The use of growth promoters in swine nutrition: Problems and perspectives concerning public health and swine production

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Published: Jan 31, 2018
DOI: https://doi.org/10.12681/jhvms.15664
Keywords:
antimicrobials antibiotics growth promoters nutrition swine public health
E. D. TZIKA (Ε. Δ. ΤΖΗΚΑ)
Clinic of Productive Animal Medicine, Faculty of Veterinary Medicine, University of Thessaloniki
A. P. SBIRAKI (Α.Π. ΣΜΠΙΡΑΚΗ)
Clinic of Productive Animal Medicine, Faculty of Veterinary Medicine, University of Thessaloniki
S. K. KRITAS (Σ. Κ. ΚΡΗΤΑΣ)
Laboratory of Pharmacology, Faculty of Veterinary Medicine, University of Thessaloniki
M. KOUTSOVITI - PAPADOPOULOU (Μ. ΚΟΥΤΣΟΒΙΤΗ-ΠΑΠΑΔΟΠΟΥΛΟΥ)
Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly
S. C. KYRIAKIS (Σ.K. ΚΥΡΙΑΚΗΣ)
Clinic of Productive Animal Medicine,Faculty of Veterinary Medicine, University of Thessaloniki
Abstract

The use of antimicrobial agents as growth promoters is widely established in modern commercial units, in order to improve and increase the animal production. Based on the controversy of the use of avoparcin which arose the last two years, as well as with spiramycin, tylosin, zinc-bacitracin and virginiamycin the past year, the use of antimicrobial agents is under severe criticism. Several scientific organizations are supportive to the ban of the use of antimicrobial agents as feed additives. The objections refer to the toxicity of some growth promoters, their lower effects under optimized housing conditions, as well as to the mode of application without veterinary prescription. Moreover, they refer to their possible incompatibility with other therapeutics, the hazard of residues in animal origin food, the intoxications in nontarget species such as ionophores in horses and especially the hazard of development of resistance in bacteria. The purpose of this paper is to present the advantages and disadvantages of the in-feed use of antimicrobial agents as growth promoters, especially in swine, which along with poultry represent the main categories of productive animals where an extended use of such pharmaceuticals is applied. Finally, some proposals are being mentioned emphasizing on the need for veterinary control of all antimicrobial agents, including the growth promoters, which are used in animals (predisposing that their application is under veterinary prescription).

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References
Buttery, Ρ. (1993): Growth promotion in animals – an overview. Περιέχεται στο Livestock productivity enchancers: An economic assessment. CAB Int., p. 7-23, UK
Βασιλόπουλος Β. (1985): Διατροφή θηλαστικών και πτηνών. Τεύχος Β, σελ. 6-25. Θεσσαλονίκη.
Tsinas, A.C.. Kyriakis, S.C, Lekkas. S., Bourtzi-Hatzopoulou, E., and Saouìidis, Κ. (1998): Control of Proliferative Enteropathy in Growing/Fattening Pigs Using Growth Promoters. J. Vet. Med. Bk 45, p. 115-127
Report from the Commission on Antimicrobial Feed Additives ( 1997). Antimicrobial Feed Additives. Norstedts Tryckeri AB. Stockholm
Prescott, J.F. and Baggot, J.D.(1988): Antimicrobial Therapy in Veterinary Medicine. Blackwell Scientific Publications, Boston.
O' Connor, O.J. (1980): Mechanisms of growth promoters in single-stomach animals. In "Studies in the Agricultural and Food Sciences. Growth in Animals": (Ed. T. J.J. Lawrence). Butterworth and Co., London.
Greife, H.A., and Berschauer, F. (1988): Leistungsförderer in der Tierproduktion: Stand und Perspektiven. Übers. Tierernährg. 16, p. 27-28
Kamphues, J. (1993): Nutzen und Risiken von Leistungsförderern für Schweine. Prakt. Tierarzt. (Collegium Veterinarium XXIV) 74, p. 96-100
Flachowsky, G., and Schulz, E. (1997): Beitrag der Futterzusätze zu einer nachhaltigen standortsicheren Tierproduktion. Mühle und Mischfuttertechnik, 134 (4), p. 101-107
Kyriakis, S.C., Vassilopoulos, V., Demade, L, Kissels, W., Polizopoulou, Z. and Milner CK. (1992): The effect of virginiamycin on sow and litter performance. Anim. Prod. 55, p. 431-436
Kantas, D., Vassilopoulos. V.. Kyriakis, S.C. and Saouìidis K. (1998): A dose titration study on the effect of virginiamycin on gilt/sow and piglet performance. J. Vet. Med.. A, 45, p. 525-533
Alexopoulos, C, Tsinas, Α., Kantas, D., Florou-Paneri, P., Read, M.P.. Vassilopoulos, V. and Kyriakis, S.C. (1998): A dose titration study on the effect of virginiamycin on specific blood parameters and milk qualitv in the sow. J. Vet. Med., A, 45, p. 535-542
EFPIA - FEFANA ( 1984): The need for antibiotics in animal production - the facts.
