Efficacy of Dietary Mycotoxins Adsorbents to Toxic Effects of Zearalenone and Fumonisin in Weaned Piglets

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Δημοσιευμένα: Ιαν 16, 2025
DOI: https://doi.org/10.12681/jhvms.37208
N Puvača
Department of Engineering Management in Biotechnology, Faculty of Economics and Engineering Management in Novi Sad, University Business Academy in Novi Sad, Cvećarska 2, 21000 Novi Sad, Serbia
https://orcid.org/0000-0002-5500-7010
S Roljević Nikolić2
Research and Development Institute Tamiš Pančevo, Novoseljanski put 33, 26000 Pančevo, Serbia
I Radojičić
INBERG d.o.o., Braće Iker 74, 11275 Boljevci, Serbia
V Bursić
Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21000 Novi Sad, Serbia
G Avantaggiato
Institute of Sciences of Food Production (ISPA), National Research Council (CNR), Via Amendola, 70126 Bari, Italy
V Tufarelli
Department of Precision and Regenerative Medicine and Jonian Area (DiMePRe-J), Section of Veterinary Science and Animal Production, University of Bari Aldo Moro, 70010 Valenzano, Italy
L Pinotti
Department of Health, Animal Science and Food Safety, University of Milan, Via Trentacoste, 20134 Milan, Italy
I Brkić
Department of Engineering Management in Biotechnology, Faculty of Economics and Engineering Management in Novi Sad, University Business Academy in Novi Sad, Cvećarska 2, 21000 Novi Sad, Serbia
Περίληψη

Mycotoxin contamination in animal feed poses a significant threat to animal health and productivity, particularly in swine production. Zearalenone (ZEN) and fumonisins (FBs) are among the most prevalent mycotoxins found in swine diets, exerting toxic effects on various organs and reproductive systems. This study investigates the efficacy of a dietary mycotoxin adsorbent in mitigating the toxic effects of ZEN and FBs on weaned piglets, focusing on vulva size, liver histology, and ovarian histology. A total of 60 weaned piglets were randomly assigned to different dietary treatments: control diet naturally contaminated diet with ZEN and FBs (T1), and experimental diets supplemented with the bentonite-based mycotoxin adsorbent named Mycostop Duplo® in two concentrations, i.e. 1.0 kg/ton (T2) and 2.5 kg/ton (T3) of complete feed. At the end of the trial, vulvas were pictured and measured, while liver and ovarian samples were collected for histological analysis. Results indicated that piglets fed the contaminated diet without the adsorbent exhibited significant increases in vulva size compared to the control group (p < 0.05). Histological examination of the liver revealed notable moderate liver dysplasia in the control group, indicative of liver damage. Similarly, ovarian histology showed alterations in follicular development and ovarian morphology in piglets exposed to ZEN. In contrast, piglets receiving the contaminated diet supplemented with the mycotoxin adsorbent showed significantly reduced vulva sizes compared to the contaminated group (p < 0.05). Histological analysis of liver and ovarian tissues from the adsorbent-supplemented group revealed mitigated histopathological changes compared to the contaminated group, suggesting protective effects against ZEN and FB toxicity. In conclusion, dietary supplementation with Mycostop Duplo® effectively mitigated the toxic effects of ZEN and FBs on weaned piglets, as evidenced by reduced vulva sizes and ameliorated histological changes in the liver and ovaries. These findings underscore the importance of mycotoxin management strategies in swine nutrition to safeguard animal health and welfare. Further research is warranted to optimize the use of mycotoxin adsorbents and evaluate their long-term effects on piglet growth and reproductive performance.

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