Cutaneous lymphohistiocytic and multifocal lymphoma in an adult mare


Published: Nov 17, 2017
Keywords:
cutaneous lymphoma horse neoplasia
K. M. SPANOUDES (Κ.Μ. ΣΠΑΝΟΥΔΗΣ)
C. M. McGOWAN
N. E. DIAKAKIS (Ν.Ε. ΔΙΑΚΑΚΗΣ)
A. F. KOUTINAS (Α.Φ. ΚΟΥΤΙΝΑΣ)
Abstract

Cutaneous or subcutaneous lymphoma is one of the four different forms appearing in the horse. This type of equine lymphoma is usually lymphohistiocytic with a Τ, Β or mixed-cell immunophenotype and with a prevalence of less than 3% among skin neoplasms. This is all about a 9-year old Warmblood mare admitted with a 5-month history of multiple cutaneous masses spreading to many parts of the body. Apart from the multiple subcutaneous nodules and plaques, which did not provide discomfort to the horse, no other abnormalities were found either in clinical or laboratory examination. Lesionai histopathology and immunohistochemistry revealed a lymphohistiocytic T-cell lymphoma, which most likely was primary. The owner elected not to have her horse treated, but readmitted it for euthanasia 5 months later, because of the worsening of skin lymphoma and the appearance of general and systemic clinical signs. The ensuing postmortem was suggestive of distant metastatic disease (liver, mediastinal lymph nodes, pharyngeal wall) most likely originating from the skin.

Article Details
  • Section
  • Case Report
Downloads
Download data is not yet available.
References
De Brujin CM., Veenman J.N., Rutten V.P.M.G., Teske E., Van Nieuwstadt R.A. and Van den Ingh T.S.G.A.M. 2007: Clinical, histopathological and immunophenotypical findings in five horses with cutaneous malignant lymphoma. Res. Vet. Sci. 83: 63-72.
Detilleux PG, Cheville NE Sheahan BJ: Ultrastructure and lectin histochemistry of equine cutaneous histiolymphocytic lymphosarcomas. Vet Path 26:409-419, 1989.
Epstein V, Hodge D: Cutaneous lymphosarcoma in a stallion. Aust. Vet. J.2005 Oct;83(10):609-ll.
Finley MR, Rebhun WC, Dee Α., Langsetmo I.: Paraneoplastic pruritus and alopecia in a horse with diffuse lymphoma J Am Vet Med Assoc. 1998 Jul l;213(l):102-4.
Gerard, M.P., Healy, L.N., Bowman, K.F., Miller, R.T., 1998. Cutaneous lymphoma with extensive periarticular involvement in a horse. J Am Vet Med Assoc. 213 (3).
Hübe, M., Meier, D., Feige, Κ., 1997. Ein Fall eines malignen epitheliotropen kutanen lymphoms (Mycosis Fungoides) bei einem Pferd. Berliner Münchner Tierartztlichen Wochenschrift HO, 86-89.
Johnson, P.J.(1998) Dermatological tumors (excluding sarcoids). Vet. Clin. Ν. Am.: Equine Pract. 14:625-659.
Kelley L.C. and Mahaffey E.A., 1998. Equine malignant lymphomas: morphologic and immunohistochemical classification. Veterinary Pathology, 35,241-252.
Littlewood, J.D., Whitwell, K.E., Day, M.J., 1995: Equine cutaneous lymphoma: a case report. Veterinary Dermatology 6 (2), 105-111.
Meyer J., DeLay J. and Bienzle D. 2006. Clinical, laboratory and histopathologic features of equine lymphoma. Vet. Pathol. 43: 914-924.
Pascoe and Knottenbelt, Manual of Equine Dermatology, WB Saunders 1999, ρ 257.
Potter, K., Anez, D., 1998. Mycosis Fungoides in a horse. J Am Vet Med Assoc. 212 (4), 550-552.
Reed SM, Bayly WM, Sellon DC (2004): Disorders of the Skin In: Equine Internal medicine. 2nd ed. Saunders Ltd Philadelphia: pp 667-720.
Scott D.W., Miller W. H. (2003) Neoplastic and Non-Neoplastic Tumors In: Equine Dermatology. Elsevier Science Ltd Missouri: pp 698-795.
Sheahan BJ, Atkins GJ, Russell RJ, O'Connor JP. Histiolymphocytic lymphosarcoma in the subcutis of two horses. Vet Pathol. 1980;17:123-133.
Staempfli H.R., McAndrew K.H., Valli V.E.O., McEwen BJ., 1988. An unusual case of lymphoma in a mare. Equine Veterinary Journal 20 (2), 141-143.
Most read articles by the same author(s)