Kamphues, J. ( 1998): The discussion on growth promoting feed additives - willing or not, especially veterinary nutritionists are involved. Under publication.
EFPIA - FEFANA (1997): Antimicrobials as feed additives - Fact Sheets. Brussels, Belgium
Kamphues, J. (1988): Untersuchungen zu Verdauungsvorgängen bei Absetzferkeln in Abhängigkeit von Futtermenge und -Zubereitung sowie von Futterzusätzen. Habilitationsschrift, Tierärztl. Hochschule Hannover
Kamphues, J. (1992): Risks of increasing feeding intensity in growing pigs. Proc. 8th Int. Conf. Production Diseases In Farm Animals, Bern 24th-27th August 1992. p. 79-81
Kyriakis, S.,C. Tsinas, A.,C, Lekkas, S., Sanis, K. and Bourtzi- Hatzopoulou, E. ( 1996): Clinical evaluation of in feed zinc bacitracin for the control of porcine intestinal adenomatosis in growing/fattening pigs. Vet. Ree. 138, p. 489-492
Kyriakis, S., C, Sarris, K., Kritas, S., K., Saouìidis, Κ., Tsinas, Α., C. and Tsiloyiannis, V., Κ. (1995): The effect of salinomycin on the control of Clostridium perfrigens type A infection in growing pigs. J. of Vet. Med., series B, 42, p. 355-359
Kyriakis, S., C, Sarris, K., Kritas. S., Tsinas, Α., C. and Giannakopoulos C. (1996): The effect of salinomycin in the control of Clostridium peifiïgens type C infection in suckling pigs. Vet. Ree, 138, p. 281-283
Kyriakis, S., C. (1989): The effects of avilamycin in the control of stress-induced post-weaning diarrhoea in piglets. J. of Vet. Phar. And Ther., 12, p. 296-301
Kyriakis, S.,C, Tsinas, A.,C. and Saouìidis Κ. ( 1995): Studying the effect of a salinomycin/tiamulin combination against swine dysentery. Vet. Med., July 1995, p. 701-705
Kyriakis. S.,C, Tsinas, A.,C, Papatsas, J., Sarris, K. and Saouìidis, Κ. (1994): The effect of avilamycin (AV) and tylosin (TY) on the adhesive E.coli and on enteric colibacillosis of
piglets pre- and post-weaning. Proc. of 13th IPVS Congress, Bangkok, Thailand, p. 217
Robertson, J.Α., and Lundeheim, N. (1994): Prohibited use of antibiotics as a feed additive for growth promotion-effects on piglet health and production parameters. Proc. 13th Congr.PigVet.Soc.,p.282
Colegrave, T. and Wesley, T. (1995): The feed additives market-performance enhancement and disease control (SR 145). Animal Pharm. Reports. PJB Publications Ltd
Gaster J ( 1992): Feed additives and DG VI (EC Commission) - What lies ahead ? International Conference on "Veterinary Medicine in post-1992 Europe", Brussels, Belgium.
Bent M (1993): The European approval procedures for livestock productivity enhancers. Περιέχεται στο Livestock productivitv enhancers: An economic assessment, CAB Int., p. 24-42, UK
Bates J.. Jordens, J.Z., and Griffiths, D.T. ( 1994): Farm animals as a putative reservoir for vancomycin resistant enterococcal in man. J. Antimicrob. Chemother. 34, p. 507-514
ΦΕΚ (1987): Προσθετικά ζωοτροφών. Τεύχος 2o, Αρ. Φύλλου 563, σελ. 5669-5687
ΦΕΚ (1992): Προσθετικά ζωοτροφίόν. Τεΐίχος 2ο, Αρ. Φύλλου 581, σελ. 5477
ΦΕΚ ( 1994): Προσθετικά ζωοτροφίόν. Τεύχος 2ο, Αρ. Φύλλου 52, σελ. 497-499
ΦΕΚ (1996α): Προσθετικά ζωοτροφών. Τεύχος 2ο, Αρ. Φύλλου 127, σελ» 1347-1354
ΦΕΚ ( 1996β): Προσθετικά ζωοτροφών. Τεύχος 2ο, Αρ. Φύλλου 128, σελ. 1357-1371
Ανώνυμος, (1998): Virginiamycin Ban in Europe Triggers Pfizer Lawsuits. Pfizer World, 3(11)
Health Council of the Netherlands (1998): No use of antibiotics as growth promoters in animals, Press release 1998
Richter, Α., Löscher, W., and Witte W.(1996): Leistungsförderer mit antibacterieller Wirkung: Probleme' aus pharmakologisch-toxikologischer und mikrobiologischer Sicht. Prakt. Tieratzt. 7, p. 603-622
Παπαπαναγκότου, Ι. Κ. (1994): Ιατρική Μικροβιολογία & Ανοσοβιολογία. Τόμος Β, σελ. 28-29. Παρατηρητής. Θεσσαλονίκη, 1994.
