Canine babesiosis


M. E. MYLONAKIS (Μ.Ε. ΜΥΛΩΝΑΚΗΣ)
C. BILLINIS (Χ. ΜΠΙΛΛΙΝΗΣ)
C. KOUTINAS (X. ΚΟΥΤΙΝΑΣ)
A. F. KOUTINAS (Α. Φ. ΚΟΥΤΙΝΑΣ)
Résumé

The causative agents of canine babesiosis are Babesia canis and B. gibsoni which are transmitted by various hard tick species and blood transfusions. In the hyperacute form of the disease hypothermia, shock, severe metabolic acidosis and disseminated intravascular coagulation usually precede the death of the dog occuring in less than 24 hours. Severe anemia, icterus, splenomegaly and peripheral lymphadenopathy characterize the acute form of the disease. Intermittent fever and progressive loss of body weight may be noticed in the chronic form of babesiosis, while its many atypical clinical manifestations (e.g. ascites, gastrointestinal signs, CNS disease, subcutaneous edema, masticatory myositis) often cause diagnostic confusion. The organism detection on RBC in thin blood smears made from the buffy coat is a must for definitive diagnosis. The IFA test is a good choice for screening large numbers of dogs for detecting the asymptomatic carriers. Complete parasitological cure can be obtained with imidocarb dipropionate, pentamidine isethionate or diminazene aceturate, while metronidazole and clindamycin have been recently suggested as good alternatives. Supportive care is considered crucial for the survival of the severely affected animals. While effective tick control is the mainstay of prevention, doxycycline and imidocarb may also play a significant role to that goal. The effectiveness of a killed vaccine is still a matter of controversy.

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Références
Taboada J, Merchant SR. Babesiosis of companion animals and man. Vet. Clin North Am Sm. Anim Pract 1989,21:103-123.
Lobetti RG. Canine Babesiosis. Comp Cont Educ Pract Vet 1998,20: 418 - 430.
Uilenberg G, Franssen FFJ, Perie NM, Spanjer AM. Three groups of Babesia canis distinguished and a proposal for nomenclature. Vet. Q 1989,11: 33 - 40.
Carret C, Walas F, Carey B, Grande N, Precigout E, Moubri K, Schetters TP, Gorenflot A. Babesia canis canis, Babesia canis vogeli, Babesia canis rossi: differentiation of the three subspecies by a restriction fragment length polymorphism analysis on amplified small subunit ribosomal RNA genes. J Eukaryot Mircobiol 1999,46: 298 - 303.
Zahler M, Schein E, Rinder H, Gothe R. Characteristic genotypes discriminate between Babesia canis isolates of differing vector specificity and pathogenicity to dogs. Parasitol
Res 1998,84: 544 - 548.
Taboada J. Babesiosis. In: Green CE (ed) Infectious Diseases of the Dog and Cat. 2nd ed, W Β Saunders, Philadelphia, 1998: 473-481.
Yamane I, Conrad PA, Gardner I. Babesia gibsoni infection in dogs. J. Protozool. Res 1993, 3: 111 -125.
Martinod S, Brossard M, Moreau Y. Immunity of dogs against Babesia canis, its vector tick Dermacentor reticulatus and Ixodes ricinus in endemic areas. J. Parasitol 1985,71:269-273.
Friedhoff KT. Transmission of Babesia. In: Ristic M (ed). Babesiosis of domestic animals and man. CRC press, Boca Raton, 1988: 23 - 52.
Taboada J, Harvey JW, Levy MG. Seroprevalence of babesiosisin greyhounds in Florida. J Am Vet Med Assoc 1992,200:47-50.
Breitschwerdt EB, Malone JB, MacWilliams P, Levy MG, Quails CW Jr, Prudich MJ. Babesiosis in the Greyhound. J Am Vet Med Assoc 1983,182: 978 - 982.
Conrad P, Thomford J, Yamane I, Whiting J, Bosma L, Uno Τ, Holshuh HJ, Shelly S. Hemolytic anemia caused by Babesia gibsoni infection in dogs. J Am Vet Med Assoc 1991, 199: 601 -605.
Jacobson LS, Clark ΙΑ. The pathophysiology of canine Babesiosis: New approaches to an old puzzle. J. S. Afr. Vet. Assoc. 1994,65:134 -145.
Morita T, Saeki H, Imai S, Ishii T. Erythrocyte oxidation in artificial Babesia gibsoni infection. Vet. Parasitol. 1996,63:1-7.
Makinde MO, Bobade PA. Osmotic fragility of erythrocytes in clinically normal dogs and dogs infected with parasites. Res. Vet. Sci. 1994,57: 343 - 348.
