Effects of Somatotropic Axis Gene Polymorphisms on Milk Yields in Simmental Cattle
Résumé
Due to the increasing world population, scientists aim to obtain high-yield products using new techniques and methods to meet needs in the fields of food, agriculture, and livestock. It is very important to selected the candidate genes and markers correctly, especially in the QTL and MAS techniques in livestock. Somatotropic axis genes affect yield traits, growth, reproduction, and milk production in cattle. In the study, we determined GH/AluI and IGFI/SnaBI gene polymorphisms using the PCR-RFLP technique in DNA samples obtained from 70 Simmental cattle. The allele frequencies of the genes were in the same proportion as 0.62 and 0.38, L and V for the GH gene and T and C for the IGFI gene. There was no significant relationship between the polymorphic genotypes of the genes we examined and lactation milk yields, 305-day milk yields, daily milk yields, and lactation periods of Simmental cattle. The probability of using bGH/AluI and IGFI/SnaBI genetic variations as markers in association studies with milk yield in cattle is extremely low.
Keywords: Axis genes; RFLP; MAS; Simmental; milk yield
Article Details
- Comment citer
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Sonmez, Z., Kopuzlu, S., & Özdemir, M. (2024). Effects of Somatotropic Axis Gene Polymorphisms on Milk Yields in Simmental Cattle. Journal of the Hellenic Veterinary Medical Society, 74(4), 6589–6598. https://doi.org/10.12681/jhvms.31661
- Numéro
- Vol. 74 No 4 (2023)
- Rubrique
- Research Articles
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Références
Afriani, T., & Putra, D. E. (2018). Association of GH, IGF1R, and PIT1
genes polymorphism with average daily gain and body measurement
in Pesisir cattle. Nusantara Bioscience, 10 (4), 221-225.
Akcay, A., Daldaban, F., Celik, E., Arslan, K., & AKYÜZ, B. (2020).
Meta-analysis of allele and genotype frequency of growth hormone
(bGH) gene AluI polymorphism, which is effective on milk yield in
Holstein cattle. KafkasÜniversitesiVeterinerFakültesiDergisi, 26 (5).
Akis, I., Oztabak, K., Gonulalp, I., Mengi, A., & Un, C. E. M. A. L.
(2010). IGF-1 and IGF-1R gene polymorphisms in East Anatolian
Red and South Anatolian Red cattle breeds. Russian journal of genetics, 46 (4), 439-442.
Amiri, S., Jemmali, B., Ferchichi, M. A., Jeljeli, H., Boulbaba, R., & Ben
Gara, A. (2018). Assessment of growth hormone gene polymorphism
effects on reproductive traits in Holstein dairy cattle in Tunisia. Archives Animal Breeding, 61 (4), 481-489.
Ararouti, T., Mirzaei, A., &Sharifiyazdi, H. (2013). Assessment of single nucleotide polymorphism in the 5'-flanking region of Insulin-like growth factor-I (IGF-I) gene as a potential genetic marker for
fertility in Holstein dairy cows. İstanbul ÜniversitesiVeterinerFakült
esiDergisi, 39 (2), 175-182.
Ardicli, S. E. N. A., Samli, H., Dincel, D. E. N. I. Z., Ekiz, B., Yalcintan, H., Vatansever, B., & Balci, F. (2018). Relationship of the bovine
IGF1, TG, DGAT1 and MYF5 genes to meat colour, tenderness and
cooking loss. Journal of the Hellenic Veterinary Medical Society, 69
(3), 1077-1087.
Balogh, O., Szepes, O., Kovacs, K., Kulcsar, M., Reiczigel, J., Alcazar, J.
A., & Huszenicza, G. (2008). Interrelationships of growth hormone
AluI polymorphism, insulin resistance, milk production and reproductive performance in Holstein-Friesian cows. Veterinarni Medicina, 53 (11), 604-616.
Bangar, Y. C., &Magotra, A. (2021). Meta-analysis of SNP in growth hormone gene associated with milk traits in dairy cows. Tropical animal
health and production, 53 (2), 1-7.
Beishova I, Nametov AM, Chuzhebaeva GD, Tegza, IM and Belaya AV
(2018). Assessment of pairwise combinations’ association of polymorphic variants of the genes of bPIT-1, bGH, bGHRbIGF somatotropic cascade with meat productivity of the cattle bred in Kazakhstan. J. Pharm. Sci. Res. 10 (8): 1906-1911.
