Reference values of the usual biochemical profile in clinically normal cats

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Published: Jan 31, 2018
DOI: https://doi.org/10.12681/jhvms.15776
A. FYTIANOU (Α. ΦΥΤΙΑΝΟΥ)
Clinic of Medicine, Faculty of Veterinary Medicine, A. U. Τ
M. SARIDOMICHELAKIS (Μ. ΣΑΡΙΔΟΜΙΧΕΛΑΚΗΣ)
Clinic of Medicine, Faculty of Veterinary Medicine, A. U. Τ
A. F. KOUTINAS (Α. Φ. ΚΟΥΤΙΝΑΣ)
Clinic of Medicine, Faculty of Veterinary Medicine, A. U. Τ
N. ROUBIES (Ν. ΡΟΥΜΠΙΕΣ)
Clinic of Medicine, Faculty of Veterinary Medicine, A. U. Τ
Z. POLIZOPOULOU (Ζ. ΠΟΛΥΖΟΠΟΥΛΟΥ)
Clinic of Medicine, Faculty of Veterinary Medicine, A. U. Τ
Abstract

The purpose of this study was the establishment of "reference values" for the commonly used blood serum constituents in the everyday practice. A total number of 23 parameters including total proteins, albumin, globulin, albumin/globulin ratio, urea nitrogen (BUN), creatinine, glucose, cholosterol, triglycerides, total and indirect bilirubin, alkaline phosphatase (AP), gamma - glutamylotransferase (γ-GT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipase, amylase, creatinine kinase (CK), lactate dehydrogenase (LDH), calcium (Ca), phosphorus (P), potassium (K) and sodium (Na) in the serum samples obtained from 1ΘΘ clinically normal cats equally distributed into two age groups (group A <12 months, group Β >12 months). For the total number of sampled cats and for each age group the mean, the standard deviation, the actual range and the 95% confidence interval were calculated separately. Statistical analysis revealed significant differences between young and adult cats (group A - group B) for as many as 13 parameters. As it was expected our results are both in agreement and disagreement with those reported in the relevant veterinary literature.

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References
Ράλλης Τ, Κουτίνας Α, Ρουμπιές Ν, Παπαστεριάδης Α. Οι τιμές των βασικών για την κλινική πράξη βιοχημικών παραμέτρων του αίματος σε κλινικά υγιείς σκύλους. Δ.Ε.Κ.Ε 1990, 40: 260-275.
Grasbeck R. Terminology and biological aspects of reference values. In Benson ES, Rubin M (eds). Logic and Economics of Clinical Laboratory Use. Elsevier, New York, 1978,77-90.
Lumsden JH. Mullen K. On establishing reference values. Can J Comp Med 1978,42: 293-300.
Solberg HE. Establishment and use of reference values. In Tietz NW (ed) Textbook of Clinical Chemistry. WB Saunders, Philadelphia, 1986,356-386.
Winkel R, Statland BE. The theory of reference values. In Henry JB (ed). Clinical Diagnosis and Management by Laboratory Methods. Edt No 17, WB Saunders, Philadelphia, 1984,51-60.
Lumsden JH, Jacobs RM. Clinical Chemistry. Vet Clin North Am Small Anim Pract 1989,19: 875-897.
Bush BM.Interpretation of Laboratory Results for Small Animal Clinicians. Blackwell Scientific Publications, London, 1991 , 1 -8, 224-234, 238-250. 254-263,267-272. 272-277. 277-290. 318-324, 324-326,329-330,356-362,376-381.
Ayiannidis AK, Voulgaropoulos AN: Phosphorus determination in biologic materials. Fresenius J Anal Chem 1990.338:816-820.
Kaneko JJ. Serum proteins and the dysproteinemias. In: Kaneko JJ (ed) Clinical Biochemistry of Domestic Animals. 4th ed, Academic Press Ine, San Diego, 1989,142-165.
Guilford WG. Strombeck DR. Fluid therapy of gastrointestinal disease. In: Small Animal Gastroenterology. 3rd ed, WB Saunders. Philadelphia, 1996.911-922.
Wiedenkeller DE, Rosenberg MP. Dysproteinemias. In August JR Consultations in Feline Internal Medicine. 2,Hl ed. WB Saunders. Philadelphia. 1994. 573-586.
Donoghue S. Nutritional support of hospitalized patients. Vet Cline North Am Small Anim Pract 1989. 19: 475-495.
Sutherland RJ. Biochemical evaluation of the hepatobiliary system in dogs and cats. Vet Clin North Am Small Anim Pract 1989.19:899-927.
Anderson JG, Washabau RJ. Icterus. Comp Contin Educ Small Anim Pract 1992,14: 1045-1059.
Ralston SL. Dietary considerations in the treatment of heart failure. In Kirk's Current Veterinary Therapy X Small Animal Practice. WB Saunders. Philadelphia. 1989.302-307.
