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Outcome after Intravenous Thhrombolysis in patients with Acute Ischemic Stroke

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Published: Feb 7, 2019
DOI: https://doi.org/10.12681/healthresj.19633
Keywords:
Thrombolysis alteplase stroke side effects
Evagelia Mallisova
RN, MSc, General Hospital of Athens
Helen Dokoutsidou
Assistant Professor, Department of Nursing,University if West Attica,Athens
Antonia Kalogianni
Assistant Professor, Nursing Department, University of West Attica, Greece
Georgios Vasilopoulos
Assistant Professor,Department of Nursing,University of West Attica, Athens, Greece
https://orcid.org/0000-0001-7753-1553
Abstract
 

Introduction: Vascular disorders represent a major cause of mortality worldwide, with ischemic stroke to be the second cause of mortality, after coronary artery disease.
Aim: The aim of the present review was to investigate the contribution of thrombolysis in the outcome of patients with ischemic stroke.

Material and Method: This is a systemic review of the literature. The sources of the literature were the databases EBSCO HOST, Elsevier Science Direct, PubMed, Medline, CINAHL, and Google Scholar.No time limit was set. The

following keywords were used: ischemic stroke, thrombolysis, infarction, outcome, time window, side effects, benefits, alteplase, etiology, diagnosis, treatment.
Results: Three multicenter studies were found to meet the inclusion criteria, the NINDS trial, the ECASS II and the STARS. Thrombolysis in ischemic stroke has been associated with a significantly lower mortality, fewer intracranial hemorrhages and improved neurological outcome when administered in less than 3 hours.

Conclusions: The therapeutic benefits of alteplase reduced with time, while it has been determined that after 4.5 hours from the onset of symptoms of ischemic stroke has a significant benefit.

 
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