Μ. Παπαόημητρίου, κ.ά. (1998): Εσωτερική Παθολογία. Τόμος Α, σελ. 125-131. University Studio Press. Θεσσαλονίκη, 1998.
Dryden, M. (1989): Antibiotic resistance in Enterococci at a teaching hospital. Pathology, 21. p. 177-179
Centers for Disease Control and Prevention (1993): Nosocomial Enterococci Resistant to Vancomycin United States, 1989-1993. Morbidity and Mortality Weekly Reports, vol. 42. no 30, August 6, 1993, p. 597-599
Payne, N.R., Schilling, CG., Steinberg, S (1994): Selecting antibiotics for nosocomial bacterial infections in patients requiring neonatal intensive care. Neonatal network, 1994,13 (3), p. 41-51
Maki. D.G., Bohn, M.J., Stolz, S.M., Kroncke, G.M., Acher, C.W. and Myerowitz, P.D. (1992): Comparative study of cefazolin, cefamandole, and vancomycin for surgical prophylaxis in cardiac and vascular operations. The Journal of Thoracic and Cardiovascular Surgery, 104 (5). p. 1423-1434
Swartz M.N. (1994): Hospital-acquired infections: Diseases with increasingly limited therapies. Proc. Natl. Acad. Sci. USA, March 1994,91, p. 2420-2427
Ελεζογλου, Β. (1995): Ο μεταβολισμός των φαρμάκων και ο σχηματισμός των καταλοίπων τους στο σώμα των παραγωγικών ζώων και τοτν προϊόντιον τους. Σεμινάριο για τα κτηνιατρικά φάρμακα. Αθήνα 1995. Οργάνωση Ε.Κ.Ε.
Newsholm, S.J., Walton, J.R., and Elliott, G.(1986): Poor growth, episodic paralysis and adrenocortica injury in swine after accidental olaquindox overdosage. Vet. Record 29, p. 367-370
Waldmann. K.H., Kikovic, D. and Stockhofe Ν. (1989): Klinische und hämatologische Veränderungen nach Olaquindoxvergiftungbei Mastschweinen. J. Vet. Med. A, 36,
p. 676-686
Sogbe, E.J., Utrera, V., and Ascanio, E. (1994): Intoxication by carbadox, effects of the simultaneous medication with furazolidone, clinical and pathological aspects. Proc. 13th Congr. Pig Vet. Soc, Bangkok, Thailand, p. 362
Plumlee, K.H., Johnson, B., and Galey, F.D.(1995): Acute salinomycin toxicosis of pigs. J. Vet. Diagnostic Investigation, 7, p. 419-420
Ballarmi, G. (1994): Feed additives in swine clinical nutrition Proc. 13th Congr. Pig Vet. Soc, Bangkok, Thailand, p. 18-20
Bent. M. (1993): The European approval procedures for livestock productivity enhancers. Περιέχεται στο Livestock productivitv enhancers: An economic assessment, CAB Int., σελ. 24-42, UK
Miller, D.J.S. (1992): Feed additives. International Conference on "Veterinary Medicine in post-1992 Europe", Brussels, Belgium
The Swedish Government, Ministry of Agriculture, Food and Fisheries (1997): Can we use less antibiotics? Västra Aros, Västeras, 1997
Anonymous (1998): The Swedish Lesson. International Hatchery Practice, 13 (1), p. 4
Ahnberg, Annika (1997). The Swedish Ban-Consequences and the Present Situation in Sweden. Today we defeat bacteria. What about tomorrow? In documentation from a Conference in Brussels, 13 November 1997, p. 11
Avery, T.D. (1999): Should we stop using antibiotics in livestock and poultry feed? Proc. of 30th annual meet, of American Association of Swine Practitioners, St. Luis, Missouri, 1999, p. 287-291
Zeddies (1992): Performance promoting feed additives. Folio of the «Bundesverbände für Tiergesundheit». University of Hohenheim
Viaene, I.J. (1997): The Swedish production system. Could it be applied across the European Union? University of Gent, Faculty of Agricultural Sciences 58. Dean, S. (1997): Licensing medicines in the European Community. The Pig Journal, 42, p. 59-65
Birzer, D., and Gropp, J. (1991): Futterzusatzstoffe im Rampenlicht (I und II). Kraftfutter 1991, p. 436-440 and 518-522
Rosen, G., D. (1995): Antibacterials in poultry and pig nutrition. In: Wallace, R., J., A. Chesson (ed.): Biotechnology in Animal Feeding. VCH Verlagsgesellschaft mbH, Weinheim, p. 143-172
Flachowsky, G., Schubert, R., Hennig, Α., and Richter, G.Η. (1994): Methology for evaluating of feed additives in ruminants. Kraftfutter 1994, (5), p. 176-185
Κυριακής Σ.Κ. (1999): Νε'ος φόβος από τα αντιβιοτικά. Κυριακάτικη Ελευθεροτυπία, 22.08.1999, Αρ. Φύλλου 1125
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