Fox SM. Management of thermal burns-Part I. Comp Contin Educ Pract Vet 1985. 7: 631-642.
Kirby R. Septic shock. In Bonagura's Current Veterinary Therapy XII Small Animal Practice. WB Saunders. Philadelphia. 1995.139-146.
Sprager EE. Feline immunodeficiency virus. In August JR Consultations in Feline Internal Medicine. Γ" ed, WB Saunders. Philadelphia, 1991,543-550.
Fineo DR. Kidney function. In: Kaneko JJ (ed) Clinical Biochemistry of Domestic Animals. 4th ed. Academic Press Ine, San Diego, 1989,496-542.
Brobst D. Urinalysis and associated laboratory procedures. Vet Clin North Am Small Anim Pract 1989,19: 929-949.
Cuilford WG, Strombeck DR. Acute hemoragic enteropathy (Hemoragic gastroenteritis: HE). In Small Animal Gastroenterology. 3rd ed, WB Saunders, Philadelphia, 1996, 433-435.
Peterson ME, Kintzer PP, Cavanagh PG, Fox PR, Ferguson DC, Johnson GF, Becker DV. Feline hyperthyroidism: Pretreatment clinical and laboratory evaluation of 131 cases. J Am Vet Med Assoc 1983,183: 103-1 10.
Peterson ME., Greco DS, Orth DN. Primary hypoadrenocortisism in ten cats. J Vet Intern Med 1989,3:55-58. 24. Feldman EC, Nelson RW. Canine and Feline Endocrinology and Reproduction. 2nd ed, WB Saunders, Philadelphia, 1996, 2-37, 118-166, 187-265,339-391,422-441.
Fineo DR. Evaluation of renal functions. In: Osborne CA, Fineo DR Canine and Feline Nephrology and Urology. Williams and Wilkins, 1995,216-229.
Kaneko JJ. Carbohydrate metabolism and its diseases. In Kaneko JJ Clinical Biochemistry of Domestic Animals. 4lh ed, Academic Press Ine, San Diego, 1989, 62-77.
Walters PC, Drobatz KJ. Hypoglycemia in cats. Comped ContinEduc Small Anim Pract 1992. 14: 1 150-1 158.
Hill RC, van Wilkie TJ. Acute necrotizing pancreatitis and acute suppurative pancreatitis in the cat. A retrospective study of 40 cases (1976-1989). J Vet Intern Med 1993, 7: 25-33.
Peterson ME, Taylor RS. Greco DS. Acromegaly in 14 cats. J Vet Intern Med 1990. 4: 192-201.
Miller E. Long-term monitoring of the diabetic dog and cat: Clinical signs, serial blood glucose determinations, urine glucose and glucated blood proteins. Vet Clin North Am Small Anim Pract 1995, 25:571-584.
Hawks D. Peterson ME, Hawkins KL. Insulin secreting pancreatic (islet cell) carcinoma in a cat. J Vet Intern Med 1992,6:193-196.
Whitney MS. Diagnostic approach to hyperlipidemia. In August JR Consultations in Feline Internal Medicine. 2nd ed, WB Saunders. Philadelphia, 1994. 177-182.
Peterson ME. Randolph JF. Mooney CT. Endocrine diseases. In Sherding RJ The Cat. Diseases and Clinical Managment. 2nd ed, Churchill Livingstone. New York. 1994.1403-1506.
Nelson RW. Feldman EC. Hyperadrenocortisism. In August JR Consultations in Feline Internal Medicine. Γ ed. WB Saunders. Philadelphia, 1991.267-270.
Jones BR, Cruflyd-Jones TJ. Sparkes AK, Lücke VM. Preliminary studies on congenital hypothyroidism in a family of Abyssinian cats. Vet Ree 1992, 131 : 145-148.
Kitchell BE. Stronberg DR. Cullen J, Harrold D. Clinical and pathologic changes in experimentally induced acute pancreatitis in cats. Am J Vet Res 1986. 47:11 70-1173.
Di Bartola SP, Rutgers HC, Zack PM. Tarr MJ. Clinicopathologic findings associated with chronic renal disease in cats: 74 cases (1973-1984). J Am Vet Med Assoc 1987. 190:1196-1202.
Jones R. Johnstone AC, Hancock WS. Inherited hyperchylomicronemia in the cat. Feline Pract 1986. 16: 7-12.
Center SA. Diagnostic procedures for evaluation of hepatic disease. In Small Animal Gastroenterology. 3rd ed. WB Saunders. Philadelphia. 1996. 118-166.
Rogers KS. Cornelius LM. Feline icterus. Comped Contin Educ Small Anim Pract 1985. 7: 391 -399.
Everett DM. Duncan JR. Prasse KW. Alkaline phosphatase in tissues and sera of cats. Am J Vet Res 1977,38:1533-1538.