Beishova IS and Poddudinskaya TV (2017). Analiz geneticheskoi struktury po genam somatotropinovogo kaskada (bPit- 1, bGH, bGHR)
porod krupnogo rogatogo skota otechestvennoi selektcii [Analysis
of the genetic structure of somatotropin cascade genes (bPit-1, bGH,
bGHR) of domestic cattle breeds]. 3i: intellect, idea, innovation 2 (1):
-265.
Beishova, I. S., Ulyanov, V., Shaikamal, G., Papusha, N., & Belaya, E. V.
(2019). Features of Holstein cattle bred in Kazakhstan by the polymorphic genes of the somatotropin cascade. Adv. Anim. Vet. Sci, 7
(1), 60-65.
Besseau, L., Fuentès, M., Sauzet, S., Beauchaud, M., Chatain, B., Covès,
D., . & Falcón, J. (2013). Somatotropic axis genes are expressed before pituitary onset during zebrafish and sea bass development. General and Comparative Endocrinology, 194, 133-141.
Bonakdar, E., Rahmani, H. R., Edriss, M. A., & Tabatabaei, B. S. (2010).
IGF-I gene polymorphism, but not its blood concentration, is associated with milk fat and protein in Holstein dairy cows. Genetics and
Molecular Research, 9 (3), 1726-1734.
Çınar, M., Akyüz, B. MetinKıyıcı, J. ., Arslan, K., Kaliber, M., & Aksel, E. (2018). Effects of GH-AluI and MYF5-TaqI polymorphisms
on weaning weight and body measurements in Holstein young bulls.
Kafkas Universitesi Veteriner FakultesiDergisi, 24 (6).
Curi, R. A., De Oliveira, H. N., Silveira, A. C., & Lopes, C. R. (2005).
Association between IGF-I, IGF-IR and GHRH gene polymorphisms
and growth and carcass traits in beef cattle. Livestock Production Science, 94 (3), 159-167.
Curi, R. A., Palmieri, D. A., Suguisawa, L., Oliveira, H. N. D., Silveira, A.
C., & Lopes, C. R. (2006). Growth and carcass traits associated with
GH1/Alu I and POU1F1/Hinf I gene polymorphisms in Zebu and
crossbred beef cattle. Genetics and Molecular Biology, 29 (1), 56-61.
Piątkowska, C. E., Szatkowska, I., Zaborski, D., Grzesiak, W., Tabor-Osińska, S., Wasielewska, M., & Pawlina, E. (2021). Single Nucleotide Polymorphism in the Promoter Region of the IGF-1 Gene
is Associated with Milk Production in Holstein and Jersey Cattle-Is
the Aspect of Present Research Still Relevant in the Era of Genomic
Selection? Pakistan Journal of Zoology, 53 (6).
Daş, A., Şahin, T., Akbulut, Ö., Bengü, A. Ş., &Bozkaya, F. (2019). Determination of genetic polymorphisms of leptin, ghrelin and insulin-like
growth factor-1 (IGF-1) genes in beef cattle raised in Turkey. Harran
Üniversitesi Veteriner Fakültesi Dergisi, 8 (1), 108-115.
Delafontaine, P., Song, Y. H., & Li, Y. (2004). Expression, regulation,
and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood
vessels. Arteriosclerosis, thrombosis, and vascular biology, 24 (3),
-444.
Echeverri J, Saldamando C I, Herrera A L, 2015. Genetic structure analysis of a Holstein cow population in Colombia. Rev ColombCiencPecu; 28:54-63.
El-Komy, S. M., Saleh, A. A., Abd El-Aziz, R. M., & El-Magd, M. A.
(2021). Association of GH polymorphisms with growth traits in buffaloes. Domestic Animal Endocrinology, 74, 106541.
Fedota O M, Ruban S, Yu Lysenko N G, Kolisnyk A I, Goraichuk I V,
Tyzhnenko T V, 2016. SNP L127V of Growth Hormone Gene In Breeding Herd of Aberdeen Angus In Kharkiv Region, Eastern
Ukraine. Journal for Veterinary Medicine, Biotechnology and Biosafety 2 (3), uDC 575. 113. 1:636. 223. 1 (477. 54)
Fontanesi L, Scotti E, Samore AB, Bagnato A, Russo V. 2015. Association
of 20 candidate gene markers with milk production and composition
traits in sires of Reggiana breed, a local dairy cattle population. Livestock Science 176: 14-21.
