Paraneoplastic exfoliative erythroderma in a cat with thymoma

PDF
Published: Nov 10, 2017
DOI: https://doi.org/10.12681/jhvms.14854
Keywords:
Cat exfoliative dermatitis thymoma
D. KASABALIS (Δ. ΚΑΣΑΜΠΑΛΗΣ)
Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly
M. E. MYLONAKIS (Μ.Ε. ΜΥΛΩΝΑΚΗΣ)
Companion Animal Clinic, Faculty of Veterinary Medicine, Arìstotle University of Thessaloniki
M. N. PATSIKAS (Μ.Ν. ΠΑΤΣΙΚΑΣ)
Companion Animal Clinic, Faculty of Veterinary Medicine, Arìstotle University of Thessaloniki
T. PETANIDES (Θ. ΠΕΤΑΝΙΔΗΣ)
Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly
A. F. KOUTINAS (Α.Φ. ΚΟΥΤΙΝΑΣ)
Companion Animal Clinic, Faculty of Veterinary Medicine, Arìstotle University of Thessaloniki
Abstract

A 14-year-old domestic shorthair cat was admitted with a 2-month history of excessive body weight loss and generalized exfoliative dermatitis with erythroderma. Radiographic and ultrasonographic examination revealed a cranioventral cavitary mass within the anterior mediastinum. An ultrasound-guided fine needle aspiration cytology from the mass revealed numerous small mature lymphocytes intermingled with much fewer inflammatory mast cells. These findings, along with a cellpoor interface and mixed cell dermatitis demonstrated on skin histopathology, made the diagnosis of paraneoplastic exfoliative dermatitis straightforward. This uncommon case illustrates the relative value of keratosebborheic skin disease as a useful indicator of an internal malignancy in the cat.

Article Details
  • Section
  • Case Report

Authors who publish with this journal agree to the following terms:

· Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution Non-Commercial License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

· Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g. post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

