Topical treatment of canine pyodermas


A. F. KOUTINAS (Α.Φ. ΚΟΥΤΙΝΑΣ)
M. N. SARIDOMICHELAKIS (Μ.Ν. ΣΑΡΙΔΟΜΙΧΕΛΑΚΗΣ)
Abstract

Topical treatment in canine pyodermas helps to reduce or eliminate the surface bacterial population and to restore the epidermal and follicular integrity. In most superficial and deep pyodermas topical treatment rarely works when used alone; however, its judicious use can make the patient more comfortable and hasten the response to systemic antibiotics. Conversely, in surface pyodermas or pseudopyodermas topicals usually suffice. Among various antimicrobials, the most commonly used include benzoyl peroxide, ethyl lactate, povidone-iodine, triclozan and some antibiotics such as mupirocin, fucidic acid, neomycin and clindamycin. In addition, other topical medication like glucocorticoids, astrigents and dessicating powders are usually applied in dogs with surface pyodermas. Finally, hydrotherapy is very helpful in deep pyoderma cases in the form of wet dressings or baths. The effectiveness of topical treatment depends on the appropriate selection of the active ingredient and its delivery system (formulations), that should accommodate the kind, the distribution and the extension of skin lesions.

Article Details
  • Section
  • Special Article
Downloads
Download data is not yet available.
References
Scott DW, Miller WH, Griffin CE. Dermatologie therapyBacterial skin diseases. In: Small Animal Dermatology. 5th ed, W.B. Saunders Co, Philadelphia, 1995:174-277,279-328.
Arndt ΚΑ, Mendenhall PV, Sloan KB, Perrin JH. The pharmacology of topical therapy. In: Dermatology in General Medicine. 4th ed, McGraw-Hill Inc., New York, 1993: 2837-2846.
Franz TJ. Kinetics of cutaneous drug penetration. Int J Dermatol 1983,22: 499-505.
Gyrd-Hansen N, Brimer L, Rasmussen F. Percutaneous absorption of organophosphorus insecticides in pigs-The influence of different vehicles. J Vet Pharmacol Ther 1993, 16:174-180
Ihrke PJ. Bacterial Skin Disease in the Dog-Α Guide to Canine Pyoderma. Bayer AG, 1996.
Kwochka ΚW. Expectations of topical therapy. Proc XIX W.S.AV.A World Congress, Durban 1994: 252-254.
Kwochka KW. Recurrent pyoderma. In: Current Veterinary Dermatology: the Science and Art of Therapy. Mosby Year Book, St. Louis 1993: 3-21.
De Boer DJ. Management of chronic and recurrent pyoderma in the dog. In: Kirk's Current Veterinary Therapy XII. W.B. Saunders Co., Philadelphia, 1995: 611-617.
Lloyd DH. Therapy for canine pyoderma. In: Kirk's Current Veterinary Therapy XI. W.B. Saunders Co., Philadelphia, 1992: 539-544.
Guaguere E. Topical treatment of canine and feline pyoderma. Vet Dermatol 1996,7:145-151.
Kwochka KW. Rational shampoo therapy in veterinary dermatology. In Proc. 11 th Ann Kal Kan Symp. for the Treatment of Small Animal Diseases, Vermon 1989: 87.
Hill PB, Monello ΚΑ. Canine pyoderma. J Am Vet Med Assoc 1994,203: 334-340.
Halliwell REW. Rational use of shampoos in veterinary dermatology. J Small Anim Pract 1991, 32: 401-407.
Lloyd DH, Reyss Brion A Le peroxyde de benzoyle: efficacitéclinique et bactériologique dans le traitement des pyodermites chroniques. Prat Med Chirurg Anim Compan 1984,19: 445-449.
Scott DW. A clinical study on the effect of two commercial veterinary benzoyl peroxide shampoos in dogs. Canine Pract 1994,19: 7.
Kligman AM, Leyden JJ, Stewart R. New uses for benzoyl peroxide. A broad spectrum antimicrobial agent. Int J Dermatol 1977,16:413-417.
Kwochka KW, Kowalski JJ. Prophylactic efficacy of four antibacterial shampoos against Staphylococcus intermedius in dogs. Amer J Vet Res 1991,52:115-118.
Scott DW. Clinical assessment of topical benzoyl peroxide in treatment of canine skin diseases. Vet Med 1979,74:808-813.
Ascher F, Maynard L, Laurent J, Goubet B. Controlled trial of ethyl lactate and benzoyl peroxide shampoos in the management of canine surface pyoderma and superficial pyoderma. In: Advances in Veterinary Dermatology. Vol 1, Baillier Tindal, London, 1990: 375-382.
Prottey G, George D, Leech RW. The mode of action of ethyl lactate as a treatment for acne. British J Dermatol 1984,110: 475-485.
Gilman AG, Rail TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics. 8th ed, Pergamon Press, New York, 1990.
Jaya J, Lagrange B. Les antiseptiques cutanés. Rev Pract 1987, 37:1900-1907.
Cambel KJ, Weisger R, Cross T, Anderson EE, Kakona J. Effects of four antibacterial soap/shampoos on surface bacteria of the skin of dogs. Proc 10th Ann Meet A.A.V.D., A.C.V.D., Santa FE, 1995: 43-44.
Lee AH, Swam SF, Mc Guire J, Hughes K. Effects of Chlorhexidine diacetate, povidone iodine and polyhydroxydine on wound healing in dogs. J Am Anim Hosp Assoc 1988,24: 77-84.
Sousa GA, Kwochka KW. Shampoos and other topical therapy. In: Advances in Veterinary Dermatology. Vol 1, Baillier Tindal, London, 1990:434-436.
Parenti MA, Hatfield SM, Keyden JJ. Mupirocin, a topical antibiotic with a unique structure and mechanism of action. Clin Pharmacol 1987,6:761-770.
Leyden JS. Mupirocin: a new topical antibiotic. Semin Dermatol 1987, 6:48-54.
Geoffray G, Chosidow O, Revuz J. La mupirocine: pharmacologie et indications thérapeutiques. Ann Dermatol Venerol 1990,177:753-757.
Ward A, Campoli-Richards DM. Mupirocine: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 1986, 32:425-444.
Lawrence GM, Mackenzie Τ, Pagasok Thow JG, Prince WT, Thawley AR, Lanham EM. Systemic absorption of mupirocin after application of mupirocin ointment to healthy and dermatologically diseased skin. J Dermatol Treatment 1989, 1:83-86.
Burrows AK. Residual antimicrobial action of 2% mupirocin ointment (Bactoderm). Proc 11th Ann Meet A.A.V.D., A.C.V.D., Charleston, 1994:35.
Rode H, Hanholo D, Dellet PM, Millar AJW, Cynes S. Efficacy of mupirocin in methicilline resistant Staphylococcus aureus, burn wound infection. Antimicrob Agents Chemother 1989,33:1358-1361.
Ihrke PJ, Gross TL. Canine mucocutaneous pyoderma. In: Kirk's Current Veterinary Therapy XII. W.B. Saunders, Philadelphia, 1995:618-619.
Schroeder H, Swan GE, Berry WL, Pearson J. Efficacy of a topical antimicrobial- antiinflamatory combination in the treatment of pyotraumatic dermatitis in dogs. Vet Dermatol 1996,7:163-170.
Ihrke PJ, Gross TL. Clinico-pathologic conferences in dermatology: Superficial spreading pyoderma. Vet Dermatol 1994,4: 33-36.
Most read articles by the same author(s)