Gabillard, J. C., Duval, H., Cauty, C., Rescan, P. Y., Weil, C., & Bail, P. Y.
L. (2003). Differential expression of the two GH genes during embryonic development of rainbow trout Oncorhynchus mykiss in relation
with the IGFs system. Molecular Reproduction and Development:
Incorporating Gamete Research, 64 (1), 32-40.
Ge W, Davis ME, Hines HC, Irvin KM, Simmen RCM. 2001. Association
of a genetic marker with blood serum insulin-like growth factor-1
concentration and growth traits in Angus cattle. J Anim Sci. 79:1757-
Ge, W., Davis, M. E., Hines, H. C., Irvin, K. M., & Simmen, R. C. M.
(2003). Association of single nucleotide polymorphisms in the
growth hormone and growth hormone receptor genes with blood serum insulin-like growth factor I concentration and growth traits in
Angus cattle. Journal of Animal Science, 81 (3), 641-648.
Gilmanov, K. K., Vafin, R. R., & Tyulkin, S. V. (2021, March). Influence
of complex genotypes of GH and PRL genes on milk productivity and
milk quality of cows. In IOP Conference Series: Earth and Environmental Science (Vol. 699, No. 1, p. 012036). IOP Publishing.
Grochowska, R., Lunden, A., Zwierzchowski, L., Snochowski, M., Oprzadek, J., 2001. Association between gene polymorphism of growth
hormone and carcass traits in dairy bulls. Anim. Sci. 72: 441-447.
Gui, L. S., Wang, Z. Y., Jia, J. L., Zhang, C. T., Chen, Y. Z., & Hou, S. Z.
(2018). IGF-1 gene polymorphisms influence bovine growth traits in
Chinese Qinchuan Cattle. KAFKAS ÜNİVERSİTESİ VETERİNER
FAKÜLTESİ DERGİSİ, 24 (3).
Harvey, A., Ruiz, E., & Shephard, N. (1994). Multivariate stochastic variance models. The Review of Economic Studies, 61 (2), 247-264.
Hax, L. T., Schneider, A., Jacometo, C. B., Mattei, P., da Silva, T. C., Farina, G., &Corrêa, M. N. (2017). Association between polymorphisms
in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology, 88, 67-72.
Hazuchova, E., Moravčíková, N., Kadlečík, O., Trakovická, A., Kasarda, R., and Pavlík, I., 2013. Effect of polymorphisms in the bovine
growth hormone gene and impact of inbreeding depression on milk
performance traits in Slovak Spotted Cattle, Journal of Microbiology,
Biotechnology and Food Sciences, 2 1, 1324-1334
Jeanmas, A., Sopannarath, P., Tumwasorn, S., &Loongyai, W. (2014). Association of SNP marker in the IGF1 gene with carcass traits in crossbred cattle among Thai Native, Brahman and Charolais. Agriculture
and Natural Resources, 48 (4), 605-610.
Kovacs K, Volgyi-Csik J, Zsolnai A, Gyorkos I, Fesus L, 2006. Associations between the AluI polymorphism of growth hormone gene and
production and reproduction traits in a Hungarian Holstein-Friesian
bull dam population. Archiv fur Tierzucht, 49, 236-249.
Laron, Z. (2001). Insulin-like growth factor 1 (IGF-1): a growth hormone.
Molecular Pathology, 54 (5), 311.
Leyva-Corona, J. C., Reyna-Granados, J. R., Zamorano-Algandar, R.,
Sanchez-Castro, M. A., Thomas, M. G., Enns, R. M.,& Luna-Nevarez, P. (2018). Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated
with fertility traits in Holstein cows raised in a hot-humid climate.
Tropical animal health and production, 50 (8), 1913-1920.
Lynch, C. O., Mullen, M. P., Waters, S. M., Howard, D. J., O’Boyle, P.,
Berry, D. P., & Diskin, M. G. (2010). Single nucleotide polymorphisms in the growth hormone and insulin-like growth factor 1 gene
are associated with production and fertility traits in dairy cows. Advances in Animal Biosciences, 1 (1), 314-314.
Maj, A., Snochowski, M., Siadkowska, E., Rowinska, B., Lisowski, P.,
Robakowska-Hyzorek, D., &Zwierzchowski, L. (2008). Polymorphism in genes of growth hormone receptor (GHR) and insulin-like
growth factor-1 (IGF1) and its association with both the IGF1 expression in liver and its level in blood in Polish Holstein-Friesian cattle.
