vibration on muscle acti-vation, metabolic cost and regional tissue oxygena-tion. IEEE Access. 2020;8:140445–140455.
Rittweger J., Belavý L.D., Hunek P., Gast U., Boerst H., Feilcke B. et al. Highly demanding resistive vibration exercise program is tolerated during 56 days of strict bed-rest. Int J Sports Med. 2006;27(7):553-9.
Belavý L.D., Beller G., Ritter Z., Felsenberg D. Bone structure and density via HR-pQCT in 60d bed-rest, 2-years recovery with and without countermeasures. Journal of musculoskeletal and neuronal interactions. 2011;11(3):215-26.
Belavý L.D., Beller G., Armbrecht G., Perschel H.F., Fitz-ner R., Bock O. et al. Evidence for an additional effect of whole-body vibration above resistive exercise alone in preventing bone loss during prolonged bed rest. Osteoporosis international. 2011;22(5):1581-91.
Van Duijnhoven T.L.N., Green J.D., Felsenberg D., Belavý L.D., Hopman T.E.M., Thijssen J.H.D. Impact of bed rest on conduit artery remodeling: effect of exer-cise countermeasures. Hypertension. 2010;56(2):240-46.
Van Duijnhoven T.L.N, Thijssen J.H.D., Green J.D., Felsenberg D., Belavý L.D., Hopman T.E.M. Resistive exercise versus resistive vibration exercise to counter-act vascular adaptations to bed rest. Journal of applied Physiology. 2010;108(1):28-33.
Vollenweider R, Manettas AI, Hänni N, de Bruin ED, Knols RH. Passive motion of the lower extremities in sedated and ventilated patients in the ICU: a systemat-ic review of early effects and replicability of interven-tions. PLoS One. 2022 May 12;17(5):e0267255. doi:10.1371/journal.pone.0267255.
Li L, Li F, Zhang X, Song Y, Li S, Yao H. The effect of electrical stimulation in critical patients: a meta-analysis of randomized controlled trials. Front Neurol. 2024;15:1403594.
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