· Authors are permitted and encouraged to post their work online (preferably in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Downloads
Download data is not yet available.
References
Affolter VK, Moore PF, Sandmaier BM (1998) Immunohistochemical characterization of canine acute graft-versus host disease and erythema multiforme. In : Kwochka KW, Wilemse T, von Tscharner C eds. Advances in veterinary dermatology Vol 3, Butterworth-Heinemann, Oxford: pp 103-115.
Bonnard Ρ, Dralez F (1992) A prupos d'un cas de thymome chez un chat. Le Point Vétérinaire 23,1089-1094.
Carpenter JL, Holzworth J (1982) Thymoma in 11 cats. J Am Vet Med Assoc 181: 240-251.
Day MJ (1997) Review of thymic pathology in 30 cats and 36 dogs. J Small Anim Pract 38:393-403.
Dubielzig RR, DeLaney RG (1980) A thymoma in a cat. Vet Med Small Anim Clin 75:1270-1272.
Fidel JL, Pargass IS, Dark MJ, Holmes SP (2008) Granulocytopenia associated with thymoma in a domestic shorthaired cat. J Am Anim Hosp Assoc 44:210-217.
Forster-van Hijfte MA, Curtis CF, White RN (1997) Resolution of exfoliative dermatitis and Malassezia pachydermatis overgrowth in a cat after surgical thymoma resection. J Small Anim Pract 38:451-454.
Godfrey DR (1999) Dermatosis and associated systemic signs in a cat with thymoma and recently treated with an imidacloprid preparation. J Small Anim Pract 40:333-337.
Gores BR, Berg J, Carpenter JL, Aronsohn MG (1994) Surgical treatment of thymomas in cats: 12 cases (1987-1992). J Am Vet Med Assoc 204:1782-1785.
Gross TL, Ihrke JP, Wälder EJ, Affolter VK (2005) Feline thymoma associated exfoliative dermatitis. In: Gross TL, Ihrke JP, Wälder EJ, Affolter VK eds. Skin Diseases Of The Dog And Cat Clinical and histopathologic diagnosis. 2nd ed, Blackwell Publishings, Iowa: pp 68-70.
Kenita SR (2001) Evaluation and treatment of cranial mediastinal masses. In: August JR ed. Consultations in feline internal medicine 4 WB Saunders, Philadelphia pp:533-540.
Lara-Garcia A, Wellman M, Burkhard MJ, Machado-Parrula C, Valli VE, Stromberg PC, Couto CG (2008) Cervical thymoma originating in ectopic thymic tissue in a cat. Vet Clin Pathol 37:397-402.
Loveday RK (1959) Thymoma in a Siamese cat. J S Afr Vet Med Assoc 30:33-34.
Moore SA, Ogilvie GK (2001) Thymoma, mesothelioma and histiocytosis. In: Ogilvie GK, Moore SA eds. Feline Oncology. A Comprehensive Guide to Compassionate Care. 1st ed, Veterinary Learning Systems, Trendon NJ: pp 389-397.
Raskin RE (2001) Lymphoid system. In: Raskin RE, Meyer DJ, eds. Atlas of canine and feline cytology. 1st ed, WB Saunders, Philadelphia PA: pp 93-134.
Riviere C, Olivry Τ (1999) Dermatite exfoliative paraneoplastique associée a un thymoma chez un chat: resolution des symptoms après thymectomie. Prat Med Clin Anim Comp 34:531-537.
Rottenberg S, von Tscharner C, Roosje PJ (2004) Thymoma-associated exfoliative dermatitis in cats. Vet Pathol 41:429-433.
Scott-Moncrief JC, Cook JR Jr, Lantz GC (1990) Acquired myasthenia gravis in a cat with thymoma. J Am Vet Med Assoc 196:1291-1293.
Scott DW, Yager JA, Johnston KM (1995) Exfoliative dermatitis in association with thymoma in three cats. Fel Pract 23:8-13.
Scott DW, Miller WH, Griffin CE (2001) Exfoliative Dermatoses. In: Scott DW, Miller WH, Griffin CE eds. Müller & Kirk's Small Animal Dermatology. 6th ed, WB Saunders, Philadelphia PA: pp 1049-1050.
Scherk MA, Center SA (2010) Toxic, metabolic, infectious, and neoplastic liver diseases. In: Ettinger SJ, Feldman EC eds. Textbook of Veterinary Internal Medicine, 7th ed, Saunders Elsevier, St Luis MI: ppl672-1689.
Singh A, Boston SE, Poma R (2010) Thymoma-associated exfoliative dermatitis and post-thymectomy myasthenia gravis in a cat. Can Vet J 51:757-760.
Smith AN, Wright JC, Brawner WR Jr, LaRue SM, Fineman L, Hogge GS, Kitchell BE, Hohenhaus AE, Burk RL, Dhaliwal RS, Duda LE (2001) Radiation therapy in the treatment of canine and feline thymomas: a retrospective study (1985-1999). J Am Anim Hosp Assoc 37:489-496.
Smits B, Reid MM (2003) Feline paraneoplastic syndrome associated with thymoma. Ν Ζ Vet J 51:244-247.
Spadavecchia C, Jaggy A (2008) Thymectomy in a cat with myasthenia gravis: a case report focusing on perianaesthetic management. Schweiz Arch Tierheilkd 150:515-518.
Stockham SL, Scott MA (2002) Leukocytes. In: Stockham SL, Scott MA, eds. Fundamentals of Veterinary Clinical Pathology. 1st ed, Iowa State Press, Iowa: pp 49-83.
Turek MM. (2003) Cutaneous paraneoplastic syndromes in dogs and cats: A review of the literature. Vet Dermatol 14:279-296.
Willard MD, Tvedten Η, Walshaw R, Aronson E (1980) Thymoma in a cat. J Am Vet Med Assoc 176:451-453.
Young Κ (2000) Thymoma. In: Feldman BF, Zinkl JG, Jain NC, eds. Schalm,s Veterinary Hematology. 6th ed, Blackwell Publishings, Iowa: pp 667-669.
Zitz JC, Birchard SJ, Couto GC, Samii VF, Weisbrode SE, Young GS (2008) Results of excision of thymomas in cats and dogs: 20 cases (1984-2005). J Am Vet Med Assoc 15:1186-1192.
Most read articles by the same author(s)