Neuroendocrinology Letters, 29 (6), 981.
Maylinda, S. (2011). Genetic polymorphism of growth hormone locus
and its association with bodyweight in Grati dairy cows. International Journal of Biotechnology and Molecular Biology Research, 2 (7),
- 120.
Moravčíková, N., Trakovická, A., &Hazuchová, E. (2012). The association of bovine growth hormone gene polymorphism with milk performance traits in Slovak Spotted cows. Anim Sci Biotechnol, 45 (1),
-210.
Mullen, M. P., Lynch, C. O., Waters, S. M., Howard, D. J., O’boyle, P.,
Kenny, D. A., Buckley, F., Horan, B. and Diskin, M. G., 2011. Single
nucleotide polymorphisms in the growth hormone and insulin-like
growth factor-1 genes are associated with milk production, body condition score and fertility traits in dairy cows. Genet. mol. Res., 10:
-1830. https:// doi. org/10. 4238/vol10-3gmr1173.
Nicolini, P., Carriquiry, M., & Meikle, A. (2013). A polymorphism in the
insulin-like growth factor 1 gene is associated with postpartum resumption of ovarian cyclicity in Holstein-Friesian cows under grazing conditions. Acta Veterinaria Scandinavica, 55 (1), 1-8.
Omer, R. M. A., Masri, M. A. R. M., Jawasreh, K. I., Nour, I. A., Biraima,
A. D. A., Musa, L. M. A., &AhMED, M. K. A. (2018). Molecular Detection of Selected Genetic Polymorphisms in Growth Hormone and
Insulin-Like Growth Factor 1 Genes in Indigenous Sudanese Baggara
Cattle. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 24 (2).
Oster, S. M. (1995). Strategic management for nonprofit organizations:
Theory and cases. Oxford University Press.
Özdemir M, 2011. Determination of allele frequencies of growth hormone
AluI polymorphism in Brown Swiss, Holstein, native East Anatolian
Red and Turkish Grey breeds. International Journal of Dairy Technology. 64 (3):350-352.
Özdemir M, Sönmez Z, Topal M, 2015. Organik yetiştirilen Holstein
Irkındab GH/Alu I ve CSN3/Hinf I Gen Polimorfizmlerinin Belirlenmesi. 9. Ulusal Zootekni Bilim Kongresi, P838-847, 3-5 Eylül 2015,
Konya.
Ozdemir, M., Topal, M., & Aksakal, V. (2018). The relationships between
performance traits and the bGH/Alu and Pit-1/Hinf I polymorphisms
in Holstein cows. Indian Journal of Animal Research, 52 (2), 186-
Özkan, E., Soysal, M. İ., Dinç, H., Sönmez, G., Okyar, M., Togan İ., 2009.
Türkiye sığır ırklarında büyüme hormonu AluIve MspI polimorfizminin PZR-RFLP yönteminin kullanılarak belirlenmesi. 6. Ulusal
Zootekni Kongresi, 24-26 Haziran, Erzurum, 93-102
Pal A, Chakravarty A K, Bhattacharya T K, Sharma A, 2005. Polymorphism of growth hormone gene and its association with expected milk
production traits in dairy bulls. J. Appl. Anim. Res. 27 (1): 29-33.
Pal, A., & Chakravarty, A. K. (2020). Mutations in growth hormone genes
affect the stability of protein structure leading to reduced growth, reproduction, and milk production in crossbred cattle—an insight. Domestic Animal Endocrinology, 71, 106405.
Pereira, A. P., Alencar, M. M. D., Oliveira, H. N. D., & Regitano, L. C. D.
A. (2005). Association of GH and IGF-1 polymorphisms with growth
traits in a synthetic beef cattle breed. Genetics and Molecular Biology, 28 (2), 230-236.
Putra, D. E. (2017). Polymorphism of Insulin-like Growth Factor 1 Gene
(IGF1/TasI, IGF1/SnaBI, IGF1/RsaI) and the Association with Daily
Gain of Pesisir Cattle Local Breed from West Sumatera, Indonesia.
Pakistan Journal of Biological Sciences: PJBS, 20 (4), 210-216.
Renaville, R., Hammadi, M., &Portetelle, D. (2002). Role of the somatotropic axis in the mammalian metabolism. Domestic animal endocrinology, 23 (1-2), 351-360.