Adachi K, Tateishi M, Horii Y, Nagatomo H, Shimizu T, Makimura S. Immunologic characteristics of anti-Erythrocyte membrane antibody produced in dogs during Babesia gibsoni infection. J. Vet. Med. Sci. 1995,57:121 -123.
Murase T, Ueda T, Yamato O, Tajima M, Maede Y. Oxidative damage and enhanced erythrophagocytosis in canine erythrocytes infected with Babesia gibsoni. J Vet Med
Sci 1996,58: 259 - 261.
Button C. Metabolic and electrolyte disturbances in acute canine Babesiosis. J Am Vet Med Assoc 1979,175: 475 - 479.
Leisewitz A, Jacobson L, Reyers F. Mixed acid-base disturbances of severe canine babesiosis. In: Proc Symposium on canine babesiosis and ehrlichiosis. South Africa 1999
(Nov): 37-44.
Weltz C, Leisewitz A, Jacobson L, Myburgh E, Vaughn – Scott T. The systemic inflammatory response syndrome and multiple organ dysfunction syndromes in canine babesiosis. In: Proc Symposium on canine babesiosis and ehrlichiosis. South Africa 1999 (Nov): 27-31.
Jacobson L, Lobetti R. Nitric oxide in canine babesiosis: indicator of disease, premunity or both? In: Proc Symposium on canine babesiosis and ehrlichiosis. South Africa, 1999
(Nov): 32-36.
Freeman MJ, Kirby BM, Panciera DL, Henik RA, Rosin E, Sullivan LJ. Hypotensive shock syndrome associated with acute Babesia canis infection in a dog. J Am Vet Med Assoc 1994,204: 94 - 96.
Jacobson L, Lobetti R, Vaughan-Scott T. Hypotension: A common event in canine Babesiosis. In: Proc Symposium on canine babesiosis and ehrlichiosis. South Africa 1999 (Nov): 50-54.
Lobetti R, Jacobson L, Vaughan-Scott T. The effect of canine babesiosis on renal function. In: Proc Symposium on canine babesiosis and ehrlichiosis South Africa 1999 (Nov): 55 - 61.
Lobetti RG, Reyers F. Met-haemoglobinuria in naturally occurring Babesia canis infection. J. S. Afr. Vet. Assoc. 1996, 67: 88 - 90.
Lobetti RG, Reyers F, Nesbit JW. The comparative role of haemoglobinaemia and hypoxia in the development of canine babesial nephropathy. J. S. Afr. Vet. Assoc. 1996,67:188-198.
Mohr B, Lobetti R. Acute pancreatitis in canine babesiosis. In: Proc Symposium on canine babesiosis and ehrlichiosis. South Africa 1999 (Nov): 62 - 68.
Miller D. The yellow patient. In; Proc Symposiun on canine babesiosis and ehrlichiosis. South Africa 1999 (Nov): 95 - 97.
Reyers F, Leisewitz AL, Lobetti RG, Milner RJ, Jacobson LS. Canine babesiosis in South Africa: more than one disease. Does this serve as a model for falciparum malaria? Ann Trop Med Parasitol 1998,92: 503 - 511.
Schetters ThPM, Moubri K, Precigout E, Kleuskens J, Scholtes NC, Gorenflot A. Different Babesia canis isolates, different diseases. Parasitology 1997,115:485-493.
Leisewitz A. Canine babesiosis caused by Babesia canis var rossi. In: Proc Symposiun on canine babesiosis and ehrlichiosis. South Africa 1999 (Nov), 98-107.
Abdullahi SU, Mohammed AA, Trimnel AR, Sannusi Α. Alafiatayo R. Clinical and hameatological findings in 70 naturally occuring cases of canine babesiosis. J. Sm. Anim.
Pract. 1990, 31:145 -147.
Kontos VJ, Koutinas AF. Clinical observation in 15 spontaneous cases of canine babesiosis. Canine Practice 1997, 22:2-6.
Farwell GE, LeGrand EK, Cobb CC. Clinical observations on Babesia gibsoni and Babesia canis infections in dogs. J Am Vet Med Assoc 1982,180: 507 - 511.
Irwin PJ, Hutchinson GW. Clinical and pathological findings of Babesia infection in dogs. Aust Vet J 1991, 68: 204 - 209.
Botros BAM, Moch RW, Barsoum IS. Some observations on experimentally induced infection of dogs with Babesia gibsoni. Am. J. Vet. Res. 1975,36: 293 - 296.
Birkenheuer AJ, Levy MG, Savary KCM, Gager RB, Breitschwerdt EB. Babesia gibsoni infections in dogs from North Carolina. J Am Anim Hosp Assoc 1999,35:125 -128.
Jacobson LS, Lobetti RG. Rhabdomyolysis as a complication of canine babesiosis. J Sm Anim Pract 1996,37: 286 - 291.