Peterson ME. Hyperadrenocorticism and hypoadrenocorticism in the cat. Procc. XXI WSAVA Congress, Jerusalim 1996, 136.
Kramer J W, Sleight SD. The isoenzymes of serum alkaline phosphatase in cats. Am J Vet Clin Pathol 1968,22: 87-91.
Hoffman WE, Renegar WE, Dorner JL. Serum half life of intravenously injected intestinal and hepatic alkalinephosphatase isoenzymes in the cat. Vet Clin Pathol 1977, 6:21-24.
Brobst DF. Pancreatic function. In Kaneko JJ Clinical Biochemistry of Domestic Animals. 4,h ed, Academic Press Ine, San Diego, 1989, 398-416.
Steiner JM, Williams DA. Feline trypsinlike immunoreactivity in feline exocrine pancreatic disease. Comp Contin Educ Small Anim Pract 1996, 18: 543-547.
Cardinet GH. Skeletal muscle function. In Kaneko JJ Clinical Biochemistry of Domestic Animals. 4th ed. Academic Press Ine, San Diego, 1989,481 -486.
Kornegay JN. Disorders of the skeletal muscles. In Ettinger SJ, Feldman EC Textbook of Veterinary Internal Medicine. 4th ed, WB Saunders, Philadelphia, 1997, 727-736.
Moreau R, Squres RA. Hypercalcemia. Comp Contin Educ Pract Vet 1992, 14:497-506.
FIanders JA, Scarlett JM, Blue JT, Neth S. Adjustment of total serum calcium concentration for binding to albumin and protein in cats: 291 cases ( 1986-1987) J Am Vet Med Assoc 1989,11: 1609-1611.
Chew DJ. Menten DJ.Disorders of calcium and phosphorous metabolism. Vet Clin North Am Small Anim Pract 1982. 12: 411-438.
Klausner JS, Bell FW, Hayden DW, Hegstad RL, Johnston SD. Hypercalcemia in two cats with sqaumous cell carcinoma. J Am Vet Med Assoc 1990, 196: 103-105.
Panciera DL. Diagnostic approach to disorders of calcium homeostasis. !n August JR Consultations on Feline Internal Medicine. 2nd ed. WB Saunders. Philadelphia. 1994.161-168.
Birchard SJ, Peterson ME. Jackobson A. Surgical treatment of feline hyperthyroidism. Results of 85 cases. J Am Anim Hosp Assoc 1984. 20: 705-709.
Peterson ME, James KM. Wallance M, Timothy SD. Joseph RJ. Idiopathic hypoparathyroidism in five cats. J Vet Inter Med 1991,5:47-51.
Waters CB. Scott-Moncrieft JCR. Hypocalcemia in cats. Comp Contin Educ Small Anim Pract 1992. 14: 497-506.
Pedersen NC. Nutritional secondary hyperparathyroidism in a cattery associated with the feeding of a diet containing horsemeat. Fel Pract 1983. 13: 19-26.
Bjerkas E. Eclampsia in the cat. J Small Anim Pract 1974,15: 411-414.
Fineo DR. Cornelius LM. Characterization and treatment of water, electrolyte and acid-base imbalance of induced urethral obstruction in the cat. Am J Vet Res 1977. 38: 823-830.
Thrall MA. Grauer GF. Mero ΚΝ. Clinicopathologic findings in dogs and cats with ehtylene glucol intoxication. J Am Vet Med Assoc 1984, 184:37-41.
Hardy RM. Adams LG. Hypophosphatemia. In Kirk's Current Veterinary Therapy X Small Animal Practice. WB Saunders. Philadelphia, 1989.43-47.
Carlson GP. Fluid, electrolyte and acid-base balance. In Kaneko JJ Clinical Biochemistry of Domestic Animals. 4th ed. Academic Press Inc. San Diego, 1989. 559-561 . 564-570.
Schaer M. Hyperkalemia and hypernatremia. In Ettinger SJ. Feldman EC Textbook of Veterinary Internal Medicine. 4th ed. WB Saunders, Philadelphia, 1995. 46-49.
Scott-Moncrieff JCR. Hyponatremia and hypokalemia. In Ettinger SJ, Feldman EC Textbook of Veterinary InternalMedicine. 4th ed, WB Saunders, Philadelphia, 1995,40-45.
Dow SW. Le Couteur RA. Hypokalemic polymyopathy of cats. In Kirk's Current Veterinary Therapy X Small Animal Practice. WB Saunders, Philadelphia. 1989. 812-815.
Kaneko JJ. Appendix VIII: Normal blood analyte values in small and some laboratory animals. In Kaneko JJ Clinical Biochemistry of Domestic Animals. 4"1 ed. Academic Press Ine, San Diego. 1989, 892-897.
Norsworthy GD. Laboratory tests and testing. In Norsworthy GD Feline Practice. JB Lippincott Co, Philadelphia, 1993,81-94.
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