Reyna XFDLR, Montoya HM, Castrellon VV, Rincon AMS, Bracamonte MP, Vera WA (2010). Polymorphisms in the IGF1 gene and their
effect on growth traits in Mexican beef cattle. Genet. Mol. Res., 9
(2):875-883.
Rogberg-Muñoz, A., Cantet, R. J., Fernández, M. E., Lirón, J. P., Prando, A., Birchmeier, A. N., &Giovambattista, G. (2013). Longitudinal
analysis of the effects of IGF1-SnaBI genotypes on the growth curve
of Angus bull calves. Livestock Science, 154 (1-3), 55-59.
Sedykh, T. A., Gizatullin, R. S., Dolmatova, I. Y., Gusev, I. V., &Kalashnikova, L. A. (2020). Growth Hormone Gene Polymorphism in relation to Beef Cattle Carcass Quality. Russian Agricultural Sciences,
(3), 289-294.
Siadkowska, E., Zwierzchowski, L., Oprzadek, J., Strzalkowska, N., Bagnicka, E., & Krzyzewski, J. (2006). Effect of polymorphism in IGF-1
gene on production traits in Polish Holstein-Friesian cattle. Anim Sci
Pap Rep, 24 (3), 225-37.
Silveira, P. A. S., Butler, W. R., da Silva, T. C., Barros, C. C., Corrêa,
M. N., & Schneider, A. (2019). Association of polymorphisms in the
IGF-I, GHR and STAT5A genes with serum IGF-I concentration and
reproductive performance of Holstein dairy cows. Animal reproduction science, 211, 106206.
Sönmez, Z., Özdemir, M., Bayram, B., & Aksakal, V. (2018). Holstein ineklerde GH/AluI polimorfizmi ile baz süt verim özellikleri arasındaki
ilişkiler. Türk Tarım-Gıda Bilimve Teknoloji Dergisi, 6 (5), 602-606.
Szewczuk, M., Bajurna, M., Zych, S., & Kruszyński, W. (2013). Association of insulin-like growth factor I gene polymorphisms (IGF1/
TasI and IGF1/SnaBI) with the growth and subsequent milk yield of
Polish Holstein-Friesian heifers. Czech Journal of Animal Science,
(9), 404-411.
Szewczuk, M. (2016). Analysis of the relationship between insulin-like
growth factor 1 receptor gene polymorphisms in Montbeliarde cows
and the birth weight of their calves. Acta Veterinaria Brno, 85 (1).
Ulyanov, V. A., Kubekova, B. Z., Beishova, I. S., Belaya, A. V., & Papusha, N. V. (2021). Preferred and undesirable genotypes of bGH and
bIGF-1 genes for the milk yield and quality of black-and-white breed.
Veterinary World, 14 (5), 1202.
Yardibi, H., Hosturk, G. T., Paya, I., Kaygısız, F., Çiftçioğlu, G., Mengi,
A., Oztabak, K., 2009. Associations of growth hormone gene polymorphism with milk production traits in South Anatolian and East
Anatolian Red cattle. J Anim Vet Adv, 8, 1040-1044.
Yazdanpanah A, Hedayatollah R, Khalil M, Morteza M, Saber K. 2013.
Polymorphism of insulin-like growth factor 1 in Najdi cattle populations. American JBiochem Biotech. 9:300-306
Yeh, F. C., Yang, R. C., & Boyle, T. (1999). PopGene: Microsoft Window-based freeware for population genetic analysis, version 1. 31.
University of Alberta: Edmonton, Canada.
Zhang W, Gao X, Zhang Y, Zhao Y, Zhang J, Jia Y, Zhu B, Xu L, Zhang
L, Gao H, Li J and Chen Y (2018). Genome-wide assessment of genetic diversity and population structure insights into admixture and
introgression in Chinese indigenous cattle. BMC Genet. 19 (1): 1-12.
https://doi. org/10. 1186/s12863- 018-0705-9.
Zhang, H. M., Brown, D. R., Denise, S. K., & Ax, R. L. (1993). Rapid communication: polymerase chain reaction-restriction fragment
length polymorphism analysis of the bovine somatotropin gene. Journal of Animal Science, 71 (8), 2276-2276.
Zhou G, Zhu Q, Jin H G, Guo S L, 2006. Genetic variation of growth hormone gene and its relationship with milk production traits in China Holstein cows. Asian-Australasian J. of Anim. Sci. 19 (3):315-318.