DuPlessis JL, Fourie N, Nel PW, Evezard DN. Concurrent Babesiosis and Ehrlichiosis in the dog: Blood smear examination supplemented by the Indirect Fluorescent Antibody Test, using Cowdria ruminantium as antigen. Onterstepoort J Vet Res 1990,57:151-155.
Lobetti RG. Leukemoid response in two dogs with Babesia canis infection. J. S. Afr. Vet. Assoc. 1995,66:182 -184.
Harvey JW, Taboada J, Lewis JC. Babesiosis in a litter of pups. J Am Vet Med Assoc 1988,192:1751 -1752.
Lobetti R, Mohr B, Dippenaar T, Myburgh E. Serum protein changes in canine babesiosis. In: Proc Symposium on canine babesiosis and ehrlichiosis. South Africa 1999 (Nov): 45-49.
Casapulla R, Baldi L, Avallone V, Sanmino R, Pazzanese L, MizzoniV. Canine piroplasmosis due to Babesia gibsoni: clinical and morphologic aspects. Vet Ree 1998,142:168-169.
Malherbe WD. Clinicopathologic studies of Babesia canis infection in dogs: IV. The effect on bilirubin metabolism. J. S. Afr. Vet. Assoc. 1965, 36: 569 - 573.
Yamane I, Thomford JW, Gardner IA. Evaluation of the indirect fluorescent antibody test for diagnosis of Babesia gibsoni infections in dogs. Am. J. Vet. Res. 1993,54:1579-1584.
Breitschwerdt EB. Laboratory diagnosis of tick-transmitted diseases in the dog. In: Kirk,s Current Veterinary Therapy Small Animal Practice XI. W Β Saunders, Philadelphia, 1992:252-255.
Adeyanju Β J. Aliu YO. Chemotherapy of canine ehrlichiosis and babesiosis with imidocarb dipropionate. J Am Anim Hosp Assoc 1982,18: 827-830.
Price JE, Dolan YY. A comparison of the efficacy of imidocarb dipropionate and tetracycline hydrochloride in the treatment of canine ehrlichiosis. Vet Ree 1980,107: 275-277.
Kuttler KL. World-wide impact of babesiosis. In: Ristic M. (ed). Babesiosis of domestic animals and man. CRC Press. Boca Raton, 1988:1-22.
Breitschwerdt EB. Babesiosis: clinical experiences. Comp Cont Educ Pract Vet (Suppl) 1997,19:54-56.
Dippenaar T. Update on blood transfusion in canine babesiosis. In: Proc Symposium on canine babesiosis and ehrlichiosis. South Africa 1999 (Nov): 84 - 88.
Merwe L. The management of complicated babesiosis. In: Proc Symposium on canine babesiosis and ehrlichiosis. South Africa 1999 (Nov): 89 - 94.
Leisewitz AL, Guthrie AJ, Berry WL. Evaluation of the effect of whole-blood transfusion on the oxygen status and acid-base balance of Babesia canis infected dogs using the oxygen status algorithm. J. S. Afr. Vet. Assoc. 1996, 67: 20 - 26.
Jacobson LS, Swan GE. Supportive treatment of canine babesiosis. J. S. Afr. Vet. Assoc. 1995,66: 95 -105.
Fourie L. Control of tick infestation in dogs. In; Proc Symposium on canine babesiosis and ehrlichiosis. South Africa 1999 (Nov):74 - 77.
Vercammen F, DeDeken R, Maes L. Prophylactic activity of imidocarb against experimental infection with Babesia canis. Veterinary Parasitology 1996,63:195 -198.
Vercammen F, DeDeken R, Maes L. Prophylactic treatment of experimental canine babesiosis (Babesia canis) with doxycycline. Veterinary Parasitology 1996, 66: 251 - 255.
Penzhorn BL, Lewis BD, DeWaal DT, Lopez Rebollar LM. Sterilization of Babesia canis infections by imnidocarb alone or in combination with diminazene. J. S. Afr. Vet. Assoc.
,66:157-159.
Vercammen F, DeDeken R, Maes L. Duration of protective immunity in experimental canine babesiosis after homologous and heterologous challenge. Vet. Parasitol. 1996, 68: 51 - 55.
Lewis BD, Penzhorn BL, Lopez Rebollar LM. Immune responses to South African Babesia canis and the development of a preliminary vaccine. J S Afr Vet Assoc 1995,
: 61-65.
Schetters ThPM, Kleuskens J. Scholtes N, Bos HJ. Strain variation limits protective activity of vaccines based on soluble Babesia canis antigens. Parasite Immunol. 1995,17:215 - 218.
Schetters ThPM, Kleuskens JAGM, Scholtes NC, Pasman JW, Goovaerts D. Vaccination of dogs against Babesia canis infection. Vet. Parasitol. 1997,73: 35 - 41.
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